Hepatolithiasis: Epidemiology, presentation, classification and management of a complex disease
World J Gastroenterol. 2024 Apr 7;30(13):1836-1850. doi: 10.3748/wjg.v30.i13.1836.ABSTRACTThe term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts, above the hilar confluence of the hepatic ducts. The disease is more prevalent in Asia, mainly owing to socioeconomic and dietary factors, as well as the prevalence of biliary parasites. In the last century, owing to migration, its global incidence has increased. The main pathophysiological mechanisms involve cholangitis, bile infection and biliary strictures, creating a self-sustaining cycle that perpetuates the disease, frequently c...
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Rodrigo V Motta Francesca Saffioti Vasileios K Mavroeidis Source Type: research
Hepatolithiasis: Epidemiology, presentation, classification and management of a complex disease
World J Gastroenterol. 2024 Apr 7;30(13):1836-1850. doi: 10.3748/wjg.v30.i13.1836.ABSTRACTThe term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts, above the hilar confluence of the hepatic ducts. The disease is more prevalent in Asia, mainly owing to socioeconomic and dietary factors, as well as the prevalence of biliary parasites. In the last century, owing to migration, its global incidence has increased. The main pathophysiological mechanisms involve cholangitis, bile infection and biliary strictures, creating a self-sustaining cycle that perpetuates the disease, frequently c...
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Rodrigo V Motta Francesca Saffioti Vasileios K Mavroeidis Source Type: research
Streptococcus pneumoniae endopeptidase O induces trained immunity against numerous pathogen infections, a key role for G-CSF
Clin Immunol. 2024 Apr 23:110226. doi: 10.1016/j.clim.2024.110226. Online ahead of print.ABSTRACTAntibiotic resistance and the surge of infectious diseases during the pandemic present significant threats to human health. Trained immunity emerges as a promising and innovative approach to address these infections. Synthetic or natural fungal, parasitic and viral components have been reported to induce trained immunity. However, it is not clear whether bacterial virulence proteins can induce protective trained immunity. Our research demonstrates Streptococcus pneumoniae virulence protein PepO, is a highly potent trained immun...
Source: Clinical Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Wenlong Xu Yuan Yuan Zhaoche Shu Ting Guo Bichen Liu Jiangming Xiao Lian Li Yibin Yin Xuemei Zhang Source Type: research
Transcript tinkering: RNA modifications in protozoan parasites
Curr Opin Microbiol. 2024 Apr 24;79:102477. doi: 10.1016/j.mib.2024.102477. Online ahead of print.ABSTRACTApicomplexan and trypanosomatid parasites have evolved a wide range of post-transcriptional processes that allow them to replicate, differentiate, and transmit within and among multiple different tissue, host, and vector environments. In this review, we highlight the recent advances that point toward the regulatory potential of RNA modifications in mediating these processes on the coding and noncoding transcriptome throughout the life cycle of protozoan parasites. We discuss the recent technical advancements enabling t...
Source: Current Opinion in Microbiology - April 25, 2024 Category: Microbiology Authors: Tiziano Vignolini Justine E C Couble Gr égory R G Doré Sebastian Baumgarten Source Type: research
Intricate balance of dually-localized catalase modulates infectivity of Leptomonas seymouri (Kinetoplastea: Trypanosomatidae)
Int J Parasitol. 2024 Apr 23:S0020-7519(24)00077-8. doi: 10.1016/j.ijpara.2024.04.007. Online ahead of print.ABSTRACTNearly all aerobic organisms are equipped with catalases, powerful enzymes scavenging hydrogen peroxide and facilitating defense against harmful reactive oxygen species. In trypanosomatids, this enzyme was not present in the common ancestor, yet it had been independently acquired by different lineages of monoxenous trypanosomatids from different bacteria at least three times. This observation posited an obvious question: why was catalase so "sought after" if many trypanosomatid groups do just fine without it...
Source: International Journal for Parasitology - April 25, 2024 Category: Parasitology Authors: Ľubomíra Chmelová Natalya Kraeva Andreu Saura Adam Krayzel Cecilia Stahl Vieira Tain á Neves Ferreira Rodrigo Pedro Soares Barbora Bu čková Arnau Galan Eva Hor áková Barbora Vojtkov á Jovana S ádlová Marina N Malysheva Anzhelika Butenko Galina Source Type: research
Biophysical Evidence for the Amyloid Formation of a Recombinant Rab2 Isoform of Leishmania donovani
CONCLUSION: To our knowledge, this is the first study to report in vitro amyloid-like behaviour of Rab proteins in L donovani. This study provides a novel opportunity to understand the complete biophysical characteristics of Rab2 protein of the lower eukaryote, L. donovani.PMID:38661034 | DOI:10.2174/0109298665299157240327084614 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - April 25, 2024 Category: Biochemistry Authors: None Roshanara Shivani A Muthu None Gulafsha Rati Tandon Angamuthu Selvapandiyan Basir Ahmad Source Type: research
Hepatolithiasis: Epidemiology, presentation, classification and management of a complex disease
World J Gastroenterol. 2024 Apr 7;30(13):1836-1850. doi: 10.3748/wjg.v30.i13.1836.ABSTRACTThe term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts, above the hilar confluence of the hepatic ducts. The disease is more prevalent in Asia, mainly owing to socioeconomic and dietary factors, as well as the prevalence of biliary parasites. In the last century, owing to migration, its global incidence has increased. The main pathophysiological mechanisms involve cholangitis, bile infection and biliary strictures, creating a self-sustaining cycle that perpetuates the disease, frequently c...
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Rodrigo V Motta Francesca Saffioti Vasileios K Mavroeidis Source Type: research
Hepatolithiasis: Epidemiology, presentation, classification and management of a complex disease
World J Gastroenterol. 2024 Apr 7;30(13):1836-1850. doi: 10.3748/wjg.v30.i13.1836.ABSTRACTThe term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts, above the hilar confluence of the hepatic ducts. The disease is more prevalent in Asia, mainly owing to socioeconomic and dietary factors, as well as the prevalence of biliary parasites. In the last century, owing to migration, its global incidence has increased. The main pathophysiological mechanisms involve cholangitis, bile infection and biliary strictures, creating a self-sustaining cycle that perpetuates the disease, frequently c...
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Rodrigo V Motta Francesca Saffioti Vasileios K Mavroeidis Source Type: research
Streptococcus pneumoniae endopeptidase O induces trained immunity against numerous pathogen infections, a key role for G-CSF
Clin Immunol. 2024 Apr 23:110226. doi: 10.1016/j.clim.2024.110226. Online ahead of print.ABSTRACTAntibiotic resistance and the surge of infectious diseases during the pandemic present significant threats to human health. Trained immunity emerges as a promising and innovative approach to address these infections. Synthetic or natural fungal, parasitic and viral components have been reported to induce trained immunity. However, it is not clear whether bacterial virulence proteins can induce protective trained immunity. Our research demonstrates Streptococcus pneumoniae virulence protein PepO, is a highly potent trained immun...
Source: Clinical Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Wenlong Xu Yuan Yuan Zhaoche Shu Ting Guo Bichen Liu Jiangming Xiao Lian Li Yibin Yin Xuemei Zhang Source Type: research
Transcript tinkering: RNA modifications in protozoan parasites
Curr Opin Microbiol. 2024 Apr 24;79:102477. doi: 10.1016/j.mib.2024.102477. Online ahead of print.ABSTRACTApicomplexan and trypanosomatid parasites have evolved a wide range of post-transcriptional processes that allow them to replicate, differentiate, and transmit within and among multiple different tissue, host, and vector environments. In this review, we highlight the recent advances that point toward the regulatory potential of RNA modifications in mediating these processes on the coding and noncoding transcriptome throughout the life cycle of protozoan parasites. We discuss the recent technical advancements enabling t...
Source: Current Opinion in Microbiology - April 25, 2024 Category: Microbiology Authors: Tiziano Vignolini Justine E C Couble Gr égory R G Doré Sebastian Baumgarten Source Type: research
Intricate balance of dually-localized catalase modulates infectivity of Leptomonas seymouri (Kinetoplastea: Trypanosomatidae)
Int J Parasitol. 2024 Apr 23:S0020-7519(24)00077-8. doi: 10.1016/j.ijpara.2024.04.007. Online ahead of print.ABSTRACTNearly all aerobic organisms are equipped with catalases, powerful enzymes scavenging hydrogen peroxide and facilitating defense against harmful reactive oxygen species. In trypanosomatids, this enzyme was not present in the common ancestor, yet it had been independently acquired by different lineages of monoxenous trypanosomatids from different bacteria at least three times. This observation posited an obvious question: why was catalase so "sought after" if many trypanosomatid groups do just fine without it...
Source: International Journal for Parasitology - April 25, 2024 Category: Parasitology Authors: Ľubomíra Chmelová Natalya Kraeva Andreu Saura Adam Krayzel Cecilia Stahl Vieira Tain á Neves Ferreira Rodrigo Pedro Soares Barbora Bu čková Arnau Galan Eva Hor áková Barbora Vojtkov á Jovana S ádlová Marina N Malysheva Anzhelika Butenko Galina Source Type: research
Exploring the modulatory influence on the antimalarial activity of amodiaquine using scaffold hybridisation with ferrocene integration
Eur J Med Chem. 2024 Apr 16;271:116429. doi: 10.1016/j.ejmech.2024.116429. Online ahead of print.ABSTRACTAmodiaquine (AQ) is a potent antimalarial drug used in combination with artesunate as part of artemisinin-based combination therapies (ACTs) for malarial treatment. Due to the rising emergence of resistant malaria parasites, some of which have been reported for ACT, the usefulness of AQ as an efficacious therapeutic drug is threatened. Employing the organometallic hybridisation approach, which has been shown to restore the antimalarial activity of chloroquine in the form of an organometallic hybrid clinical candidate fe...
Source: European Journal of Medicinal Chemistry - April 25, 2024 Category: Chemistry Authors: Mziyanda Mbaba Taryn M Golding Reinner O Omondi Roxanne Mohunlal Timothy J Egan Janette Reader Lyn-Marie Birkholtz Gregory S Smith Source Type: research
Biophysical Evidence for the Amyloid Formation of a Recombinant Rab2 Isoform of Leishmania donovani
CONCLUSION: To our knowledge, this is the first study to report in vitro amyloid-like behaviour of Rab proteins in L donovani. This study provides a novel opportunity to understand the complete biophysical characteristics of Rab2 protein of the lower eukaryote, L. donovani.PMID:38661034 | DOI:10.2174/0109298665299157240327084614 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - April 25, 2024 Category: Biochemistry Authors: None Roshanara Shivani A Muthu None Gulafsha Rati Tandon Angamuthu Selvapandiyan Basir Ahmad Source Type: research
Hepatolithiasis: Epidemiology, presentation, classification and management of a complex disease
World J Gastroenterol. 2024 Apr 7;30(13):1836-1850. doi: 10.3748/wjg.v30.i13.1836.ABSTRACTThe term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts, above the hilar confluence of the hepatic ducts. The disease is more prevalent in Asia, mainly owing to socioeconomic and dietary factors, as well as the prevalence of biliary parasites. In the last century, owing to migration, its global incidence has increased. The main pathophysiological mechanisms involve cholangitis, bile infection and biliary strictures, creating a self-sustaining cycle that perpetuates the disease, frequently c...
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Rodrigo V Motta Francesca Saffioti Vasileios K Mavroeidis Source Type: research
Autochthonous Plasmodium vivax Infections, Florida, USA, 2023
Emerg Infect Dis. 2024 Apr 25;30(6). doi: 10.3201/eid3006.240336. Online ahead of print.ABSTRACTDuring May-July 2023, a cluster of 7 patients at local hospitals in Florida, USA, received a diagnosis of Plasmodium vivax malaria. Whole-genome sequencing of the organism from 4 patients and phylogenetic analysis with worldwide representative P. vivax genomes indicated probable single parasite introduction from Central/South America.PMID:38662728 | DOI:10.3201/eid3006.240336 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - April 25, 2024 Category: Infectious Diseases Authors: Azhar Muneer Swamy R Adapa Suzane Silbert Kelly Scanlan Harold Vore Andrew Cannons Andrea M Morrison Danielle Stanek Carina Blackmore John H Adams Kami Kim Rays H Y Jiang Liwang Cui Source Type: research
