Ultrasound-Guided External Oblique Intercostal Plane Block for Postoperative Analgesia in Laparoscopic Sleeve Gastrectomy: A Prospective, Randomized, Controlled, Patient and Observer-Blinded Study
ConclusionThe results of the current study demonstrated that bilateral EOI block reduced postoperative opioid consumption and postoperative pain in patients with obesity undergoing laparoscopic sleeve gastrectomy.Trial RegistrationClinicaltrials.gov identifier: NCT05663658.Graphical Abstract (Source: Obesity Surgery)
Source: Obesity Surgery - March 18, 2024 Category: Surgery Source Type: research
Persistent Opioid Use After Hospital Admission From Surgery in New Zealand: A Population-Based Study
CONCLUSIONS: Approximately 1 in 11 opioid-naïve patients who were dispensed opioids on surgical discharge, developed POU. Potentially modifiable risk factors for POU, related to how opioids were prescribed included changing opioids after discharge, receiving multiple opioids, and higher total dose of opioids given on discharge. Clinicians should discuss the possibility of developing POU with patients before and after surgery and consider potentially modifiable risk factors for POU when prescribing analgesia on discharge after surgery.PMID:38493440 | DOI:10.1213/ANE.0000000000006911 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 17, 2024 Category: Anesthesiology Authors: Jiayi Gong Peter Jones Chris Frampton Kebede Beyene Amy Hai Yan Chan Source Type: research
Persistent Opioid Use After Hospital Admission From Surgery in New Zealand: A Population-Based Study
CONCLUSIONS: Approximately 1 in 11 opioid-naïve patients who were dispensed opioids on surgical discharge, developed POU. Potentially modifiable risk factors for POU, related to how opioids were prescribed included changing opioids after discharge, receiving multiple opioids, and higher total dose of opioids given on discharge. Clinicians should discuss the possibility of developing POU with patients before and after surgery and consider potentially modifiable risk factors for POU when prescribing analgesia on discharge after surgery.PMID:38493440 | DOI:10.1213/ANE.0000000000006911 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 17, 2024 Category: Anesthesiology Authors: Jiayi Gong Peter Jones Chris Frampton Kebede Beyene Amy Hai Yan Chan Source Type: research
Persistent Opioid Use After Hospital Admission From Surgery in New Zealand: A Population-Based Study
CONCLUSIONS: Approximately 1 in 11 opioid-naïve patients who were dispensed opioids on surgical discharge, developed POU. Potentially modifiable risk factors for POU, related to how opioids were prescribed included changing opioids after discharge, receiving multiple opioids, and higher total dose of opioids given on discharge. Clinicians should discuss the possibility of developing POU with patients before and after surgery and consider potentially modifiable risk factors for POU when prescribing analgesia on discharge after surgery.PMID:38493440 | DOI:10.1213/ANE.0000000000006911 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 17, 2024 Category: Anesthesiology Authors: Jiayi Gong Peter Jones Chris Frampton Kebede Beyene Amy Hai Yan Chan Source Type: research
Persistent Opioid Use After Hospital Admission From Surgery in New Zealand: A Population-Based Study
CONCLUSIONS: Approximately 1 in 11 opioid-naïve patients who were dispensed opioids on surgical discharge, developed POU. Potentially modifiable risk factors for POU, related to how opioids were prescribed included changing opioids after discharge, receiving multiple opioids, and higher total dose of opioids given on discharge. Clinicians should discuss the possibility of developing POU with patients before and after surgery and consider potentially modifiable risk factors for POU when prescribing analgesia on discharge after surgery.PMID:38493440 | DOI:10.1213/ANE.0000000000006911 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 17, 2024 Category: Anesthesiology Authors: Jiayi Gong Peter Jones Chris Frampton Kebede Beyene Amy Hai Yan Chan Source Type: research
Corrigendum to "Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?" [European Journal of Pharmaceutical Sciences 187 (2023) 106482]
Eur J Pharm Sci. 2024 Mar 14:106736. doi: 10.1016/j.ejps.2024.106736. Online ahead of print.NO ABSTRACTPMID:38490876 | DOI:10.1016/j.ejps.2024.106736 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - March 15, 2024 Category: Drugs & Pharmacology Authors: Berfin G ülave Divakar Budda Mohammed Aa Saleh Jg Coen van Hasselt Elizabeth Cm de Lange Source Type: research
Corrigendum to "Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?" [European Journal of Pharmaceutical Sciences 187 (2023) 106482]
Eur J Pharm Sci. 2024 Mar 14:106736. doi: 10.1016/j.ejps.2024.106736. Online ahead of print.NO ABSTRACTPMID:38490876 | DOI:10.1016/j.ejps.2024.106736 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - March 15, 2024 Category: Drugs & Pharmacology Authors: Berfin G ülave Divakar Budda Mohammed Aa Saleh Jg Coen van Hasselt Elizabeth Cm de Lange Source Type: research
Corrigendum to "Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?" [European Journal of Pharmaceutical Sciences 187 (2023) 106482]
Eur J Pharm Sci. 2024 Mar 14:106736. doi: 10.1016/j.ejps.2024.106736. Online ahead of print.NO ABSTRACTPMID:38490876 | DOI:10.1016/j.ejps.2024.106736 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - March 15, 2024 Category: Drugs & Pharmacology Authors: Berfin G ülave Divakar Budda Mohammed Aa Saleh Jg Coen van Hasselt Elizabeth Cm de Lange Source Type: research
Does morphine attenuate the Inhibition of Platelet Aggregation for both oral and parenteral P2Y12 inhibitors?
Cangrelor is an intravenous P2Y12 inhibitor characterized by rapid and reversible Inhibition of Platelet Aggregation (IPA) which was shown to reduce the risk of periprocedural ischemic complications in patients undergoing percutaneous coronary intervention (PCI) [1]. Pivotal studies investigating pharmacodynamic (PD) and clinical effects of cangrelor included a relatively low proportion of patients with ST-segment elevation myocardial infarction (STEMI), albeit in this setting cangrelor showed treatment effects which were consistent with the overall trial results [1]. (Source: Thrombosis Research)
Source: Thrombosis Research - March 15, 2024 Category: Hematology Authors: Antonio Landi, Giuseppe Gargiulo, Giovanni Esposito, Gianluca Campo, Simone Biscaglia, Dik Heg, Marco Valgimigli Tags: Letter to the Editors-in-Chief Source Type: research
Paynantheine more effectively reverses multidrug resistance in malignant EPG85.257RDB and MCF7MX cells than morphine and speciociliatine
Cell Biol Int. 2024 Mar 13. doi: 10.1002/cbin.12152. Online ahead of print.ABSTRACTThe possible interactions of morphine, paynantheine and speciociliatine alkaloids with ATP-binding cassette (ABC) transporters was investigated. The compounds were docked against ABCG2 and ABCB1 to predict the binding mode of alkaloids in active binding sites. The cytotoxicity of morphine, paynantheine and speciociliatine for EPG85.257RDB and MCF7MX cells was determined and ABCB1 and ABCG2 gene and protein expression were determined. The binding score of paynantheine to ABCB1 was higher in the docking studies. Paynantheine and speciociliatin...
Source: Cell Biology International - March 14, 2024 Category: Cytology Authors: Nayereh Abdali Mohammad Nadipour Borujeni Sayedeh Azimeh Hosseini Rahim Malekzadeh Marzieh Abolhasani Seyed Abbas Mirzaei Fatemeh Elahian Source Type: research
Paynantheine more effectively reverses multidrug resistance in malignant EPG85.257RDB and MCF7MX cells than morphine and speciociliatine
Cell Biol Int. 2024 Mar 13. doi: 10.1002/cbin.12152. Online ahead of print.ABSTRACTThe possible interactions of morphine, paynantheine and speciociliatine alkaloids with ATP-binding cassette (ABC) transporters was investigated. The compounds were docked against ABCG2 and ABCB1 to predict the binding mode of alkaloids in active binding sites. The cytotoxicity of morphine, paynantheine and speciociliatine for EPG85.257RDB and MCF7MX cells was determined and ABCB1 and ABCG2 gene and protein expression were determined. The binding score of paynantheine to ABCB1 was higher in the docking studies. Paynantheine and speciociliatin...
Source: Cell Biology International - March 14, 2024 Category: Cytology Authors: Nayereh Abdali Mohammad Nadipour Borujeni Sayedeh Azimeh Hosseini Rahim Malekzadeh Marzieh Abolhasani Seyed Abbas Mirzaei Fatemeh Elahian Source Type: research
Paynantheine more effectively reverses multidrug resistance in malignant EPG85.257RDB and MCF7MX cells than morphine and speciociliatine
Cell Biol Int. 2024 Mar 13. doi: 10.1002/cbin.12152. Online ahead of print.ABSTRACTThe possible interactions of morphine, paynantheine and speciociliatine alkaloids with ATP-binding cassette (ABC) transporters was investigated. The compounds were docked against ABCG2 and ABCB1 to predict the binding mode of alkaloids in active binding sites. The cytotoxicity of morphine, paynantheine and speciociliatine for EPG85.257RDB and MCF7MX cells was determined and ABCB1 and ABCG2 gene and protein expression were determined. The binding score of paynantheine to ABCB1 was higher in the docking studies. Paynantheine and speciociliatin...
Source: Cell Biology International - March 14, 2024 Category: Cytology Authors: Nayereh Abdali Mohammad Nadipour Borujeni Sayedeh Azimeh Hosseini Rahim Malekzadeh Marzieh Abolhasani Seyed Abbas Mirzaei Fatemeh Elahian Source Type: research
Paynantheine more effectively reverses multidrug resistance in malignant EPG85.257RDB and MCF7MX cells than morphine and speciociliatine
Cell Biol Int. 2024 Mar 13. doi: 10.1002/cbin.12152. Online ahead of print.ABSTRACTThe possible interactions of morphine, paynantheine and speciociliatine alkaloids with ATP-binding cassette (ABC) transporters was investigated. The compounds were docked against ABCG2 and ABCB1 to predict the binding mode of alkaloids in active binding sites. The cytotoxicity of morphine, paynantheine and speciociliatine for EPG85.257RDB and MCF7MX cells was determined and ABCB1 and ABCG2 gene and protein expression were determined. The binding score of paynantheine to ABCB1 was higher in the docking studies. Paynantheine and speciociliatin...
Source: Cell Biology International - March 14, 2024 Category: Cytology Authors: Nayereh Abdali Mohammad Nadipour Borujeni Sayedeh Azimeh Hosseini Rahim Malekzadeh Marzieh Abolhasani Seyed Abbas Mirzaei Fatemeh Elahian Source Type: research
Paynantheine more effectively reverses multidrug resistance in malignant EPG85.257RDB and MCF7MX cells than morphine and speciociliatine
Cell Biol Int. 2024 Mar 13. doi: 10.1002/cbin.12152. Online ahead of print.ABSTRACTThe possible interactions of morphine, paynantheine and speciociliatine alkaloids with ATP-binding cassette (ABC) transporters was investigated. The compounds were docked against ABCG2 and ABCB1 to predict the binding mode of alkaloids in active binding sites. The cytotoxicity of morphine, paynantheine and speciociliatine for EPG85.257RDB and MCF7MX cells was determined and ABCB1 and ABCG2 gene and protein expression were determined. The binding score of paynantheine to ABCB1 was higher in the docking studies. Paynantheine and speciociliatin...
Source: Cell Biology International - March 14, 2024 Category: Cytology Authors: Nayereh Abdali Mohammad Nadipour Borujeni Sayedeh Azimeh Hosseini Rahim Malekzadeh Marzieh Abolhasani Seyed Abbas Mirzaei Fatemeh Elahian Source Type: research
