Former smoking, but not active smoking, is associated with delirium in postoperative ICU patients: a matched case-control study
DiscussionNicotine’s complex neuropharmacological impact on the brain is still not fully understood, especially its short-term and long-term implications for critically ill patients. Although our retrospective study cannot establish causality, our findings suggest that smoking may induce structural changes in the brain, potentially heightening the risk of postoperative delirium. Intriguingly, this effect seems to be obscured in active smokers, potentially due to the recognized neuroprotective properties of nicotine. Our results motivate future prospective studies, the results of which hold the potential to substantially ...
Source: Frontiers in Psychiatry - March 14, 2024 Category: Psychiatry Source Type: research
Low-Dose Morphine Does Not Cause Sleepiness in COPD: A Secondary Analysis of a Randomized Trial
CONCLUSIONS: Regular, low-dose morphine does not worsen sleepiness when used for breathlessness in COPD. Individual improvements in breathlessness with morphine may be related to improvements in sleep.PMID:38477675 | DOI:10.1164/rccm.202310-1780OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - March 13, 2024 Category: Respiratory Medicine Authors: Thomas J Altree Barbara Toson Kelly A Loffler Magnus Ekstr öm David C Currow Danny J Eckert Source Type: research
Low-Dose Morphine Does Not Cause Sleepiness in COPD: A Secondary Analysis of a Randomized Trial
CONCLUSIONS: Regular, low-dose morphine does not worsen sleepiness when used for breathlessness in COPD. Individual improvements in breathlessness with morphine may be related to improvements in sleep.PMID:38477675 | DOI:10.1164/rccm.202310-1780OC (Source: Respiratory Care)
Source: Respiratory Care - March 13, 2024 Category: Respiratory Medicine Authors: Thomas J Altree Barbara Toson Kelly A Loffler Magnus Ekstr öm David C Currow Danny J Eckert Source Type: research
Low-Dose Morphine Does Not Cause Sleepiness in COPD: A Secondary Analysis of a Randomized Trial
CONCLUSIONS: Regular, low-dose morphine does not worsen sleepiness when used for breathlessness in COPD. Individual improvements in breathlessness with morphine may be related to improvements in sleep.PMID:38477675 | DOI:10.1164/rccm.202310-1780OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - March 13, 2024 Category: Intensive Care Authors: Thomas J Altree Barbara Toson Kelly A Loffler Magnus Ekstr öm David C Currow Danny J Eckert Source Type: research
Impact of pharmacogenomic profiles on post-surgical pain following laparotomy for gynecologic pathology
CONCLUSIONS: A positive association existed between increased CYP2D6 activity and in-hospital opioid requirements, especially in the first 24 h after surgery. This provides important information to further individualize opioid prescriptions for patients undergoing laparotomy for gynecologic pathology.PMID:38479169 | DOI:10.1016/j.ygyno.2024.03.001 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 13, 2024 Category: Cancer & Oncology Authors: Gretchen E Glaser Brandon Maddy Amanika Kumar Karen Ishitani Maureen A Lemens Kristine Hanson Ann M Moyer Elizabeth Habermann Sean C Dowdy Source Type: research
