Efficacy of Liposomal Bupivacaine in Reducing Opioid Use After Posterior Lumbar Spinal Decompression and Fusion
CONCLUSION: The findings of this study suggest that the addition of liposomal bupivacaine to traditional pain management modalities can augment pain management for patients undergoing posterior lumbar surgery, as evidenced by the significant decrease in postoperative morphine milligram equivalents required. [Orthopedics. 202x;4x(x):xx-xx.].PMID:38568003 | DOI:10.3928/01477447-20240325-07 (Source: Orthopedics)
Source: Orthopedics - April 3, 2024 Category: Orthopaedics Authors: Amber McClure Olivia C Silveri Megan Foddrell Karen Duteil Laura E Madar ász Christopher P Silveri Source Type: research
Efficacy of Liposomal Bupivacaine in Reducing Opioid Use After Posterior Lumbar Spinal Decompression and Fusion
CONCLUSION: The findings of this study suggest that the addition of liposomal bupivacaine to traditional pain management modalities can augment pain management for patients undergoing posterior lumbar surgery, as evidenced by the significant decrease in postoperative morphine milligram equivalents required. [Orthopedics. 202x;4x(x):xx-xx.].PMID:38568003 | DOI:10.3928/01477447-20240325-07 (Source: Orthopedics)
Source: Orthopedics - April 3, 2024 Category: Orthopaedics Authors: Amber McClure Olivia C Silveri Megan Foddrell Karen Duteil Laura E Madar ász Christopher P Silveri Source Type: research
Receipt of prescription opioid medication is associated with increased mortality in an Israeli population
ConclusionIncreased opioid use is independently associated with increased all-cause mortality among non-oncological patients. This result is most notable among young adults with little or no known comorbidities. These findings are consistent with results in other countries and seem more credible than previous Israeli reports. Healthcare regulators and providers should, therefore, act to curtail the increasing opioid prescriptions and devise and enhance controls in the healthcare system, which, until 2020, had very limited mechanisms in place. (Source: Israel Journal of Health Policy Research)
Source: Israel Journal of Health Policy Research - April 3, 2024 Category: International Medicine & Public Health Source Type: research
PBPK-PD model for predicting morphine pharmacokinetics, CNS effects and naloxone antagonism in humans
Acta Pharmacologica Sinica, Published online: 03 April 2024; doi:10.1038/s41401-024-01255-2PBPK-PD model for predicting morphine pharmacokinetics, CNS effects and naloxone antagonism in humans (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 3, 2024 Category: Drugs & Pharmacology Authors: Rui-jing Mu Tian-lei Liu Xiao-dong Liu Li Liu Source Type: research
Is a Rapid Recovery Protocol for THA and TKA Associated With Decreased 90-day Complications, Opioid Use, and Readmissions in a Health Safety-net Hospital?
CONCLUSION: Surgeons should consider developing an RRP in health safety-net hospitals. Such protocols emphasize preparing patients for surgery and supporting them through the acute recovery phase. There are possible benefits of neuraxial and nonopioid perioperative anesthesia, with emphasis on early mobility, which should be further characterized in comparative studies. Continued analysis of opioid use trends after discharge would be a future area of interest. Analysis of RRPs with expanded inclusion criteria should be undertaken to better understand the role of these protocols in patients who undergo revision TKA and THA....
Source: Clinical Orthopaedics and Related Research - April 2, 2024 Category: Orthopaedics Authors: Michael W Buchanan Brian Gibbs Andrew A Ronald David Novikov Allen Yang Seroos Salavati Ayesha Abdeen Source Type: research
Predictors of persistent opioid use in bladder cancer patients undergoing radical cystectomy: A SEER-Medicare analysis
CONCLUSIONS: Non-opioid naïve patients have higher rates of post-operative opioid prescription than opioid-naïve patients. Physician prescribing practices play a role in persistent use, as initial prescription amount predicts persistent use even in non-opioid naïve patients. Significant physician variation in both prescribing practices and rates of persistent use suggest a role for standardizing practices.PMID:38565428 | DOI:10.1016/j.urolonc.2024.03.010 (Source: Urologic Oncology)
Source: Urologic Oncology - April 2, 2024 Category: Urology & Nephrology Authors: Christopher J Staniorski Michelle Yu Danielle Sharbaugh Michael G Stencel John M Myrga Benjamin J Davies Jonathan G Yabes Bruce Jacobs Source Type: research
Is a Rapid Recovery Protocol for THA and TKA Associated With Decreased 90-day Complications, Opioid Use, and Readmissions in a Health Safety-net Hospital?
CONCLUSION: Surgeons should consider developing an RRP in health safety-net hospitals. Such protocols emphasize preparing patients for surgery and supporting them through the acute recovery phase. There are possible benefits of neuraxial and nonopioid perioperative anesthesia, with emphasis on early mobility, which should be further characterized in comparative studies. Continued analysis of opioid use trends after discharge would be a future area of interest. Analysis of RRPs with expanded inclusion criteria should be undertaken to better understand the role of these protocols in patients who undergo revision TKA and THA....
Source: Clinical Orthopaedics and Related Research - April 2, 2024 Category: Orthopaedics Authors: Michael W Buchanan Brian Gibbs Andrew A Ronald David Novikov Allen Yang Seroos Salavati Ayesha Abdeen Source Type: research
Predictors of persistent opioid use in bladder cancer patients undergoing radical cystectomy: A SEER-Medicare analysis
CONCLUSIONS: Non-opioid naïve patients have higher rates of post-operative opioid prescription than opioid-naïve patients. Physician prescribing practices play a role in persistent use, as initial prescription amount predicts persistent use even in non-opioid naïve patients. Significant physician variation in both prescribing practices and rates of persistent use suggest a role for standardizing practices.PMID:38565428 | DOI:10.1016/j.urolonc.2024.03.010 (Source: Urologic Oncology)
Source: Urologic Oncology - April 2, 2024 Category: Urology & Nephrology Authors: Christopher J Staniorski Michelle Yu Danielle Sharbaugh Michael G Stencel John M Myrga Benjamin J Davies Jonathan G Yabes Bruce Jacobs Source Type: research
Evaluation of the antinociceptive activities of natural propolis extract derived from stingless bee < em > Trigona thoracica < /em > in mice
CONCLUSIONS: : APE from Trigona thoracica, containing p-coumaric acid and caffeic acid, exhibited antinociceptive effects, which supports its potential use in targeting the prevention or reversal of central and peripheral sensitization that may produce clinical pain conditions.PMID:38557655 | DOI:10.3344/kjp.23318 (Source: Korean Journal of Pain)
Source: Korean Journal of Pain - April 1, 2024 Category: Anesthesiology Authors: Nurul Alina Muhamad Suhaini Mohd Faeiz Pauzi Siti Norazlina Juhari Noor Azlina Abu Bakar Jee Youn Moon Source Type: research
Storage, Disposal, and Use of Opioids Among Cancer Patients in Central China: A Multi-Center Cross-Sectional Study
CONCLUSION: A significant proportion of Chinese patients with cancer exhibit unsafe practices in the storage, disposal, and use of opioids. The study highlights an urgent need for implementing routine education programs and drug "take-back" initiatives to improve opioid-related practices.PMID:38557816 | DOI:10.1093/oncolo/oyae049 (Source: The Oncologist)
Source: The Oncologist - April 1, 2024 Category: Cancer & Oncology Authors: Mi Zhang Huili Chen Chenxi Luo Xuanxuan Wang Liang Liu Dongfang Wu Hong Cheng Source Type: research
Low-dose ketamine safely reduces acute pain in the ED with a more rapid and shorter effect than morphine
Ann Intern Med. 2024 Apr 2. doi: 10.7326/J24-0017. Online ahead of print.ABSTRACTGuo J, Zhao F, Bian J, et al. Low-dose ketamine versus morphine in the treatment of acute pain in the emergency department: a meta-analysis of 15 randomized controlled trials. Am J Emerg Med. 2024;76:140-149. 38071883.PMID:38560909 | DOI:10.7326/J24-0017 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 1, 2024 Category: Internal Medicine Authors: Evan S Schwarz Source Type: research
Evaluation of the antinociceptive activities of natural propolis extract derived from stingless bee < em > Trigona thoracica < /em > in mice
CONCLUSIONS: : APE from Trigona thoracica, containing p-coumaric acid and caffeic acid, exhibited antinociceptive effects, which supports its potential use in targeting the prevention or reversal of central and peripheral sensitization that may produce clinical pain conditions.PMID:38557655 | PMC:PMC10985486 | DOI:10.3344/kjp.23318 (Source: Korean Journal of Pain)
Source: Korean Journal of Pain - April 1, 2024 Category: Anesthesiology Authors: Nurul Alina Muhamad Suhaini Mohd Faeiz Pauzi Siti Norazlina Juhari Noor Azlina Abu Bakar Jee Youn Moon Source Type: research
Storage, Disposal, and Use of Opioids Among Cancer Patients in Central China: A Multi-Center Cross-Sectional Study
CONCLUSION: A significant proportion of Chinese patients with cancer exhibit unsafe practices in the storage, disposal, and use of opioids. The study highlights an urgent need for implementing routine education programs and drug "take-back" initiatives to improve opioid-related practices.PMID:38557816 | DOI:10.1093/oncolo/oyae049 (Source: The Oncologist)
Source: The Oncologist - April 1, 2024 Category: Cancer & Oncology Authors: Mi Zhang Huili Chen Chenxi Luo Xuanxuan Wang Liang Liu Dongfang Wu Hong Cheng Source Type: research
Low-dose ketamine safely reduces acute pain in the ED with a more rapid and shorter effect than morphine
Ann Intern Med. 2024 Apr 2. doi: 10.7326/J24-0017. Online ahead of print.ABSTRACTGuo J, Zhao F, Bian J, et al. Low-dose ketamine versus morphine in the treatment of acute pain in the emergency department: a meta-analysis of 15 randomized controlled trials. Am J Emerg Med. 2024;76:140-149. 38071883.PMID:38560909 | DOI:10.7326/J24-0017 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 1, 2024 Category: Internal Medicine Authors: Evan S Schwarz Source Type: research
Evaluation of the antinociceptive activities of natural propolis extract derived from stingless bee < em > Trigona thoracica < /em > in mice
CONCLUSIONS: : APE from Trigona thoracica, containing p-coumaric acid and caffeic acid, exhibited antinociceptive effects, which supports its potential use in targeting the prevention or reversal of central and peripheral sensitization that may produce clinical pain conditions.PMID:38557655 | PMC:PMC10985486 | DOI:10.3344/kjp.23318 (Source: Korean Journal of Pain)
Source: Korean Journal of Pain - April 1, 2024 Category: Anesthesiology Authors: Nurul Alina Muhamad Suhaini Mohd Faeiz Pauzi Siti Norazlina Juhari Noor Azlina Abu Bakar Jee Youn Moon Source Type: research
