BET-ting on histone proteomics in schizophrenia
Trends Neurosci. 2022 Jun 16:S0166-2236(22)00119-9. doi: 10.1016/j.tins.2022.06.001. Online ahead of print.ABSTRACTIn a recent study, Farrelly, Zheng, and colleagues used a histone proteomics approach and patient-derived neurons to show increase in histone variant H2A.Z acetylation associated with schizophrenia (SCZ). They identified the bromo- and extraterminal (BET) protein BRD4 as an H2A.Z acetylation 'reader', and showed that a BRD4 inhibitor ameliorated the SCZ-associated transcriptional signature, revealing a new candidate target for treatment.PMID:35718601 | DOI:10.1016/j.tins.2022.06.001 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - June 19, 2022 Category: Neuroscience Authors: Marija Kundakovic Source Type: research

BET-ting on histone proteomics in schizophrenia
Trends Neurosci. 2022 Jun 16:S0166-2236(22)00119-9. doi: 10.1016/j.tins.2022.06.001. Online ahead of print.ABSTRACTIn a recent study, Farrelly, Zheng, and colleagues used a histone proteomics approach and patient-derived neurons to show increase in histone variant H2A.Z acetylation associated with schizophrenia (SCZ). They identified the bromo- and extraterminal (BET) protein BRD4 as an H2A.Z acetylation 'reader', and showed that a BRD4 inhibitor ameliorated the SCZ-associated transcriptional signature, revealing a new candidate target for treatment.PMID:35718601 | DOI:10.1016/j.tins.2022.06.001 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - June 19, 2022 Category: Neuroscience Authors: Marija Kundakovic Source Type: research

BET-ting on histone proteomics in schizophrenia
Trends Neurosci. 2022 Jun 16:S0166-2236(22)00119-9. doi: 10.1016/j.tins.2022.06.001. Online ahead of print.ABSTRACTIn a recent study, Farrelly, Zheng, and colleagues used a histone proteomics approach and patient-derived neurons to show increase in histone variant H2A.Z acetylation associated with schizophrenia (SCZ). They identified the bromo- and extraterminal (BET) protein BRD4 as an H2A.Z acetylation 'reader', and showed that a BRD4 inhibitor ameliorated the SCZ-associated transcriptional signature, revealing a new candidate target for treatment.PMID:35718601 | DOI:10.1016/j.tins.2022.06.001 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - June 19, 2022 Category: Neuroscience Authors: Marija Kundakovic Source Type: research

BET-ting on histone proteomics in schizophrenia
Trends Neurosci. 2022 Jun 16:S0166-2236(22)00119-9. doi: 10.1016/j.tins.2022.06.001. Online ahead of print.ABSTRACTIn a recent study, Farrelly, Zheng, and colleagues used a histone proteomics approach and patient-derived neurons to show increase in histone variant H2A.Z acetylation associated with schizophrenia (SCZ). They identified the bromo- and extraterminal (BET) protein BRD4 as an H2A.Z acetylation 'reader', and showed that a BRD4 inhibitor ameliorated the SCZ-associated transcriptional signature, revealing a new candidate target for treatment.PMID:35718601 | DOI:10.1016/j.tins.2022.06.001 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - June 19, 2022 Category: Neuroscience Authors: Marija Kundakovic Source Type: research

BET-ting on histone proteomics in schizophrenia
Trends Neurosci. 2022 Jun 16:S0166-2236(22)00119-9. doi: 10.1016/j.tins.2022.06.001. Online ahead of print.ABSTRACTIn a recent study, Farrelly, Zheng, and colleagues used a histone proteomics approach and patient-derived neurons to show increase in histone variant H2A.Z acetylation associated with schizophrenia (SCZ). They identified the bromo- and extraterminal (BET) protein BRD4 as an H2A.Z acetylation 'reader', and showed that a BRD4 inhibitor ameliorated the SCZ-associated transcriptional signature, revealing a new candidate target for treatment.PMID:35718601 | DOI:10.1016/j.tins.2022.06.001 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - June 19, 2022 Category: Neuroscience Authors: Marija Kundakovic Source Type: research

Spinal ascending pathways for somatosensory information processing
Trends Neurosci. 2022 Jun 11:S0166-2236(22)00099-6. doi: 10.1016/j.tins.2022.05.005. Online ahead of print.ABSTRACTThe somatosensory system processes diverse types of information including mechanical, thermal, and chemical signals. It has an essential role in sensory perception and body movement and, thus, is crucial for organism survival. The neural network for processing somatosensory information comprises multiple key nodes. Spinal projection neurons represent the key node for transmitting somatosensory information from the periphery to the brain. Although the anatomy of spinal ascending pathways has been characterized,...
Source: Trends in Neurosciences - June 14, 2022 Category: Neuroscience Authors: Lin-Han Wang Wen-Qun Ding Yan-Gang Sun Source Type: research

Spinal ascending pathways for somatosensory information processing
Trends Neurosci. 2022 Jun 11:S0166-2236(22)00099-6. doi: 10.1016/j.tins.2022.05.005. Online ahead of print.ABSTRACTThe somatosensory system processes diverse types of information including mechanical, thermal, and chemical signals. It has an essential role in sensory perception and body movement and, thus, is crucial for organism survival. The neural network for processing somatosensory information comprises multiple key nodes. Spinal projection neurons represent the key node for transmitting somatosensory information from the periphery to the brain. Although the anatomy of spinal ascending pathways has been characterized,...
Source: Trends in Neurosciences - June 14, 2022 Category: Neuroscience Authors: Lin-Han Wang Wen-Qun Ding Yan-Gang Sun Source Type: research

Spinal ascending pathways for somatosensory information processing
Trends Neurosci. 2022 Jun 11:S0166-2236(22)00099-6. doi: 10.1016/j.tins.2022.05.005. Online ahead of print.ABSTRACTThe somatosensory system processes diverse types of information including mechanical, thermal, and chemical signals. It has an essential role in sensory perception and body movement and, thus, is crucial for organism survival. The neural network for processing somatosensory information comprises multiple key nodes. Spinal projection neurons represent the key node for transmitting somatosensory information from the periphery to the brain. Although the anatomy of spinal ascending pathways has been characterized,...
Source: Trends in Neurosciences - June 14, 2022 Category: Neuroscience Authors: Lin-Han Wang Wen-Qun Ding Yan-Gang Sun Source Type: research

Spinal ascending pathways for somatosensory information processing
Trends Neurosci. 2022 Jun 11:S0166-2236(22)00099-6. doi: 10.1016/j.tins.2022.05.005. Online ahead of print.ABSTRACTThe somatosensory system processes diverse types of information including mechanical, thermal, and chemical signals. It has an essential role in sensory perception and body movement and, thus, is crucial for organism survival. The neural network for processing somatosensory information comprises multiple key nodes. Spinal projection neurons represent the key node for transmitting somatosensory information from the periphery to the brain. Although the anatomy of spinal ascending pathways has been characterized,...
Source: Trends in Neurosciences - June 14, 2022 Category: Neuroscience Authors: Lin-Han Wang Wen-Qun Ding Yan-Gang Sun Source Type: research

Spinal ascending pathways for somatosensory information processing
Trends Neurosci. 2022 Jun 11:S0166-2236(22)00099-6. doi: 10.1016/j.tins.2022.05.005. Online ahead of print.ABSTRACTThe somatosensory system processes diverse types of information including mechanical, thermal, and chemical signals. It has an essential role in sensory perception and body movement and, thus, is crucial for organism survival. The neural network for processing somatosensory information comprises multiple key nodes. Spinal projection neurons represent the key node for transmitting somatosensory information from the periphery to the brain. Although the anatomy of spinal ascending pathways has been characterized,...
Source: Trends in Neurosciences - June 14, 2022 Category: Neuroscience Authors: Lin-Han Wang Wen-Qun Ding Yan-Gang Sun Source Type: research

Neural consequences of chronic sleep disruption
Trends Neurosci. 2022 Jun 9:S0166-2236(22)00101-1. doi: 10.1016/j.tins.2022.05.007. Online ahead of print.ABSTRACTRecent studies in both humans and animal models call into question the completeness of recovery after chronic sleep disruption. Studies in humans have identified cognitive domains particularly vulnerable to delayed or incomplete recovery after chronic sleep disruption, including sustained vigilance and episodic memory. These findings, in turn, provide a focus for animal model studies to critically test the lasting impact of sleep loss on the brain. Here, we summarize the human response to sleep disruption and t...
Source: Trends in Neurosciences - June 12, 2022 Category: Neuroscience Authors: Zachary Zamore Sigrid C Veasey Source Type: research

Neural consequences of chronic sleep disruption
Trends Neurosci. 2022 Jun 9:S0166-2236(22)00101-1. doi: 10.1016/j.tins.2022.05.007. Online ahead of print.ABSTRACTRecent studies in both humans and animal models call into question the completeness of recovery after chronic sleep disruption. Studies in humans have identified cognitive domains particularly vulnerable to delayed or incomplete recovery after chronic sleep disruption, including sustained vigilance and episodic memory. These findings, in turn, provide a focus for animal model studies to critically test the lasting impact of sleep loss on the brain. Here, we summarize the human response to sleep disruption and t...
Source: Trends in Neurosciences - June 12, 2022 Category: Neuroscience Authors: Zachary Zamore Sigrid C Veasey Source Type: research

A blueprint for examining striatal control of cognition
Trends Neurosci. 2022 Jun 8:S0166-2236(22)00103-5. doi: 10.1016/j.tins.2022.05.009. Online ahead of print.ABSTRACTIn a recent study, Bolkan, Stone, and colleagues demonstrated that direct and indirect striatal pathways in mice exert opponent control over choice behavior in a task- and state-dependent manner. This work highlights the need for rigorously controlled behavioral experiments and novel behavioral modeling in investigations of the neural mechanisms of decision making.PMID:35690496 | DOI:10.1016/j.tins.2022.05.009 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - June 11, 2022 Category: Neuroscience Authors: Elizabeth N Holly Edgar Di áz-Hernández Marc V Fuccillo Source Type: research

A blueprint for examining striatal control of cognition
Trends Neurosci. 2022 Jun 8:S0166-2236(22)00103-5. doi: 10.1016/j.tins.2022.05.009. Online ahead of print.ABSTRACTIn a recent study, Bolkan, Stone, and colleagues demonstrated that direct and indirect striatal pathways in mice exert opponent control over choice behavior in a task- and state-dependent manner. This work highlights the need for rigorously controlled behavioral experiments and novel behavioral modeling in investigations of the neural mechanisms of decision making.PMID:35690496 | DOI:10.1016/j.tins.2022.05.009 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - June 11, 2022 Category: Neuroscience Authors: Elizabeth N Holly Edgar Di áz-Hernández Marc V Fuccillo Source Type: research

A step forward for stress-induced ataxia
Trends Neurosci. 2022 Jun 4:S0166-2236(22)00104-7. doi: 10.1016/j.tins.2022.05.010. Online ahead of print.ABSTRACTPatients with episodic ataxia type 2 (EA2) display attacks of severe incoordination and dystonia that can be triggered by stress. In a recent study, Snell et al. found a mechanistic pathway by which norepinephrine (NE) alters cerebellar Purkinje output to trigger attacks in a mouse model of EA2 and identified a pharmacological intervention that effectively reduces them.PMID:35672171 | DOI:10.1016/j.tins.2022.05.010 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - June 7, 2022 Category: Neuroscience Authors: Hugo G Marques Pedro L Castelhanito Megan R Carey Source Type: research