Non-resident definitive host presence is sufficient to sustain avian schistosome populations
This study demonstrates that the diversity of avian schistosomes at the study lakes would likely make targeting a single species of swimmer's itch-causing parasite meaningless from a swimmer's itch control perspective. Our data also suggest that removing the common merganser is not an effective control strategy for the T. stagnicolae parasite, likely due to contributions of the parasite made by non-resident birds, possibly migrants, in the autumn and spring. It appears likely that only minimal contact time between the definitive host and the lake ecosystem is required to contribute sufficient parasite numbers to maintain a...
Source: International Journal for Parasitology - January 10, 2022 Category: Parasitology Authors: Sydney P Rudko Brooke A McPhail Ronald L Reimink Kelsey Froelich Alyssa Turnbull Patrick C Hanington Source Type: research

Non-resident definitive host presence is sufficient to sustain avian schistosome populations
This study demonstrates that the diversity of avian schistosomes at the study lakes would likely make targeting a single species of swimmer's itch-causing parasite meaningless from a swimmer's itch control perspective. Our data also suggest that removing the common merganser is not an effective control strategy for the T. stagnicolae parasite, likely due to contributions of the parasite made by non-resident birds, possibly migrants, in the autumn and spring. It appears likely that only minimal contact time between the definitive host and the lake ecosystem is required to contribute sufficient parasite numbers to maintain a...
Source: International Journal for Parasitology - January 10, 2022 Category: Parasitology Authors: Sydney P Rudko Brooke A McPhail Ronald L Reimink Kelsey Froelich Alyssa Turnbull Patrick C Hanington Source Type: research

Non-resident definitive host presence is sufficient to sustain avian schistosome populations
This study demonstrates that the diversity of avian schistosomes at the study lakes would likely make targeting a single species of swimmer's itch-causing parasite meaningless from a swimmer's itch control perspective. Our data also suggest that removing the common merganser is not an effective control strategy for the T. stagnicolae parasite, likely due to contributions of the parasite made by non-resident birds, possibly migrants, in the autumn and spring. It appears likely that only minimal contact time between the definitive host and the lake ecosystem is required to contribute sufficient parasite numbers to maintain a...
Source: International Journal for Parasitology - January 10, 2022 Category: Parasitology Authors: Sydney P Rudko Brooke A McPhail Ronald L Reimink Kelsey Froelich Alyssa Turnbull Patrick C Hanington Source Type: research

Non-resident definitive host presence is sufficient to sustain avian schistosome populations
This study demonstrates that the diversity of avian schistosomes at the study lakes would likely make targeting a single species of swimmer's itch-causing parasite meaningless from a swimmer's itch control perspective. Our data also suggest that removing the common merganser is not an effective control strategy for the T. stagnicolae parasite, likely due to contributions of the parasite made by non-resident birds, possibly migrants, in the autumn and spring. It appears likely that only minimal contact time between the definitive host and the lake ecosystem is required to contribute sufficient parasite numbers to maintain a...
Source: International Journal for Parasitology - January 10, 2022 Category: Parasitology Authors: Sydney P Rudko Brooke A McPhail Ronald L Reimink Kelsey Froelich Alyssa Turnbull Patrick C Hanington Source Type: research

Non-resident definitive host presence is sufficient to sustain avian schistosome populations
This study demonstrates that the diversity of avian schistosomes at the study lakes would likely make targeting a single species of swimmer's itch-causing parasite meaningless from a swimmer's itch control perspective. Our data also suggest that removing the common merganser is not an effective control strategy for the T. stagnicolae parasite, likely due to contributions of the parasite made by non-resident birds, possibly migrants, in the autumn and spring. It appears likely that only minimal contact time between the definitive host and the lake ecosystem is required to contribute sufficient parasite numbers to maintain a...
Source: International Journal for Parasitology - January 10, 2022 Category: Parasitology Authors: Sydney P Rudko Brooke A McPhail Ronald L Reimink Kelsey Froelich Alyssa Turnbull Patrick C Hanington Source Type: research

Non-resident definitive host presence is sufficient to sustain avian schistosome populations
This study demonstrates that the diversity of avian schistosomes at the study lakes would likely make targeting a single species of swimmer's itch-causing parasite meaningless from a swimmer's itch control perspective. Our data also suggest that removing the common merganser is not an effective control strategy for the T. stagnicolae parasite, likely due to contributions of the parasite made by non-resident birds, possibly migrants, in the autumn and spring. It appears likely that only minimal contact time between the definitive host and the lake ecosystem is required to contribute sufficient parasite numbers to maintain a...
Source: International Journal for Parasitology - January 10, 2022 Category: Parasitology Authors: Sydney P Rudko Brooke A McPhail Ronald L Reimink Kelsey Froelich Alyssa Turnbull Patrick C Hanington Source Type: research

Come with me if you want to live: sympatric parasites follow different transmission routes through aquatic host communities
Int J Parasitol. 2021 Dec 30:S0020-7519(21)00351-9. doi: 10.1016/j.ijpara.2021.11.009. Online ahead of print.ABSTRACTCommunity composition, including the relative density of each host species, plays a vital role in the transmission of parasites or disease in freshwater ecosystems. Whereas some host species can effectively transmit parasites, others can act as dead ends (non-viable transmission routes), accumulating large numbers of parasites throughout their life, thus becoming important sinks for parasite populations. Although population sinks have been identified in certain host-parasite systems, robust field estimates o...
Source: International Journal for Parasitology - January 2, 2022 Category: Parasitology Authors: Jean-Fran çois Doherty Robert Poulin Source Type: research

Come with me if you want to live: sympatric parasites follow different transmission routes through aquatic host communities
Int J Parasitol. 2021 Dec 30:S0020-7519(21)00351-9. doi: 10.1016/j.ijpara.2021.11.009. Online ahead of print.ABSTRACTCommunity composition, including the relative density of each host species, plays a vital role in the transmission of parasites or disease in freshwater ecosystems. Whereas some host species can effectively transmit parasites, others can act as dead ends (non-viable transmission routes), accumulating large numbers of parasites throughout their life, thus becoming important sinks for parasite populations. Although population sinks have been identified in certain host-parasite systems, robust field estimates o...
Source: International Journal for Parasitology - January 2, 2022 Category: Parasitology Authors: Jean-Fran çois Doherty Robert Poulin Source Type: research

Come with me if you want to live: sympatric parasites follow different transmission routes through aquatic host communities
Int J Parasitol. 2021 Dec 30:S0020-7519(21)00351-9. doi: 10.1016/j.ijpara.2021.11.009. Online ahead of print.ABSTRACTCommunity composition, including the relative density of each host species, plays a vital role in the transmission of parasites or disease in freshwater ecosystems. Whereas some host species can effectively transmit parasites, others can act as dead ends (non-viable transmission routes), accumulating large numbers of parasites throughout their life, thus becoming important sinks for parasite populations. Although population sinks have been identified in certain host-parasite systems, robust field estimates o...
Source: International Journal for Parasitology - January 2, 2022 Category: Parasitology Authors: Jean-Fran çois Doherty Robert Poulin Source Type: research

B cell clonal expansion and mutation in the immunoglobulin heavy chain variable domain in response to Pfs230 and Pfs25 malaria vaccines
Int J Parasitol. 2021 Dec 9:S0020-7519(21)00335-0. doi: 10.1016/j.ijpara.2021.11.008. Online ahead of print.ABSTRACTMalaria transmission-blocking vaccines induce antibodies that target Plasmodium in the mosquito vector. We recently reported that Pfs230 vaccine achieves activity superior to Pfs25 in humans. Here, we describe clonal expansion in the variable region of immunoglobulin heavy chains (VH) of antigen-specific single B cells collected from humans immunised with Pfs230D1-EPA or Pfs25-EPA conjugate vaccines formulated in Alhydrogel®. Based on studies of CD27+ memory B cells following Pfs230 vaccination, clonal ex...
Source: International Journal for Parasitology - December 13, 2021 Category: Parasitology Authors: Camila H Coelho Jacob D Galson Johannes Tr ück Patrick E Duffy Source Type: research

B cell clonal expansion and mutation in the immunoglobulin heavy chain variable domain in response to Pfs230 and Pfs25 malaria vaccines
Int J Parasitol. 2021 Dec 9:S0020-7519(21)00335-0. doi: 10.1016/j.ijpara.2021.11.008. Online ahead of print.ABSTRACTMalaria transmission-blocking vaccines induce antibodies that target Plasmodium in the mosquito vector. We recently reported that Pfs230 vaccine achieves activity superior to Pfs25 in humans. Here, we describe clonal expansion in the variable region of immunoglobulin heavy chains (VH) of antigen-specific single B cells collected from humans immunised with Pfs230D1-EPA or Pfs25-EPA conjugate vaccines formulated in Alhydrogel®. Based on studies of CD27+ memory B cells following Pfs230 vaccination, clonal ex...
Source: International Journal for Parasitology - December 13, 2021 Category: Parasitology Authors: Camila H Coelho Jacob D Galson Johannes Tr ück Patrick E Duffy Source Type: research

B cell clonal expansion and mutation in the immunoglobulin heavy chain variable domain in response to Pfs230 and Pfs25 malaria vaccines
Int J Parasitol. 2021 Dec 9:S0020-7519(21)00335-0. doi: 10.1016/j.ijpara.2021.11.008. Online ahead of print.ABSTRACTMalaria transmission-blocking vaccines induce antibodies that target Plasmodium in the mosquito vector. We recently reported that Pfs230 vaccine achieves activity superior to Pfs25 in humans. Here, we describe clonal expansion in the variable region of immunoglobulin heavy chains (VH) of antigen-specific single B cells collected from humans immunised with Pfs230D1-EPA or Pfs25-EPA conjugate vaccines formulated in Alhydrogel®. Based on studies of CD27+ memory B cells following Pfs230 vaccination, clonal ex...
Source: International Journal for Parasitology - December 13, 2021 Category: Parasitology Authors: Camila H Coelho Jacob D Galson Johannes Tr ück Patrick E Duffy Source Type: research

B cell clonal expansion and mutation in the immunoglobulin heavy chain variable domain in response to Pfs230 and Pfs25 malaria vaccines
Int J Parasitol. 2021 Dec 9:S0020-7519(21)00335-0. doi: 10.1016/j.ijpara.2021.11.008. Online ahead of print.ABSTRACTMalaria transmission-blocking vaccines induce antibodies that target Plasmodium in the mosquito vector. We recently reported that Pfs230 vaccine achieves activity superior to Pfs25 in humans. Here, we describe clonal expansion in the variable region of immunoglobulin heavy chains (VH) of antigen-specific single B cells collected from humans immunised with Pfs230D1-EPA or Pfs25-EPA conjugate vaccines formulated in Alhydrogel®. Based on studies of CD27+ memory B cells following Pfs230 vaccination, clonal ex...
Source: International Journal for Parasitology - December 13, 2021 Category: Parasitology Authors: Camila H Coelho Jacob D Galson Johannes Tr ück Patrick E Duffy Source Type: research

B cell clonal expansion and mutation in the immunoglobulin heavy chain variable domain in response to Pfs230 and Pfs25 malaria vaccines
Int J Parasitol. 2021 Dec 9:S0020-7519(21)00335-0. doi: 10.1016/j.ijpara.2021.11.008. Online ahead of print.ABSTRACTMalaria transmission-blocking vaccines induce antibodies that target Plasmodium in the mosquito vector. We recently reported that Pfs230 vaccine achieves activity superior to Pfs25 in humans. Here, we describe clonal expansion in the variable region of immunoglobulin heavy chains (VH) of antigen-specific single B cells collected from humans immunised with Pfs230D1-EPA or Pfs25-EPA conjugate vaccines formulated in Alhydrogel®. Based on studies of CD27+ memory B cells following Pfs230 vaccination, clonal ex...
Source: International Journal for Parasitology - December 13, 2021 Category: Parasitology Authors: Camila H Coelho Jacob D Galson Johannes Tr ück Patrick E Duffy Source Type: research

B cell clonal expansion and mutation in the immunoglobulin heavy chain variable domain in response to Pfs230 and Pfs25 malaria vaccines
Int J Parasitol. 2021 Dec 9:S0020-7519(21)00335-0. doi: 10.1016/j.ijpara.2021.11.008. Online ahead of print.ABSTRACTMalaria transmission-blocking vaccines induce antibodies that target Plasmodium in the mosquito vector. We recently reported that Pfs230 vaccine achieves activity superior to Pfs25 in humans. Here, we describe clonal expansion in the variable region of immunoglobulin heavy chains (VH) of antigen-specific single B cells collected from humans immunised with Pfs230D1-EPA or Pfs25-EPA conjugate vaccines formulated in Alhydrogel®. Based on studies of CD27+ memory B cells following Pfs230 vaccination, clonal ex...
Source: International Journal for Parasitology - December 13, 2021 Category: Parasitology Authors: Camila H Coelho Jacob D Galson Johannes Tr ück Patrick E Duffy Source Type: research

B cell clonal expansion and mutation in the immunoglobulin heavy chain variable domain in response to Pfs230 and Pfs25 malaria vaccines
Int J Parasitol. 2021 Dec 9:S0020-7519(21)00335-0. doi: 10.1016/j.ijpara.2021.11.008. Online ahead of print.ABSTRACTMalaria transmission-blocking vaccines induce antibodies that target Plasmodium in the mosquito vector. We recently reported that Pfs230 vaccine achieves superior activity to Pfs25 in humans. Here, we describe clonal expansion in the variable region of immunoglobulin heavy chains (VH) of antigen-specific single B cells collected from humans immunized with Pfs230D1-EPA or Pfs25-EPA conjugate vaccines formulated in Alhydrogel®. Based on studies of CD27+ memory B cells following Pfs230 vaccination, clonal ex...
Source: International Journal for Parasitology - December 13, 2021 Category: Parasitology Authors: Camila H Coelho Jacob D Galson Johannes Tr ück Patrick E Duffy Source Type: research

B cell clonal expansion and mutation in the immunoglobulin heavy chain variable domain in response to Pfs230 and Pfs25 malaria vaccines
Int J Parasitol. 2021 Dec 9:S0020-7519(21)00335-0. doi: 10.1016/j.ijpara.2021.11.008. Online ahead of print.ABSTRACTMalaria transmission-blocking vaccines induce antibodies that target Plasmodium in the mosquito vector. We recently reported that Pfs230 vaccine achieves superior activity to Pfs25 in humans. Here, we describe clonal expansion in the variable region of immunoglobulin heavy chains (VH) of antigen-specific single B cells collected from humans immunized with Pfs230D1-EPA or Pfs25-EPA conjugate vaccines formulated in Alhydrogel®. Based on studies of CD27+ memory B cells following Pfs230 vaccination, clonal ex...
Source: International Journal for Parasitology - December 13, 2021 Category: Parasitology Authors: Camila H Coelho Jacob D Galson Johannes Tr ück Patrick E Duffy Source Type: research

B cell clonal expansion and mutation in the immunoglobulin heavy chain variable domain in response to Pfs230 and Pfs25 malaria vaccines
Int J Parasitol. 2021 Dec 9:S0020-7519(21)00335-0. doi: 10.1016/j.ijpara.2021.11.008. Online ahead of print.ABSTRACTMalaria transmission-blocking vaccines induce antibodies that target Plasmodium in the mosquito vector. We recently reported that Pfs230 vaccine achieves superior activity to Pfs25 in humans. Here, we describe clonal expansion in the variable region of immunoglobulin heavy chains (VH) of antigen-specific single B cells collected from humans immunized with Pfs230D1-EPA or Pfs25-EPA conjugate vaccines formulated in Alhydrogel®. Based on studies of CD27+ memory B cells following Pfs230 vaccination, clonal ex...
Source: International Journal for Parasitology - December 13, 2021 Category: Parasitology Authors: Camila H Coelho Jacob D Galson Johannes Tr ück Patrick E Duffy Source Type: research

B cell clonal expansion and mutation in the immunoglobulin heavy chain variable domain in response to Pfs230 and Pfs25 malaria vaccines
Int J Parasitol. 2021 Dec 9:S0020-7519(21)00335-0. doi: 10.1016/j.ijpara.2021.11.008. Online ahead of print.ABSTRACTMalaria transmission-blocking vaccines induce antibodies that target Plasmodium in the mosquito vector. We recently reported that Pfs230 vaccine achieves superior activity to Pfs25 in humans. Here, we describe clonal expansion in the variable region of immunoglobulin heavy chains (VH) of antigen-specific single B cells collected from humans immunized with Pfs230D1-EPA or Pfs25-EPA conjugate vaccines formulated in Alhydrogel®. Based on studies of CD27+ memory B cells following Pfs230 vaccination, clonal ex...
Source: International Journal for Parasitology - December 13, 2021 Category: Parasitology Authors: Camila H Coelho Jacob D Galson Johannes Tr ück Patrick E Duffy Source Type: research

B cell clonal expansion and mutation in the immunoglobulin heavy chain variable domain in response to Pfs230 and Pfs25 malaria vaccines
Int J Parasitol. 2021 Dec 9:S0020-7519(21)00335-0. doi: 10.1016/j.ijpara.2021.11.008. Online ahead of print.ABSTRACTMalaria transmission-blocking vaccines induce antibodies that target Plasmodium in the mosquito vector. We recently reported that Pfs230 vaccine achieves superior activity to Pfs25 in humans. Here, we describe clonal expansion in the variable region of immunoglobulin heavy chains (VH) of antigen-specific single B cells collected from humans immunized with Pfs230D1-EPA or Pfs25-EPA conjugate vaccines formulated in Alhydrogel®. Based on studies of CD27+ memory B cells following Pfs230 vaccination, clonal ex...
Source: International Journal for Parasitology - December 13, 2021 Category: Parasitology Authors: Camila H Coelho Jacob D Galson Johannes Tr ück Patrick E Duffy Source Type: research

B cell clonal expansion and mutation in the immunoglobulin heavy chain variable domain in response to Pfs230 and Pfs25 malaria vaccines
Int J Parasitol. 2021 Dec 9:S0020-7519(21)00335-0. doi: 10.1016/j.ijpara.2021.11.008. Online ahead of print.ABSTRACTMalaria transmission-blocking vaccines induce antibodies that target Plasmodium in the mosquito vector. We recently reported that Pfs230 vaccine achieves superior activity to Pfs25 in humans. Here, we describe clonal expansion in the variable region of immunoglobulin heavy chains (VH) of antigen-specific single B cells collected from humans immunized with Pfs230D1-EPA or Pfs25-EPA conjugate vaccines formulated in Alhydrogel®. Based on studies of CD27+ memory B cells following Pfs230 vaccination, clonal ex...
Source: International Journal for Parasitology - December 13, 2021 Category: Parasitology Authors: Camila H Coelho Jacob D Galson Johannes Tr ück Patrick E Duffy Source Type: research

B cell clonal expansion and mutation in the immunoglobulin heavy chain variable domain in response to Pfs230 and Pfs25 malaria vaccines
Int J Parasitol. 2021 Dec 9:S0020-7519(21)00335-0. doi: 10.1016/j.ijpara.2021.11.008. Online ahead of print.ABSTRACTMalaria transmission-blocking vaccines induce antibodies that target Plasmodium in the mosquito vector. We recently reported that Pfs230 vaccine achieves superior activity to Pfs25 in humans. Here, we describe clonal expansion in the variable region of immunoglobulin heavy chains (VH) of antigen-specific single B cells collected from humans immunized with Pfs230D1-EPA or Pfs25-EPA conjugate vaccines formulated in Alhydrogel®. Based on studies of CD27+ memory B cells following Pfs230 vaccination, clonal ex...
Source: International Journal for Parasitology - December 13, 2021 Category: Parasitology Authors: Camila H Coelho Jacob D Galson Johannes Tr ück Patrick E Duffy Source Type: research

B cell clonal expansion and mutation in the immunoglobulin heavy chain variable domain in response to Pfs230 and Pfs25 malaria vaccines
Int J Parasitol. 2021 Dec 9:S0020-7519(21)00335-0. doi: 10.1016/j.ijpara.2021.11.008. Online ahead of print.ABSTRACTMalaria transmission-blocking vaccines induce antibodies that target Plasmodium in the mosquito vector. We recently reported that Pfs230 vaccine achieves superior activity to Pfs25 in humans. Here, we describe clonal expansion in the variable region of immunoglobulin heavy chains (VH) of antigen-specific single B cells collected from humans immunized with Pfs230D1-EPA or Pfs25-EPA conjugate vaccines formulated in Alhydrogel®. Based on studies of CD27+ memory B cells following Pfs230 vaccination, clonal ex...
Source: International Journal for Parasitology - December 13, 2021 Category: Parasitology Authors: Camila H Coelho Jacob D Galson Johannes Tr ück Patrick E Duffy Source Type: research

B cell clonal expansion and mutation in the immunoglobulin heavy chain variable domain in response to Pfs230 and Pfs25 malaria vaccines
Int J Parasitol. 2021 Dec 9:S0020-7519(21)00335-0. doi: 10.1016/j.ijpara.2021.11.008. Online ahead of print.ABSTRACTMalaria transmission-blocking vaccines induce antibodies that target Plasmodium in the mosquito vector. We recently reported that Pfs230 vaccine achieves superior activity to Pfs25 in humans. Here, we describe clonal expansion in the variable region of immunoglobulin heavy chains (VH) of antigen-specific single B cells collected from humans immunized with Pfs230D1-EPA or Pfs25-EPA conjugate vaccines formulated in Alhydrogel®. Based on studies of CD27+ memory B cells following Pfs230 vaccination, clonal ex...
Source: International Journal for Parasitology - December 13, 2021 Category: Parasitology Authors: Camila H Coelho Jacob D Galson Johannes Tr ück Patrick E Duffy Source Type: research

Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B
Int J Parasitol. 2021 Dec 4:S0020-7519(21)00315-5. doi: 10.1016/j.ijpara.2021.11.007. Online ahead of print.ABSTRACTSchistosomiasis is a tropical parasitic disease, in which the major clinical manifestation includes hepatosplenomegaly, portal hypertension, and organs fibrosis. Clinically, treatment of schistosomiasis involves the use of praziquantel (PZQ) and supportive care, which does not improve the patient's outcome as liver injuries persist. Here we show the beneficial effects of using PZQ in combination with Schisandrin B (Sch B). Concomitant treatment with PZQ and Sch B resulted in a significant improvement of hepat...
Source: International Journal for Parasitology - December 7, 2021 Category: Parasitology Authors: Ho Yin Pekkle Lam Po-Ching Cheng Shih-Yi Peng Source Type: research

Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B
Int J Parasitol. 2021 Dec 4:S0020-7519(21)00315-5. doi: 10.1016/j.ijpara.2021.11.007. Online ahead of print.ABSTRACTSchistosomiasis is a tropical parasitic disease, in which the major clinical manifestation includes hepatosplenomegaly, portal hypertension, and organs fibrosis. Clinically, treatment of schistosomiasis involves the use of praziquantel (PZQ) and supportive care, which does not improve the patient's outcome as liver injuries persist. Here we show the beneficial effects of using PZQ in combination with Schisandrin B (Sch B). Concomitant treatment with PZQ and Sch B resulted in a significant improvement of hepat...
Source: International Journal for Parasitology - December 7, 2021 Category: Parasitology Authors: Ho Yin Pekkle Lam Po-Ching Cheng Shih-Yi Peng Source Type: research

Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B
Int J Parasitol. 2021 Dec 4:S0020-7519(21)00315-5. doi: 10.1016/j.ijpara.2021.11.007. Online ahead of print.ABSTRACTSchistosomiasis is a tropical parasitic disease, in which the major clinical manifestation includes hepatosplenomegaly, portal hypertension, and organs fibrosis. Clinically, treatment of schistosomiasis involves the use of praziquantel (PZQ) and supportive care, which does not improve the patient's outcome as liver injuries persist. Here we show the beneficial effects of using PZQ in combination with Schisandrin B (Sch B). Concomitant treatment with PZQ and Sch B resulted in a significant improvement of hepat...
Source: International Journal for Parasitology - December 7, 2021 Category: Parasitology Authors: Ho Yin Pekkle Lam Po-Ching Cheng Shih-Yi Peng Source Type: research

Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B
Int J Parasitol. 2021 Dec 4:S0020-7519(21)00315-5. doi: 10.1016/j.ijpara.2021.11.007. Online ahead of print.ABSTRACTSchistosomiasis is a tropical parasitic disease, in which the major clinical manifestation includes hepatosplenomegaly, portal hypertension, and organs fibrosis. Clinically, treatment of schistosomiasis involves the use of praziquantel (PZQ) and supportive care, which does not improve the patient's outcome as liver injuries persist. Here we show the beneficial effects of using PZQ in combination with Schisandrin B (Sch B). Concomitant treatment with PZQ and Sch B resulted in a significant improvement of hepat...
Source: International Journal for Parasitology - December 7, 2021 Category: Parasitology Authors: Ho Yin Pekkle Lam Po-Ching Cheng Shih-Yi Peng Source Type: research

Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B
Int J Parasitol. 2021 Dec 4:S0020-7519(21)00315-5. doi: 10.1016/j.ijpara.2021.11.007. Online ahead of print.ABSTRACTSchistosomiasis is a tropical parasitic disease, in which the major clinical manifestation includes hepatosplenomegaly, portal hypertension, and organs fibrosis. Clinically, treatment of schistosomiasis involves the use of praziquantel (PZQ) and supportive care, which does not improve the patient's outcome as liver injuries persist. Here we show the beneficial effects of using PZQ in combination with Schisandrin B (Sch B). Concomitant treatment with PZQ and Sch B resulted in a significant improvement of hepat...
Source: International Journal for Parasitology - December 7, 2021 Category: Parasitology Authors: Ho Yin Pekkle Lam Po-Ching Cheng Shih-Yi Peng Source Type: research

A new species of mammalian trypanosome, Trypanosoma (Megatrypanum) bubalisi sp. nov., found in the freshwater leech Hirudinaria manillensis
Int J Parasitol. 2021 Dec 1:S0020-7519(21)00316-7. doi: 10.1016/j.ijpara.2021.10.009. Online ahead of print.ABSTRACTLeeches have long been considered potential vectors for the aquatic lineage of trypanosomes, while bloodsucking insects are generally considered as the vectors for the terrestrial lineage of trypanosomes. The freshwater leech, Hirudinaria manillensis, is a widely distributed species in southern China and could potentially act as the vector for trypanosomes. Prior to this study, no trypanosomes had been reported from this leech. However, in this study, leeches were collected from three different places in Guan...
Source: International Journal for Parasitology - December 5, 2021 Category: Parasitology Authors: Bi-Xiu Su Ju-Feng Wang Ting-Bao Yang Geoff Hide De-Hua Lai Zhao-Rong Lun Source Type: research

Helminth-induced CD9 < sup > + < /sup > B-cell subset alleviates obesity-associated inflammation via IL-10 production
In conclusion, schistosome infection can induce regulatory CD9+ B cell production, which plays a critical role in the regulation of metabolic disorders through IL-10 production.PMID:34863801 | DOI:10.1016/j.ijpara.2021.08.009 (Source: International Journal for Parasitology)
Source: International Journal for Parasitology - December 5, 2021 Category: Parasitology Authors: Maining Li Huiquan Wang Yangyue Ni Chen Li Xuejun Xu Hao Chang Zhipeng Xu Min Hou Minjun Ji Source Type: research

Bacterial community dynamics following antibiotic exposure in a trematode parasite
Int J Parasitol. 2021 Dec 1:S0020-7519(21)00313-1. doi: 10.1016/j.ijpara.2021.11.006. Online ahead of print.ABSTRACTParasites harbour rich microbial communities that may play a role in host-parasite interactions, from influencing the parasite's infectivity to modulating its virulence. Experimental manipulation of a parasite's microbes would be essential, however, in order to establish their causal role. Here, we tested whether indirect exposure of a trematode parasite within its snail intermediate host to a variety of antibiotics could alter its bacterial community. Based on sequencing the prokaryotic 16S ssrRNA gene, we c...
Source: International Journal for Parasitology - December 5, 2021 Category: Parasitology Authors: F átima Jorge C éline Froissard Nolwenn M Dheilly Robert Poulin Source Type: research

Sex-biased parasitism, host mass and mutualistic bat flies: an antagonistic individual-based network of bat-bat fly interactions
Int J Parasitol. 2021 Dec 1:S0020-7519(21)00317-9. doi: 10.1016/j.ijpara.2021.10.010. Online ahead of print.ABSTRACTIndividual-based networks provide the building blocks for community-level networks. However, network studies of bats and their parasites have focused only on the species level. Intrapopulation variation may allow certain host individuals to play important roles in the dynamics of the parasites. Therefore, we evaluated how the variation in host sex, body size, ectoparasite abundance and co-occurrence configure individual-based networks of the lesser bulldog bat Noctilio albiventris and bat flies. We expected b...
Source: International Journal for Parasitology - December 5, 2021 Category: Parasitology Authors: Daniel Maximo Correa Alcantara Gustavo Graciolli Ronaldo Toma Camila Silveira Souza Source Type: research

A new species of mammalian trypanosome, Trypanosoma (Megatrypanum) bubalisi sp. nov., found in the freshwater leech Hirudinaria manillensis
Int J Parasitol. 2021 Dec 1:S0020-7519(21)00316-7. doi: 10.1016/j.ijpara.2021.10.009. Online ahead of print.ABSTRACTLeeches have long been considered potential vectors for the aquatic lineage of trypanosomes, while bloodsucking insects are generally considered as the vectors for the terrestrial lineage of trypanosomes. The freshwater leech, Hirudinaria manillensis, is a widely distributed species in southern China and could potentially act as the vector for trypanosomes. Prior to this study, no trypanosomes had been reported from this leech. However, in this study, leeches were collected from three different places in Guan...
Source: International Journal for Parasitology - December 5, 2021 Category: Parasitology Authors: Bi-Xiu Su Ju-Feng Wang Ting-Bao Yang Geoff Hide De-Hua Lai Zhao-Rong Lun Source Type: research

Helminth-induced CD9 < sup > + < /sup > B-cell subset alleviates obesity-associated inflammation via IL-10 production
In conclusion, schistosome infection can induce regulatory CD9+ B cell production, which plays a critical role in the regulation of metabolic disorders through IL-10 production.PMID:34863801 | DOI:10.1016/j.ijpara.2021.08.009 (Source: International Journal for Parasitology)
Source: International Journal for Parasitology - December 5, 2021 Category: Parasitology Authors: Maining Li Huiquan Wang Yangyue Ni Chen Li Xuejun Xu Hao Chang Zhipeng Xu Min Hou Minjun Ji Source Type: research

Bacterial community dynamics following antibiotic exposure in a trematode parasite
Int J Parasitol. 2021 Dec 1:S0020-7519(21)00313-1. doi: 10.1016/j.ijpara.2021.11.006. Online ahead of print.ABSTRACTParasites harbour rich microbial communities that may play a role in host-parasite interactions, from influencing the parasite's infectivity to modulating its virulence. Experimental manipulation of a parasite's microbes would be essential, however, in order to establish their causal role. Here, we tested whether indirect exposure of a trematode parasite within its snail intermediate host to a variety of antibiotics could alter its bacterial community. Based on sequencing the prokaryotic 16S ssrRNA gene, we c...
Source: International Journal for Parasitology - December 5, 2021 Category: Parasitology Authors: F átima Jorge C éline Froissard Nolwenn M Dheilly Robert Poulin Source Type: research

Sex-biased parasitism, host mass and mutualistic bat flies: an antagonistic individual-based network of bat-bat fly interactions
Int J Parasitol. 2021 Dec 1:S0020-7519(21)00317-9. doi: 10.1016/j.ijpara.2021.10.010. Online ahead of print.ABSTRACTIndividual-based networks provide the building blocks for community-level networks. However, network studies of bats and their parasites have focused only on the species level. Intrapopulation variation may allow certain host individuals to play important roles in the dynamics of the parasites. Therefore, we evaluated how the variation in host sex, body size, ectoparasite abundance and co-occurrence configure individual-based networks of the lesser bulldog bat Noctilio albiventris and bat flies. We expected b...
Source: International Journal for Parasitology - December 5, 2021 Category: Parasitology Authors: Daniel Maximo Correa Alcantara Gustavo Graciolli Ronaldo Toma Camila Silveira Souza Source Type: research

The anticancer drug imatinib induces autophagy in Schistosoma mansoni
Int J Parasitol. 2021 Nov 24:S0020-7519(21)00312-X. doi: 10.1016/j.ijpara.2021.10.008. Online ahead of print.ABSTRACTSchistosomiasis, caused by schistosome parasites, is a neglected tropical disease affecting humans and animals. There is no vaccine available yet, and fear of upcoming resistance against the only widely used drug, praziquantel, is omnipresent. Previously, we showed that imatinib (Gleevec), an anticancer drug, affected schistosome physiology and caused the death of adult Schistosoma mansoni in vitro. Here, we present the first known evidence that one effect of imatinib is the induction of autophagy in S. mans...
Source: International Journal for Parasitology - November 28, 2021 Category: Parasitology Authors: Mudassar N Mughal Christoph G Grevelding Simone Haeberlein Source Type: research

The anticancer drug imatinib induces autophagy in Schistosoma mansoni
Int J Parasitol. 2021 Nov 24:S0020-7519(21)00312-X. doi: 10.1016/j.ijpara.2021.10.008. Online ahead of print.ABSTRACTSchistosomiasis, caused by schistosome parasites, is a neglected tropical disease affecting humans and animals. There is no vaccine available yet, and fear of upcoming resistance against the only widely used drug, praziquantel, is omnipresent. Previously, we showed that imatinib (Gleevec), an anticancer drug, affected schistosome physiology and caused the death of adult Schistosoma mansoni in vitro. Here, we present the first known evidence that one effect of imatinib is the induction of autophagy in S. mans...
Source: International Journal for Parasitology - November 28, 2021 Category: Parasitology Authors: Mudassar N Mughal Christoph G Grevelding Simone Haeberlein Source Type: research

The anticancer drug imatinib induces autophagy in Schistosoma mansoni
Int J Parasitol. 2021 Nov 24:S0020-7519(21)00312-X. doi: 10.1016/j.ijpara.2021.10.008. Online ahead of print.ABSTRACTSchistosomiasis, caused by schistosome parasites, is a neglected tropical disease affecting humans and animals. There is no vaccine available yet, and fear of upcoming resistance against the only widely used drug, praziquantel, is omnipresent. Previously, we showed that imatinib (Gleevec), an anticancer drug, affected schistosome physiology and caused the death of adult Schistosoma mansoni in vitro. Here, we present the first known evidence that one effect of imatinib is the induction of autophagy in S. mans...
Source: International Journal for Parasitology - November 28, 2021 Category: Parasitology Authors: Mudassar N Mughal Christoph G Grevelding Simone Haeberlein Source Type: research

The anticancer drug imatinib induces autophagy in Schistosoma mansoni
Int J Parasitol. 2021 Nov 24:S0020-7519(21)00312-X. doi: 10.1016/j.ijpara.2021.10.008. Online ahead of print.ABSTRACTSchistosomiasis, caused by schistosome parasites, is a neglected tropical disease affecting humans and animals. There is no vaccine available yet, and fear of upcoming resistance against the only widely used drug, praziquantel, is omnipresent. Previously, we showed that imatinib (Gleevec), an anticancer drug, affected schistosome physiology and caused the death of adult Schistosoma mansoni in vitro. Here, we present the first known evidence that one effect of imatinib is the induction of autophagy in S. mans...
Source: International Journal for Parasitology - November 28, 2021 Category: Parasitology Authors: Mudassar N Mughal Christoph G Grevelding Simone Haeberlein Source Type: research

The anticancer drug imatinib induces autophagy in Schistosoma mansoni
Int J Parasitol. 2021 Nov 24:S0020-7519(21)00312-X. doi: 10.1016/j.ijpara.2021.10.008. Online ahead of print.ABSTRACTSchistosomiasis, caused by schistosome parasites, is a neglected tropical disease affecting humans and animals. There is no vaccine available yet, and fear of upcoming resistance against the only widely used drug, praziquantel, is omnipresent. Previously, we showed that imatinib (Gleevec), an anticancer drug, affected schistosome physiology and caused the death of adult Schistosoma mansoni in vitro. Here, we present the first known evidence that one effect of imatinib is the induction of autophagy in S. mans...
Source: International Journal for Parasitology - November 28, 2021 Category: Parasitology Authors: Mudassar N Mughal Christoph G Grevelding Simone Haeberlein Source Type: research

The anticancer drug imatinib induces autophagy in Schistosoma mansoni
Int J Parasitol. 2021 Nov 24:S0020-7519(21)00312-X. doi: 10.1016/j.ijpara.2021.10.008. Online ahead of print.ABSTRACTSchistosomiasis, caused by schistosome parasites, is a neglected tropical disease affecting humans and animals. There is no vaccine available yet, and fear of upcoming resistance against the only widely used drug, praziquantel, is omnipresent. Previously, we showed that imatinib (Gleevec), an anticancer drug, affected schistosome physiology and caused the death of adult Schistosoma mansoni in vitro. Here, we present the first known evidence that one effect of imatinib is the induction of autophagy in S. mans...
Source: International Journal for Parasitology - November 28, 2021 Category: Parasitology Authors: Mudassar N Mughal Christoph G Grevelding Simone Haeberlein Source Type: research

Alan David Donald AM BVSc PhD FASP FRSB (UK) FTSE MANZCVS Editor-in-Chief, IJP, 1993-1997
Int J Parasitol. 2021 Nov 18:S0020-7519(21)00308-8. doi: 10.1016/j.ijpara.2021.11.003. Online ahead of print.NO ABSTRACTPMID:34802697 | DOI:10.1016/j.ijpara.2021.11.003 (Source: International Journal for Parasitology)
Source: International Journal for Parasitology - November 22, 2021 Category: Parasitology Authors: Nicholas Sangster Source Type: research

Alan David Donald AM BVSc PhD FASP FRSB (UK) FTSE MANZCVS Editor-in-Chief, IJP, 1993-1997
Int J Parasitol. 2021 Nov 18:S0020-7519(21)00308-8. doi: 10.1016/j.ijpara.2021.11.003. Online ahead of print.NO ABSTRACTPMID:34802697 | DOI:10.1016/j.ijpara.2021.11.003 (Source: International Journal for Parasitology)
Source: International Journal for Parasitology - November 22, 2021 Category: Parasitology Authors: Nicholas Sangster Source Type: research

Alan David Donald AM BVSc PhD FASP FRSB (UK) FTSE MANZCVS Editor-in-Chief, IJP, 1993-1997
Int J Parasitol. 2021 Nov 18:S0020-7519(21)00308-8. doi: 10.1016/j.ijpara.2021.11.003. Online ahead of print.NO ABSTRACTPMID:34802697 | DOI:10.1016/j.ijpara.2021.11.003 (Source: International Journal for Parasitology)
Source: International Journal for Parasitology - November 22, 2021 Category: Parasitology Authors: Nicholas Sangster Source Type: research

Alan David Donald AM BVSc PhD FASP FRSB (UK) FTSE MANZCVS Editor-in-Chief, IJP, 1993-1997
Int J Parasitol. 2021 Nov 18:S0020-7519(21)00308-8. doi: 10.1016/j.ijpara.2021.11.003. Online ahead of print.NO ABSTRACTPMID:34802697 | DOI:10.1016/j.ijpara.2021.11.003 (Source: International Journal for Parasitology)
Source: International Journal for Parasitology - November 22, 2021 Category: Parasitology Authors: Nicholas Sangster Source Type: research

Alan David Donald AM BVSc PhD FASP FRSB (UK) FTSE MANZCVS Editor-in-Chief, IJP, 1993-1997
Int J Parasitol. 2021 Nov 18:S0020-7519(21)00308-8. doi: 10.1016/j.ijpara.2021.11.003. Online ahead of print.NO ABSTRACTPMID:34802697 | DOI:10.1016/j.ijpara.2021.11.003 (Source: International Journal for Parasitology)
Source: International Journal for Parasitology - November 22, 2021 Category: Parasitology Authors: Nicholas Sangster Source Type: research

Alan David Donald AM BVSc PhD FASP FRSB (UK) FTSE MANZCVS Editor-in-Chief, IJP, 1993-1997
Int J Parasitol. 2021 Nov 18:S0020-7519(21)00308-8. doi: 10.1016/j.ijpara.2021.11.003. Online ahead of print.NO ABSTRACTPMID:34802697 | DOI:10.1016/j.ijpara.2021.11.003 (Source: International Journal for Parasitology)
Source: International Journal for Parasitology - November 22, 2021 Category: Parasitology Authors: Nicholas Sangster Source Type: research

Malaria research in Australia: looking through the lens of the past towards the future
This article will provide an insight into 50 years of Australian efforts to discover mechanisms and targets of immunity and pathogenesis; develop new diagnostics, drugs, vaccines, and therapeutics; and assess new public health interventions and control measures in malaria-endemic settings.PMID:34780720 | DOI:10.1016/j.ijpara.2021.11.005 (Source: International Journal for Parasitology)
Source: International Journal for Parasitology - November 15, 2021 Category: Parasitology Authors: Denise L Doolan Source Type: research