Effects of (2 < i > R < /i > ,6 < i > R < /i > )-hydroxynorketamine in assays of acute pain-stimulated and pain-depressed behaviors in mice
by Todd M. Hillhouse, Kaitlyn J. Partridge, Patrick I. Garrett, Sarah C. Honeycutt, Joseph H. Porter
Ketamine has been shown to produce analgesia in various acute and chronic pain states; however, abuse liability concerns have limited its utility. The ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) has been shown to produce antidepressant-like effects similar to ketamine without abuse liability concerns. (2R,6R)-HNK produces sustained analgesia in models of chronic pain, but has yet to be evaluated in models of acute pain. The present study evaluated the efficacy of acute (2R,6R)-HNK administration (one injection) in...
Source: PLoS One - April 19, 2024 Category: Biomedical Science Authors: Todd M. Hillhouse Source Type: research
Cocaine seems to hijack brain pathways that prioritise food and water
Cocaine and morphine hijacked neural responses in the brains of mice, which resulted in them consuming less food and water (Source: New Scientist - Health)
Source: New Scientist - Health - April 18, 2024 Category: Consumer Health News Source Type: research
Current management of neonatal abstinence syndrome: a survey of practice in the UK and Ireland
Conclusion and relevance
Compared with the previous survey, improvements in evidence-based practices were noted, highlighting the benefits of this type of research. Nonetheless, significant variation still exists in some aspects of the management of NAS. Post-discharge follow-up varies widely, with particular deficits in ophthalmology follow-up. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 18, 2024 Category: Perinatology & Neonatology Authors: Dempsey, S., O Grady, M. J. Tags: Original research Source Type: research
Teneurin C-terminal associated peptide (TCAP)-1 attenuates the development and expression of naloxone-precipitated morphine withdrawal in male Swiss Webster mice
ConclusionsThese findings establish TCAP-1 as a potential therapeutic candidate for the prevention and treatment of morphine withdrawal. (Source: Psychopharmacology)
Source: Psychopharmacology - April 17, 2024 Category: Psychiatry Source Type: research
Clinical prediction of opioid use disorder in chronic pain patients: a cohort-retrospective study with a pharmacogenetic approach
CONCLUSIONS: Functional polymorphisms related to OPRM1 variant and CYP2D6 phenotypes may predict a higher OUD risk. Established risk factors such as young age, elevated MEDD and lower incomes were identified. A predictive model is expected to be implemented in clinical setting among CNCP patients under long-term opioids use.PMID:38619184 | DOI:10.23736/S0375-9393.24.17864-9 (Source: Minerva Anestesiologica)
Source: Minerva Anestesiologica - April 15, 2024 Category: Anesthesiology Authors: M ónica Escorial Javier Muriel Laura Agull ó Thomas Zandonai C ésar Margarit Domingo Morales Ana M Peir ó Source Type: research
Perioperative intravenous lidocaine in thoracoscopic surgery for improved postoperative pain control: a randomized, placebo-controlled, double-blind, superiority trial
CONCLUSIONS: Our results suggest that perioperative intravenous lidocaine administration reduces pain scores after VATS. The beneficial clinical effects are limited. Nevertheless, intravenous lidocaine may be helpful as part of a multimodal analgesia protocol or with patients in whom the use of other analgesics is contraindicated.TRIAL REGISTRATION: ClinicalTrials.gov NCT03677817.PMID:38617784 | PMC:PMC11009578 | DOI:10.21037/jtd-23-1438 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Aljaz Hojski Daniel Bolliger Makhmudbek Mallaev Sandrine Dackam Nikolay Tsvetkov Mark Wiese Tobias Schneider Andreas Lampart Didier Lardinois Source Type: research
Clinical prediction of opioid use disorder in chronic pain patients: a cohort-retrospective study with a pharmacogenetic approach
CONCLUSIONS: Functional polymorphisms related to OPRM1 variant and CYP2D6 phenotypes may predict a higher OUD risk. Established risk factors such as young age, elevated MEDD and lower incomes were identified. A predictive model is expected to be implemented in clinical setting among CNCP patients under long-term opioids use.PMID:38619184 | DOI:10.23736/S0375-9393.24.17864-9 (Source: Minerva Anestesiologica)
Source: Minerva Anestesiologica - April 15, 2024 Category: Anesthesiology Authors: M ónica Escorial Javier Muriel Laura Agull ó Thomas Zandonai C ésar Margarit Domingo Morales Ana M Peir ó Source Type: research
Perioperative intravenous lidocaine in thoracoscopic surgery for improved postoperative pain control: a randomized, placebo-controlled, double-blind, superiority trial
CONCLUSIONS: Our results suggest that perioperative intravenous lidocaine administration reduces pain scores after VATS. The beneficial clinical effects are limited. Nevertheless, intravenous lidocaine may be helpful as part of a multimodal analgesia protocol or with patients in whom the use of other analgesics is contraindicated.TRIAL REGISTRATION: ClinicalTrials.gov NCT03677817.PMID:38617784 | PMC:PMC11009578 | DOI:10.21037/jtd-23-1438 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Aljaz Hojski Daniel Bolliger Makhmudbek Mallaev Sandrine Dackam Nikolay Tsvetkov Mark Wiese Tobias Schneider Andreas Lampart Didier Lardinois Source Type: research
Clinical prediction of opioid use disorder in chronic pain patients: a cohort-retrospective study with a pharmacogenetic approach
CONCLUSIONS: Functional polymorphisms related to OPRM1 variant and CYP2D6 phenotypes may predict a higher OUD risk. Established risk factors such as young age, elevated MEDD and lower incomes were identified. A predictive model is expected to be implemented in clinical setting among CNCP patients under long-term opioids use.PMID:38619184 | DOI:10.23736/S0375-9393.24.17864-9 (Source: Minerva Anestesiologica)
Source: Minerva Anestesiologica - April 15, 2024 Category: Anesthesiology Authors: M ónica Escorial Javier Muriel Laura Agull ó Thomas Zandonai C ésar Margarit Domingo Morales Ana M Peir ó Source Type: research
Perioperative intravenous lidocaine in thoracoscopic surgery for improved postoperative pain control: a randomized, placebo-controlled, double-blind, superiority trial
CONCLUSIONS: Our results suggest that perioperative intravenous lidocaine administration reduces pain scores after VATS. The beneficial clinical effects are limited. Nevertheless, intravenous lidocaine may be helpful as part of a multimodal analgesia protocol or with patients in whom the use of other analgesics is contraindicated.TRIAL REGISTRATION: ClinicalTrials.gov NCT03677817.PMID:38617784 | PMC:PMC11009578 | DOI:10.21037/jtd-23-1438 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Aljaz Hojski Daniel Bolliger Makhmudbek Mallaev Sandrine Dackam Nikolay Tsvetkov Mark Wiese Tobias Schneider Andreas Lampart Didier Lardinois Source Type: research
