Effects of morphine on conditioned place preference and pain are independent of uptake ‑2
This study was done to assess the effect of uptake‑2 inhibition on morphine‑induced conditioned place preference (CPP) and analgesia. In this study, the effects of morphine and/or D22 on CPP were evaluated following intraperitoneal injection in mice. Afterward, changes in motor activity were evaluated by the open field test. Using the tail‑flick model, the effects of D22 and/or morphine were evaluated on the pain threshold. The results showed that 20 mg/kg of morphine induced a place preference response. D22, at the dose of 0.03 mg/kg, caused place avoidance, while at the dose of 0.3 mg/kg, it produced a notable plac...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Mohammad Saeid Souri Mohaddeseh Sadat Alavi Ali Ahmadian Salami Ali Roohbakhsh Source Type: research
The effect of morphine administration on GluN3B NMDA receptor subunit mRNA expression in rat brain
Acta Neurobiol Exp (Wars). 2024 Mar 28;84(1):89-97. doi: 10.55782/ane-2024-2545.ABSTRACTOpioid addiction is critically dependent on the activation of N‑methyl‑D‑aspartate (NMDA) receptors, which are widely found in the mesocorticolimbic system. Meanwhile, opioid addiction may affect the expression level of NMDA receptor subunits. The existence of GluN3 subunits in the NMDA receptor's tetramer structure reduces the excitatory current of the receptor channel. We evaluated the changes in the mRNA expression pattern of the GluN3B subunit of the NMDA receptor in rat brains following acute and chronic exposure to morphine....
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Shahrzad Nazari Mitra-Sadat Sadat-Shirazi Ali Shahbazi Kamran Ghaffari Nasim Vousooghi Source Type: research
Effects of morphine on conditioned place preference and pain are independent of uptake ‑2
This study was done to assess the effect of uptake‑2 inhibition on morphine‑induced conditioned place preference (CPP) and analgesia. In this study, the effects of morphine and/or D22 on CPP were evaluated following intraperitoneal injection in mice. Afterward, changes in motor activity were evaluated by the open field test. Using the tail‑flick model, the effects of D22 and/or morphine were evaluated on the pain threshold. The results showed that 20 mg/kg of morphine induced a place preference response. D22, at the dose of 0.03 mg/kg, caused place avoidance, while at the dose of 0.3 mg/kg, it produced a notable plac...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Mohammad Saeid Souri Mohaddeseh Sadat Alavi Ali Ahmadian Salami Ali Roohbakhsh Source Type: research
The effect of morphine administration on GluN3B NMDA receptor subunit mRNA expression in rat brain
Acta Neurobiol Exp (Wars). 2024 Mar 28;84(1):89-97. doi: 10.55782/ane-2024-2545.ABSTRACTOpioid addiction is critically dependent on the activation of N‑methyl‑D‑aspartate (NMDA) receptors, which are widely found in the mesocorticolimbic system. Meanwhile, opioid addiction may affect the expression level of NMDA receptor subunits. The existence of GluN3 subunits in the NMDA receptor's tetramer structure reduces the excitatory current of the receptor channel. We evaluated the changes in the mRNA expression pattern of the GluN3B subunit of the NMDA receptor in rat brains following acute and chronic exposure to morphine....
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Shahrzad Nazari Mitra-Sadat Sadat-Shirazi Ali Shahbazi Kamran Ghaffari Nasim Vousooghi Source Type: research
Effects of morphine on conditioned place preference and pain are independent of uptake ‑2
This study was done to assess the effect of uptake‑2 inhibition on morphine‑induced conditioned place preference (CPP) and analgesia. In this study, the effects of morphine and/or D22 on CPP were evaluated following intraperitoneal injection in mice. Afterward, changes in motor activity were evaluated by the open field test. Using the tail‑flick model, the effects of D22 and/or morphine were evaluated on the pain threshold. The results showed that 20 mg/kg of morphine induced a place preference response. D22, at the dose of 0.03 mg/kg, caused place avoidance, while at the dose of 0.3 mg/kg, it produced a notable plac...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Mohammad Saeid Souri Mohaddeseh Sadat Alavi Ali Ahmadian Salami Ali Roohbakhsh Source Type: research
The effect of morphine administration on GluN3B NMDA receptor subunit mRNA expression in rat brain
Acta Neurobiol Exp (Wars). 2024 Mar 28;84(1):89-97. doi: 10.55782/ane-2024-2545.ABSTRACTOpioid addiction is critically dependent on the activation of N‑methyl‑D‑aspartate (NMDA) receptors, which are widely found in the mesocorticolimbic system. Meanwhile, opioid addiction may affect the expression level of NMDA receptor subunits. The existence of GluN3 subunits in the NMDA receptor's tetramer structure reduces the excitatory current of the receptor channel. We evaluated the changes in the mRNA expression pattern of the GluN3B subunit of the NMDA receptor in rat brains following acute and chronic exposure to morphine....
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Shahrzad Nazari Mitra-Sadat Sadat-Shirazi Ali Shahbazi Kamran Ghaffari Nasim Vousooghi Source Type: research
Effects of morphine on conditioned place preference and pain are independent of uptake ‑2
This study was done to assess the effect of uptake‑2 inhibition on morphine‑induced conditioned place preference (CPP) and analgesia. In this study, the effects of morphine and/or D22 on CPP were evaluated following intraperitoneal injection in mice. Afterward, changes in motor activity were evaluated by the open field test. Using the tail‑flick model, the effects of D22 and/or morphine were evaluated on the pain threshold. The results showed that 20 mg/kg of morphine induced a place preference response. D22, at the dose of 0.03 mg/kg, caused place avoidance, while at the dose of 0.3 mg/kg, it produced a notable plac...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Mohammad Saeid Souri Mohaddeseh Sadat Alavi Ali Ahmadian Salami Ali Roohbakhsh Source Type: research
The effect of morphine administration on GluN3B NMDA receptor subunit mRNA expression in rat brain
Acta Neurobiol Exp (Wars). 2024 Mar 28;84(1):89-97. doi: 10.55782/ane-2024-2545.ABSTRACTOpioid addiction is critically dependent on the activation of N‑methyl‑D‑aspartate (NMDA) receptors, which are widely found in the mesocorticolimbic system. Meanwhile, opioid addiction may affect the expression level of NMDA receptor subunits. The existence of GluN3 subunits in the NMDA receptor's tetramer structure reduces the excitatory current of the receptor channel. We evaluated the changes in the mRNA expression pattern of the GluN3B subunit of the NMDA receptor in rat brains following acute and chronic exposure to morphine....
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Shahrzad Nazari Mitra-Sadat Sadat-Shirazi Ali Shahbazi Kamran Ghaffari Nasim Vousooghi Source Type: research
Effects of morphine on conditioned place preference and pain are independent of uptake ‑2
This study was done to assess the effect of uptake‑2 inhibition on morphine‑induced conditioned place preference (CPP) and analgesia. In this study, the effects of morphine and/or D22 on CPP were evaluated following intraperitoneal injection in mice. Afterward, changes in motor activity were evaluated by the open field test. Using the tail‑flick model, the effects of D22 and/or morphine were evaluated on the pain threshold. The results showed that 20 mg/kg of morphine induced a place preference response. D22, at the dose of 0.03 mg/kg, caused place avoidance, while at the dose of 0.3 mg/kg, it produced a notable plac...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Mohammad Saeid Souri Mohaddeseh Sadat Alavi Ali Ahmadian Salami Ali Roohbakhsh Source Type: research
The effect of morphine administration on GluN3B NMDA receptor subunit mRNA expression in rat brain
Acta Neurobiol Exp (Wars). 2024 Mar 28;84(1):89-97. doi: 10.55782/ane-2024-2545.ABSTRACTOpioid addiction is critically dependent on the activation of N‑methyl‑D‑aspartate (NMDA) receptors, which are widely found in the mesocorticolimbic system. Meanwhile, opioid addiction may affect the expression level of NMDA receptor subunits. The existence of GluN3 subunits in the NMDA receptor's tetramer structure reduces the excitatory current of the receptor channel. We evaluated the changes in the mRNA expression pattern of the GluN3B subunit of the NMDA receptor in rat brains following acute and chronic exposure to morphine....
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Shahrzad Nazari Mitra-Sadat Sadat-Shirazi Ali Shahbazi Kamran Ghaffari Nasim Vousooghi Source Type: research
Effects of morphine on conditioned place preference and pain are independent of uptake ‑2
This study was done to assess the effect of uptake‑2 inhibition on morphine‑induced conditioned place preference (CPP) and analgesia. In this study, the effects of morphine and/or D22 on CPP were evaluated following intraperitoneal injection in mice. Afterward, changes in motor activity were evaluated by the open field test. Using the tail‑flick model, the effects of D22 and/or morphine were evaluated on the pain threshold. The results showed that 20 mg/kg of morphine induced a place preference response. D22, at the dose of 0.03 mg/kg, caused place avoidance, while at the dose of 0.3 mg/kg, it produced a notable plac...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Mohammad Saeid Souri Mohaddeseh Sadat Alavi Ali Ahmadian Salami Ali Roohbakhsh Source Type: research
The effect of morphine administration on GluN3B NMDA receptor subunit mRNA expression in rat brain
Acta Neurobiol Exp (Wars). 2024 Mar 28;84(1):89-97. doi: 10.55782/ane-2024-2545.ABSTRACTOpioid addiction is critically dependent on the activation of N‑methyl‑D‑aspartate (NMDA) receptors, which are widely found in the mesocorticolimbic system. Meanwhile, opioid addiction may affect the expression level of NMDA receptor subunits. The existence of GluN3 subunits in the NMDA receptor's tetramer structure reduces the excitatory current of the receptor channel. We evaluated the changes in the mRNA expression pattern of the GluN3B subunit of the NMDA receptor in rat brains following acute and chronic exposure to morphine....
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Shahrzad Nazari Mitra-Sadat Sadat-Shirazi Ali Shahbazi Kamran Ghaffari Nasim Vousooghi Source Type: research
Effects of morphine on conditioned place preference and pain are independent of uptake ‑2
This study was done to assess the effect of uptake‑2 inhibition on morphine‑induced conditioned place preference (CPP) and analgesia. In this study, the effects of morphine and/or D22 on CPP were evaluated following intraperitoneal injection in mice. Afterward, changes in motor activity were evaluated by the open field test. Using the tail‑flick model, the effects of D22 and/or morphine were evaluated on the pain threshold. The results showed that 20 mg/kg of morphine induced a place preference response. D22, at the dose of 0.03 mg/kg, caused place avoidance, while at the dose of 0.3 mg/kg, it produced a notable plac...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Mohammad Saeid Souri Mohaddeseh Sadat Alavi Ali Ahmadian Salami Ali Roohbakhsh Source Type: research
The effect of morphine administration on GluN3B NMDA receptor subunit mRNA expression in rat brain
Acta Neurobiol Exp (Wars). 2024 Mar 28;84(1):89-97. doi: 10.55782/ane-2024-2545.ABSTRACTOpioid addiction is critically dependent on the activation of N‑methyl‑D‑aspartate (NMDA) receptors, which are widely found in the mesocorticolimbic system. Meanwhile, opioid addiction may affect the expression level of NMDA receptor subunits. The existence of GluN3 subunits in the NMDA receptor's tetramer structure reduces the excitatory current of the receptor channel. We evaluated the changes in the mRNA expression pattern of the GluN3B subunit of the NMDA receptor in rat brains following acute and chronic exposure to morphine....
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Shahrzad Nazari Mitra-Sadat Sadat-Shirazi Ali Shahbazi Kamran Ghaffari Nasim Vousooghi Source Type: research
Effects of morphine on conditioned place preference and pain are independent of uptake ‑2
This study was done to assess the effect of uptake‑2 inhibition on morphine‑induced conditioned place preference (CPP) and analgesia. In this study, the effects of morphine and/or D22 on CPP were evaluated following intraperitoneal injection in mice. Afterward, changes in motor activity were evaluated by the open field test. Using the tail‑flick model, the effects of D22 and/or morphine were evaluated on the pain threshold. The results showed that 20 mg/kg of morphine induced a place preference response. D22, at the dose of 0.03 mg/kg, caused place avoidance, while at the dose of 0.3 mg/kg, it produced a notable plac...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Mohammad Saeid Souri Mohaddeseh Sadat Alavi Ali Ahmadian Salami Ali Roohbakhsh Source Type: research
