Ocular Brugia pahangi Filariasis Complicated by Severe Macular Damage in Thailand: Case Report and Literature Review
Am J Trop Med Hyg. 2024 Apr 30:tpmd240047. doi: 10.4269/ajtmh.24-0047. Online ahead of print.ABSTRACTExtralymphatic filariasis caused by filaria of zoonotic origins has been frequently reported in Thailand over recent years. Here, we report the first case of ocular filariasis in a 7.5-year-old Thai boy who initially presented with progressive conjunctival redness and blurred vision in his right eye. A small, slender, coiled worm was found and surgically removed from the right anterior chamber. Histopathological examination illustrated predominant eosinophilic inflammation surrounding the parasite, which showed smooth and t...
Source: The American Journal of Tropical Medicine and Hygiene - April 30, 2024 Category: Tropical Medicine Authors: Narut Suphap Thanapong Somkijrungroj Wijak Kongwattananon Wajamon Supawatjariyakul Thanapat Pataradool Kanyarat Kraivichian Watsamon Jantarabenjakul Wasee Tulvatana Kanok Preativatanyou Source Type: research
Deletions of Histidine-Rich Protein 2/3 Genes in Natural Plasmodium falciparum Populations from Cameroon and India: Role of Asymptomatic and Submicroscopic Infections
This study outlines that double deletions that result in false negative RDTs are uncommon in our settings, and highlights the importance of active molecular surveillance for pfhrp2/3 deletions in Cameroon and India.PMID:38688260 | DOI:10.4269/ajtmh.23-0896 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - April 30, 2024 Category: Tropical Medicine Authors: Loick Pradel Kojom Foko Carole Else Eboumbou Moukoko Jahnvi Jakhan Geetika Narang Joseph Hawadak Francine Dorgelesse Kouemo Motse Veena Pande Vineeta Singh Source Type: research
Time to switch gears: how long noncoding RNAs function as epigenetic regulators in Apicomplexan parasites
Curr Opin Microbiol. 2024 Apr 29;79:102484. doi: 10.1016/j.mib.2024.102484. Online ahead of print.ABSTRACTLong noncoding RNAs (lncRNA) are emerging as important regulators of gene expression in eukaryotes. In recent years, a large repertoire of lncRNA were discovered in Apicomplexan parasites and were implicated in several mechanisms of gene expression, including marking genes for activation, contributing to the formation of subnuclear compartments and organization, regulating the deposition of epigenetic modifications, influencing chromatin and chromosomal structure and manipulating host gene expression. Here, we aim to u...
Source: Current Opinion in Microbiology - April 30, 2024 Category: Microbiology Authors: Vera Mitesser Karina Simantov Ron Dzikowski Source Type: research
The ecto-3'-nucleotidase activity of Acanthamoeba castellanii trophozoites increases their adhesion to host cells through the generation of extracellular adenosine
Eur J Protistol. 2024 Apr 26;94:126086. doi: 10.1016/j.ejop.2024.126086. Online ahead of print.ABSTRACTAcanthamoeba castellanii, a free-living amoeba, can be pathogenic to humans causing a corneal infection named Acanthamoeba keratitis (AK). The mannose-binding protein (MBP) is well established as the major factor related to Acanthamoeba pathogenesis. However, additional factors that participate in the adhesion process and protect trophozoites from cytolytic effects caused by host immune responses remain unknown. Ectonucleotidases, including 3'-nucleotidase/nuclease (3'-NT/NU), a bifunctional enzyme that was recently repor...
Source: European Journal of Protistology - April 30, 2024 Category: Microbiology Authors: Eduarda de Souza-Maciel Luiz Fernando Carvalho-Kelly Anita Leocadio Freitas-Mesquita Jos é Roberto Meyer-Fernandes Source Type: research
Drugs in preclinical and early clinical development for the treatment of chagas disease: the current status
Expert Opin Investig Drugs. 2024 Apr 30. doi: 10.1080/13543784.2024.2349289. Online ahead of print.ABSTRACTINTRODUCTION: Chagas disease is spreading faster than expected in different countries and little progress has been reported in the discovery of new drugs to combat Trypanosoma cruzi infection in humans. Recent clinical trials have ended with small hope. The pathophysiology of this neglected disease and the genetic diversity of parasites are exceptionally complex. The only two drugs available to treat patients are far from being safe, and their efficacy in the chronic phase is still unsatisfactory.AREAS COVERED: This r...
Source: Expert Opinion on Investigational Drugs - April 30, 2024 Category: Drugs & Pharmacology Authors: Fernanda Karoline Vieira da Silva Torchelsen Ana Lia Mazzeti Vanessa Carla Furtado Mosqueira Source Type: research
Ocular Brugia pahangi Filariasis Complicated by Severe Macular Damage in Thailand: Case Report and Literature Review
Am J Trop Med Hyg. 2024 Apr 30:tpmd240047. doi: 10.4269/ajtmh.24-0047. Online ahead of print.ABSTRACTExtralymphatic filariasis caused by filaria of zoonotic origins has been frequently reported in Thailand over recent years. Here, we report the first case of ocular filariasis in a 7.5-year-old Thai boy who initially presented with progressive conjunctival redness and blurred vision in his right eye. A small, slender, coiled worm was found and surgically removed from the right anterior chamber. Histopathological examination illustrated predominant eosinophilic inflammation surrounding the parasite, which showed smooth and t...
Source: Am J Trop Med Hyg - April 30, 2024 Category: Infectious Diseases Authors: Narut Suphap Thanapong Somkijrungroj Wijak Kongwattananon Wajamon Supawatjariyakul Thanapat Pataradool Kanyarat Kraivichian Watsamon Jantarabenjakul Wasee Tulvatana Kanok Preativatanyou Source Type: research
Seroprevalence of Toxoplasma gondii and Associated Risk Factors among Pregnant Women in Algeria
Am J Trop Med Hyg. 2024 Apr 30:tpmd230187. doi: 10.4269/ajtmh.23-0187. Online ahead of print.ABSTRACTToxoplasma gondii is an obligate intracellular protozoan parasite affecting all warm-blooded vertebrates, including humans. Infections in humans can lead to severe clinical manifestations in pregnant women and immunocompromised patients. The aim of the present study was to assess seroprevalence of T. gondii infection and to identify the associated risk factors among pregnant women from southern Algeria. A cross-sectional study was conducted from March 2021 to May 2022 among 1,345 pregnant women. A structured questionnaire w...
Source: Am J Trop Med Hyg - April 30, 2024 Category: Infectious Diseases Authors: Soumia Sebaa Jerzy M Behnke Amina Labed Marawan A Abu-Madi Source Type: research
Deletions of Histidine-Rich Protein 2/3 Genes in Natural Plasmodium falciparum Populations from Cameroon and India: Role of Asymptomatic and Submicroscopic Infections
This study outlines that double deletions that result in false negative RDTs are uncommon in our settings, and highlights the importance of active molecular surveillance for pfhrp2/3 deletions in Cameroon and India.PMID:38688260 | DOI:10.4269/ajtmh.23-0896 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - April 30, 2024 Category: Infectious Diseases Authors: Loick Pradel Kojom Foko Carole Else Eboumbou Moukoko Jahnvi Jakhan Geetika Narang Joseph Hawadak Francine Dorgelesse Kouemo Motse Veena Pande Vineeta Singh Source Type: research
Exploring the genetic diversity pattern of PvEBP/DBP2: A promising candidate for an effective Plasmodium vivax vaccine
Acta Trop. 2024 Apr 27:107231. doi: 10.1016/j.actatropica.2024.107231. Online ahead of print.ABSTRACTMalaria remains a public health challenge. Since many control strategies have proven ineffective in eradicating this disease, new strategies are required, among which the design of a multivalent vaccine stands out. However, the effectiveness of this strategy has been hindered, among other reasons, by the genetic diversity observed in parasite antigens. In Plasmodium vivax, the Erythrocyte Binding Protein (PvEBP, also known as DBP2) is an alternate ligand to Duffy Binding Protein (DBP); given its structural resemblance to DB...
Source: Acta Tropica - April 30, 2024 Category: Infectious Diseases Authors: Laura J Hern ández-Zambrano Heliairis Alfonso-Gonz ález Sindy P Buitrago Carlos J Castro-Cavad ía Diego Garz ón-Ospina Source Type: research
Drugs in preclinical and early clinical development for the treatment of chagas disease: the current status
Expert Opin Investig Drugs. 2024 Apr 30. doi: 10.1080/13543784.2024.2349289. Online ahead of print.ABSTRACTINTRODUCTION: Chagas disease is spreading faster than expected in different countries and little progress has been reported in the discovery of new drugs to combat Trypanosoma cruzi infection in humans. Recent clinical trials have ended with small hope. The pathophysiology of this neglected disease and the genetic diversity of parasites are exceptionally complex. The only two drugs available to treat patients are far from being safe, and their efficacy in the chronic phase is still unsatisfactory.AREAS COVERED: This r...
Source: Expert Opinion on Investigational Drugs - April 30, 2024 Category: Drugs & Pharmacology Authors: Fernanda Karoline Vieira da Silva Torchelsen Ana Lia Mazzeti Vanessa Carla Furtado Mosqueira Source Type: research
GSE263298 Safety, effectiveness, and skin immune response in a controlled human infection model of sand fly transmitted cutaneous leishmaniasis.
Contributors : Vivak Parkash ; Helen Ashwin ; Shoumit Dey ; Jovana Sadlova ; Barbora Vojtkova ; Kat Van Bocxlaer ; Rebecca Wiggins ; David Thompson ; Nidhi S Dey ; Charles L Jaffe ; Eli Schwartz ; Petr Volf ; Charles J Lacey ; Alison M Layton ; Paul M KayeSeries Type : OtherOrganism : Homo sapiensThe leishmaniases are globally important parasitic diseases for which no human vaccines are currently available. To facilitate vaccine development, we conducted an open label observational study to establish a controlled human infection model of sand fly-transmitted cutaneous leishmaniasis caused by L. major. Between 24t...
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Canine leishmaniasis in the Americas: etiology, distribution, and clinical and zoonotic importance
Canine leishmaniasis is a widespread disease on the American continent, with cases reported from Uruguay to the USA and Canada. While numerous Leishmania spp. have been reported in dogs in this region, Leishmania... (Source: Parasites and Vectors)
Source: Parasites and Vectors - April 30, 2024 Category: Microbiology Authors: Filipe Dantas-Torres Tags: Review Source Type: research
Molecules, Vol. 29, Pages 2072: Designing Antitrypanosomal and Antileishmanial BODIPY Derivatives: A Computational and In Vitro Assessment
M. Raposo
Leishmaniasis and Human African trypanosomiasis pose significant public health threats in resource-limited regions, accentuated by the drawbacks of the current antiprotozoal treatments and the lack of approved vaccines. Considering the demand for novel therapeutic drugs, a series of BODIPY derivatives with several functionalizations at the meso, 2 and/or 6 positions of the core were synthesized and characterized. The in vitro activity against Trypanosoma brucei and Leishmania major parasites was carried out alongside a human healthy cell line (MRC-5) to establish selectivity indices (SIs). Notably, the meso-s...
Source: Molecules - April 30, 2024 Category: Chemistry Authors: Raquel C. R. Gon çalves Filipe Teixeira Pablo Pe ñalver Susana P. G. Costa Juan C. Morales M. Manuela M. Raposo Tags: Article Source Type: research
Sensors, Vol. 24, Pages 2858: The Mechanism of Short-Circuit Oscillations in Automotive-Grade Multi-Chip Parallel Power Modules and an Effective Mitigation Approach
ng Zhou
Sheng Liu
This paper presents an in-depth analysis of the oscillation phenomenon occurring in multi-chip parallel automotive-grade power modules under short-circuit conditions and investigates three suppression methods. We tested and analyzed two commercial automotive-grade power modules, one containing two chips and the other containing a single chip, and found that short-circuit gate oscillations were more likely to occur in multi-chip parallel packaged modules than in single-chip packaged modules. Through experimental and simulation analyses, we observed that gate oscillations were mainly caused by the int...
Source: Sensors - April 30, 2024 Category: Biotechnology Authors: Kun Ma Yameng Sun Xun Liu Yifan Song Xuehan Li Huimin Shi Zheng Feng Xiao Zhang Yang Zhou Sheng Liu Tags: Article Source Type: research
Seroprevalence of < em > Toxocara < /em > spp. in Pregnant Women: A Systematic Review and Meta-Analysis
CONCLUSIONS: In the present study, significant prevalence was reported; however, considering the limited number of studies, it seems that the actual prevalence of the disease is higher. Therefore, it seems necessary to monitor this health problem in pregnant women.PMID:38682081 | PMC:PMC11055642 | DOI:10.1155/2024/1943353 (Source: Infectious Diseases in Obstetrics and Gynecology)
Source: Infectious Diseases in Obstetrics and Gynecology - April 29, 2024 Category: OBGYN Authors: Sara Shayanfar Saeed Bahadory Ali Taghipour Masoud Foroutan Amir Abdoli Source Type: research
