Hepatolithiasis: Epidemiology, presentation, classification and management of a complex disease
World J Gastroenterol. 2024 Apr 7;30(13):1836-1850. doi: 10.3748/wjg.v30.i13.1836.ABSTRACTThe term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts, above the hilar confluence of the hepatic ducts. The disease is more prevalent in Asia, mainly owing to socioeconomic and dietary factors, as well as the prevalence of biliary parasites. In the last century, owing to migration, its global incidence has increased. The main pathophysiological mechanisms involve cholangitis, bile infection and biliary strictures, creating a self-sustaining cycle that perpetuates the disease, frequently c...
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Rodrigo V Motta Francesca Saffioti Vasileios K Mavroeidis Source Type: research
Autochthonous Plasmodium vivax Infections, Florida, USA, 2023
Emerg Infect Dis. 2024 Apr 25;30(6). doi: 10.3201/eid3006.240336. Online ahead of print.ABSTRACTDuring May-July 2023, a cluster of 7 patients at local hospitals in Florida, USA, received a diagnosis of Plasmodium vivax malaria. Whole-genome sequencing of the organism from 4 patients and phylogenetic analysis with worldwide representative P. vivax genomes indicated probable single parasite introduction from Central/South America.PMID:38662728 | DOI:10.3201/eid3006.240336 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - April 25, 2024 Category: Infectious Diseases Authors: Azhar Muneer Swamy R Adapa Suzane Silbert Kelly Scanlan Harold Vore Andrew Cannons Andrea M Morrison Danielle Stanek Carina Blackmore John H Adams Kami Kim Rays H Y Jiang Liwang Cui Source Type: research
Streptococcus pneumoniae endopeptidase O induces trained immunity against numerous pathogen infections, a key role for G-CSF
Clin Immunol. 2024 Apr 23:110226. doi: 10.1016/j.clim.2024.110226. Online ahead of print.ABSTRACTAntibiotic resistance and the surge of infectious diseases during the pandemic present significant threats to human health. Trained immunity emerges as a promising and innovative approach to address these infections. Synthetic or natural fungal, parasitic and viral components have been reported to induce trained immunity. However, it is not clear whether bacterial virulence proteins can induce protective trained immunity. Our research demonstrates Streptococcus pneumoniae virulence protein PepO, is a highly potent trained immun...
Source: Clinical Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Wenlong Xu Yuan Yuan Zhaoche Shu Ting Guo Bichen Liu Jiangming Xiao Lian Li Yibin Yin Xuemei Zhang Source Type: research
Hepatolithiasis: Epidemiology, presentation, classification and management of a complex disease
World J Gastroenterol. 2024 Apr 7;30(13):1836-1850. doi: 10.3748/wjg.v30.i13.1836.ABSTRACTThe term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts, above the hilar confluence of the hepatic ducts. The disease is more prevalent in Asia, mainly owing to socioeconomic and dietary factors, as well as the prevalence of biliary parasites. In the last century, owing to migration, its global incidence has increased. The main pathophysiological mechanisms involve cholangitis, bile infection and biliary strictures, creating a self-sustaining cycle that perpetuates the disease, frequently c...
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Rodrigo V Motta Francesca Saffioti Vasileios K Mavroeidis Source Type: research
Anti-Anisakis antibodies in colon cancer patients and their relationship with γδ T-cells
Parasitol Res. 2024 Apr 25;123(4):196. doi: 10.1007/s00436-024-08216-y.ABSTRACTMany pathogens are related to carcinogenesis. Chronic inflammation, as a result of persistent infection, leads to DNA damage, higher expression of oncogenes, decreased apoptosis and immunosuppression, which are some of the reasons for cancer induction. Among parasites, Schistosoma, Opistorchis and Clonorchis are recognised as infectious agents which contribute to cancer. A relationship between Anisakis and cancer was hypothesised because cellular responses to Anisakis products could result in inflammation and DNA damage. Previous research has sh...
Source: Cell Research - April 25, 2024 Category: Cytology Authors: Juan C Andreu-Ballester Carmen Cu éllar Javier Colmena-Zaragoza Lorena Galindo-Regal Carolina Hurtado-Marcos Juan Gonz ález-Fernández Zutoia Balciscueta Carlos Garc ía-Ballesteros Francisca L ópez-Chuliá Ana I Jim énez Antonio Llombart-Cussac Source Type: research
Transcript tinkering: RNA modifications in protozoan parasites
Curr Opin Microbiol. 2024 Apr 24;79:102477. doi: 10.1016/j.mib.2024.102477. Online ahead of print.ABSTRACTApicomplexan and trypanosomatid parasites have evolved a wide range of post-transcriptional processes that allow them to replicate, differentiate, and transmit within and among multiple different tissue, host, and vector environments. In this review, we highlight the recent advances that point toward the regulatory potential of RNA modifications in mediating these processes on the coding and noncoding transcriptome throughout the life cycle of protozoan parasites. We discuss the recent technical advancements enabling t...
Source: Current Opinion in Microbiology - April 25, 2024 Category: Microbiology Authors: Tiziano Vignolini Justine E C Couble Gr égory R G Doré Sebastian Baumgarten Source Type: research
Intricate balance of dually-localized catalase modulates infectivity of Leptomonas seymouri (Kinetoplastea: Trypanosomatidae)
Int J Parasitol. 2024 Apr 23:S0020-7519(24)00077-8. doi: 10.1016/j.ijpara.2024.04.007. Online ahead of print.ABSTRACTNearly all aerobic organisms are equipped with catalases, powerful enzymes scavenging hydrogen peroxide and facilitating defense against harmful reactive oxygen species. In trypanosomatids, this enzyme was not present in the common ancestor, yet it had been independently acquired by different lineages of monoxenous trypanosomatids from different bacteria at least three times. This observation posited an obvious question: why was catalase so "sought after" if many trypanosomatid groups do just fine without it...
Source: International Journal for Parasitology - April 25, 2024 Category: Parasitology Authors: Ľubomíra Chmelová Natalya Kraeva Andreu Saura Adam Krayzel Cecilia Stahl Vieira Tain á Neves Ferreira Rodrigo Pedro Soares Barbora Bu čková Arnau Galan Eva Hor áková Barbora Vojtkov á Jovana S ádlová Marina N Malysheva Anzhelika Butenko Galina Source Type: research
Biophysical Evidence for the Amyloid Formation of a Recombinant Rab2 Isoform of Leishmania donovani
CONCLUSION: To our knowledge, this is the first study to report in vitro amyloid-like behaviour of Rab proteins in L donovani. This study provides a novel opportunity to understand the complete biophysical characteristics of Rab2 protein of the lower eukaryote, L. donovani.PMID:38661034 | DOI:10.2174/0109298665299157240327084614 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - April 25, 2024 Category: Biochemistry Authors: None Roshanara Shivani A Muthu None Gulafsha Rati Tandon Angamuthu Selvapandiyan Basir Ahmad Source Type: research
Hepatolithiasis: Epidemiology, presentation, classification and management of a complex disease
World J Gastroenterol. 2024 Apr 7;30(13):1836-1850. doi: 10.3748/wjg.v30.i13.1836.ABSTRACTThe term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts, above the hilar confluence of the hepatic ducts. The disease is more prevalent in Asia, mainly owing to socioeconomic and dietary factors, as well as the prevalence of biliary parasites. In the last century, owing to migration, its global incidence has increased. The main pathophysiological mechanisms involve cholangitis, bile infection and biliary strictures, creating a self-sustaining cycle that perpetuates the disease, frequently c...
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Rodrigo V Motta Francesca Saffioti Vasileios K Mavroeidis Source Type: research
Hepatolithiasis: Epidemiology, presentation, classification and management of a complex disease
World J Gastroenterol. 2024 Apr 7;30(13):1836-1850. doi: 10.3748/wjg.v30.i13.1836.ABSTRACTThe term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts, above the hilar confluence of the hepatic ducts. The disease is more prevalent in Asia, mainly owing to socioeconomic and dietary factors, as well as the prevalence of biliary parasites. In the last century, owing to migration, its global incidence has increased. The main pathophysiological mechanisms involve cholangitis, bile infection and biliary strictures, creating a self-sustaining cycle that perpetuates the disease, frequently c...
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Rodrigo V Motta Francesca Saffioti Vasileios K Mavroeidis Source Type: research
Assessment of the in vitro acaricidal activity of Bravecto ® (fluralaner) and a proposed orange oil-based formulation vehicle for the treatment of Sarcoptes scabiei
Sarcoptic mange is a serious animal welfare concern in bare-nosed wombats (Vombatus ursinus). Fluralaner (Bravecto ®) is a novel acaricide that has recently been utilised for treating mange in wombats. The topical... (Source: Parasites and Vectors)
Source: Parasites and Vectors - April 25, 2024 Category: Microbiology Authors: Kotaro Takano, Scott Carver, Yolandi Vermaak, Katja Fischer, Robert J. Harvey and Kate E. Mounsey Tags: Research Source Type: research
A prevalence study on gastrointestinal parasitic infections of pig (Sus scrofa) in and around Meerut, Western Uttar Pradesh, India
AbstractThe present study was conducted to record the prevalence of gastrointestinal parasites of pigs by faecal sample examination. Faecal samples were collected in three different seasons viz; monsoon, post monsoon and pre monsoon, from in and around Meerut district of Western Uttar Pradesh. A total of 642 faecal samples were collected for a period of one year (2020 –21). The overall prevalence rate recorded for gastrointestinal parasites in pigs was 64.4%.The findings of the present work showed that seasons have a significant role on the prevalence of gastrointestinal parasites infection in pigs, with highest prevalen...
Source: Journal of Parasitic Diseases - April 25, 2024 Category: Parasitology Source Type: research
Sampling is decisive to determination of < i > Leishmania (Viannia) < /i > species
ConclusionsThe type of clinical sample can directly influence the detection and identification ofLeishmania (Viannia) species. Here, we demonstrated that lancet scraping samples consistently allowed the identification of more leishmaniasis cases compared to filter paper imprints or biopsies. This procedure is inexpensive, painless, and easy to implement at the point of care and avoids the need for anesthesia, surgery, and hospitalization and therefore could be used in resource limited settings for both military and civilian populations. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 25, 2024 Category: Tropical Medicine Authors: Maxy B. De los Santos Source Type: research
Spatio-temporal distribution of hospitalizations for chronic Chagas disease and risk factors associated with in-hospital mortality and surgical intervention in Chile
by Nicolhole Atero, Marisa Torres, Ang élica Domínguez, Benjamín Diethelm-Varela, Francisca Córdova-Bührle, Fernando O. Mardones
Chagas disease (CD) is a neglected parasitic zoonotic disease that affects over 6 million people worldwide. We conducted a retrospective study to analyze the spatiotemporal trends and risk factors for hospitalization rates of CD with cardiac and digestive diagnoses in Chile. We used the Mann-Kendall analysis for temporal trends, Global Moran ’s Index, and Local Indicators of Spatial Association to identify spatial autocorrelation, and regression models to determine the risk factors associ...
Source: PLoS Neglected Tropical Diseases - April 25, 2024 Category: Tropical Medicine Authors: Nicolhole Atero Source Type: research
Ancestral aneuploidy and stable chromosomal duplication resulting in differential genome structure and gene expression control in trypanosomatid parasites [RESEARCH]
Aneuploidy is widely observed in both unicellular and multicellular eukaryotes, usually associated with adaptation to stress conditions. Chromosomal duplication stability is a tradeoff between the fitness cost of having unbalanced gene copies and the potential fitness gained from increased dosage of specific advantageous genes. Trypanosomatids, a family of protozoans that include species that cause neglected tropical diseases, are a relevant group to study aneuploidies. Their life cycle has several stressors that could select for different patterns of chromosomal duplications and/or losses, and their nearly universal use o...
Source: Genome Research - April 25, 2024 Category: Genetics & Stem Cells Authors: Reis-Cunha, J. L., Pimenta-Carvalho, S. A., Almeida, L. V., Coqueiro-dos-Santos, A., Marques, C. A., Black, J. A., Damasceno, J., McCulloch, R., Bartholomeu, D. C., Jeffares, D. C. Tags: RESEARCH Source Type: research
