Advances in animal models of prenatal opioid exposure
Trends Neurosci. 2024 Apr 12:S0166-2236(24)00042-0. doi: 10.1016/j.tins.2024.03.005. Online ahead of print.ABSTRACTNeonatal opioid withdrawal syndrome (NOWS) is a growing public health concern. The complexity of in utero opioid exposure in clinical studies makes it difficult to investigate underlying mechanisms that could ultimately inform early diagnosis and treatments. Clinical studies are unable to dissociate the influence of maternal polypharmacy or the environment from direct effects of in utero opioid exposure, highlighting the need for effective animal models. Early animal models of prenatal opioid exposure primaril...
Source: Trends in Neurosciences - April 13, 2024 Category: Neuroscience Authors: Julia R Ferrante Julie A Blendy Source Type: research
Orchestrating neuronal activity-dependent translation via the integrated stress response protein GADD34
Trends Neurosci. 2024 Apr 12:S0166-2236(24)00058-4. doi: 10.1016/j.tins.2024.03.008. Online ahead of print.ABSTRACTIn a recent study, Oliveira and colleagues revealed how growth arrest and DNA damage-inducible protein 34 (GADD34), an effector of the integrated stress response, initiates the translation of synaptic plasticity-related mRNAs following brain-derived neurotrophic factor (BDNF) stimulation. This work suggests that GADD34 may link transcriptional products with translation control upon neuronal activation, illuminating how protein synthesis is orchestrated in neuronal plasticity.PMID:38614892 | DOI:10.1016/j.tins....
Source: Trends in Neurosciences - April 13, 2024 Category: Neuroscience Authors: Xingzhi He Wenwen Li Huan Ma Source Type: research
Advances in animal models of prenatal opioid exposure
Trends Neurosci. 2024 Apr 12:S0166-2236(24)00042-0. doi: 10.1016/j.tins.2024.03.005. Online ahead of print.ABSTRACTNeonatal opioid withdrawal syndrome (NOWS) is a growing public health concern. The complexity of in utero opioid exposure in clinical studies makes it difficult to investigate underlying mechanisms that could ultimately inform early diagnosis and treatments. Clinical studies are unable to dissociate the influence of maternal polypharmacy or the environment from direct effects of in utero opioid exposure, highlighting the need for effective animal models. Early animal models of prenatal opioid exposure primaril...
Source: Trends in Neurosciences - April 13, 2024 Category: Neuroscience Authors: Julia R Ferrante Julie A Blendy Source Type: research
Orchestrating neuronal activity-dependent translation via the integrated stress response protein GADD34
Trends Neurosci. 2024 Apr 12:S0166-2236(24)00058-4. doi: 10.1016/j.tins.2024.03.008. Online ahead of print.ABSTRACTIn a recent study, Oliveira and colleagues revealed how growth arrest and DNA damage-inducible protein 34 (GADD34), an effector of the integrated stress response, initiates the translation of synaptic plasticity-related mRNAs following brain-derived neurotrophic factor (BDNF) stimulation. This work suggests that GADD34 may link transcriptional products with translation control upon neuronal activation, illuminating how protein synthesis is orchestrated in neuronal plasticity.PMID:38614892 | DOI:10.1016/j.tins....
Source: Trends in Neurosciences - April 13, 2024 Category: Neuroscience Authors: Xingzhi He Wenwen Li Huan Ma Source Type: research
Advances in animal models of prenatal opioid exposure
Trends Neurosci. 2024 Apr 12:S0166-2236(24)00042-0. doi: 10.1016/j.tins.2024.03.005. Online ahead of print.ABSTRACTNeonatal opioid withdrawal syndrome (NOWS) is a growing public health concern. The complexity of in utero opioid exposure in clinical studies makes it difficult to investigate underlying mechanisms that could ultimately inform early diagnosis and treatments. Clinical studies are unable to dissociate the influence of maternal polypharmacy or the environment from direct effects of in utero opioid exposure, highlighting the need for effective animal models. Early animal models of prenatal opioid exposure primaril...
Source: Trends in Neurosciences - April 13, 2024 Category: Neuroscience Authors: Julia R Ferrante Julie A Blendy Source Type: research
Orchestrating neuronal activity-dependent translation via the integrated stress response protein GADD34
Trends Neurosci. 2024 Apr 12:S0166-2236(24)00058-4. doi: 10.1016/j.tins.2024.03.008. Online ahead of print.ABSTRACTIn a recent study, Oliveira and colleagues revealed how growth arrest and DNA damage-inducible protein 34 (GADD34), an effector of the integrated stress response, initiates the translation of synaptic plasticity-related mRNAs following brain-derived neurotrophic factor (BDNF) stimulation. This work suggests that GADD34 may link transcriptional products with translation control upon neuronal activation, illuminating how protein synthesis is orchestrated in neuronal plasticity.PMID:38614892 | DOI:10.1016/j.tins....
Source: Trends in Neurosciences - April 13, 2024 Category: Neuroscience Authors: Xingzhi He Wenwen Li Huan Ma Source Type: research
What does preferential viewing tell us about the neurobiology of recognition memory?
Trends Neurosci. 2024 Apr 5:S0166-2236(24)00040-7. doi: 10.1016/j.tins.2024.03.003. Online ahead of print.ABSTRACTThe two tests most widely used in nonhuman primates to assess the neurobiology of recognition memory produce conflicting results. Preferential viewing tests (e.g., visual paired comparison) produce robust impairments following hippocampal lesions, whereas matching tests (e.g., delayed nonmatching-to-sample) often show complete sparing. Here, we review the data, the proposed explanations for this discrepancy, and then critically evaluate those explanations. The most likely explanation is that preferential viewin...
Source: Trends in Neurosciences - April 6, 2024 Category: Neuroscience Authors: Benjamin M Basile Spencer J Waters Elisabeth A Murray Source Type: research
What does preferential viewing tell us about the neurobiology of recognition memory?
Trends Neurosci. 2024 Apr 5:S0166-2236(24)00040-7. doi: 10.1016/j.tins.2024.03.003. Online ahead of print.ABSTRACTThe two tests most widely used in nonhuman primates to assess the neurobiology of recognition memory produce conflicting results. Preferential viewing tests (e.g., visual paired comparison) produce robust impairments following hippocampal lesions, whereas matching tests (e.g., delayed nonmatching-to-sample) often show complete sparing. Here, we review the data, the proposed explanations for this discrepancy, and then critically evaluate those explanations. The most likely explanation is that preferential viewin...
Source: Trends in Neurosciences - April 6, 2024 Category: Neuroscience Authors: Benjamin M Basile Spencer J Waters Elisabeth A Murray Source Type: research
What does preferential viewing tell us about the neurobiology of recognition memory?
Trends Neurosci. 2024 Apr 5:S0166-2236(24)00040-7. doi: 10.1016/j.tins.2024.03.003. Online ahead of print.ABSTRACTThe two tests most widely used in nonhuman primates to assess the neurobiology of recognition memory produce conflicting results. Preferential viewing tests (e.g., visual paired comparison) produce robust impairments following hippocampal lesions, whereas matching tests (e.g., delayed nonmatching-to-sample) often show complete sparing. Here, we review the data, the proposed explanations for this discrepancy, and then critically evaluate those explanations. The most likely explanation is that preferential viewin...
Source: Trends in Neurosciences - April 6, 2024 Category: Neuroscience Authors: Benjamin M Basile Spencer J Waters Elisabeth A Murray Source Type: research
What does preferential viewing tell us about the neurobiology of recognition memory?
Trends Neurosci. 2024 Apr 5:S0166-2236(24)00040-7. doi: 10.1016/j.tins.2024.03.003. Online ahead of print.ABSTRACTThe two tests most widely used in nonhuman primates to assess the neurobiology of recognition memory produce conflicting results. Preferential viewing tests (e.g., visual paired comparison) produce robust impairments following hippocampal lesions, whereas matching tests (e.g., delayed nonmatching-to-sample) often show complete sparing. Here, we review the data, the proposed explanations for this discrepancy, and then critically evaluate those explanations. The most likely explanation is that preferential viewin...
Source: Trends in Neurosciences - April 6, 2024 Category: Neuroscience Authors: Benjamin M Basile Spencer J Waters Elisabeth A Murray Source Type: research
What does preferential viewing tell us about the neurobiology of recognition memory?
Trends Neurosci. 2024 Apr 5:S0166-2236(24)00040-7. doi: 10.1016/j.tins.2024.03.003. Online ahead of print.ABSTRACTThe two tests most widely used in nonhuman primates to assess the neurobiology of recognition memory produce conflicting results. Preferential viewing tests (e.g., visual paired comparison) produce robust impairments following hippocampal lesions, whereas matching tests (e.g., delayed nonmatching-to-sample) often show complete sparing. Here, we review the data, the proposed explanations for this discrepancy, and then critically evaluate those explanations. The most likely explanation is that preferential viewin...
Source: Trends in Neurosciences - April 6, 2024 Category: Neuroscience Authors: Benjamin M Basile Spencer J Waters Elisabeth A Murray Source Type: research
What does preferential viewing tell us about the neurobiology of recognition memory?
Trends Neurosci. 2024 Apr 5:S0166-2236(24)00040-7. doi: 10.1016/j.tins.2024.03.003. Online ahead of print.ABSTRACTThe two tests most widely used in nonhuman primates to assess the neurobiology of recognition memory produce conflicting results. Preferential viewing tests (e.g., visual paired comparison) produce robust impairments following hippocampal lesions, whereas matching tests (e.g., delayed nonmatching-to-sample) often show complete sparing. Here, we review the data, the proposed explanations for this discrepancy, and then critically evaluate those explanations. The most likely explanation is that preferential viewin...
Source: Trends in Neurosciences - April 6, 2024 Category: Neuroscience Authors: Benjamin M Basile Spencer J Waters Elisabeth A Murray Source Type: research
The neuronal cilium - a highly diverse and dynamic organelle involved in sensory detection and neuromodulation
Trends Neurosci. 2024 Apr 4:S0166-2236(24)00041-9. doi: 10.1016/j.tins.2024.03.004. Online ahead of print.ABSTRACTCilia are fascinating organelles that act as cellular antennae, sensing the cellular environment. Cilia gained significant attention in the late 1990s after their dysfunction was linked to genetic diseases known as ciliopathies. Since then, several breakthrough discoveries have uncovered the mechanisms underlying cilia biogenesis and function. Like most cells in the animal kingdom, neurons also harbor cilia, which are enriched in neuromodulatory receptors. Yet, how neuronal cilia modulate neuronal physiology an...
Source: Trends in Neurosciences - April 5, 2024 Category: Neuroscience Authors: Nathalie Jurisch-Yaksi Dagmar Wachten Jay Gopalakrishnan Source Type: research
The neuronal cilium - a highly diverse and dynamic organelle involved in sensory detection and neuromodulation
Trends Neurosci. 2024 Apr 4:S0166-2236(24)00041-9. doi: 10.1016/j.tins.2024.03.004. Online ahead of print.ABSTRACTCilia are fascinating organelles that act as cellular antennae, sensing the cellular environment. Cilia gained significant attention in the late 1990s after their dysfunction was linked to genetic diseases known as ciliopathies. Since then, several breakthrough discoveries have uncovered the mechanisms underlying cilia biogenesis and function. Like most cells in the animal kingdom, neurons also harbor cilia, which are enriched in neuromodulatory receptors. Yet, how neuronal cilia modulate neuronal physiology an...
Source: Trends in Neurosciences - April 5, 2024 Category: Neuroscience Authors: Nathalie Jurisch-Yaksi Dagmar Wachten Jay Gopalakrishnan Source Type: research
Infant neuroscience: how to measure brain activity in the youngest minds
Trends Neurosci. 2024 Apr 2:S0166-2236(24)00019-5. doi: 10.1016/j.tins.2024.02.003. Online ahead of print.ABSTRACTThe functional properties of the infant brain are poorly understood. Recent advances in cognitive neuroscience are opening new avenues for measuring brain activity in human infants. These include novel uses of existing technologies such as electroencephalography (EEG) and magnetoencephalography (MEG), the availability of newer technologies including functional near-infrared spectroscopy (fNIRS) and optically pumped magnetometry (OPM), and innovative applications of functional magnetic resonance imaging (fMRI) i...
Source: Trends in Neurosciences - April 3, 2024 Category: Neuroscience Authors: Nicholas B Turk-Browne Richard N Aslin Source Type: research
