Enhanced recovery after surgery improves clinical outcomes in adolescent bariatric surgery
CONCLUSIONS: The described ERAS protocol is safe and effective in adolescents undergoing laparoscopic VSG and is associated with shorter time to oral intake, reduced opioid requirements, and shorter hospital lengths of stay with no increase in return ED visits or readmissions.PMID:38653653 | DOI:10.1016/j.soard.2024.03.016 (Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery)
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - April 23, 2024 Category: Surgery Authors: Nicholas Schmoke Christopher Nemeh Tania Gennell Dana Schapiro Ashley Hiep-Catarino Matthew Alexander Alexander V Chalphin Robert W Crum Leign Holynskyj Tatiana Kubacki William S Schechter Jeffrey Zitsman Source Type: research

Enhanced recovery after surgery improves clinical outcomes in adolescent bariatric surgery
CONCLUSIONS: The described ERAS protocol is safe and effective in adolescents undergoing laparoscopic VSG and is associated with shorter time to oral intake, reduced opioid requirements, and shorter hospital lengths of stay with no increase in return ED visits or readmissions.PMID:38653653 | DOI:10.1016/j.soard.2024.03.016 (Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery)
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - April 23, 2024 Category: Surgery Authors: Nicholas Schmoke Christopher Nemeh Tania Gennell Dana Schapiro Ashley Hiep-Catarino Matthew Alexander Alexander V Chalphin Robert W Crum Leign Holynskyj Tatiana Kubacki William S Schechter Jeffrey Zitsman Source Type: research

Enhanced recovery after surgery improves clinical outcomes in adolescent bariatric surgery
CONCLUSIONS: The described ERAS protocol is safe and effective in adolescents undergoing laparoscopic VSG and is associated with shorter time to oral intake, reduced opioid requirements, and shorter hospital lengths of stay with no increase in return ED visits or readmissions.PMID:38653653 | DOI:10.1016/j.soard.2024.03.016 (Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery)
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - April 23, 2024 Category: Surgery Authors: Nicholas Schmoke Christopher Nemeh Tania Gennell Dana Schapiro Ashley Hiep-Catarino Matthew Alexander Alexander V Chalphin Robert W Crum Leign Holynskyj Tatiana Kubacki William S Schechter Jeffrey Zitsman Source Type: research

Enhanced recovery after surgery improves clinical outcomes in adolescent bariatric surgery
CONCLUSIONS: The described ERAS protocol is safe and effective in adolescents undergoing laparoscopic VSG and is associated with shorter time to oral intake, reduced opioid requirements, and shorter hospital lengths of stay with no increase in return ED visits or readmissions.PMID:38653653 | DOI:10.1016/j.soard.2024.03.016 (Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery)
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - April 23, 2024 Category: Surgery Authors: Nicholas Schmoke Christopher Nemeh Tania Gennell Dana Schapiro Ashley Hiep-Catarino Matthew Alexander Alexander V Chalphin Robert W Crum Leign Holynskyj Tatiana Kubacki William S Schechter Jeffrey Zitsman Source Type: research

Cancers, Vol. 16, Pages 1604: Treatment of Pelvic and Spinal Bone Metastases: Radiotherapy and Hyperthermia Alone vs. in Combination
The objective of our study was to present the results of RT combined with a special kind of HT (modulated electrohyperthermia, mEHT), in which some of the thermal effect is contributed by equivalent nonthermal components, drastically reducing the necessary power and energy. This retrospective study included 61 patients divided into three groups with pelvic and spinal bone metastases to compare the effects of RT and mEHT alone and in combination (RT + mEHT). A detailed evaluation of pain intensity, measured by the brief pain inventory score, MeM use, and breakthrough pain episodes, revealed no significant differences betwee...
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Jong-Hun Kim Jin-Yong Shin Sun-Young Lee Tags: Article Source Type: research

Journal update monthly top five
This month’s update comes from the Emergency Department at Northern General Hospital, Sheffield. We used a multimodal search strategy, drawing on free open-access medical education resources and literature searches. We identified the five most interesting and relevant papers (decided by consensus) and highlight the main findings, key limitations and clinical bottom line for each paper. Worth a peek—interesting, but not yet ready for prime time. Head turner—new concepts. Game changer—this paper could/should change practice. A non-inferiority randomised controlled trial comparing nebulised ketamine to...
Source: Emergency Medicine Journal - April 22, 2024 Category: Emergency Medicine Authors: Trimble, A., Sampson, B., Underwood, C. G., Cherian, R., McDonald, F., Webster, V., Shepherd, J., van Oppen, J. D. Tags: Journal update Source Type: research

Incidence and risk factors for potential drug-drug interactions in outpatients receiving opioid analgesics
CONCLUSIONS: Outpatients taking opioid analgesics had a higher incidence of pDDIs. As consequently, optimized monitoring and management of patients taking opioid analgesics is recommended in order to ensure patient medication safety.PMID:38641999 | DOI:10.1080/14740338.2024.2346101 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 20, 2024 Category: Drugs & Pharmacology Authors: Fei Chu Yang Yao Bei Gao Mingzhi Huang Lingti Kong Source Type: research

A Randomized Controlled Trial of Intrathecal versus Caudal Morphine-Bupivacaine on Postoperative Analgesia and Cortisol Levels in Pediatric Patients
CONCLUSIONS: Intrathecal morphine and bupivacaine results in longer duration of analgesia, lower analgesic consumption, prevents surgical-stress-related elevation of serum cortisol, and improves parent satisfaction compared to caudal morphine with bupivacaine in children undergoing lower abdominal surgeries.PMID:38639890 | DOI:10.1213/ANE.0000000000006962 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 19, 2024 Category: Anesthesiology Authors: Neha Pangasa Rajeshwari Subramaniam Gunjan Singh Mani Kalaivani Manpreet Kaur Viveka P Jyotsna Devalina Goswami Source Type: research

WITHANICANDRIN ISOLATED FROM Datura Ferox PROMOTES ANTINOCICEPTION BY MODULATING THE ASICS AND TRPS CHANNELS AND ANTI-INFLAMMATION IN ADULT ZEBRAFISH
Chem Biodivers. 2024 Apr 19:e202400538. doi: 10.1002/cbdv.202400538. Online ahead of print.ABSTRACTThis is the first study to analyze the anti-inflammatory and antinociceptive effect of withanicandrin, isolated from Datura Ferox leaves, and the possible mechanism of action involved in adult zebrafish (ZFa). To this end, the animals were treated intraperitoneally (i.p.) with withanicandrin (4; 20 and 40 mg/kg; 20 μL) and subjected to locomotor activity and acute toxicity. Nociception tests were also carried out with chemical agents, in addition to tests to evaluate inflammatory processes induced by κ-Carrageenan 1.5% and ...
Source: Chemistry and Biodiversity - April 19, 2024 Category: Biochemistry Authors: J éssica Bezerra Maciel Hort ência Ribeiro Liberato Ant ônio Wlisses da Silva Jo ão Pedro Vieira da Silva Francisco das Chagas L Pinto Emanuela de Lima Rebou ças Francisco Sydney Henrique da Silva Maria Kuerislene Am âncio Ferreira Marcia Machado Ma Source Type: research

A Randomized Controlled Trial of Intrathecal versus Caudal Morphine-Bupivacaine on Postoperative Analgesia and Cortisol Levels in Pediatric Patients
CONCLUSIONS: Intrathecal morphine and bupivacaine results in longer duration of analgesia, lower analgesic consumption, prevents surgical-stress-related elevation of serum cortisol, and improves parent satisfaction compared to caudal morphine with bupivacaine in children undergoing lower abdominal surgeries.PMID:38639890 | DOI:10.1213/ANE.0000000000006962 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 19, 2024 Category: Anesthesiology Authors: Neha Pangasa Rajeshwari Subramaniam Gunjan Singh Mani Kalaivani Manpreet Kaur Viveka P Jyotsna Devalina Goswami Source Type: research

A Randomized Controlled Trial of Intrathecal versus Caudal Morphine-Bupivacaine on Postoperative Analgesia and Cortisol Levels in Pediatric Patients
CONCLUSIONS: Intrathecal morphine and bupivacaine results in longer duration of analgesia, lower analgesic consumption, prevents surgical-stress-related elevation of serum cortisol, and improves parent satisfaction compared to caudal morphine with bupivacaine in children undergoing lower abdominal surgeries.PMID:38639890 | DOI:10.1213/ANE.0000000000006962 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 19, 2024 Category: Anesthesiology Authors: Neha Pangasa Rajeshwari Subramaniam Gunjan Singh Mani Kalaivani Manpreet Kaur Viveka P Jyotsna Devalina Goswami Source Type: research

A Randomized Controlled Trial of Intrathecal versus Caudal Morphine-Bupivacaine on Postoperative Analgesia and Cortisol Levels in Pediatric Patients
CONCLUSIONS: Intrathecal morphine and bupivacaine results in longer duration of analgesia, lower analgesic consumption, prevents surgical-stress-related elevation of serum cortisol, and improves parent satisfaction compared to caudal morphine with bupivacaine in children undergoing lower abdominal surgeries.PMID:38639890 | DOI:10.1213/ANE.0000000000006962 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 19, 2024 Category: Anesthesiology Authors: Neha Pangasa Rajeshwari Subramaniam Gunjan Singh Mani Kalaivani Manpreet Kaur Viveka P Jyotsna Devalina Goswami Source Type: research

A Randomized Controlled Trial of Intrathecal versus Caudal Morphine-Bupivacaine on Postoperative Analgesia and Cortisol Levels in Pediatric Patients
CONCLUSIONS: Intrathecal morphine and bupivacaine results in longer duration of analgesia, lower analgesic consumption, prevents surgical-stress-related elevation of serum cortisol, and improves parent satisfaction compared to caudal morphine with bupivacaine in children undergoing lower abdominal surgeries.PMID:38639890 | DOI:10.1213/ANE.0000000000006962 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 19, 2024 Category: Anesthesiology Authors: Neha Pangasa Rajeshwari Subramaniam Gunjan Singh Mani Kalaivani Manpreet Kaur Viveka P Jyotsna Devalina Goswami Source Type: research

A Randomized Controlled Trial of Intrathecal versus Caudal Morphine-Bupivacaine on Postoperative Analgesia and Cortisol Levels in Pediatric Patients
CONCLUSIONS: Intrathecal morphine and bupivacaine results in longer duration of analgesia, lower analgesic consumption, prevents surgical-stress-related elevation of serum cortisol, and improves parent satisfaction compared to caudal morphine with bupivacaine in children undergoing lower abdominal surgeries.PMID:38639890 | DOI:10.1213/ANE.0000000000006962 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 19, 2024 Category: Anesthesiology Authors: Neha Pangasa Rajeshwari Subramaniam Gunjan Singh Mani Kalaivani Manpreet Kaur Viveka P Jyotsna Devalina Goswami Source Type: research

A Randomized Controlled Trial of Intrathecal versus Caudal Morphine-Bupivacaine on Postoperative Analgesia and Cortisol Levels in Pediatric Patients
CONCLUSIONS: Intrathecal morphine and bupivacaine results in longer duration of analgesia, lower analgesic consumption, prevents surgical-stress-related elevation of serum cortisol, and improves parent satisfaction compared to caudal morphine with bupivacaine in children undergoing lower abdominal surgeries.PMID:38639890 | DOI:10.1213/ANE.0000000000006962 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 19, 2024 Category: Anesthesiology Authors: Neha Pangasa Rajeshwari Subramaniam Gunjan Singh Mani Kalaivani Manpreet Kaur Viveka P Jyotsna Devalina Goswami Source Type: research