Preoperative Disability in US Veterans.
Abstract Using the 12-item World Health Organization Disability Assessment Schedule (WHODAS-12), we measured the prevalence of disability in all eligible patients during a 4-month period who were presenting for preoperative evaluation at a US Veterans Affairs hospital. Overall disability was at least moderate in more than half of these patients (total n = 472 at Durham, NC). Two of the 6 WHODAS domains, "Getting Around" and "Participation in Society," contributed most to the overall scores-25% and 20%, respectively. Further studies are needed to determine the impact of domain-specific disabilit...
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Sora A, Pyati S, Kuo M, Schroeder R, Barbeito A, Corcoran C, Raghunathan K Tags: Anesth Analg Source Type: research

The Violinist's Thumb: And Other Lost Tales of Love, War, and Genius as Written by Our Genetic Code.
PMID: 33094966 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Brindley PG Tags: Anesth Analg Source Type: research

Exposed: Why Our Health Insurance Is Incomplete and What Can Be Done About It.
PMID: 33094967 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Posner KL Tags: Anesth Analg Source Type: research

Hemostasis and Thrombosis, 4th ed.
PMID: 33094968 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Smeltz A, Arora H Tags: Anesth Analg Source Type: research

Advances in Anesthesia, Volume 37.
PMID: 33094969 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Deflandre E Tags: Anesth Analg Source Type: research

Surgical Metabolism: The Metabolic Care of the Surgical Patient, 2nd ed.
PMID: 33094970 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Ashikhmina E Tags: Anesth Analg Source Type: research

Manual Trigger Point Therapy: Recognizing, Understanding and Treating Myofascial Pain and Dysfunction.
PMID: 33094971 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Banik S Tags: Anesth Analg Source Type: research

Paediatric Anaesthesia, 2nd ed.
PMID: 33094972 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Rafiq M, Cole M Tags: Anesth Analg Source Type: research

Violence, Trauma, and Trauma Surgery: Ethical Issues, Interventions, and Innovations.
PMID: 33094973 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Rubulotta F, McMonagle M Tags: Anesth Analg Source Type: research

Neurointensive Care Unit: Clinical Practice and Organization.
PMID: 33094974 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Burbridge MA Tags: Anesth Analg Source Type: research

Pick Your Poison.
PMID: 33094975 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Cottrell JE, Hartung J Tags: Anesth Analg Source Type: research

In Response.
PMID: 33094976 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Fritz BA, Avidan MS Tags: Anesth Analg Source Type: research

Addressing the Challenge of Pain Education in Low-Resource Countries: Essential Pain Management in Papua New Guinea.
PMID: 33094977 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Ottaway AJ, Roche AM, Sarma M Tags: Anesth Analg Source Type: research

In Response.
PMID: 33094978 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Marun GN, Morriss WW, Lim JS, Morriss JL, Goucke CR Tags: Anesth Analg Source Type: research

Pecs Blocks: Anatomical Points to Ponder.
PMID: 33094979 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Raghuraman MS Tags: Anesth Analg Source Type: research

In Response.
PMID: 33094980 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Maniker RB, Johnson RL, Tran Q Tags: Anesth Analg Source Type: research

Essential Pain Management: Perspective From Nepal.
PMID: 33094981 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Subedi A, Thapa P, Gurung R, Shrestha N Tags: Anesth Analg Source Type: research

In Response.
PMID: 33094982 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Morriss JL, Marun GN, Morriss WW, Lim JS, Goucke CR Tags: Anesth Analg Source Type: research

COVID-19: The New Ultrasound Alphabet in SARS-CoV-2 Era.
llo M PMID: 33094983 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Anile A, Castiglione G, Zangara C, Calabrò C, Vaccaro M, Sorbello M Tags: Anesth Analg Source Type: research

In Response.
PMID: 33094984 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Gibson LE, Convissar D, Berra L, Bittner EA, Chang MG Tags: Anesth Analg Source Type: research

In Response.
PMID: 33094985 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Pascarella G, Strumia A, Stone MB, Piliego C Tags: Anesth Analg Source Type: research

Airway Alert Bracelets: Enhancing Safety in the COVID-19 Era.
PMID: 33094986 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Matthews LJ, OʼConnor M, Chaggar RS, Vaughan D Tags: Anesth Analg Source Type: research

In Response.
PMID: 33094987 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Authors: Berkow L, Kanowitz A Tags: Anesth Analg Source Type: research

Intravascular Volume Replacement Therapy with Synthetic Colloids: Is There an Influence on Renal Function?: Retraction.
Authors: PMID: 33094988 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Tags: Anesth Analg Source Type: research

Notice of Retraction.
Authors: PMID: 33094989 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Tags: Anesth Analg Source Type: research

Notice of Retraction.
Authors: PMID: 33094990 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Tags: Anesth Analg Source Type: research

Fourth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting: Erratum.
Authors: PMID: 33094991 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 25, 2020 Category: Anesthesiology Tags: Anesth Analg Source Type: research

COVID-19 Coagulopathy and Inflammation: The Knowns and Unknowns.
PMID: 33079849 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Wanderer JP, Nathan N Tags: Anesth Analg Source Type: research

COVID-19-Associated Coagulopathy and Inflammatory Response: What Do We Know Already and What Are the Knowledge Gaps?
This article summarizes what we know already about COVID-19-associated coagulopathy and-perhaps even more importantly-characterizes important knowledge gaps. PMID: 33079850 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Görlinger K, Dirkmann D, Gandhi A, Simioni P Tags: Anesth Analg Source Type: research

Intensive Care Unit Capacity, Cancellation of Elective Surgery, and the US Pandemic Response.
PMID: 33079851 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Nurok M, Kahn JM Tags: Anesth Analg Source Type: research

Cancellation of Elective Surgery and Intensive Care Unit Capacity in New York State: A Retrospective Cohort Analysis.
CONCLUSIONS: Patients undergoing elective surgery comprised a small fraction of ICU bed and mechanical ventilation use in New York State. Suspension of elective surgeries in response to the COVID-19 pandemic may thus have a minor impact on ICU capacity when compared to other sources of ICU admission such as emergent/urgent admissions/trauma surgery and medical admissions. More study is needed to better understand how best to maximize ICU capacity for pandemics requiring heavy use of critical care resources. PMID: 33079852 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Poeran J, Zhong H, Wilson L, Liu J, Memtsoudis SG Tags: Anesth Analg Source Type: research

Infection Prevention Precautions for Routine Anesthesia Care During the SARS-CoV-2 Pandemic.
Abstract Many health care systems around the world continue to struggle with large numbers of SARS-CoV-2-infected patients, while others have diminishing numbers of cases following an initial surge. There will most likely be significant oscillations in numbers of cases for the foreseeable future, based on the regional epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Less affected hospitals and facilities will attempt to progressively resume elective procedures and surgery. Ramping up elective care in hospitals that deliberately curtailed elective care to focus on SARS-CoV-2-infected pa...
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Bowdle A, Jelacic S, Shishido S, Munoz-Price LS Tags: Anesth Analg Source Type: research

A Novel Clinical Consideration to Conserve Parenteral Fentanyl During the COVID-19 Pandemic.
PMID: 33079854 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Herndon KT, Claussen KS, Braithwaite JJ Tags: Anesth Analg Source Type: research

The Journey to Wellness: Overcoming Obstacles and Interventions for Well-Being.
PMID: 33079855 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Woo J, Weber G, Nathan N Tags: Anesth Analg Source Type: research

Postpartum Hemorrhage: Wherefore Art Thou, Hyperfibrinolysis?
PMID: 33079857 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Butwick AJ Tags: Anesth Analg Source Type: research

Thromboelastographic Assessment of Fibrinolytic Activity in Postpartum Hemorrhage: A Retrospective Single-Center Observational Study.
CONCLUSIONS: Our observation that none of the patients in our sample with kaolin TEG Ly30 values ≥3% had a nonzero functional fibrinogen TEG Ly30 value suggests that the observed elevations in kaolin TEG Ly30 may have been secondary to platelet-mediated clot retraction as opposed to fibrinolysis. Platelet-mediated clot retraction should be distinguished from fibrinolysis when assayed using viscoelastic techniques in postpartum hemorrhage. Further research is necessary to determine the optimal methods to assess fibrinolytic activity in postpartum hemorrhage. PMID: 33079858 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Arnolds DE, Scavone BM Tags: Anesth Analg Source Type: research

Cardiac Anesthesia Practices: The Known Unknowns.
PMID: 33079859 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Rehfeldt KH, Skubas NJ Tags: Anesth Analg Source Type: research

Hypertension: A Changing Role for Anesthesiologists.
JW PMID: 33079861 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Foëx P, Sear JW Tags: Anesth Analg Source Type: research

A Multicenter, Cross-Sectional Quality Improvement Project: The Perioperative Implementation of a Hypertension Protocol by Anesthesiologists.
CONCLUSIONS: Anesthesiologists successfully implemented a quality improvement project for diagnosis and management of hypertension in the perioperative period. This has the potential to reduce the public health burden of hypertension in limited resource environments. Successful ongoing prescription and follow-up requires cooperation within a multidisciplinary team. PMID: 33079862 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Pfister CL, Govender S, Dyer RA, Rayner B, Flint M, Roodt F, Davids J, Nejthardt MB, Swanevelder JL, Chiu CE, Cloete E, Koller V, Pretorius T, Fullerton Z, Roos J, Van Zyl R, Biccard BM Tags: Anesth Analg Source Type: research

The American Board of Anesthesiology Gets a Passing Grade on Its New Objective Structured Clinical Examination.
PMID: 33079863 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Saddawi-Konefka D, Baker KH Tags: Anesth Analg Source Type: research

First-Year Results of the American Board of Anesthesiology's Objective Structured Clinical Examination for Initial Certification.
This report presents the results of the first-year OSCE administration. A total of 1410 candidates took both the OSCE and the SOE in 2018. Candidate performance approximated a normal distribution for both the OSCE and the SOE, and was not associated with the timing of the examination, including day of the week, morning versus afternoon session, and order of the OSCE and the SOE. Practice-based Learning and Improvement was the most difficult station, while Application of Ultrasonography was the least difficult. The correlation coefficient between SOE and OSCE scores was 0.35 ([95% confidence interval {CI}, 0.30-0.39]; P
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Warner DO, Lien CA, Wang T, Zhou Y, Isaak RS, Peterson-Layne C, Harman AE, Macario A, Gaiser RR, Suresh S, Culley DJ, Rathmell JP, Keegan MT, Cole DJ, Fahy BG, Dainer RJ, Sun H Tags: Anesth Analg Source Type: research

Missing Data and Imputation Methods.
PMID: 33079865 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Schober P, Vetter TR Tags: Anesth Analg Source Type: research

Exposure to General Anesthesia for Cesarean Delivery and Odds of Severe Postpartum Depression Requiring Hospitalization.
CONCLUSIONS: General anesthesia for cesarean delivery is associated with increased odds of severe PPD requiring hospitalization, suicidal ideation, and self-inflicted injury. If confirmed, these preliminary findings underscore the need to avoid the use of general anesthesia for cesarean delivery whenever possible, and to provide mental health screening, counseling, and other follow-up services to obstetric patients exposed to general anesthesia. PMID: 33079866 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Guglielminotti J, Li G Tags: Anesth Analg Source Type: research

Effect of Perioperative Active Body Surface Warming Systems on Analgesic and Clinical Outcomes: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
The objective of this study was to provide an updated review on the effect of ABSW on clinical outcomes and temperature maintenance. METHODS: We conducted a systematic review of randomized controlled trials evaluating ABSW systems compared to nonactive warming controls in noncardiac surgeries. Outcomes studied included postoperative pain scores and opioid consumption (primary outcomes) and other perioperative clinical variables such as temperature changes, blood loss, and wound infection (secondary outcomes). We searched Ovid MEDLINE daily, Ovid MEDLINE, EMBASE, CINHAL, Cochrane CENTRAL, and Web of Science from incept...
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Balki I, Khan JS, Staibano P, Duceppe E, Bessissow A, Sloan EN, Morley EE, Thompson AN, Devereaux B, Rojas C, Rojas C, Siddiqui N, Sessler DI, Devereaux PJ Tags: Anesth Analg Source Type: research

American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on the Role of Neuromonitoring in Perioperative Outcomes: Cerebral Near-Infrared Spectroscopy.
Abstract Some neurological complications following surgery have been related to a mismatch in cerebral oxygen supply and demand that may either lead to more subtle changes of brain function or overt complications like stroke or coma. Discovery of a perioperative neurological complication may be outside the treatment window, thereby making prevention an important focus. Early commercial devices used differential spectroscopy to measure relative changes from baseline of 2 chromophores: oxy- and deoxyhemoglobin. It was the introduction of spatially resolved spectroscopy techniques that allowed near-infrared spectrosc...
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Thiele RH, Shaw AD, Bartels K, Brown CH, Grocott H, Heringlake M, Gan TJ, Miller TE, McEvoy MD, Perioperative Quality Initiative (POQI) 6 Workgroup Tags: Anesth Analg Source Type: research

Urine Electrolytes in the Intensive Care Unit: From Pathophysiology to Clinical Practice.
Abstract Assessment of urine concentrations of sodium, chloride, and potassium is a widely available, rapid, and low-cost diagnostic option for the management of critically ill patients. Urine electrolytes have long been suggested in the diagnostic workup of hypovolemia, kidney injury, and acid-base and electrolyte disturbances. However, due to the wide range of normal reference values and challenges in interpretation, their use is controversial. To clarify their potential role in managing critical patients, we reviewed existing evidence on the use of urine electrolytes for diagnostic and therapeutic evaluation an...
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Umbrello M, Formenti P, Chiumello D Tags: Anesth Analg Source Type: research

The Role of MicroRNAs in Acute Respiratory Distress Syndrome and Sepsis, From Targets to Therapies: A Narrative Review.
Abstract Acute respiratory distress syndrome (ARDS) is a significant cause of morbidity and mortality in the intensive care unit (ICU) and is characterized by lung epithelial and endothelial cell injury, with increased permeability of the alveolar-capillary membrane, leading to pulmonary edema, severe hypoxia, and difficulty with ventilation. The most common cause of ARDS is sepsis, and currently, treatment of ARDS and sepsis has consisted mostly of supportive care because targeted therapies have largely been unsuccessful. The molecular mechanisms behind ARDS remain elusive. Recently, a number of microRNAs (miRNAs...
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Lee LK, Medzikovic L, Eghbali M, Eltzschig HK, Yuan X Tags: Anesth Analg Source Type: research

Airway Rupture Caused by Double-Lumen Tubes: A Review of 187 Cases.
Abstract The double-lumen tubes (DLTs) are the most widely used devices to provide perioperative lung isolation. Airway rupture is a rare but life-threatening complication of DLTs. The primary aim of this review was to collect all cases reported in the literature about airway rupture caused by DLTs and to describe the reported possible contributors, diagnosis, treatment, and outcomes of this complication. Another aim of this review was to assess the possible factors associated with mortality after airway rupture by DLTs. A comprehensive literature search for all cases of airway rupture caused by DLTs was performed...
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Liu S, Mao Y, Qiu P, Faridovich KA, Dong Y Tags: Anesth Analg Source Type: research

Neither Preoperative Pulse Pressure nor Systolic Blood Pressure Is Associated With Cardiac Complications After Coronary Artery Bypass Grafting.
We examined whether cardiac surgical patients with elevated pulse pressure are more susceptible to myocardial injury, dysfunction, cardiac-related complications, and mortality. Secondarily, we examined whether pulse pressure was a stronger predictor of the outcomes than systolic blood pressure. METHODS: This retrospective observational study included adult cardiac surgical patients having elective isolated on-pump coronary artery bypass grafting (CABG) between 2010 and 2017 at the Cleveland Clinic. The association between elevated pulse pressure and (1) perioperative myocardial injury, measured by postoperative tropon...
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Zhang K, Alfirevic A, Ramos D, Liang C, Soltesz EG, Duncan AE Tags: Anesth Analg Source Type: research

The Performance of an Artificial Neural Network Model in Predicting the Early Distribution Kinetics of Propofol in Morbidly Obese and Lean Subjects.
CONCLUSIONS: A recirculatory model and gated recurrent unit artificial neural network that incorporated ensemble learning both had similar performance and were both superior to a compartmental model in describing our high-resolution pharmacokinetic data of propofol. The potential of neural networks in pharmacokinetic modeling is encouraging but may be limited by the amount of training data available for these models. PMID: 33079873 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 22, 2020 Category: Anesthesiology Authors: Ingrande J, Gabriel RA, McAuley J, Krasinska K, Chien A, Lemmens HJM Tags: Anesth Analg Source Type: research