Sensing Inflammation in the Skin and Beyond
The type 2 immune response has evolved to arm the mammalian host with the capacity to expel parasites and noxious environmental substances from barrier surfaces. One critical aspect of this defense mechanism is stimulating protective behavioral responses such as coughing, sneezing, and scratching. Increasingly, it is appreciated that cytokines associated with type 2 immunity such as IL-4, IL-13, and IL-31 play critical roles in triggering mechanical reflexes like itch via direct interactions with sensory neurons. However, the tissue- and cell-specific manner in which these cytokines imprint unique sensory and neuroinflamma...
Source: Videocast - All Events - November 22, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH-FDA Immunology Interest Group 1.11.23
Klaus Fr ü h ’ s research focuses on understanding the molecular interaction between viral pathogens and their hosts, particularly the identification and characterization of viral gene products that modulate the innate and adaptive immune responses. This knowledge is translated into the development and improvement of cytomegalovirus (CMV)-vectored vaccines which are unique in their ability to persistently maintain an immune shield of so called effector memory T cells, including highly unconventional (MHC-II and MHC-E) restricted CD8+ T cells. CMV vectored vaccines have shown protection in non-human primate models of AID...
Source: Videocast - All Events - December 13, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Critical cooperation at the interface between infection and immunity - Day 1
Celebration of Dr. Alan Sher and Immunobiology Section of Laboratory of Parasitic Diseases scientific achievementsAir date: 6/2/2022 9:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - May 23, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Malaria parasites growing inside an infected red blood cell
(blue) will eventually burst out in unison, with millions of other parasites lurking in red blood cells around them, a feat of timing that's coordinated by the parasite’s internal clock.
[Research supported by a U.S. National Science ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - July 21, 2020 Category: Science Source Type: video
IIG Seminar: Defining malaria vaccine responses by single B cell IG sequencing and plasma IgG proteomics
IIG Seminar
Malaria elimination is a global priority and WHO has projected that malaria deaths could double due to COVID19-related health care disruptions. Vaccines have been pivotal for campaigns to eliminate or eradicate other infectious diseases. Malaria transmission blocking vaccines (TBVs) target surface antigens expressed by parasites during their development in mosquitoes in order to interrupt transmission and contribute to malaria elimination. We collected antigen-specific memory B cells from Malian adults immunized with TBV and obtained B cell receptor IG sequences that were used to define the antibody repertoire ...
Source: Videocast - All Events - June 15, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Some plumped-up prawns are doing their part to help curtail the spread of disease
New research provides a roadmap for how entrepreneurs can harness freshwater prawns' voracious appetite for snails to reduce the transmission of parasites that cause schistosomiasis -- the second most devastating parasitic disease worldwide, after malaria -- while still making a profit selling the ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - August 9, 2019 Category: Science Source Type: video
Defining mechanisms of pathogenesis in cutaneous leishmaniasis to develop new approaches to therapy
IIG Seminar
Phil Scott received his Ph.D. from the University of Pennsylvania in 1980 where he studied immunoregulatory mechanisms in experimental cutaneous leishmaniasis, and from there went to Dr. Alan Sher ’ s laboratory at NIH where he defined the role of CD4+ Th1 and Th2 cells in controlling leishmaniasis. He left NIH in 1989 to return to Penn, and rose through the ranks to become Professor of Immunology in 1995. During his time at Penn he served for 12 years as Chair of the Department of Pathobiology in the School of Veterinary Medicine, and is currently Vice Dean for Research& Academic Resources. Dr. Scott ’ s c...
Source: Videocast - All Events - November 26, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Sounding the Alarm and Putting Out the Fire: New Mechanistic Insights into Inflammation Triggered by Invasive Infection
NIH Director ’ s Wednesday Afternoon Lecture Series
The Lieberman laboratory studies cytotoxic T lymphocytes and their role in infection and tumor immunity. They study the molecular pathways used by killer lymphocytes and their cytotoxic granule proteases, called granzymes, and pore-forming proteins, perforin and granulysin, to induce programmed cell death. They have defined a caspase-independent programmed cell death pathway activated by granzyme A. Recent work has identified an unexpected role for granzymes and granulysin in protection against bacteria and parasites. They recently uncovered the molecular basis for infl...
Source: Videocast - All Events - May 23, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
American house dust mite (Dermatophagoides farina) (Image 1)
A scanning electron microscope image of an American house dust mite (Dermatophagoides farina). [See related image Here.]
More about this image
House dust mites are tiny, free-living animals that evolved from a parasitic ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - April 13, 2018 Category: Science Source Type: video
American house dust mite (Dermatophagoides farina) (Image 2)
A scanning electron microscope image of an American house dust mite (Dermatophagoides farina). [See related image Here.]
More about this image
House dust mites are tiny, free-living animals that evolved from a parasitic ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - April 13, 2018 Category: Science Source Type: video
Making the most of it: How malaria parasites use our fibrinolytic proteins to infect the mammalian host and the mosquito
This event is a Stadtman Candidate Seminar in the field of Vector Biology presented by Dr. Joel Vega-Rodr í guez entitled “ Making the most of it: How malaria parasites use our fibrinolytic proteins to infect the mammalian host and the mosquito. ” This seminar is hosted by the Laboratory of Malaria and Vector Research (LMVR), Division of Intramural Research (DIR), NIAIDAir date: 1/24/2018 11:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - January 19, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Innate allergy
Immunology Interest Group Seminar Series
Despite clear roles for classical arms of immunity in maintenance of a healthy commensal microbial flora and protection from invasive pathogenic organisms, the purpose of allergic immunity, which underlies increasingly prevalent diseases like food allergy, asthma and atopic dermatitis, remains puzzling. The discovery of innate lymphoid cells that are programmed to produce cytokines associated with allergic immunity has provided new opportunities to assess basal physiologic processes that involve this canonical tissue response, and may reveal opportunities for re-tuning this arm of i...
Source: Videocast - All Events - March 30, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Is the Right Flavor of Inflammation the Key to Successful Cancer Therapy?
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Romina Goldszmid received her Ph.D. working on dendritic cell-based vaccines for melanoma immunotherapy from the University of Buenos Aires, Argentina, part of which was performed as a visiting scholar in the laboratory of Dr. Ralph Steinman at the Rockefeller University. She then did her postdoctoral training in infectious diseases immunology with Dr. Alan Sher in the Laboratory of Parasitic Diseases (LPD) at NIAID. There, Dr. Goldszmid focused on the interplay between dendritic cells and natural killer cells during the early response to Toxoplasma gondii infecti...
Source: Videocast - All Events - January 23, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Danger-based immunology course, session seven: parasites
Presented by: polly matzingerCategory: SpecialAired date: 11/09/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - November 11, 2015 Category: Journals (General) Tags: Past Events Source Type: video
Danger-based immunology course, session seven: parasites
This is the seventh session of the immunology course based on the Danger model. in it we will discuss the influence of parasites on immune responses. as alan sher puts it, parasites and pathogens are the best immunologists, having had evolutionary time to figure us out.Air date: 11/9/2015 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 6, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
