A novel insight into the neuroprotective effects of cannabidiol: maintained apelin/dopamine synthesis, NRF2 signaling, and AKT/CREB/BDNF gene expressions
This study aimed to investigate the protective effects of cannabidiol (CBD) against neuroinflammation through various mechanisms. Thirty‑two female rats were randomly divided into 4 groups as control, lipopolysaccharide (LPS), LPS + CBD and CBD groups. After six hours following LPS administration, rats were sacrificed, brain and cerebellum tissues were obtained. Tissues were stained with hematoxylin‑eosin for histopathological analysis. Apelin and tyrosine hydroxylase synthesis were determined immunohistochemically. Total oxidant status and total antioxidant status levels were measured, and an oxidative stress index wa...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Melike Do ğan Ünlü Sanem A şçı Orhan İmeci Adem Milletsever Özlem Özmen Serdar Sezer Serpil Demirci Source Type: research
The effect of morphine administration on GluN3B NMDA receptor subunit mRNA expression in rat brain
Acta Neurobiol Exp (Wars). 2024 Mar 28;84(1):89-97. doi: 10.55782/ane-2024-2545.ABSTRACTOpioid addiction is critically dependent on the activation of N‑methyl‑D‑aspartate (NMDA) receptors, which are widely found in the mesocorticolimbic system. Meanwhile, opioid addiction may affect the expression level of NMDA receptor subunits. The existence of GluN3 subunits in the NMDA receptor's tetramer structure reduces the excitatory current of the receptor channel. We evaluated the changes in the mRNA expression pattern of the GluN3B subunit of the NMDA receptor in rat brains following acute and chronic exposure to morphine....
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Shahrzad Nazari Mitra-Sadat Sadat-Shirazi Ali Shahbazi Kamran Ghaffari Nasim Vousooghi Source Type: research
Evaluation of neurogranin levels in a rat model of diffuse axonal injury
This study showed a dichotomy of post‑DAI serum NRGN levels in consecutive time periods. NRGN levels in CSF were higher in the one‑hour group than in the sham group and returned to baseline by 72 hours, although not significantly. Our study provides an impression of serum and CSF NRGN levels in a rat DAI model in consecutive time periods. Further studies are needed to understand the diagnostic value of NRGN.PMID:38587321 | DOI:10.55782/ane-2024-2543 (Source: Acta Neurobiologiae Experimentalis)
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Ozan Baskurt Seckin Aydin Idris Avci Pinar Ozay Nayir Mehmet Volkan Aydin Source Type: research
Time ‑dependent changes in blood cells, NIHSS and mRS according to reperfusion treatment type in stroke patients who developed hemorrhagic complication
In conclusion, there is a relation between the type of reperfusion therapy and the time‑dependent changes in blood cells and ratios as well as mRS scores among AIS patients who have undergone rtPA and/or thrombectomy and developed cerebral hemorrhage.PMID:38587322 | DOI:10.55782/ane-2024-2540 (Source: Acta Neurobiologiae Experimentalis)
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Hatice Ferhan K ömürcü Eren G özke Irmak Salt I şil Kalyoncu Aslan Pelin Do ğan Ak Source Type: research
Preventive effects of crocin, a natural compound from saffron, against nicotine ‑induced oxidative stress and neurobehavioral disturbances
In this study, we explore the neuroprotective effects of crocin, a bioactive agent commonly found in saffron - a spice derived from the flower of Crocus sativus - using a rat model. The dose‑dependent effects of crocin were evaluated in nicotine‑induced neurodegeneration and compared with a control group. Neurobehavioral changes, assessed through the elevated plus maze, the open field test, the forced swim test, and the Morris water maze, as well as oxidative stress in the hippocampus, were evaluated. Interestingly, nicotine administration resulted in depression, anxiety, and abnormal motor and cognitive functions, whi...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Majid Motaghinejad Manijeh Motevalian Antoni Sureda Source Type: research
Effect of levetiracetam on DNA oxidation and glutathione content in a temporal lobe epilepsy model
Acta Neurobiol Exp (Wars). 2024 Mar 28;84(1):51-58. doi: 10.55782/ane-2024-2537.ABSTRACTLevetiracetam (LEV) is a drug commonly used as an anticonvulsant. However, recent evidence points to a possible role as an antioxidant. We previously demonstrated the antioxidant properties of LEV by significantly increasing catalase and superoxide dismutase activities and decreasing the hydrogen peroxide (H2O2) levels in the hippocampus of rats with temporal lobe epilepsy (TLE) showing scavenging properties against the hydroxyl radical. The aim of the present work was to evaluate, the effect of LEV on DNA oxidation, by determining 8‑...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Itzel Jatziri Contreras-Garc ía Cindy Bandala Iv án Ignacio-Mejía Luz Adriana Pichardo-Mac ías Julieta Griselda Mendoza-Torreblanca Mercedes Edna Garc ía-Cruz Sa úl Gómez-Manzo Noem í Cárdenas-Rodríguez Source Type: research
Abnormal expression of long non ‑coding RNA LINC01270 in glioma and its correlation with X‑ray computed tomography signs
This study focused on the association of LINC01270 and computed tomography (CT) signs with glioma development, to evaluate their potential in the early detection of glioma. Serum LINC01270 was evaluated in glioma patients and healthy individuals using PCR. The involvement of LINC01270 in glioma onset and development was evaluated by ROC and chi‑square test. The association of LINC01270 with the CT signs and their combined effects in the diagnosis in glioma were also estimated. Serum LINC01270 was significantly elevated in glioma patients, which was closely associated with patients' advanced WHO grades and lower KPS. Both...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Ying Liu Yuntao Zhang Yongjun E Xianglin Zhang Heji Ma Furen Dong Source Type: research
Alarin potentiates ongoing epileptiform activity in rat brain slices: an in vitro electrophysiological study
In this study, we investigated if alarin induced any synchronous discharges or epileptiform activity, and if it had any effect on already initiated epileptiform discharges. We used thick acute horizontal hippocampal slices obtained from 30‑ to 35‑day‑old rats. Extracellular field potential recordings were evaluated in the CA1 region of the hippocampus. Our data demonstrated that, alarin application did not result in any epileptiform activity or abnormal discharges. 4‑aminopyridine was applied to induce epileptiform activity in the slices. We found that alarin increased the frequency of interictal‑like events and ...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Ömer Faruk Kalkan Hilal Öztürk Zafer Şahin Harun Ba şoğlu Selcen Aydin Abidin İsmail Abidin Source Type: research
Effects of morphine on conditioned place preference and pain are independent of uptake ‑2
This study was done to assess the effect of uptake‑2 inhibition on morphine‑induced conditioned place preference (CPP) and analgesia. In this study, the effects of morphine and/or D22 on CPP were evaluated following intraperitoneal injection in mice. Afterward, changes in motor activity were evaluated by the open field test. Using the tail‑flick model, the effects of D22 and/or morphine were evaluated on the pain threshold. The results showed that 20 mg/kg of morphine induced a place preference response. D22, at the dose of 0.03 mg/kg, caused place avoidance, while at the dose of 0.3 mg/kg, it produced a notable plac...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Mohammad Saeid Souri Mohaddeseh Sadat Alavi Ali Ahmadian Salami Ali Roohbakhsh Source Type: research
Optical imaging of the intrinsic signal as a tool to characterize orientation sensitivity in the primary visual cortex of the young mouse
Acta Neurobiol Exp (Wars). 2024 Mar 28;84(1):1-25. doi: 10.55782/ane-2024-2397.ABSTRACTWe employed intrinsic signal optical imaging (ISOI) to investigate orientation sensitivity bias in the visual cortex of young mice. Optical signals were recorded in response to the moving light gratings stimulating ipsi‑, contra‑ and binocular eye inputs. ISOI allowed visualization of cortical areas activated by gratings of specific orientation and temporal changes of light scatter during visual stimulation. These results confirmed ISOI as a reliable technique for imaging the activity of large populations of neurons in the mouse visu...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Ida Raciborska Piotr Dzwiniel Katarzyna Kordecka Anna Pos łuszny Wioletta Waleszczyk Andrzej Wr óbel Source Type: research
A novel insight into the neuroprotective effects of cannabidiol: maintained apelin/dopamine synthesis, NRF2 signaling, and AKT/CREB/BDNF gene expressions
This study aimed to investigate the protective effects of cannabidiol (CBD) against neuroinflammation through various mechanisms. Thirty‑two female rats were randomly divided into 4 groups as control, lipopolysaccharide (LPS), LPS + CBD and CBD groups. After six hours following LPS administration, rats were sacrificed, brain and cerebellum tissues were obtained. Tissues were stained with hematoxylin‑eosin for histopathological analysis. Apelin and tyrosine hydroxylase synthesis were determined immunohistochemically. Total oxidant status and total antioxidant status levels were measured, and an oxidative stress index wa...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Melike Do ğan Ünlü Sanem A şçı Orhan İmeci Adem Milletsever Özlem Özmen Serdar Sezer Serpil Demirci Source Type: research
The effect of morphine administration on GluN3B NMDA receptor subunit mRNA expression in rat brain
Acta Neurobiol Exp (Wars). 2024 Mar 28;84(1):89-97. doi: 10.55782/ane-2024-2545.ABSTRACTOpioid addiction is critically dependent on the activation of N‑methyl‑D‑aspartate (NMDA) receptors, which are widely found in the mesocorticolimbic system. Meanwhile, opioid addiction may affect the expression level of NMDA receptor subunits. The existence of GluN3 subunits in the NMDA receptor's tetramer structure reduces the excitatory current of the receptor channel. We evaluated the changes in the mRNA expression pattern of the GluN3B subunit of the NMDA receptor in rat brains following acute and chronic exposure to morphine....
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Shahrzad Nazari Mitra-Sadat Sadat-Shirazi Ali Shahbazi Kamran Ghaffari Nasim Vousooghi Source Type: research
Evaluation of neurogranin levels in a rat model of diffuse axonal injury
This study showed a dichotomy of post‑DAI serum NRGN levels in consecutive time periods. NRGN levels in CSF were higher in the one‑hour group than in the sham group and returned to baseline by 72 hours, although not significantly. Our study provides an impression of serum and CSF NRGN levels in a rat DAI model in consecutive time periods. Further studies are needed to understand the diagnostic value of NRGN.PMID:38587321 | DOI:10.55782/ane-2024-2543 (Source: Acta Neurobiologiae Experimentalis)
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Ozan Baskurt Seckin Aydin Idris Avci Pinar Ozay Nayir Mehmet Volkan Aydin Source Type: research
Time ‑dependent changes in blood cells, NIHSS and mRS according to reperfusion treatment type in stroke patients who developed hemorrhagic complication
In conclusion, there is a relation between the type of reperfusion therapy and the time‑dependent changes in blood cells and ratios as well as mRS scores among AIS patients who have undergone rtPA and/or thrombectomy and developed cerebral hemorrhage.PMID:38587322 | DOI:10.55782/ane-2024-2540 (Source: Acta Neurobiologiae Experimentalis)
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Hatice Ferhan K ömürcü Eren G özke Irmak Salt I şil Kalyoncu Aslan Pelin Do ğan Ak Source Type: research
Preventive effects of crocin, a natural compound from saffron, against nicotine ‑induced oxidative stress and neurobehavioral disturbances
In this study, we explore the neuroprotective effects of crocin, a bioactive agent commonly found in saffron - a spice derived from the flower of Crocus sativus - using a rat model. The dose‑dependent effects of crocin were evaluated in nicotine‑induced neurodegeneration and compared with a control group. Neurobehavioral changes, assessed through the elevated plus maze, the open field test, the forced swim test, and the Morris water maze, as well as oxidative stress in the hippocampus, were evaluated. Interestingly, nicotine administration resulted in depression, anxiety, and abnormal motor and cognitive functions, whi...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Majid Motaghinejad Manijeh Motevalian Antoni Sureda Source Type: research
