Liposomal bupivacaine intercostal block placed under direct vision reduces morphine use in thoracic surgery
CONCLUSIONS: Compared to TEA, LB intercostal block placed under direct vision reduced morphine use 48 hours after thoracic surgery. It was also associated with fewer postoperative complications and shorter median hospital LOS. LB is a good alternative to TEA for pain management after minimally invasive lung resection.PMID:38505026 | PMC:PMC10944765 | DOI:10.21037/jtd-23-1405 (Source: Cancer Control)
Source: Cancer Control - March 20, 2024 Category: Cancer & Oncology Authors: Anupama Singh Miles McAllister Luis E De Le ón Suden K ücükak Matthew M Rochefort Emanuele Mazzola Luisa Maldonado Phillip M Hartigan Michael T Jaklitsch Scott J Swanson Raphael Bueno Ashley L Deeb Namrata Patil Source Type: research
Effect of a Multidisciplinary Review Panel on Daily Morphine Milligram Equivalents for Patients With Chronic Pain
CONCLUSIONS: Referral of patients receiving COT to a multidisciplinary review panel may reduce their daily opioid dose.PMID:38500333 | DOI:10.1177/21501319241240345 (Source: Primary Care)
Source: Primary Care - March 19, 2024 Category: Primary Care Authors: Glenn R Kauppila Sarah M Strahm Erica L Vogel Stephanie M Raap Dana H Cash Kaitlin J Yost Source Type: research
Effect of a Multidisciplinary Review Panel on Daily Morphine Milligram Equivalents for Patients With Chronic Pain
CONCLUSIONS: Referral of patients receiving COT to a multidisciplinary review panel may reduce their daily opioid dose.PMID:38500333 | PMC:PMC10949542 | DOI:10.1177/21501319241240345 (Source: Primary Care)
Source: Primary Care - March 19, 2024 Category: Primary Care Authors: Glenn R Kauppila Sarah M Strahm Erica L Vogel Stephanie M Raap Dana H Cash Kaitlin J Yost Source Type: research
Natural distribution, structures, synthesis, and bioactivity of hasubanan alkaloids
ChemMedChem. 2024 Mar 19:e202300721. doi: 10.1002/cmdc.202300721. Online ahead of print.ABSTRACTHasubanan alkaloids represent a distinct class of alkaloids bearing a structural resemblance to morphine, predominantly found in herbals of the Stephania genus. Their intriguing molecular architecture and potential analgesic properties have captured the interest of medicinal chemists worldwide. This review meticulously examines the natural distribution, structural characteristics, biosynthetic pathways, synthetic methodologies, and biological activities of hasubanans.PMID:38503694 | DOI:10.1002/cmdc.202300721 (Source: ChemMedChem)
Source: ChemMedChem - March 19, 2024 Category: Chemistry Authors: Yingjie Wang Fuxin Sun Yapeng Liang Di Zhou Gang Chen Ning Li Source Type: research
Preconception opioids interact with mouse strain to alter morphine withdrawal in the next generation
AbstractRationaleTransgenerational effects of preconception morphine exposure in female rats have been reported which suggest that epigenetic modifications triggered by female opioid exposure, even when that exposure ends several weeks prior to pregnancy, has significant ramifications for their future offspring.ObjectiveThe current study compares two mouse strains with well-established genetic variation in their response to mu opioid receptor agonists, C57BL/6J (BL6) and 129S1/svlmJ (129) to determine whether genetic background modifies the impact of preconception opioid exposure.MethodsAdolescentfemales from both strains ...
Source: Psychopharmacology - March 19, 2024 Category: Psychiatry Source Type: research
Gastrointestinal adverse effects associated with the use of intravenous oliceridine compared with intravenous hydromorphone or fentanyl in acute pain management utilizing adjusted indirect treatment comparison methods
Conclusion: In ITC analyses, oliceridine significantly reduced the incidence of nausea and/or vomiting or the need for antiemetics in orthopedic surgery compared with hydromorphone and a non-significant trend toward reduced risk versus fentanyl.PMID:38497192 | DOI:10.57264/cer-2023-0041 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 18, 2024 Category: General Medicine Authors: Joseph Biskupiak Gary Oderda Diana Brixner Todd L Wandstrat Source Type: research
Corrigendum to "Involvement of the N/OFQ-NOP system in rat morphine antinociceptive tolerance: are astrocytes the crossroad?" [Eur. J. Pharmacol. 823 (2018) 79-86]
Eur J Pharmacol. 2024 Mar 17:176497. doi: 10.1016/j.ejphar.2024.176497. Online ahead of print.NO ABSTRACTPMID:38499455 | DOI:10.1016/j.ejphar.2024.176497 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 18, 2024 Category: Drugs & Pharmacology Authors: Laura Micheli Elena Lucarini Francesca Corti Roberto Ciccocioppo Girolamo Cal ò Anna Rizzi Carla Ghelardini Lorenzo Di Cesare Mannelli Source Type: research
Gastrointestinal adverse effects associated with the use of intravenous oliceridine compared with intravenous hydromorphone or fentanyl in acute pain management utilizing adjusted indirect treatment comparison methods
Conclusion: In ITC analyses, oliceridine significantly reduced the incidence of nausea and/or vomiting or the need for antiemetics in orthopedic surgery compared with hydromorphone and a non-significant trend toward reduced risk versus fentanyl.PMID:38497192 | DOI:10.57264/cer-2023-0041 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 18, 2024 Category: General Medicine Authors: Joseph Biskupiak Gary Oderda Diana Brixner Todd L Wandstrat Source Type: research
Corrigendum to "Involvement of the N/OFQ-NOP system in rat morphine antinociceptive tolerance: are astrocytes the crossroad?" [Eur. J. Pharmacol. 823 (2018) 79-86]
Eur J Pharmacol. 2024 Mar 17:176497. doi: 10.1016/j.ejphar.2024.176497. Online ahead of print.NO ABSTRACTPMID:38499455 | DOI:10.1016/j.ejphar.2024.176497 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 18, 2024 Category: Drugs & Pharmacology Authors: Laura Micheli Elena Lucarini Francesca Corti Roberto Ciccocioppo Girolamo Cal ò Anna Rizzi Carla Ghelardini Lorenzo Di Cesare Mannelli Source Type: research
Gastrointestinal adverse effects associated with the use of intravenous oliceridine compared with intravenous hydromorphone or fentanyl in acute pain management utilizing adjusted indirect treatment comparison methods
Conclusion: In ITC analyses, oliceridine significantly reduced the incidence of nausea and/or vomiting or the need for antiemetics in orthopedic surgery compared with hydromorphone and a non-significant trend toward reduced risk versus fentanyl.PMID:38497192 | DOI:10.57264/cer-2023-0041 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - March 18, 2024 Category: General Medicine Authors: Joseph Biskupiak Gary Oderda Diana Brixner Todd L Wandstrat Source Type: research
