Preoperative Erythropoietin vs Placebo: What Does the Latest Meta-analysis Say?
PMID: 30994539 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 19, 2019 Category: Anesthesiology Authors: Nathan N Tags: Anesth Analg Source Type: research

The Artificial Pancreas: Coming to an OR Near You?
PMID: 30994540 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 19, 2019 Category: Anesthesiology Authors: Wanderer JP, Nathan N Tags: Anesth Analg Source Type: research

Decision Aids Are a Solution, but to Which Problem?
PMID: 30994541 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 19, 2019 Category: Anesthesiology Authors: Clapp JT, Fleisher LA, Lane-Fall MB Tags: Anesth Analg Source Type: research

With Better Information, Can We Stop Blowing Smoke About Prophylactic Antibiotics?
PMID: 30994542 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 19, 2019 Category: Anesthesiology Authors: Murphy WP, Murphy M, Bearman G, Butterworth JF Tags: Anesth Analg Source Type: research

Acute Kidney Injury, Chronic Kidney Disease, and Mortality: Understanding the Association.
PMID: 30994543 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 19, 2019 Category: Anesthesiology Authors: Meersch M Tags: Anesth Analg Source Type: research

Centers of Excellence for Anesthesia Care of Obstetric Patients.
PMID: 30994544 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 19, 2019 Category: Anesthesiology Authors: Carvalho B, Mhyre JM Tags: Anesth Analg Source Type: research

Quality Improvement Interventions Associated With Improved Postoperative Nausea and Vomiting: Separating the Signal From the Noise.
PMID: 30994545 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 19, 2019 Category: Anesthesiology Authors: Mascha EJ, Gan TJ, Vetter TR Tags: Anesth Analg Source Type: research

Blood Pressure, One of the Most Important Factors Is Missing in the Analysis of the Association Between Intraoperative Oliguria and Acute Kidney Injury.
PMID: 30994546 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 19, 2019 Category: Anesthesiology Authors: Godai K Tags: Anesth Analg Source Type: research

In Response.
PMID: 30994547 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 19, 2019 Category: Anesthesiology Authors: Shiba A, Uchino S Tags: Anesth Analg Source Type: research

Pharmacokinetics of Cefazolin and Vancomycin in Infants Undergoing Open-Heart Surgery With Cardiopulmonary Bypass.
CONCLUSIONS: Prophylactic treatment of vancomycin 15 mg·kg infused>1 hour with 12-hour redosing and cefazolin 30 mg·kg infused>10 minutes with 4-hour redosing will maintain serum levels of each antibiotic above the susceptibility cut-offs for susceptible staphylococci in infants undergoing cardiac surgery. Cefazolin levels may be adequate for some, but not all, Gram-negative bacteria. The effect of cardiopulmonary bypass on pharmacokinetics is negligible. PMID: 30995208 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 19, 2019 Category: Anesthesiology Authors: Ingrande J, Gutierrez K, Lemmens HJ, Verma A, Nicolau DP, Sutherland CA, Ramamoorthy C Tags: Anesth Analg Source Type: research

Contemplating Our Maternity Care Crisis in the United States: Reflections of an Obstetrician Anesthesiologist.
PMID: 30995209 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 19, 2019 Category: Anesthesiology Authors: Pryde PG Tags: Anesth Analg Source Type: research

Consensus Recommendations for the Conduct, Training, Implementation, and Research of Perioperative Handoffs.
PMID: 30995210 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 19, 2019 Category: Anesthesiology Authors: Agarwala AV, Lane-Fall MB, Greilich PE, Burden AR, Ambardekar AP, Banerjee A, Barbeito A, Bryson TD, Greenberg S, Lorinc AN, Lynch IP, Pukenas E, Cooper JB Tags: Anesth Analg Source Type: research

Using Pupillary Pain Index to Assess Nociception in Sedated Critically Ill Patients.
Abstract BACKGROUND: Pupillary reflex dilation is a reliable indicator of response to noxious stimulation. In a proof of concept study, we investigated the performance of pupillary pain index, a new score derived from pupillary reflex dilation measurements, to predict nociceptive response to endotracheal suctioning in sedated critically ill patients. METHODS: Twenty brain-injured and 20 non-brain-injured patients were studied within 48 hours of admission (T1) in the intensive care unit and at 48-72 hours later (T2). Video-based pupillometer was used to determine pupillary reflex dilation during tetanic stimul...
Source: Anesthesia and Analgesia - April 15, 2019 Category: Anesthesiology Authors: Vinclair M, Schilte C, Roudaud F, Lavolaine J, Francony G, Bouzat P, Bosson JL, Payen JF Tags: Anesth Analg Source Type: research

Obtaining and Modeling Variability in Travel Times From Off-Site Satellite Clinics to Hospitals and Surgery Centers for Surgeons and Proceduralists Seeing Office Patients in the Morning and Performing a To-Follow List of Cases in the Afternoon.
Abstract BACKGROUND: Hospitals achieve growth in surgical caseload primarily from the additive contribution of many surgeons with low caseloads. Such surgeons often see clinic patients in the morning then travel to a facility to do 1 or 2 scheduled afternoon cases. Uncertainty in travel time is a factor that might need to be considered when scheduling the cases of to-follow surgeons. However, this has not been studied. We evaluated variability in travel times within a city with high traffic density. METHODS: We used the Google Distance Matrix application programming interface to prospectively determine drivin...
Source: Anesthesia and Analgesia - April 15, 2019 Category: Anesthesiology Authors: Epstein RH, Dexter F, Smaka TJ Tags: Anesth Analg Source Type: research

New Role for the Anesthesia Preoperative Clinic: Helping to Ensure That Surgery Is the Right Choice for Patients With Serious Illness.
PMID: 30985381 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 9, 2019 Category: Anesthesiology Authors: Goldenberg E, Saffary R, Schmiesing C Tags: Anesth Analg Source Type: research

Perioperative Management of the Pediatric Patient on Medicinal Marijuana: What Anesthesiologists Should Know.
This article will review the literature regarding the use of each of these compounds in the literature, with particular attention to data in children. The history, known pharmacology, data from nonmedicinal use, current evidence, and anesthetic considerations will be described. PMID: 30985382 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 9, 2019 Category: Anesthesiology Authors: Flannery KM, D'Souza G, Agarwal R Tags: Anesth Analg Source Type: research

Chemical Hip Denervation for Inoperable Hip Fracture.
Abstract BACKGROUND: Hip fracture is a challenging geriatric problem for the health care professionals, especially in patients with multiple comorbidities. In patients with inoperable hip fracture secondary to severe comorbid conditions, the pain can lead to significant challenges in nursing care. With the current understanding of the innervation of hip joint, we are now able to perform selective chemical denervation of the articular branches of femoral and obturator nerves to manage the pain associated with inoperable hip fracture. METHODS: In this retrospective case series, we analyzed 20 consecutive patien...
Source: Anesthesia and Analgesia - April 9, 2019 Category: Anesthesiology Authors: Kwun-Tung Ng T, Chan WS, Peng PWH, Sham P, Sasaki S, Tsui HF Tags: Anesth Analg Source Type: research

In Response.
PMID: 30985374 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 8, 2019 Category: Anesthesiology Authors: Brown EN Tags: Anesth Analg Source Type: research

Normal Saline and Dextrose 5% in Water Do Not Support Bacterial Growth 24 Hours After Being Spiked in the Perioperative Environment.
CONCLUSIONS: No bacterial growth was noted in any of the 257 samples collected. Normal saline and dextrose 5% in water do not support bacterial growth 24 hours after their preparation using standard sterile techniques in the perioperative space. PMID: 30985375 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 8, 2019 Category: Anesthesiology Authors: Baronos S, Yarmush JM, Stedman JL, Kamath S, Xavier C, Ahmed K Tags: Anesth Analg Source Type: research

Outcomes and Safety Among Patients With Obstructive Sleep Apnea Undergoing Cancer Surgery Procedures in a Freestanding Ambulatory Surgical Facility.
CONCLUSIONS: Our results contribute to the body of evidence supporting that patients with moderate-risk, high-risk, or diagnosed OSA can safely undergo outpatient and advanced ambulatory oncology surgery without increased health care burden of extended stay or hospital admission and avoiding adverse postoperative outcomes. Our results support the adoption of several national OSA guidelines focusing on preoperative identification of patients with OSA and clinical pathways for perioperative management and postoperative monitoring. PMID: 30985376 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 8, 2019 Category: Anesthesiology Authors: Szeto B, Vertosick EA, Ruiz K, Tokita H, Vickers A, Assel M, Simon BA, Twersky RS Tags: Anesth Analg Source Type: research

Is the Balance in Anesthesia Right? Multitarget Approach and Alteration of Systemic Inflammation.
PMID: 30985377 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 8, 2019 Category: Anesthesiology Authors: de Boer HD, Carlos RV, Mulier JP Tags: Anesth Analg Source Type: research

To the Editor.
PMID: 30985378 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 8, 2019 Category: Anesthesiology Authors: Jerath A, Yang QJ, Wasowicz M, Pang KS Tags: Anesth Analg Source Type: research

Effects of Dexmedetomidine on Myocardial Repolarization in Children Undergoing General Anesthesia: A Randomized Controlled Trial.
SD Abstract BACKGROUND: Dexmedetomidine is a highly selective α2-adrenergic agonist, which is increasingly used in pediatric anesthesia and intensive care. Potential adverse effects that have not been rigorously evaluated in children include its effects on myocardial repolarization, which is important given that the drug is listed as a possible risk factor for torsades de pointes. We investigated the effect of 3 different doses of dexmedetomidine on myocardial repolarization and transmural dispersion in children undergoing elective surgery with total IV anesthesia. METHODS: Sixty-four American Society ...
Source: Anesthesia and Analgesia - April 8, 2019 Category: Anesthesiology Authors: Görges M, Sherwin ED, Poznikoff AK, West NC, Brodie SM, Whyte SD Tags: Anesth Analg Source Type: research

Comparison of Nitroglycerin and Terbutaline for External Cephalic Version in Women Who Received Neuraxial Anesthesia: A Retrospective Analysis.
Abstract External cephalic version is a technique that decreases the need for cesarean delivery in patients with breech presentation. Several techniques exist to increase the success of external cephalic version; however, there are no studies comparing different tocolytics in patients who also received neuraxial anesthesia. We, therefore, performed a review of 198 patients who presented for external cephalic version and compared their success rates based on the tocolytic medication utilized. The external cephalic version success rate for patients who received terbutaline was significantly higher than for those who...
Source: Anesthesia and Analgesia - April 8, 2019 Category: Anesthesiology Authors: Katz D, Riley K, Kim E, Beilin Y Tags: Anesth Analg Source Type: research

In Response.
PMID: 30973377 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 3, 2019 Category: Anesthesiology Authors: Tawfik MM, Tolba MA Tags: Anesth Analg Source Type: research

Routine Fluid Coloading During Spinal Anesthesia Should Be Abandoned.
PMID: 30973378 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 3, 2019 Category: Anesthesiology Authors: Muggleton E, Muggleton T Tags: Anesth Analg Source Type: research

Effect of Right-Lateral Versus Left-Lateral Tilt Position on Compression of the Inferior Vena Cava in Pregnant Women Determined by Magnetic Resonance Imaging.
Abstract BACKGROUND: Despite the existing dogma that women undergoing cesarean delivery under spinal anesthesia should be positioned with a 15° left-lateral tilt, the patients were actually positioned in a right-lateral tilt position in several of the original studies. The superiority of right versus left positioning for optimal inferior vena cava volume is unknown. We used magnetic resonance imaging to compare the effects of right-lateral and left-lateral tilt positions on abdominal aortic and inferior vena cava volumes in pregnant women. METHODS: Thirteen women with singleton pregnancies and gestational...
Source: Anesthesia and Analgesia - April 3, 2019 Category: Anesthesiology Authors: Fujita N, Higuchi H, Sakuma S, Takagi S, Latif MAHM, Ozaki M Tags: Anesth Analg Source Type: research

Questions Regarding the Use of Neostigmine-Atropine to Treat Postdural Puncture Headache.
PMID: 30973380 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 3, 2019 Category: Anesthesiology Authors: Nair AS Tags: Anesth Analg Source Type: research

Safety of Beach Chair Position Shoulder Surgery: A Review of the Current Literature.
Abstract Although uncommon, severe neurological events have been reported in patients undergoing shoulder surgery in the beach chair position. The presumed etiology of central nervous system injury is hypotension and subsequent cerebral hypoperfusion that occurs after alterations in positioning under general anesthesia. Most clinical trials have demonstrated that beach chair positioning results in reductions in regional brain oxygenation, cerebral blood flow, and jugular bulb oxygenation, as well as impairment in cerebral autoregulation and electroencephalographic/processed electroencephalographic variables. Furth...
Source: Anesthesia and Analgesia - April 3, 2019 Category: Anesthesiology Authors: Murphy GS, Greenberg SB, Szokol JW Tags: Anesth Analg Source Type: research

In Response.
PMID: 30973382 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 3, 2019 Category: Anesthesiology Authors: Abdelaal Ahmed Mahmoud A Tags: Anesth Analg Source Type: research

Point-of-Care Blood Testing: The Technology Behind the Numbers.
This article outlines the technical aspects and summarizes pitfalls in accuracy for 2 of the most commonly utilized point-of-care testing devices: glucose meters and hemoglobin meters. PMID: 30973383 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 3, 2019 Category: Anesthesiology Authors: Siegrist KK, Rice MJ Tags: Anesth Analg Source Type: research

A Double-edged Sword: Microglial Reactivity and Anesthesia in the Developing Brain.
PMID: 30883407 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: Nathan N Tags: Anesth Analg Source Type: research

Inflamed in the Membrane: Neuroinflammation and Perioperative Neurocognitive Disorders.
PMID: 30883408 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: Nathan N Tags: Anesth Analg Source Type: research

Cerebral Oximetry in Children: So NIRS Yet So Far.
PMID: 30883409 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: DiNardo JA Tags: Anesth Analg Source Type: research

Benefits of Knowing Your Risks: A Step Toward Shared Surgical Decision-Making and High-Value Care.
PMID: 30883410 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: Allen MB, Bader AM Tags: Anesth Analg Source Type: research

Publications by Graduating Residents: Don't Turn Off the Alarm Clock Yet.
PMID: 30883411 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: Gaiser R Tags: Anesth Analg Source Type: research

Falling Dominoes.
PMID: 30883412 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: Polaner DM, Shafer SL Tags: Anesth Analg Source Type: research

To Changing Your Mind.
PMID: 30883413 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: Crosby G Tags: Anesth Analg Source Type: research

Assessing Long-term Neurodevelopmental Outcome Following General Anesthesia in Early Childhood: Challenges and Opportunities.
Abstract Neurodegeneration has been reported in young animals after exposure to all commonly used general anesthetic agents. The brain may be particularly vulnerable to anesthetic toxicity during peak synaptogenesis (in gestation and infancy). Human studies of long-term neurodevelopmental outcome following general anesthesia in early childhood report contradictory findings. This review assesses the strengths and deficiencies in human research methodologies to inform future studies. We identified 76 studies, published between 1990 and 2017, of long-term neurodevelopmental outcome following early childhood or in ute...
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: Walkden GJ, Pickering AE, Gill H Tags: Anesth Analg Source Type: research

Anesthetic Management of Emergency Endovascular Thrombectomy for Acute Ischemic Stroke, Part 1: Patient Characteristics, Determinants of Effectiveness, and Effect of Blood Pressure on Outcome.
Abstract In the United States, stroke ranks fifth among all causes of death and is the leading cause of serious long-term disability. The 2018 American Heart Association stroke care guidelines consider endovascular thrombectomy to be the standard of care for patients who have acute ischemic stroke in the anterior circulation when arterial puncture can be made within 6 hours of symptom onset or within 6-24 hours of symptom onset when specific eligibility criteria are satisfied. The aim of this 2-part review is to provide practical perspective on the clinical literature regarding anesthesia care of patients treated ...
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: Hindman BJ Tags: Anesth Analg Source Type: research

Anesthetic Management of Emergency Endovascular Thrombectomy for Acute Ischemic Stroke, Part 2: Integrating and Applying Observational Reports and Randomized Clinical Trials.
This article concludes with a pragmatic approach to real-time anesthesia decision-making (sedation versus general anesthesia) and the goals and methods of acute phase anesthesia management of endovascular thrombectomy patients. PMID: 30883416 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: Hindman BJ, Dexter F Tags: Anesth Analg Source Type: research

Neuroinflammation in the Developing Brain: Risk Factors, Involvement of Microglial Cells, and Implication for Early Anesthesia.
Abstract Microglia cells, the resident macrophages of the central nervous system, are key actors for specific brain functions that are critical for development and health. Microglial reactivity and functions, even when immature, play a major role if the developing brain is subjected to abnormal perinatal events. Brain exposure to general anesthesia, surgery, or analgesic drugs during early infancy may adversely affect its maturation and plasticity after injury. A better understanding of the regulation of microglial activation in the developing brain and interactions with specific anesthetic drugs is expected to gi...
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: Baud O, Saint-Faust M Tags: Anesth Analg Source Type: research

Escape From Oblivion: Neural Mechanisms of Emergence From General Anesthesia.
olt K Abstract The question of how general anesthetics suppress consciousness has persisted since the mid-19th century, but it is only relatively recently that the field has turned its focus to a systematic understanding of emergence. Once assumed to be a purely passive process, spontaneously occurring as residual levels of anesthetics dwindle below a critical value, emergence from general anesthesia has been reconsidered as an active and controllable process. Emergence is driven by mechanisms that can be distinct from entry to the anesthetized state. In this narrative review, we focus on the burgeoning scientific...
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: Kelz MB, García PS, Mashour GA, Solt K Tags: Anesth Analg Source Type: research

Microglial Modulation as a Target for Chronic Pain: From the Bench to the Bedside and Back.
Abstract With a widespread opioid epidemic and profound biopsychosocial implications, chronic pain is a multifaceted public health issue requiring urgent attention. The treatment of chronic pain is particularly important to anesthesiologists given our unique role as perioperative physicians and pain medicine specialists. The present review details the recent shift from a neuronal theory of chronic pain to one that includes complex neuron-glia interactions. In particular, we highlight microglia, the myeloid-lineage cells of the central nervous system, as initiators of a postinjury neuroimmune response that contribu...
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: Haight ES, Forman TE, Cordonnier SA, James ML, Tawfik VL Tags: Anesth Analg Source Type: research

Glymphatic System Function in Relation to Anesthesia and Sleep States.
Abstract The brain is one of the most metabolically active organs in the body. The brain's high energy demand associated with wakefulness persists during rapid eye movement sleep, and even during non-rapid eye movement sleep, cerebral oxygen consumption is only reduced by 20%. The active bioenergetic state parallels metabolic waste production at a higher rate than in other organs, and the lack of lymphatic vasculature in brain parenchyma is therefore a conundrum. A common assumption has been that with a tight blood-brain barrier restricting solute and fluid movements, a lymphatic system is superfluous in the centr...
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: Benveniste H, Heerdt PM, Fontes M, Rothman DL, Volkow ND Tags: Anesth Analg Source Type: research

Blood Pressure and the Brain: How Low Can You Go?
Abstract There are occasionally intraoperative circumstances in which reduction of mean arterial pressure (MAP) to levels well below those that occur in nonanesthetized adults is necessary or unavoidable. In these situations, clinicians are inevitably concerned about the limits of the tolerance of the brain for hypotension. Reference to the phenomenon of cerebral blood flow autoregulation is frequently made in discussions of safe MAP limits. However, in several respects, prevalent conceptions about cerebral blood flow autoregulation may be incomplete or inaccurate. The principal theses offered by this review are: ...
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: Drummond JC Tags: Anesth Analg Source Type: research

Long-term Cognitive and Functional Impairments After Critical Illness.
Abstract As critical illness survivorship increases, patients and health care providers are faced with management of long-term sequelae including cognitive and functional impairment. Longitudinal studies have demonstrated impairments persisting at least 1-5 years after hospitalization for critical illness. Cognitive domains impacted include memory, attention, and processing speed. Functional impairments include physical weakness, reduced endurance, and dependence on others for basic tasks of daily living such as bathing or feeding. In characterizing the trajectory of long-term recovery, multiple risk factors have ...
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: Rengel KF, Hayhurst CJ, Pandharipande PP, Hughes CG Tags: Anesth Analg Source Type: research

Neuroinflammation and Perioperative Neurocognitive Disorders.
Abstract Neuroinflammation has become a key hallmark of neurological complications including perioperative pathologies such as postoperative delirium and longer-lasting postoperative cognitive dysfunction. Dysregulated inflammation and neuronal injury are emerging from clinical studies as key features of perioperative neurocognitive disorders. These findings are paralleled by a growing body of preclinical investigations aimed at better understanding how surgery and anesthesia affect the central nervous system and possibly contribute to cognitive decline. Herein, we review the role of postoperative neuroinflammatio...
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: Subramaniyan S, Terrando N Tags: Anesth Analg Source Type: research

Evaluation of Job Stress and Burnout Among Anesthesiologists Working in Academic Institutions in 2 Major Cities in Pakistan.
In conclusion, a high rate of burnout was identified in anesthesiologists working in 2 major cities in Pakistan. Some new associated factors such as initial choice of specialty and city of work were highlighted. Based on these findings, preventive and coping strategies need to be introduced at institutional and national levels. PMID: 30883424 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: Khan FA, Shamim MH, Ali L, Taqi A Tags: Anesth Analg Source Type: research

The Need to Consider the Women's Perspective: Neuraxial Anesthesia and Cesarean Delivery for Morbidly Adherent Placenta.
PMID: 30883425 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2019 Category: Anesthesiology Authors: Bamber JH, Sobers S Tags: Anesth Analg Source Type: research