Single Dose Intravenous Paracetamol versus Placebo in Postorthognathic Surgery Pain: A Randomized Clinical Trial
CONCLUSION: A single dose of intravenous paracetamol as part of multimodal analgesia was effective for postorthognathic surgery pain. It provided significant benefits to patients, including reduced pain scores, decreased opioid consumption, reduced nausea and vomiting, and improved satisfaction. This trial is registered with TCTR20210908002.PMID:38525206 | PMC:PMC10957247 | DOI:10.1155/2024/8898553 (Source: Anesthesiology Research and Practice)
Source: Anesthesiology Research and Practice - March 25, 2024 Category: Anesthesiology Authors: Thunshuda Sumphaongern Pornchai Jansisyanont Source Type: research
The impact of tightened prescribing restrictions for PBS-subsidised opioid medicines and the introduction of half-pack sizes, Australia, 2020-21: an interrupted time series analysis
CONCLUSIONS: The introduction of new PBS rules for subsidised opioid medicines was followed by a decline in PBS-subsidised dispensing. Some people may have bypassed the new restrictions by switching to private prescriptions, but our findings suggest that opioid medicine use in Australia declined as a result of the new restrictions.PMID:38522006 | DOI:10.5694/mja2.52257 (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - March 24, 2024 Category: General Medicine Authors: Forrest C Koch Jake Olivier Jonathan Brett Nicholas A Buckley Natasa Gisev Sallie Pearson Benjamin Daniels Source Type: research
The impact of tightened prescribing restrictions for PBS-subsidised opioid medicines and the introduction of half-pack sizes, Australia, 2020-21: an interrupted time series analysis
CONCLUSIONS: The introduction of new PBS rules for subsidised opioid medicines was followed by a decline in PBS-subsidised dispensing. Some people may have bypassed the new restrictions by switching to private prescriptions, but our findings suggest that opioid medicine use in Australia declined as a result of the new restrictions.PMID:38522006 | DOI:10.5694/mja2.52257 (Source: Med J Aust)
Source: Med J Aust - March 24, 2024 Category: General Medicine Authors: Forrest C Koch Jake Olivier Jonathan Brett Nicholas A Buckley Natasa Gisev Sallie Pearson Benjamin Daniels Source Type: research
Real-time monitoring of cortical brain activity in response to acute pain using wide-area Ca < sup > 2+ < /sup > imaging
Biochem Biophys Res Commun. 2024 Mar 18;708:149800. doi: 10.1016/j.bbrc.2024.149800. Online ahead of print.ABSTRACTPrevious human and rodent studies indicated that nociceptive stimuli activate many brain regions that is involved in the somatosensory and emotional sensation. Although these studies have identified several important brain regions involved in pain perception, it has been a challenge to observe neural activity directly and simultaneously in these multiple brain regions during pain perception. Using a transgenic mouse expressing G-CaMP7 in majority of astrocytes and a subpopulation of excitatory neurons, we reco...
Source: Biochemical and Biophysical Research communications - March 24, 2024 Category: Biochemistry Authors: Chihiro Inami Makito Haruta Yasumi Ohta Motoshi Tanaka MinHye So Kazuya Sobue Yasemin Akay Kazuhiko Kume Jun Ohta Metin Akay Masahiro Ohsawa Source Type: research
The impact of tightened prescribing restrictions for PBS-subsidised opioid medicines and the introduction of half-pack sizes, Australia, 2020-21: an interrupted time series analysis
CONCLUSIONS: The introduction of new PBS rules for subsidised opioid medicines was followed by a decline in PBS-subsidised dispensing. Some people may have bypassed the new restrictions by switching to private prescriptions, but our findings suggest that opioid medicine use in Australia declined as a result of the new restrictions.PMID:38522006 | DOI:10.5694/mja2.52257 (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - March 24, 2024 Category: General Medicine Authors: Forrest C Koch Jake Olivier Jonathan Brett Nicholas A Buckley Natasa Gisev Sallie Pearson Benjamin Daniels Source Type: research
The impact of tightened prescribing restrictions for PBS-subsidised opioid medicines and the introduction of half-pack sizes, Australia, 2020-21: an interrupted time series analysis
CONCLUSIONS: The introduction of new PBS rules for subsidised opioid medicines was followed by a decline in PBS-subsidised dispensing. Some people may have bypassed the new restrictions by switching to private prescriptions, but our findings suggest that opioid medicine use in Australia declined as a result of the new restrictions.PMID:38522006 | DOI:10.5694/mja2.52257 (Source: Med J Aust)
Source: Med J Aust - March 24, 2024 Category: General Medicine Authors: Forrest C Koch Jake Olivier Jonathan Brett Nicholas A Buckley Natasa Gisev Sallie Pearson Benjamin Daniels Source Type: research
Real-time monitoring of cortical brain activity in response to acute pain using wide-area Ca < sup > 2+ < /sup > imaging
Biochem Biophys Res Commun. 2024 Mar 18;708:149800. doi: 10.1016/j.bbrc.2024.149800. Online ahead of print.ABSTRACTPrevious human and rodent studies indicated that nociceptive stimuli activate many brain regions that is involved in the somatosensory and emotional sensation. Although these studies have identified several important brain regions involved in pain perception, it has been a challenge to observe neural activity directly and simultaneously in these multiple brain regions during pain perception. Using a transgenic mouse expressing G-CaMP7 in majority of astrocytes and a subpopulation of excitatory neurons, we reco...
Source: Biochemical and Biophysical Research communications - March 24, 2024 Category: Biochemistry Authors: Chihiro Inami Makito Haruta Yasumi Ohta Motoshi Tanaka MinHye So Kazuya Sobue Yasemin Akay Kazuhiko Kume Jun Ohta Metin Akay Masahiro Ohsawa Source Type: research
The impact of tightened prescribing restrictions for PBS-subsidised opioid medicines and the introduction of half-pack sizes, Australia, 2020-21: an interrupted time series analysis
CONCLUSIONS: The introduction of new PBS rules for subsidised opioid medicines was followed by a decline in PBS-subsidised dispensing. Some people may have bypassed the new restrictions by switching to private prescriptions, but our findings suggest that opioid medicine use in Australia declined as a result of the new restrictions.PMID:38522006 | DOI:10.5694/mja2.52257 (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - March 24, 2024 Category: General Medicine Authors: Forrest C Koch Jake Olivier Jonathan Brett Nicholas A Buckley Natasa Gisev Sallie Pearson Benjamin Daniels Source Type: research
The impact of tightened prescribing restrictions for PBS-subsidised opioid medicines and the introduction of half-pack sizes, Australia, 2020-21: an interrupted time series analysis
CONCLUSIONS: The introduction of new PBS rules for subsidised opioid medicines was followed by a decline in PBS-subsidised dispensing. Some people may have bypassed the new restrictions by switching to private prescriptions, but our findings suggest that opioid medicine use in Australia declined as a result of the new restrictions.PMID:38522006 | DOI:10.5694/mja2.52257 (Source: Med J Aust)
Source: Med J Aust - March 24, 2024 Category: General Medicine Authors: Forrest C Koch Jake Olivier Jonathan Brett Nicholas A Buckley Natasa Gisev Sallie Pearson Benjamin Daniels Source Type: research
Opioid Use in Pelvic Fractures: The Impact of Opioid Prescribing Laws in Pennsylvania
This study suggests a modest impact of these laws, but further study is needed.PMID:38516756 | DOI:10.1177/00031348241241644 (Source: The American Surgeon)
Source: The American Surgeon - March 22, 2024 Category: Surgery Authors: Nicole Ann E Villa Kristina Shum Allison Atkinson Adrian Ong Alison Muller Eduardo Espiridion Source Type: research
Evidence for the induction of analgesic cross-tolerance between opioid and apelin/APJ systems in male rats
CONCLUSION: Chronic administration of apelin or morphine induces analgesic cross-tolerance that may, in part, be mediated through receptor interactions and downregulation. The demonstrated efficacy of F13-A in these experiments highlights its potential as a novel target for improving pain management through the inhibition of the apelin/APJ signaling pathway, meriting further investigation.PMID:38517751 | DOI:10.15288/jsad.23-00377 (Source: Journal of Studies on Alcohol and Drugs)
Source: Journal of Studies on Alcohol and Drugs - March 22, 2024 Category: Addiction Authors: Elham Abbasloo Saeed Esmaeili-Mahani Firas Kobeissy Theresa Currier Thomas Source Type: research
Opioid Use in Pelvic Fractures: The Impact of Opioid Prescribing Laws in Pennsylvania
This study suggests a modest impact of these laws, but further study is needed.PMID:38516756 | DOI:10.1177/00031348241241644 (Source: The American Surgeon)
Source: The American Surgeon - March 22, 2024 Category: Surgery Authors: Nicole Ann E Villa Kristina Shum Allison Atkinson Adrian Ong Alison Muller Eduardo Espiridion Source Type: research
Evidence for the induction of analgesic cross-tolerance between opioid and apelin/APJ systems in male rats
CONCLUSION: Chronic administration of apelin or morphine induces analgesic cross-tolerance that may, in part, be mediated through receptor interactions and downregulation. The demonstrated efficacy of F13-A in these experiments highlights its potential as a novel target for improving pain management through the inhibition of the apelin/APJ signaling pathway, meriting further investigation.PMID:38517751 | DOI:10.15288/jsad.23-00377 (Source: Journal of Studies on Alcohol and Drugs)
Source: Journal of Studies on Alcohol and Drugs - March 22, 2024 Category: Addiction Authors: Elham Abbasloo Saeed Esmaeili-Mahani Firas Kobeissy Theresa Currier Thomas Source Type: research
