Effects of (2 < i > R < /i > ,6 < i > R < /i > )-hydroxynorketamine in assays of acute pain-stimulated and pain-depressed behaviors in mice
by Todd M. Hillhouse, Kaitlyn J. Partridge, Patrick I. Garrett, Sarah C. Honeycutt, Joseph H. Porter
Ketamine has been shown to produce analgesia in various acute and chronic pain states; however, abuse liability concerns have limited its utility. The ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) has been shown to produce antidepressant-like effects similar to ketamine without abuse liability concerns. (2R,6R)-HNK produces sustained analgesia in models of chronic pain, but has yet to be evaluated in models of acute pain. The present study evaluated the efficacy of acute (2R,6R)-HNK administration (one injection) in...
Source: PLoS One - April 19, 2024 Category: Biomedical Science Authors: Todd M. Hillhouse Source Type: research
Cocaine seems to hijack brain pathways that prioritise food and water
Cocaine and morphine hijacked neural responses in the brains of mice, which resulted in them consuming less food and water (Source: New Scientist - Health)
Source: New Scientist - Health - April 18, 2024 Category: Consumer Health News Source Type: research
Current management of neonatal abstinence syndrome: a survey of practice in the UK and Ireland
Conclusion and relevance
Compared with the previous survey, improvements in evidence-based practices were noted, highlighting the benefits of this type of research. Nonetheless, significant variation still exists in some aspects of the management of NAS. Post-discharge follow-up varies widely, with particular deficits in ophthalmology follow-up. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 18, 2024 Category: Perinatology & Neonatology Authors: Dempsey, S., O Grady, M. J. Tags: Original research Source Type: research
Teneurin C-terminal associated peptide (TCAP)-1 attenuates the development and expression of naloxone-precipitated morphine withdrawal in male Swiss Webster mice
ConclusionsThese findings establish TCAP-1 as a potential therapeutic candidate for the prevention and treatment of morphine withdrawal. (Source: Psychopharmacology)
Source: Psychopharmacology - April 17, 2024 Category: Psychiatry Source Type: research
Clinical prediction of opioid use disorder in chronic pain patients: a cohort-retrospective study with a pharmacogenetic approach
CONCLUSIONS: Functional polymorphisms related to OPRM1 variant and CYP2D6 phenotypes may predict a higher OUD risk. Established risk factors such as young age, elevated MEDD and lower incomes were identified. A predictive model is expected to be implemented in clinical setting among CNCP patients under long-term opioids use.PMID:38619184 | DOI:10.23736/S0375-9393.24.17864-9 (Source: Minerva Anestesiologica)
Source: Minerva Anestesiologica - April 15, 2024 Category: Anesthesiology Authors: M ónica Escorial Javier Muriel Laura Agull ó Thomas Zandonai C ésar Margarit Domingo Morales Ana M Peir ó Source Type: research
Perioperative intravenous lidocaine in thoracoscopic surgery for improved postoperative pain control: a randomized, placebo-controlled, double-blind, superiority trial
CONCLUSIONS: Our results suggest that perioperative intravenous lidocaine administration reduces pain scores after VATS. The beneficial clinical effects are limited. Nevertheless, intravenous lidocaine may be helpful as part of a multimodal analgesia protocol or with patients in whom the use of other analgesics is contraindicated.TRIAL REGISTRATION: ClinicalTrials.gov NCT03677817.PMID:38617784 | PMC:PMC11009578 | DOI:10.21037/jtd-23-1438 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Aljaz Hojski Daniel Bolliger Makhmudbek Mallaev Sandrine Dackam Nikolay Tsvetkov Mark Wiese Tobias Schneider Andreas Lampart Didier Lardinois Source Type: research
Clinical prediction of opioid use disorder in chronic pain patients: a cohort-retrospective study with a pharmacogenetic approach
CONCLUSIONS: Functional polymorphisms related to OPRM1 variant and CYP2D6 phenotypes may predict a higher OUD risk. Established risk factors such as young age, elevated MEDD and lower incomes were identified. A predictive model is expected to be implemented in clinical setting among CNCP patients under long-term opioids use.PMID:38619184 | DOI:10.23736/S0375-9393.24.17864-9 (Source: Minerva Anestesiologica)
Source: Minerva Anestesiologica - April 15, 2024 Category: Anesthesiology Authors: M ónica Escorial Javier Muriel Laura Agull ó Thomas Zandonai C ésar Margarit Domingo Morales Ana M Peir ó Source Type: research
Perioperative intravenous lidocaine in thoracoscopic surgery for improved postoperative pain control: a randomized, placebo-controlled, double-blind, superiority trial
CONCLUSIONS: Our results suggest that perioperative intravenous lidocaine administration reduces pain scores after VATS. The beneficial clinical effects are limited. Nevertheless, intravenous lidocaine may be helpful as part of a multimodal analgesia protocol or with patients in whom the use of other analgesics is contraindicated.TRIAL REGISTRATION: ClinicalTrials.gov NCT03677817.PMID:38617784 | PMC:PMC11009578 | DOI:10.21037/jtd-23-1438 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Aljaz Hojski Daniel Bolliger Makhmudbek Mallaev Sandrine Dackam Nikolay Tsvetkov Mark Wiese Tobias Schneider Andreas Lampart Didier Lardinois Source Type: research
Clinical prediction of opioid use disorder in chronic pain patients: a cohort-retrospective study with a pharmacogenetic approach
CONCLUSIONS: Functional polymorphisms related to OPRM1 variant and CYP2D6 phenotypes may predict a higher OUD risk. Established risk factors such as young age, elevated MEDD and lower incomes were identified. A predictive model is expected to be implemented in clinical setting among CNCP patients under long-term opioids use.PMID:38619184 | DOI:10.23736/S0375-9393.24.17864-9 (Source: Minerva Anestesiologica)
Source: Minerva Anestesiologica - April 15, 2024 Category: Anesthesiology Authors: M ónica Escorial Javier Muriel Laura Agull ó Thomas Zandonai C ésar Margarit Domingo Morales Ana M Peir ó Source Type: research
Analgesic Efficacy and Safety of Intrathecal Morphine or Intercostal Levobupivacaine in Lung Cancer Patients after Major Lung Resection Surgery by Videothoracoscopy: A Prospective Randomized Controlled Trial
Conclusions: ITM can be considered an adequate and satisfactory regional technique for the control of acute postoperative pain in VATS, compatible with the multimodal rehabilitation and early discharge protocols used in these types of surgeries.PMID:38610735 | DOI:10.3390/jcm13071972 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 13, 2024 Category: Cancer & Oncology Authors: Silvia Gonz ález-Santos Borja Mugabure Manuel Granell Borja Aguinagalde Iker J L ópez Ainhoa Aginaga Inmaculada Zubelzu Haritz Iraeta Jon Zabaleta Jose Miguel Izquierdo Nuria Gonz ález-Jorrín Cristina Sarasqueta Alejandro Herreros-Pomares Source Type: research
Analgesic Efficacy and Safety of Intrathecal Morphine or Intercostal Levobupivacaine in Lung Cancer Patients after Major Lung Resection Surgery by Videothoracoscopy: A Prospective Randomized Controlled Trial
Conclusions: ITM can be considered an adequate and satisfactory regional technique for the control of acute postoperative pain in VATS, compatible with the multimodal rehabilitation and early discharge protocols used in these types of surgeries.PMID:38610735 | DOI:10.3390/jcm13071972 (Source: Cancer Control)
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Silvia Gonz ález-Santos Borja Mugabure Manuel Granell Borja Aguinagalde Iker J L ópez Ainhoa Aginaga Inmaculada Zubelzu Haritz Iraeta Jon Zabaleta Jose Miguel Izquierdo Nuria Gonz ález-Jorrín Cristina Sarasqueta Alejandro Herreros-Pomares Source Type: research
Analgesic Efficacy and Safety of Intrathecal Morphine or Intercostal Levobupivacaine in Lung Cancer Patients after Major Lung Resection Surgery by Videothoracoscopy: A Prospective Randomized Controlled Trial
Conclusions: ITM can be considered an adequate and satisfactory regional technique for the control of acute postoperative pain in VATS, compatible with the multimodal rehabilitation and early discharge protocols used in these types of surgeries.PMID:38610735 | PMC:PMC11012894 | DOI:10.3390/jcm13071972 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 13, 2024 Category: Cancer & Oncology Authors: Silvia Gonz ález-Santos Borja Mugabure Manuel Granell Borja Aguinagalde Iker J L ópez Ainhoa Aginaga Inmaculada Zubelzu Haritz Iraeta Jon Zabaleta Jose Miguel Izquierdo Nuria Gonz ález-Jorrín Cristina Sarasqueta Alejandro Herreros-Pomares Source Type: research
Advances in animal models of prenatal opioid exposure
Trends Neurosci. 2024 Apr 12:S0166-2236(24)00042-0. doi: 10.1016/j.tins.2024.03.005. Online ahead of print.ABSTRACTNeonatal opioid withdrawal syndrome (NOWS) is a growing public health concern. The complexity of in utero opioid exposure in clinical studies makes it difficult to investigate underlying mechanisms that could ultimately inform early diagnosis and treatments. Clinical studies are unable to dissociate the influence of maternal polypharmacy or the environment from direct effects of in utero opioid exposure, highlighting the need for effective animal models. Early animal models of prenatal opioid exposure primaril...
Source: Trends in Neurosciences - April 13, 2024 Category: Neuroscience Authors: Julia R Ferrante Julie A Blendy Source Type: research
Intravenous Administration of Recombinant Ph α1β: Antinociceptive Properties and Morphine Tolerance Reversal in a Cancer-Associated Pain Model
This study aims to assess the antinociceptive effects resulting from intravenous administration of the recombinant form of Phα1β (r-Phα1β) in an experimental model of cancer-related pain in mice, tolerant or not to morphine. The model of cancer-induced pain was used to evaluate these effects, with the injection of B16F10 cells, followed by the administration of the r-Phα1β, and evaluation of the mechanical threshold by the von Frey test. Also, adverse effects were assessed using a score scale, the rotarod, and open field tests. Results indicate that the administration of r-Phα1β provoked antinociception in animals ...
Source: Toxicon - April 13, 2024 Category: Toxicology Authors: Mariana de Melo Cardoso Rahisa Scussel Jessica da Silva Abel Fernando Oriques Pereira Lidiane Anast ácio Cruz Franciane da Costa Constante Ellen De Pieri Helena Mendes Abelaira Juliano Ferreira Marcus Vin ícius Gomez Fl ávia K Rigo Ricardo Andrez Macha Source Type: research
