Inhibition of endoplasmic reticulum stress attenuates morphine protracted abstinence-induced anxiety-like behaviors in the male mice
In this study, by using behavioral test, western blot, immunofluorescence, electron transmission microscope, we found that: (1) Inhibition of endoplasmic reticulum stress by 4-Phenylbutyric acid (4-PBA) could attenuate anxiety-like behaviors induced by morphine withdrawal. (2) The endoplasmic reticulum stress-related proteins in the lateral habenula (LHb) but not in the nucleus accumbens (NAc), ventral pallidum (VP), basolateral amygdala (BLA) and CA1 of hippocampus was upregulated by morphine withdrawal, upregulation of endoplasmic reticulum stress-related proteins in the lateral habenula induced by morphine withdrawal wa...
Source: Brain Research - April 11, 2024 Category: Neurology Authors: Lu Liu Jie Wu Changlin Zhang Tong Cao Yongli Lu Zhi He Zicheng Li Source Type: research
Comparison of sequential and mixture injections of opioids and hyperbaric bupivacaine for subarachnoid block for lower segment caesarean section: a randomised controlled study
ConclusionSequential injection of intrathecal opioids and hyperbaric bupivacaine resulted in greater early haemodynamic instability and slightly better postoperative analgesia without any difference in block height or patient satisfaction.Clinical trial registrationNCT04403724. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 11, 2024 Category: General Medicine Source Type: research
Comparison of Pain Management Strategies to Reduce Opioid Use Postoperatively in Free Flap Breast Reconstruction: Pain Catheter versus Nerve Block in Addition to Refinements in the Oral Pain Management Regime
Conclusion Introduction of the CP reduced opioid use and LOS was shorter.PMID:38596158 | PMC:PMC11001454 | DOI:10.1055/s-0043-1777673 (Source: Archives of Plastic Surgery)
Source: Archives of Plastic Surgery - April 10, 2024 Category: Cosmetic Surgery Authors: Andrea B Stefansdottir Luis Vieira Arni Johnsen Daniel Isacson Andres Rodriguez Maria Mani Source Type: research
Correction: Patient-controlled analgesia morphine for the management of acute pain in the emergency department: a systematic review and meta-analysis
(Source: International Journal of Emergency Medicine)
Source: International Journal of Emergency Medicine - April 10, 2024 Category: Emergency Medicine Source Type: research
