Scheduled and Breakthrough Opioid Use for Cancer Pain in an Inpatient Setting at a Tertiary Cancer Hospital
Conclusions: BTO/SCH ratios are frequently prescribed higher than the recommended dose. Daily pain scores, BTO MEDDs, scheduled opioid MEDDs, and total MEDDs were higher among the SCC group than the pre-SCC group, but the number of BTO doses/day was lower.PMID:38534934 | PMC:PMC10969060 | DOI:10.3390/curroncol31030101 (Source: Current Oncology)
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Aline Rozman de Moraes Elif Erdogan Ahsan Azhar Suresh K Reddy Zhanni Lu Joshua A Geller David Mill Graves Michal J Kubiak Janet L Williams Jimin Wu Eduardo Bruera Sriram Yennurajalingam Source Type: research
Short-term healthcare resource utilization associated with receipt of CDC-informed opioid thresholds among commercially insured new chronic opioid users
CONCLUSIONS: There was no difference in odds of an all-cause or opioid-related ACE associated with the thresholds. Early-intervention programs and policies exploring reduction of MME/day among NCOUs may not result in short-term reduction in all-cause or opioid-related ACEs. Further assessment of potential long-term reduction in ACEs among this cohort may be insightful.PMID:38533714 | DOI:10.5055/jom.0848 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - March 27, 2024 Category: Addiction Authors: Martin J Calabrese Fadia T Shaya Francis Palumbo Mary Lynn McPherson Ester Villalonga-Olives Zafar Zafari Ryan Mutter Source Type: research
Molecular and Structural Insights into Buffalo Interleukin-17A
Journal of Interferon&Cytokine Research, Ahead of Print. (Source: Journal of Interferon)
Source: Journal of Interferon - March 26, 2024 Category: Research Authors: Savita Budania Surinder Kumar Kadian Karuppiah Kanagarajadurai Vikas Yadav Aman Kumar Akhil Kumar Gupta Source Type: research
Single Dose Intravenous Paracetamol versus Placebo in Postorthognathic Surgery Pain: A Randomized Clinical Trial
CONCLUSION: A single dose of intravenous paracetamol as part of multimodal analgesia was effective for postorthognathic surgery pain. It provided significant benefits to patients, including reduced pain scores, decreased opioid consumption, reduced nausea and vomiting, and improved satisfaction. This trial is registered with TCTR20210908002.PMID:38525206 | PMC:PMC10957247 | DOI:10.1155/2024/8898553 (Source: Anesthesiology Research and Practice)
Source: Anesthesiology Research and Practice - March 25, 2024 Category: Anesthesiology Authors: Thunshuda Sumphaongern Pornchai Jansisyanont Source Type: research
The impact of tightened prescribing restrictions for PBS-subsidised opioid medicines and the introduction of half-pack sizes, Australia, 2020-21: an interrupted time series analysis
CONCLUSIONS: The introduction of new PBS rules for subsidised opioid medicines was followed by a decline in PBS-subsidised dispensing. Some people may have bypassed the new restrictions by switching to private prescriptions, but our findings suggest that opioid medicine use in Australia declined as a result of the new restrictions.PMID:38522006 | DOI:10.5694/mja2.52257 (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - March 24, 2024 Category: General Medicine Authors: Forrest C Koch Jake Olivier Jonathan Brett Nicholas A Buckley Natasa Gisev Sallie Pearson Benjamin Daniels Source Type: research
The impact of tightened prescribing restrictions for PBS-subsidised opioid medicines and the introduction of half-pack sizes, Australia, 2020-21: an interrupted time series analysis
CONCLUSIONS: The introduction of new PBS rules for subsidised opioid medicines was followed by a decline in PBS-subsidised dispensing. Some people may have bypassed the new restrictions by switching to private prescriptions, but our findings suggest that opioid medicine use in Australia declined as a result of the new restrictions.PMID:38522006 | DOI:10.5694/mja2.52257 (Source: Med J Aust)
Source: Med J Aust - March 24, 2024 Category: General Medicine Authors: Forrest C Koch Jake Olivier Jonathan Brett Nicholas A Buckley Natasa Gisev Sallie Pearson Benjamin Daniels Source Type: research
Real-time monitoring of cortical brain activity in response to acute pain using wide-area Ca < sup > 2+ < /sup > imaging
Biochem Biophys Res Commun. 2024 Mar 18;708:149800. doi: 10.1016/j.bbrc.2024.149800. Online ahead of print.ABSTRACTPrevious human and rodent studies indicated that nociceptive stimuli activate many brain regions that is involved in the somatosensory and emotional sensation. Although these studies have identified several important brain regions involved in pain perception, it has been a challenge to observe neural activity directly and simultaneously in these multiple brain regions during pain perception. Using a transgenic mouse expressing G-CaMP7 in majority of astrocytes and a subpopulation of excitatory neurons, we reco...
Source: Biochemical and Biophysical Research communications - March 24, 2024 Category: Biochemistry Authors: Chihiro Inami Makito Haruta Yasumi Ohta Motoshi Tanaka MinHye So Kazuya Sobue Yasemin Akay Kazuhiko Kume Jun Ohta Metin Akay Masahiro Ohsawa Source Type: research
The impact of tightened prescribing restrictions for PBS-subsidised opioid medicines and the introduction of half-pack sizes, Australia, 2020-21: an interrupted time series analysis
CONCLUSIONS: The introduction of new PBS rules for subsidised opioid medicines was followed by a decline in PBS-subsidised dispensing. Some people may have bypassed the new restrictions by switching to private prescriptions, but our findings suggest that opioid medicine use in Australia declined as a result of the new restrictions.PMID:38522006 | DOI:10.5694/mja2.52257 (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - March 24, 2024 Category: General Medicine Authors: Forrest C Koch Jake Olivier Jonathan Brett Nicholas A Buckley Natasa Gisev Sallie Pearson Benjamin Daniels Source Type: research
The impact of tightened prescribing restrictions for PBS-subsidised opioid medicines and the introduction of half-pack sizes, Australia, 2020-21: an interrupted time series analysis
CONCLUSIONS: The introduction of new PBS rules for subsidised opioid medicines was followed by a decline in PBS-subsidised dispensing. Some people may have bypassed the new restrictions by switching to private prescriptions, but our findings suggest that opioid medicine use in Australia declined as a result of the new restrictions.PMID:38522006 | DOI:10.5694/mja2.52257 (Source: Med J Aust)
Source: Med J Aust - March 24, 2024 Category: General Medicine Authors: Forrest C Koch Jake Olivier Jonathan Brett Nicholas A Buckley Natasa Gisev Sallie Pearson Benjamin Daniels Source Type: research
Real-time monitoring of cortical brain activity in response to acute pain using wide-area Ca < sup > 2+ < /sup > imaging
Biochem Biophys Res Commun. 2024 Mar 18;708:149800. doi: 10.1016/j.bbrc.2024.149800. Online ahead of print.ABSTRACTPrevious human and rodent studies indicated that nociceptive stimuli activate many brain regions that is involved in the somatosensory and emotional sensation. Although these studies have identified several important brain regions involved in pain perception, it has been a challenge to observe neural activity directly and simultaneously in these multiple brain regions during pain perception. Using a transgenic mouse expressing G-CaMP7 in majority of astrocytes and a subpopulation of excitatory neurons, we reco...
Source: Biochemical and Biophysical Research communications - March 24, 2024 Category: Biochemistry Authors: Chihiro Inami Makito Haruta Yasumi Ohta Motoshi Tanaka MinHye So Kazuya Sobue Yasemin Akay Kazuhiko Kume Jun Ohta Metin Akay Masahiro Ohsawa Source Type: research
