Analgesic Efficacy and Safety of Intrathecal Morphine or Intercostal Levobupivacaine in Lung Cancer Patients after Major Lung Resection Surgery by Videothoracoscopy: A Prospective Randomized Controlled Trial
Conclusions: ITM can be considered an adequate and satisfactory regional technique for the control of acute postoperative pain in VATS, compatible with the multimodal rehabilitation and early discharge protocols used in these types of surgeries.PMID:38610735 | DOI:10.3390/jcm13071972 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 13, 2024 Category: Cancer & Oncology Authors: Silvia Gonz ález-Santos Borja Mugabure Manuel Granell Borja Aguinagalde Iker J L ópez Ainhoa Aginaga Inmaculada Zubelzu Haritz Iraeta Jon Zabaleta Jose Miguel Izquierdo Nuria Gonz ález-Jorrín Cristina Sarasqueta Alejandro Herreros-Pomares Source Type: research
Analgesic Efficacy and Safety of Intrathecal Morphine or Intercostal Levobupivacaine in Lung Cancer Patients after Major Lung Resection Surgery by Videothoracoscopy: A Prospective Randomized Controlled Trial
Conclusions: ITM can be considered an adequate and satisfactory regional technique for the control of acute postoperative pain in VATS, compatible with the multimodal rehabilitation and early discharge protocols used in these types of surgeries.PMID:38610735 | DOI:10.3390/jcm13071972 (Source: Cancer Control)
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Silvia Gonz ález-Santos Borja Mugabure Manuel Granell Borja Aguinagalde Iker J L ópez Ainhoa Aginaga Inmaculada Zubelzu Haritz Iraeta Jon Zabaleta Jose Miguel Izquierdo Nuria Gonz ález-Jorrín Cristina Sarasqueta Alejandro Herreros-Pomares Source Type: research
Analgesic Efficacy and Safety of Intrathecal Morphine or Intercostal Levobupivacaine in Lung Cancer Patients after Major Lung Resection Surgery by Videothoracoscopy: A Prospective Randomized Controlled Trial
Conclusions: ITM can be considered an adequate and satisfactory regional technique for the control of acute postoperative pain in VATS, compatible with the multimodal rehabilitation and early discharge protocols used in these types of surgeries.PMID:38610735 | PMC:PMC11012894 | DOI:10.3390/jcm13071972 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 13, 2024 Category: Cancer & Oncology Authors: Silvia Gonz ález-Santos Borja Mugabure Manuel Granell Borja Aguinagalde Iker J L ópez Ainhoa Aginaga Inmaculada Zubelzu Haritz Iraeta Jon Zabaleta Jose Miguel Izquierdo Nuria Gonz ález-Jorrín Cristina Sarasqueta Alejandro Herreros-Pomares Source Type: research
Advances in animal models of prenatal opioid exposure
Trends Neurosci. 2024 Apr 12:S0166-2236(24)00042-0. doi: 10.1016/j.tins.2024.03.005. Online ahead of print.ABSTRACTNeonatal opioid withdrawal syndrome (NOWS) is a growing public health concern. The complexity of in utero opioid exposure in clinical studies makes it difficult to investigate underlying mechanisms that could ultimately inform early diagnosis and treatments. Clinical studies are unable to dissociate the influence of maternal polypharmacy or the environment from direct effects of in utero opioid exposure, highlighting the need for effective animal models. Early animal models of prenatal opioid exposure primaril...
Source: Trends in Neurosciences - April 13, 2024 Category: Neuroscience Authors: Julia R Ferrante Julie A Blendy Source Type: research
Intravenous Administration of Recombinant Ph α1β: Antinociceptive Properties and Morphine Tolerance Reversal in a Cancer-Associated Pain Model
This study aims to assess the antinociceptive effects resulting from intravenous administration of the recombinant form of Phα1β (r-Phα1β) in an experimental model of cancer-related pain in mice, tolerant or not to morphine. The model of cancer-induced pain was used to evaluate these effects, with the injection of B16F10 cells, followed by the administration of the r-Phα1β, and evaluation of the mechanical threshold by the von Frey test. Also, adverse effects were assessed using a score scale, the rotarod, and open field tests. Results indicate that the administration of r-Phα1β provoked antinociception in animals ...
Source: Toxicon - April 13, 2024 Category: Toxicology Authors: Mariana de Melo Cardoso Rahisa Scussel Jessica da Silva Abel Fernando Oriques Pereira Lidiane Anast ácio Cruz Franciane da Costa Constante Ellen De Pieri Helena Mendes Abelaira Juliano Ferreira Marcus Vin ícius Gomez Fl ávia K Rigo Ricardo Andrez Macha Source Type: research
Advances in animal models of prenatal opioid exposure
Trends Neurosci. 2024 Apr 12:S0166-2236(24)00042-0. doi: 10.1016/j.tins.2024.03.005. Online ahead of print.ABSTRACTNeonatal opioid withdrawal syndrome (NOWS) is a growing public health concern. The complexity of in utero opioid exposure in clinical studies makes it difficult to investigate underlying mechanisms that could ultimately inform early diagnosis and treatments. Clinical studies are unable to dissociate the influence of maternal polypharmacy or the environment from direct effects of in utero opioid exposure, highlighting the need for effective animal models. Early animal models of prenatal opioid exposure primaril...
Source: Trends in Neurosciences - April 13, 2024 Category: Neuroscience Authors: Julia R Ferrante Julie A Blendy Source Type: research
Advances in animal models of prenatal opioid exposure
Trends Neurosci. 2024 Apr 12:S0166-2236(24)00042-0. doi: 10.1016/j.tins.2024.03.005. Online ahead of print.ABSTRACTNeonatal opioid withdrawal syndrome (NOWS) is a growing public health concern. The complexity of in utero opioid exposure in clinical studies makes it difficult to investigate underlying mechanisms that could ultimately inform early diagnosis and treatments. Clinical studies are unable to dissociate the influence of maternal polypharmacy or the environment from direct effects of in utero opioid exposure, highlighting the need for effective animal models. Early animal models of prenatal opioid exposure primaril...
Source: Trends in Neurosciences - April 13, 2024 Category: Neuroscience Authors: Julia R Ferrante Julie A Blendy Source Type: research
Advances in animal models of prenatal opioid exposure
Trends Neurosci. 2024 Apr 12:S0166-2236(24)00042-0. doi: 10.1016/j.tins.2024.03.005. Online ahead of print.ABSTRACTNeonatal opioid withdrawal syndrome (NOWS) is a growing public health concern. The complexity of in utero opioid exposure in clinical studies makes it difficult to investigate underlying mechanisms that could ultimately inform early diagnosis and treatments. Clinical studies are unable to dissociate the influence of maternal polypharmacy or the environment from direct effects of in utero opioid exposure, highlighting the need for effective animal models. Early animal models of prenatal opioid exposure primaril...
Source: Trends in Neurosciences - April 13, 2024 Category: Neuroscience Authors: Julia R Ferrante Julie A Blendy Source Type: research
Advances in animal models of prenatal opioid exposure
Trends Neurosci. 2024 Apr 12:S0166-2236(24)00042-0. doi: 10.1016/j.tins.2024.03.005. Online ahead of print.ABSTRACTNeonatal opioid withdrawal syndrome (NOWS) is a growing public health concern. The complexity of in utero opioid exposure in clinical studies makes it difficult to investigate underlying mechanisms that could ultimately inform early diagnosis and treatments. Clinical studies are unable to dissociate the influence of maternal polypharmacy or the environment from direct effects of in utero opioid exposure, highlighting the need for effective animal models. Early animal models of prenatal opioid exposure primaril...
Source: Trends in Neurosciences - April 13, 2024 Category: Neuroscience Authors: Julia R Ferrante Julie A Blendy Source Type: research
Predictors of postoperative opioid use in ventral and incisional hernia repair
ConclusionPreoperative opioid use during 45-day pre-admission correlated strongly with postoperative prescription filling in VIHR patients, and several independent risk factors were identified. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 12, 2024 Category: Surgery Source Type: research
Inhibition of endoplasmic reticulum stress attenuates morphine protracted abstinence-induced anxiety-like behaviors in the male mice
In this study, by using behavioral test, western blot, immunofluorescence, electron transmission microscope, we found that: (1) Inhibition of endoplasmic reticulum stress by 4-Phenylbutyric acid (4-PBA) could attenuate anxiety-like behaviors induced by morphine withdrawal. (2) The endoplasmic reticulum stress-related proteins in the lateral habenula (LHb) but not in the nucleus accumbens (NAc), ventral pallidum (VP), basolateral amygdala (BLA) and CA1 of hippocampus was upregulated by morphine withdrawal, upregulation of endoplasmic reticulum stress-related proteins in the lateral habenula induced by morphine withdrawal wa...
Source: Brain Research - April 11, 2024 Category: Neurology Authors: Lu Liu Jie Wu Changlin Zhang Tong Cao Yongli Lu Zhi He Zicheng Li Source Type: research
