The impact of perioperative nonsteroidal anti-inflammatory drugs on the postoperative outcomes of spinal surgery: a meta-analysis of 23 randomized controlled trials
AbstractIn recent years, nonsteroidal anti-inflammatory drug (NSAIDs), which are considered to affect the prognosis of spinal surgery, have been widely used in perioperative analgesia in spinal surgery, but the relationship between these two factors remains unclear. The purpose of this study was to explore the effect of perioperative use of NSAIDs on the prognosis of patients treated with spinal surgery. We systematically searched PubMed, Embase, and Cochrane Library for relevant articles published on or before July 14, 2023. We used a random-effect model for the meta-analysis to calculate the standardized mean difference ...
Source: Neurosurgical Review - April 5, 2024 Category: Neurosurgery Source Type: research
PBPK-PD model for predicting morphine pharmacokinetics, CNS effects and naloxone antagonism in humans
In conclusion, the pharmacokinetics and pharmacodynamics of morphine and M6G, antagonistic effects of naloxone against morphine-induced CNS effects may be successfully predicted using the developed PBPK-PD model based on the parameters derived from in vitro, in silico, or animal studies.PMID:38570601 | DOI:10.1038/s41401-024-01255-2 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 3, 2024 Category: Drugs & Pharmacology Authors: Rui-Jing Mu Tian-Lei Liu Xiao-Dong Liu Li Liu Source Type: research
Efficacy of Liposomal Bupivacaine in Reducing Opioid Use After Posterior Lumbar Spinal Decompression and Fusion
CONCLUSION: The findings of this study suggest that the addition of liposomal bupivacaine to traditional pain management modalities can augment pain management for patients undergoing posterior lumbar surgery, as evidenced by the significant decrease in postoperative morphine milligram equivalents required. [Orthopedics. 202x;4x(x):xx-xx.].PMID:38568003 | DOI:10.3928/01477447-20240325-07 (Source: Orthopedics)
Source: Orthopedics - April 3, 2024 Category: Orthopaedics Authors: Amber McClure Olivia C Silveri Megan Foddrell Karen Duteil Laura E Madar ász Christopher P Silveri Source Type: research
Analgesic effect of a cholinergic agonist (carbachol) in a sural nerve ligation-induced hypersensitivity mouse model
CONCLUSION: These findings suggest that cholinergic nerves are involved in allodynia and hyperalgesia of the SN ligation neuropathic pain model.PMID:38569563 | DOI:10.1080/01616412.2024.2337512 (Source: Neurological Research)
Source: Neurological Research - April 3, 2024 Category: Neurology Authors: Nodoka Kato Toshie Kambe Terumasa Chiba Kyoji Taguchi Kenji Abe Source Type: research
PBPK-PD model for predicting morphine pharmacokinetics, CNS effects and naloxone antagonism in humans
In conclusion, the pharmacokinetics and pharmacodynamics of morphine and M6G, antagonistic effects of naloxone against morphine-induced CNS effects may be successfully predicted using the developed PBPK-PD model based on the parameters derived from in vitro, in silico, or animal studies.PMID:38570601 | DOI:10.1038/s41401-024-01255-2 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 3, 2024 Category: Drugs & Pharmacology Authors: Rui-Jing Mu Tian-Lei Liu Xiao-Dong Liu Li Liu Source Type: research
Efficacy of Liposomal Bupivacaine in Reducing Opioid Use After Posterior Lumbar Spinal Decompression and Fusion
CONCLUSION: The findings of this study suggest that the addition of liposomal bupivacaine to traditional pain management modalities can augment pain management for patients undergoing posterior lumbar surgery, as evidenced by the significant decrease in postoperative morphine milligram equivalents required. [Orthopedics. 202x;4x(x):xx-xx.].PMID:38568003 | DOI:10.3928/01477447-20240325-07 (Source: Orthopedics)
Source: Orthopedics - April 3, 2024 Category: Orthopaedics Authors: Amber McClure Olivia C Silveri Megan Foddrell Karen Duteil Laura E Madar ász Christopher P Silveri Source Type: research
Analgesic effect of a cholinergic agonist (carbachol) in a sural nerve ligation-induced hypersensitivity mouse model
CONCLUSION: These findings suggest that cholinergic nerves are involved in allodynia and hyperalgesia of the SN ligation neuropathic pain model.PMID:38569563 | DOI:10.1080/01616412.2024.2337512 (Source: Neurological Research)
Source: Neurological Research - April 3, 2024 Category: Neurology Authors: Nodoka Kato Toshie Kambe Terumasa Chiba Kyoji Taguchi Kenji Abe Source Type: research
PBPK-PD model for predicting morphine pharmacokinetics, CNS effects and naloxone antagonism in humans
In conclusion, the pharmacokinetics and pharmacodynamics of morphine and M6G, antagonistic effects of naloxone against morphine-induced CNS effects may be successfully predicted using the developed PBPK-PD model based on the parameters derived from in vitro, in silico, or animal studies.PMID:38570601 | DOI:10.1038/s41401-024-01255-2 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 3, 2024 Category: Drugs & Pharmacology Authors: Rui-Jing Mu Tian-Lei Liu Xiao-Dong Liu Li Liu Source Type: research
Efficacy of Liposomal Bupivacaine in Reducing Opioid Use After Posterior Lumbar Spinal Decompression and Fusion
CONCLUSION: The findings of this study suggest that the addition of liposomal bupivacaine to traditional pain management modalities can augment pain management for patients undergoing posterior lumbar surgery, as evidenced by the significant decrease in postoperative morphine milligram equivalents required. [Orthopedics. 202x;4x(x):xx-xx.].PMID:38568003 | DOI:10.3928/01477447-20240325-07 (Source: Orthopedics)
Source: Orthopedics - April 3, 2024 Category: Orthopaedics Authors: Amber McClure Olivia C Silveri Megan Foddrell Karen Duteil Laura E Madar ász Christopher P Silveri Source Type: research
PBPK-PD model for predicting morphine pharmacokinetics, CNS effects and naloxone antagonism in humans
In conclusion, the pharmacokinetics and pharmacodynamics of morphine and M6G, antagonistic effects of naloxone against morphine-induced CNS effects may be successfully predicted using the developed PBPK-PD model based on the parameters derived from in vitro, in silico, or animal studies.PMID:38570601 | DOI:10.1038/s41401-024-01255-2 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 3, 2024 Category: Drugs & Pharmacology Authors: Rui-Jing Mu Tian-Lei Liu Xiao-Dong Liu Li Liu Source Type: research
Efficacy of Liposomal Bupivacaine in Reducing Opioid Use After Posterior Lumbar Spinal Decompression and Fusion
CONCLUSION: The findings of this study suggest that the addition of liposomal bupivacaine to traditional pain management modalities can augment pain management for patients undergoing posterior lumbar surgery, as evidenced by the significant decrease in postoperative morphine milligram equivalents required. [Orthopedics. 202x;4x(x):xx-xx.].PMID:38568003 | DOI:10.3928/01477447-20240325-07 (Source: Orthopedics)
Source: Orthopedics - April 3, 2024 Category: Orthopaedics Authors: Amber McClure Olivia C Silveri Megan Foddrell Karen Duteil Laura E Madar ász Christopher P Silveri Source Type: research
PBPK-PD model for predicting morphine pharmacokinetics, CNS effects and naloxone antagonism in humans
In conclusion, the pharmacokinetics and pharmacodynamics of morphine and M6G, antagonistic effects of naloxone against morphine-induced CNS effects may be successfully predicted using the developed PBPK-PD model based on the parameters derived from in vitro, in silico, or animal studies.PMID:38570601 | DOI:10.1038/s41401-024-01255-2 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 3, 2024 Category: Drugs & Pharmacology Authors: Rui-Jing Mu Tian-Lei Liu Xiao-Dong Liu Li Liu Source Type: research
Efficacy of Liposomal Bupivacaine in Reducing Opioid Use After Posterior Lumbar Spinal Decompression and Fusion
CONCLUSION: The findings of this study suggest that the addition of liposomal bupivacaine to traditional pain management modalities can augment pain management for patients undergoing posterior lumbar surgery, as evidenced by the significant decrease in postoperative morphine milligram equivalents required. [Orthopedics. 202x;4x(x):xx-xx.].PMID:38568003 | DOI:10.3928/01477447-20240325-07 (Source: Orthopedics)
Source: Orthopedics - April 3, 2024 Category: Orthopaedics Authors: Amber McClure Olivia C Silveri Megan Foddrell Karen Duteil Laura E Madar ász Christopher P Silveri Source Type: research
Efficacy of Liposomal Bupivacaine in Reducing Opioid Use After Posterior Lumbar Spinal Decompression and Fusion
CONCLUSION: The findings of this study suggest that the addition of liposomal bupivacaine to traditional pain management modalities can augment pain management for patients undergoing posterior lumbar surgery, as evidenced by the significant decrease in postoperative morphine milligram equivalents required. [Orthopedics. 202x;4x(x):xx-xx.].PMID:38568003 | DOI:10.3928/01477447-20240325-07 (Source: Orthopedics)
Source: Orthopedics - April 3, 2024 Category: Orthopaedics Authors: Amber McClure Olivia C Silveri Megan Foddrell Karen Duteil Laura E Madar ász Christopher P Silveri Source Type: research
