Modulation of anxiety behavior in gonadectomized animals.
Abstract Anxiety is a complex psychological state which happens after stressful life experiences. Many factors such as daily life events, neurotransmitter systems, and different brain areas could influence anxiety behavior in humans and animals. For example, opioids and androgens decrease anxiety behavior both in humans and animals. Furthermore, removing the testes (gonadectomy) causes higher levels of anxiety‑like behaviors, in which the administration of testosterone and opioid antagonist can reverse some of these behaviors. We review the effects of morphine and androgens on the modulation of anxiety behavior ...
Source: Acta Neurobiologiae Experimentalis - October 1, 2020 Category: Neurology Authors: Khakpay R, Khakpai F Tags: Acta Neurobiol Exp (Wars) Source Type: research

Antistress and antidepressant properties of dapoxetine and vortioxetine.
ska E Abstract The studies aimed to determine the antidepressant efficacy of single and chronic administration of dapoxetine alone and vortioxetine alone, as well as in the combination of these drugs. An additional objective of the study was to measure the effect of the active substances on the corticosterone level in chronically stressed animals. The study was conducted on male Wistar rats using non‑stressed and stressed groups (chronic restraint stress). The experiment comprised both forced swimming test (immobility time test) and corticosterone level measurement using Corticosterone ELISA Kit. The obtained re...
Source: Acta Neurobiologiae Experimentalis - October 1, 2020 Category: Neurology Authors: Ratajczak P, Kus K, Zielińska-Przyjemska M, Skórczewska B, Zaprutko T, Kopciuch D, Paczkowska A, Nowakowska E Tags: Acta Neurobiol Exp (Wars) Source Type: research

RhoA/Rock2/Limk1/cofilin1 pathway is involved in attenuation of neuronal dendritic spine loss by paeonol in the frontal cortex of D-galactose and aluminum ‑induced Alzheimer's disease‑like rat model.
RhoA/Rock2/Limk1/cofilin1 pathway is involved in attenuation of neuronal dendritic spine loss by paeonol in the frontal cortex of D-galactose and aluminum‑induced Alzheimer's disease‑like rat model. Acta Neurobiol Exp (Wars). 2020;80(3):225-244 Authors: Han F, Xu H, Shen JX, Pan C, Yu ZH, Chen JJ, Zhu XL, Cai YF, Lu YP Abstract Alzheimer's disease (AD) has become the most prevalent neurodegenerative disorder. Given the pathogenesis of AD is unclear, there is currently no drug approved to halt or delay the progression of AD. Therefore, it is pressing to explore new targets and drugs for AD. In Chin...
Source: Acta Neurobiologiae Experimentalis - October 1, 2020 Category: Neurology Authors: Han F, Xu H, Shen JX, Pan C, Yu ZH, Chen JJ, Zhu XL, Cai YF, Lu YP Tags: Acta Neurobiol Exp (Wars) Source Type: research

Aerobic exercise has an anxiolytic effect on streptozotocin ‑induced diabetic rats.
This study aims to evaluate potential anxiolytic effects of aerobic exercise in streptozotocin (STZ)‑induced diabetes. Male Wistar albino rats (n=40) were randomly divided into four groups of control, exercise, diabetes, and diabetes + exercise. Diabetes was induced with a single i.p. injection of STZ. The incremental load test was applied to exercise groups to determine maximal exercise capacity. Rats exercised on a treadmill at 70% of their maximal capacity for 45 min, five days per week for 12 weeks. On the day after the last exercise session the open field test and elevated plus maze test were carried out. Diabetes c...
Source: Acta Neurobiologiae Experimentalis - October 1, 2020 Category: Neurology Authors: Caliskan H, Akat F, Omercioglu G, Bastug G, Ficicilar H, Bastug M Tags: Acta Neurobiol Exp (Wars) Source Type: research

Neuromyelitis optica spectrum disorder: an overview.
Abstract Neuromyelitis optica also known as Devic's syndrome is a rare autoimmune disorder that predominantly targets the optic nerves and the spinal cord. It is a debilitating disorder that damages a person's health. Initially it was considered as a variant of multiple sclerosis (MS). But, in 2004, a water channel protein associated antibody was found to be responsible for the disease. This helped in distinguishing the disease from multiple sclerosis. Multiple molecular mechanisms like complement dependent cytotoxicity, antibody‑dependent cellular cytotoxicity etc. contribute to the disease. Certain environment...
Source: Acta Neurobiologiae Experimentalis - October 1, 2020 Category: Neurology Authors: Ramakrishnan P, Nagarajan D Tags: Acta Neurobiol Exp (Wars) Source Type: research

The application of iPSCs in Parkinson's disease.
Orlowski D Abstract The discovery and application of induced pluripotent stem cells (iPSCs) provide a novel treatment modality for diseases, which remain incurable. Particularly, in the treatment of neurodegenerative diseases such as Parkinson's disease (PD), iPSC‑technology holds an interesting prospect for replacement therapy. Currently, the prognostic improvement of PD is limited and relies on symptomatic treatment. However, the symptomatic dopamine‑replacement therapies lose their long‑duration responses, and novel regenerative treatment modalities are needed. Animal models have provided valuable informa...
Source: Acta Neurobiologiae Experimentalis - October 1, 2020 Category: Neurology Authors: Jarbæk Nielsen JJ, Lillethorup TP, Glud AN, Hedemann Sørensen JC, Orlowski D Tags: Acta Neurobiol Exp (Wars) Source Type: research

Subchronic effects of ligands of cannabinoid receptors on learning and memory processes of olfactory bulbectomized rats.
Abstract The brain endocannabinoid system has been shown to play a role in many physiological processes, including mood, learning and memory. It is also involved in the pathogenesis of anxiety, depression, mood disorders, as well as neurodegenerative disorders, although the exact mechanisms by which cannabinoid receptors interfere in these disorders are not well established. The aim of the present study was to evaluate the effects of cannabinoid ligands HU‑210 (CB1 receptor agonist) and SR 141716A (CB1 receptor antagonist) on learning and memory processes of rats with depressive - like state, induced by bilatera...
Source: Acta Neurobiologiae Experimentalis - October 1, 2020 Category: Neurology Authors: Velikova M, Doncheva D, Tashev R Tags: Acta Neurobiol Exp (Wars) Source Type: research

Serum levels of hepcidin and interleukin 6 in Parkinson's disease.
Abstract Neurodegeneration in Parkinson's disease (PD) includes processes of chronic inflammation and oxidative stress which are related to dysregulation in the homeostasis of iron metabolism. Hepcidin is a peptide hormone responsible for systemic iron homeostasis and simultaneously the inflammatory response protein, induced in response to interleukin 6 (IL‑6). We assessed the serum concentration of hepcidin and IL‑6 in the groups of patients with PD treated only pharmacologically with optimal individualized therapy (MT) and treated additionally with deep brain stimulation (DBS), compared to the control group....
Source: Acta Neurobiologiae Experimentalis - October 1, 2020 Category: Neurology Authors: Kwiatek-Majkusiak J, Geremek M, Koziorowski D, Tomasiuk R, Szlufik S, Friedman A Tags: Acta Neurobiol Exp (Wars) Source Type: research

Phenylbutyrate administration reduces changes in the cerebellar Purkinje cells population in PDC ‑deficient mice.
Phenylbutyrate administration reduces changes in the cerebellar Purkinje cells population in PDC‑deficient mice. Acta Neurobiol Exp (Wars). 2020;80(3):305-321 Authors: Klejbor I, Mahmood S, Melka N, Ebertowska A, Morys J, Stachowiak EK, Stachowiak MK, Patel MS Abstract In humans, pyruvate dehydrogenase complex (PDC) deficiency impairs brain energy metabolism by reducing the availability of the functional acetyl‑CoA pool. This "hypometabolic defect" results in congenital lactic acidosis and abnormalities of brain morphology and function, ranging from mild ataxia to profound psychomotor re...
Source: Acta Neurobiologiae Experimentalis - October 1, 2020 Category: Neurology Authors: Klejbor I, Mahmood S, Melka N, Ebertowska A, Morys J, Stachowiak EK, Stachowiak MK, Patel MS Tags: Acta Neurobiol Exp (Wars) Source Type: research

Diazepam and electrical stimulation of paleocerebellar cortex inhibits seizures in pentylenetetrazol ‑kindled rats.
Diazepam and electrical stimulation of paleocerebellar cortex inhibits seizures in pentylenetetrazol‑kindled rats. Acta Neurobiol Exp (Wars). 2020;80(3):322-330 Authors: Godlevsky LS, Shandra OO, Pervak MP, Shandra AA Abstract The cerebellum is a potent anti‑epileptic target for deep brain stimulation in patients with drug‑resistant epilepsy. The effects of such stimulation, however, may also favor seizure activity. Our goal was to investigate the effect of cerebellar electrical stimulation (ES) alone and in combination with the anti‑epileptic drug diazepam (DIA) on seizure outcome. We used a ...
Source: Acta Neurobiologiae Experimentalis - October 1, 2020 Category: Neurology Authors: Godlevsky LS, Shandra OO, Pervak MP, Shandra AA Tags: Acta Neurobiol Exp (Wars) Source Type: research

Temporal specificity of latent inhibition in rats with daily water restriction prior to taste conditioning.
Abstract Temporal specificity of latent inhibition of conditioned taste aversion (CTA) has been demonstrated after prolonged habituation to temporal contexts in the stages preceding conditioning, and it has been eliminated by restricting consumption during conditioning. However, it is not known if latent inhibition of CTA is still dependent on the temporal context when fluid consumption is limited in the stages prior to conditioning. We tested temporal specificity of latent inhibition in rats with (different time of day for the conditioning stage) and without (same time of day for pre-exposure and conditioning sta...
Source: Acta Neurobiologiae Experimentalis - July 2, 2020 Category: Neurology Authors: Molero-Chamizo A, Rivera-Urbina GN Tags: Acta Neurobiol Exp (Wars) Source Type: research

The inhibitory effects of bile acids on catalytic and non ‑catalytic functions of acetylcholinesterase as a therapeutic target in Alzheimer's disease.
This study clarifies the roles of natural bile acids in the nervous system and in AChE function through multiple experimental and simulation methods. PMID: 32602852 [PubMed - in process] (Source: Acta Neurobiologiae Experimentalis)
Source: Acta Neurobiologiae Experimentalis - July 2, 2020 Category: Neurology Authors: Sadeghi L, Yekta R, Dehghan G Tags: Acta Neurobiol Exp (Wars) Source Type: research

Effects of sex steroid hormones on memory.
Abstract Many evidences have elucidated relevant mechanisms of action of estrogen, progesterone, and testosterone on cognition, including learning and memory processes, both in animal models and humans. This influence may depend on their modulator role on several neurotransmitter systems, and the extensive presence of their receptors in cerebral areas, involved in cognitive functions, including the amygdala, hippocampal formation, and cerebral cortex. The present brief review summarizes data of our research and others with the aim of clarifying, in mammals, the involvement of sex hormones on memory. In particular,...
Source: Acta Neurobiologiae Experimentalis - July 2, 2020 Category: Neurology Authors: Pompili A, Iorio C, Gasbarri A Tags: Acta Neurobiol Exp (Wars) Source Type: research

Putative shared mechanisms in autism spectrum disorders and attention deficit hyperactivity disorder, a systematic review of the role of oxidative stress.
Abstract Oxidative stress is now believed to play a crucial role for neurodevelopment disorders such as autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD). To review the most recent literature regarding the role of oxidative stress for the pathophysiology of ASD and ADHD, we conducted a systematic search of the relevant literature and further discuss the clinical and research implications of this knowledge. A systematic search in PubMed database retrieved 132 articles, of which 33 were included in the review. This review found relevant evidence concerning the role of oxidative stat...
Source: Acta Neurobiologiae Experimentalis - July 2, 2020 Category: Neurology Authors: Sa-Carneiro F, Calhau C, Coelho R, Figueiredo-Braga M Tags: Acta Neurobiol Exp (Wars) Source Type: research

Dependence of the filled-space illusion on the size and location of contextual distractors.
Abstract For most observers, the part of the stimulus that is filled with some visual elements (e.g., distractors) appears larger than the unfilled part of the same size. This illusion of interrupted spatial extent is also known as the \'filled‑space' or 'Oppel‑Kundt' illusion. Although the continuously filled‑space illusion has been systematically studied for over a century, there is still no generally accepted explanation of its origin. The present study aimed to further develop our computational model of the continuously filled‑space illusion and to examine whether the model predictions successfully acc...
Source: Acta Neurobiologiae Experimentalis - July 2, 2020 Category: Neurology Authors: Marma V, Bulatov A, Bulatova N Tags: Acta Neurobiol Exp (Wars) Source Type: research

Intracerebroventricular streptozotocin induces behavioral impairments and increases short ‑term C3 gene expression in the hippocampus of Wistar rats.
Intracerebroventricular streptozotocin induces behavioral impairments and increases short‑term C3 gene expression in the hippocampus of Wistar rats. Acta Neurobiol Exp (Wars). 2020;80(2):160-171 Authors: Pfutzenreuter G, Nieradka K, Pincerati MR, da Silva IS Abstract A non‑transgenic rat model based on intracerebroventricular injection of streptozotocin (STZ) has been used as an animal model to investigate mechanisms associated to the late onset of sporadic Alzheimer's disease, such as anatomical and behavioral impairments. However, molecular aspects related to gene expression, mainly in the hippo...
Source: Acta Neurobiologiae Experimentalis - July 2, 2020 Category: Neurology Authors: Pfutzenreuter G, Nieradka K, Pincerati MR, da Silva IS Tags: Acta Neurobiol Exp (Wars) Source Type: research

Hypothermia in the course of acute traumatic spinal cord injury.
Abstract In this review we briefly discuss animal experiments involving acute traumatic spinal cord injury (SCI) and the need for larger animals in testing experimental therapies. This literature overview, including the discussion of our own results from animal models, examines the use of hypothermia as a treatment method for SCI. Finally, we report the results of hypothermia application in clinical trials. Minipigs have been proposed as a potentially preferable model to rodents (typically rats) for predicting outcomes in human SCI due to their closer anatomical similarity to humans. In various animal studies, hyp...
Source: Acta Neurobiologiae Experimentalis - July 2, 2020 Category: Neurology Authors: Kafka J, Lukacova N, Sulla I, Maloveska M, Vikartovska Z, Cizkova D Tags: Acta Neurobiol Exp (Wars) Source Type: research

Anandamide in the anterior hypothalamus diminishes defensive responses elicited in mice threatened by Epicrates cenchria constrictor serpents.
In conclusion, the pattern of dose‑response curve of anandamide microinjected in the AH does not seem to be the same classical pattern compared with other hypothalamic nuclei. PMID: 32602858 [PubMed - in process] (Source: Acta Neurobiologiae Experimentalis)
Source: Acta Neurobiologiae Experimentalis - July 2, 2020 Category: Neurology Authors: Dos Anjos-Garcia T, Coimbra NC Tags: Acta Neurobiol Exp (Wars) Source Type: research

Effects of HCN channel blockade on the intensity ‑response function of electroretinographic ON and OFF responses in dark adapted frogs.
In this study we investigated the effects of pharmacological blockade of HCN channels (with ZD7288 or ivabradine) on the ERG b‑ and d‑waves in dark adapted frog eyecup preparations. Initially, the dose‑response relationship of ZD7288 effects on the b‑ and d‑waves was investigated. Afterwards, the effects of 75 μM ZD7288 on the stimulus ‑ response function of the ERG b‑ and d‑waves were explored over a wide intensity range (10 log units). Finally, the effects of 30 μM ivabradine on the same function were studied. Perfusion with 75 μM ZD7288 did not change the absolute and relative sensitivity of the...
Source: Acta Neurobiologiae Experimentalis - July 2, 2020 Category: Neurology Authors: Popova E, Kupenova P Tags: Acta Neurobiol Exp (Wars) Source Type: research

Neuroprotective effect of poly(lactic-co-glycolic acid) nanoparticle-bound brain-derived neurotrophic factor in a permanent middle cerebral artery occlusion model of ischemia in rats.
Abstract Poly (lactide‑co‑glycolide) (PLGA) nanoparticles (NPs) are biodegradable carriers that participate in the transport of neuroprotective drugs across the blood brain barrier (BBB). Targeted brain‑derived neurotrophic factor (BDNF) delivery across the BBB could provide neuroprotection in brain injury. We tested the neuroprotective effect of PLGA nanoparticle‑bound BDNF in a permanent middle cerebral artery occlusion (pMCAO) model of ischemia in rats. Sprague‑Dawley rats were subjected to pMCAO. Four hours after pMCAO, two groups were intravenously treated with BDNF and NP‑BDNF, respectively. Func...
Source: Acta Neurobiologiae Experimentalis - March 28, 2020 Category: Neurology Authors: Kamarudin SN, Iezhitsa I, Tripathy M, Alyautdin R, Ismail NM Tags: Acta Neurobiol Exp (Wars) Source Type: research

Local field potential power spectra and locomotor activity following treatment with pseudoephedrine in mice.
This study aimed to examine and compare the locomotor activities, local field potential (LFP) and sleep‑wake patterns produced by PSE and morphine, which is a standard drug used to promote psychomotor activity. Male Swiss albino mice were anesthetized and implanted with an intracranial electrode into the striatum. Animals were divided into four groups, which received either saline, PSE or morphine. Locomotor activity and LFP signals were continuously monitored following pseudoephedrine or morphine treatment. One‑way ANOVA revealed that locomotor count was significantly increased by morphine, but not PSE. Frequency anal...
Source: Acta Neurobiologiae Experimentalis - March 28, 2020 Category: Neurology Authors: Sa-Ih N, Reakkamnuan C, Samerphob N, Cheaha D, Niyomdecha S, Kumarnsit E Tags: Acta Neurobiol Exp (Wars) Source Type: research

C60 fullerenes increase the intensity of rotational movements in non ‑anesthetized hemiparkinsonic rats.
C60 fullerenes increase the intensity of rotational movements in non‑anesthetized hemiparkinsonic rats. Acta Neurobiol Exp (Wars). 2020;80(1):32-37 Authors: Maznychenko AV, Mankivska OP, Sokolowska Vereshchaka IV, Kopyak BS, Tomiak T, Bulgakova NV, Gonchar OO, Prylutskyy YI, Ritter U, Mishchenko IV, Kostyukov AI Abstract The effect of C60 fullerene aqueous colloid solution (C60FAS) on the intensity of long‑lasting (persisting for one hour) rotational movements in non‑anesthetized rats was investigated. For this purpose, an experimental hemiparkinsonic animal model was used in the study. Rotation...
Source: Acta Neurobiologiae Experimentalis - March 28, 2020 Category: Neurology Authors: Maznychenko AV, Mankivska OP, Sokolowska Vereshchaka IV, Kopyak BS, Tomiak T, Bulgakova NV, Gonchar OO, Prylutskyy YI, Ritter U, Mishchenko IV, Kostyukov AI Tags: Acta Neurobiol Exp (Wars) Source Type: research

Investigating the synergic effects of valproic acid and crocin on BDNF and GDNF expression in epidermal neural crest stem cells.
Abstract Following nerve tissue damage, various events, such as inflammatory responses, microglial activation, endoplasmic reticulum stress, and apoptosis, can occur, which all lead to cell death, prevent axonal growth, and cause axonal circumvolution. So far, several researchers have tended to adopt strategies to reduce the harmful conditions associated with neurological disorders, and stem‑cell‑based therapy is one of those promising strategies. Epidermal neural crest stem cells (EPI‑NCSCs) are a type of stem cell that has widely been employed for the treatment of various neurological disorders. It has bee...
Source: Acta Neurobiologiae Experimentalis - March 28, 2020 Category: Neurology Authors: Baharvand Z, Nabiuni M, Tahmaseb M, Amini E, Pandamooz S Tags: Acta Neurobiol Exp (Wars) Source Type: research

Moderate exercise prevents the cell atrophy caused by hypothyroidism in rats.
In this study we evaluated the capacity of a moderate forced‑exercise routine to counteract the neurodegenerative effects of a hypothyroid condition induced during adulthood. Simultaneously with a chronic anti‑thyroid chemical treatment, a group of rats was forced to walk in a motorized wheel for 30 min daily five times a week. In four weeks of treatment the rats developed a plain hypothyroid condition that in non‑exercised rats was accompanied by a marked increase in the number of atrophic cells in all CA regions of the hippocampus. The forced‑exercise treatment did not counter the development of hypothyroidism an...
Source: Acta Neurobiologiae Experimentalis - March 28, 2020 Category: Neurology Authors: Martínez-Salazar C, Villanueva I, Pacheco-Rosado J, Alva-Sánchez C Tags: Acta Neurobiol Exp (Wars) Source Type: research

Hindbrain metabolic deficiency regulates ventromedial hypothalamic nucleus glycogen metabolism and glucose ‑regulatory signaling.
Hindbrain metabolic deficiency regulates ventromedial hypothalamic nucleus glycogen metabolism and glucose‑regulatory signaling. Acta Neurobiol Exp (Wars). 2020;80(1):57-65 Authors: Briski KP, Mandal SK Abstract The catecholamine norepinephrine (NE) links hindbrain metabolic‑sensory neurons with downstream gluco‑regulatory loci, including the ventromedial hypothalamic nucleus (VMN). Exogenous NE up‑regulates VMN expression of glutamate decarboxylase (GAD), biomarker for the gluco‑inhibitory transmitter γ‑aminobutryic acid (GABA). Brain glycogen phosphorylase (GP)‑muscle (GPmm) and ...
Source: Acta Neurobiologiae Experimentalis - March 28, 2020 Category: Neurology Authors: Briski KP, Mandal SK Tags: Acta Neurobiol Exp (Wars) Source Type: research

A ten year longitudinal examination of the incidence rate and age of childhood encephalopathy diagnoses in an autism spectrum disorder diagnosed cohort.
Abstract Autism spectrum disorder (ASD) is defined by persistent deficits in social communication/interaction and stereotypic behaviors with many diagnosed persons experiencing a developmental regression at>1 year‑old. It was hypothesized that progressive childhood encephalopathy is an important etiological factor in ASD pathogenesis. This hypothesis‑testing study examined the relationship between diagnosed childhood encephalopathy and ASD. The Independent Healthcare Research Database is composed of de‑identified linked eligibility and claim healthcare records prospectively generated from the Florida Medi...
Source: Acta Neurobiologiae Experimentalis - March 28, 2020 Category: Neurology Authors: Kern JK, Geier DA, Homme KG, Geier MR Tags: Acta Neurobiol Exp (Wars) Source Type: research

EEG correlates of cognitive load in a multiple choice reaction task.
n I Abstract The present study aimed to examine EEG correlates of cognitive load in a task, in which multiple stimulus‑response mappings have to be maintained in working memory (WM) combined with selective inhibition of irrelevant stimulus‑response mappings on every trial. Twenty‑four healthy younger adults had to perform choice reaction tasks differed in the number of S‑R mappings and motor response requirements. Performance was lower in the high load than in the low load condition. Performance decline at higher WM loads was accompanied by an increase of EEG power in delta, theta, and beta frequency bands...
Source: Acta Neurobiologiae Experimentalis - March 28, 2020 Category: Neurology Authors: Schapkin SA, Raggatz J, Hillmert M, Böckelmann I Tags: Acta Neurobiol Exp (Wars) Source Type: research

Association between scripture memorization and brain atrophy using magnetic resonance imaging.
Abstract We investigated the association between scripture memorization and brain tissue using magnetic resonance imaging techniques. Participants comprised 63 healthy adults between the ages of 35 and 80 years old with no neurological or psychological disorders. Of these, 19 had completely memorized the Quran, 28 had partially memorized parts of Quran while 16, the control group, had not committed the Quran into their memory. White matter, grey matter and cerebrospinal fluid volumes were calculated. The brain tissue volumes of those who memorized the entire Quran and those who memorized only a small portion were ...
Source: Acta Neurobiologiae Experimentalis - March 28, 2020 Category: Neurology Authors: Rahman MA, Aribisala BS, Ullah I, Omer H Tags: Acta Neurobiol Exp (Wars) Source Type: research

Influence of rhythmic light stimulation on orientation signal within visual cortex columns in the cat.
Abstract The present study used optical imaging to investigate the development of the optical signal within orientational columns in primary visual cortex of cats reared under conditions of rhythmic light stimulation. Results showed that, although inter-columnar spacing was unchanged, a 3-5-fold decrement in optical signal from orientation columns and a drastic decline in contrast sensitivity was observed in both areas 18 and 17. These data suggest the modification of cortical columnar functioning under artificially correlated synchronization of retinal input. PMID: 31587014 [PubMed - in process] (Source: Act...
Source: Acta Neurobiologiae Experimentalis - October 8, 2019 Category: Neurology Authors: Merkulyeva N, Mikhalkin А, Bondar I Tags: Acta Neurobiol Exp (Wars) Source Type: research

Alteration of oxidative stress markers and behavior of rats in a novel model of depression.
In this study an ultrasound model of emotional stress developed in our laboratory was applied. It is characterized by the use of ultrasound as the stressor agent. Animals are triggered not by any organic or physical disturbances but by the perception of adverse information. This type of stress can induce depressive-like behavioral changes in rodents, manifested by decreased sucrose preference and increased time of immobility in a forced swim test. Ultrasound stress also increased the levels of oxidative stress markers. This is important, as stress has an established association with increased oxidative processes in the cen...
Source: Acta Neurobiologiae Experimentalis - October 8, 2019 Category: Neurology Authors: Gorlova A, Pavlov D, Zubkov E, Zorkina Y, Inozemtsev A, Morozova A, Chekhonin V Tags: Acta Neurobiol Exp (Wars) Source Type: research

Differential expression of the c-fos protein and synaptophysin in zebrin II positive and zebrin II negative cerebellar cortical areas in 4-aminopyridine seizures.
A, Tóth Z Abstract The present study examined temporal activation patterns of rat cerebellar cortical neurons in 4-aminopyridine induced seizures, using c-fos protein as a marker of neuronal activity. C-fos-containing cells were counted in each cerebellar cortical layer, and cell count was compared between zebrin II positive and zebrin II negative bands of the lobules of the vermis and cerebellar hemispheres. We found significant activation of granule cells and interneurons of the molecular layer in zebrin II positive bands. The Purkinje cells, in contrast, exhibited non-significant, scattered c-fos immuno...
Source: Acta Neurobiologiae Experimentalis - October 8, 2019 Category: Neurology Authors: Krisztin-Péva B, Mihály A, Tóth Z Tags: Acta Neurobiol Exp (Wars) Source Type: research

Dexamethasone induces alterations of slow wave oscillation, rapid eye movement sleep and high-voltage spindle in rats.
This study aimed to monitor electroencephalographic (EEG) patterns induced by prolonged dexamethasone exposure. Adult male Wistar rats implanted with electrodes on the skull over the frontal and parietal cortices were intraperitoneally injected with either saline or dexamethasone (0.5 mg/kg) once daily for 21 consecutive days. Longitudinal EEG recording was performed on day 6, 11, 16 and 21. Fast Fourier transform was used for frequency power analysis. One-way ANOVA revealed significant increases in parietal EEG power of slow frequencies (delta, theta and alpha) particularly, with the dominant theta activity seen as early ...
Source: Acta Neurobiologiae Experimentalis - October 8, 2019 Category: Neurology Authors: Issuriya A, Kumarnsit E, Reakkamnuan C, Samerphob N, Sathirapanya P, Cheaha D Tags: Acta Neurobiol Exp (Wars) Source Type: research

Isolation and characterization of human amniotic fluid and SH-SY5Y/ BE(2)-M17 cell derived exosomes.
Abstract The application of stem cells as a therapy for degenerative disease holds great promise. Substantial evidence suggests that stem cell derived exosomes are a novel cell-free therapy for the corresponding cells. Exosomes are less complex as compared to their parental cells, due to the fewer number of membrane proteins. In addition, the smaller size and lower risk of immunogenicity makes exosomes potentially safe therapeutic nano-carriers. A large number of ongoing research studies are focused on characterizing exosomes that were derived from different sources, for their potential use in various therapeutic ...
Source: Acta Neurobiologiae Experimentalis - October 8, 2019 Category: Neurology Authors: Seyfizadeh N, Seyfizadeh N, Rahbarghazi R, Nourazarian A, Borzouisileh S, Palideh A, Elahimanesh F, Hamishehkar H, Salimi L, Nouri M, Abtin M Tags: Acta Neurobiol Exp (Wars) Source Type: research

Effects of maternal thyroid hormone deficiency on differentiation of mesenchymal stem cells in CSF-exposed neonatal Wistar rats.
This study aimed to survey the effects of rat neonatal CSF collected from induced hypothyroid mothers on differentiation of bone marrow mesenchymal stem cells (BM-MSCs). We hypothesized that hypothyroidism affected levels of growth factor in CSF. To induce hypothyroidism, pregnant Wistar rats received methimazole at the third day of gestation. BM-MSCs were obtained from rat femurs and tibias and cultured in medium. CSF was collected from the cisterna magna of newborn rats, and cells were subsequently exposed to CSF with concentrations of 5,7, and 10 /100 (v/v) for 72 h. MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazo...
Source: Acta Neurobiologiae Experimentalis - October 8, 2019 Category: Neurology Authors: Mafikandi V, Roodbari NH, Nabiuni M, Yaghmaei A Tags: Acta Neurobiol Exp (Wars) Source Type: research

The interplay between parkin and alpha-synuclein; possible implications for the pathogenesis of Parkinson's disease.
Abstract Parkin and alpha-synuclein (α-syn) are two key proteins involved in the pathophysiology of Parkinson's disease (PD). Oligomerization/aggregation and excessive secretion of α-syn contributes to PD through free radical stress, mitochondrial impairment, and synaptic dysfunction. Parkin, an E3 ubiquitin ligase, is considered to be a pleiotropic, neuroprotective protein that modulates metabolic turnover and the accumulation of α-syn. This is in addition to parkin's role in counteracting the more distant effects of α-syn on cellular survival by altering proteasomal, autophagic, and calpa...
Source: Acta Neurobiologiae Experimentalis - October 8, 2019 Category: Neurology Authors: Jęśko H, Lenkiewicz AM, Wilkaniec A, Adamczyk A Tags: Acta Neurobiol Exp (Wars) Source Type: research

Anodal transcranial direct current stimulation with monopolar pulses improves limb use after stroke by enhancing inter-hemispheric coherence.
Abstract Post-stroke neurological deficits, such as sensorimotor impairments, are often permanent and a leading cause of disability. Stroke is also associated with changes in neuronal synchrony among different brain areas. Multiple studies demonstrated that non-invasive brain stimulation, such as transcranial direct current stimulation (tDCS), enhances the efficacy of existing rehabilitative therapies. We hypothesized that the therapeutic effects of tDCS could be due to its influence on neuronal synchrony. To study this, we recorded local field potentials in rats treated with anodal tDCS (a-tDCS) after unilateral ...
Source: Acta Neurobiologiae Experimentalis - October 8, 2019 Category: Neurology Authors: Schjetnan AG, Gidyk DC, Metz GA, Luczak A Tags: Acta Neurobiol Exp (Wars) Source Type: research

Cell-based immunofluorescence assay for screening the neurogenesis potential of new drugs in adult hippocampal neural progenitor cells.
Abstract Preclinical studies have suggested that increased adult neurogenesis in the hippocampus might have potential therapeutic effects for Alzheimer's disease and depression; therefore, it is a target for the treatment of some brain diseases. In this technical communication, we propose a cell-based fluorescence assay to study the neurogenesis of adult hippocampal progenitor cells that can be used for high-throughput screening of drugs promoting neurogenesis. Three fluorescent dyes (DAPI, Alexa Fluor 488, and Alexa Fluor 594) and a fluorescence spectrophotometry reader were used, which confirmed that the mutual ...
Source: Acta Neurobiologiae Experimentalis - October 8, 2019 Category: Neurology Authors: Zhang K, Li B, Li P, Yang X, Cui H, Liu X Tags: Acta Neurobiol Exp (Wars) Source Type: research

Stimulus-seeking in rats is accompanied by increased c ‑Fos expression in hippocampal CA1 as well as short 22 kHz and flat 50 kHz calls.
Stimulus-seeking in rats is accompanied by increased c‑Fos expression in hippocampal CA1 as well as short 22 kHz and flat 50 kHz calls. Acta Neurobiol Exp (Wars). 2019;79(3):309-317 Authors: Robakiewicz I, Polak M, Rawska M, Alberski D, Polowy R, Wytrychiewicz K, Syperek M, Matysiak J, Filipkowski RK Abstract We determined CA1 hippocampal field to be involved in self-exposure, a type of novelty‑seeking behaviour that has also been associated with short 22 kHz and flat 50 kHz ultrasonic vocalizations (USV) in adult male Long-Evans rats. Rats were habituated for three days to a self-exposure cage wi...
Source: Acta Neurobiologiae Experimentalis - October 8, 2019 Category: Neurology Authors: Robakiewicz I, Polak M, Rawska M, Alberski D, Polowy R, Wytrychiewicz K, Syperek M, Matysiak J, Filipkowski RK Tags: Acta Neurobiol Exp (Wars) Source Type: research

Autism spectrum disorder and mercury toxicity: use of genomic and epigenetic methods to solve the etiologic puzzle.
Abstract Autism spectrum disorder (ASD) is an increasingly prevalent neurodevelopmental condition of unknown etiology. Mercury is a common, highly neurotoxic heavy metal. The similarities of neurologic manifestations of mercury exposure and ASD raise an intriguing hypothetical question: Is ASD, at least partially, a manifestation of mercury toxicity? The fetus is particularly vulnerable to mercury exposure from the "double jeopardy" combination of the genetics of his mother and his own genetics, as relates to mercury toxicity. In this paper, I review the evidence suggesting relationships between ASD and ...
Source: Acta Neurobiologiae Experimentalis - July 27, 2019 Category: Neurology Authors: McCaulley ME Tags: Acta Neurobiol Exp (Wars) Source Type: research

Coumarins as potential supportive medication for the treatment of epilepsy.
This article focuses on the most recent research reports available in the literature relating to the use of several selected coumarins in different experimental models of epilepsy. PMID: 31342949 [PubMed - in process] (Source: Acta Neurobiologiae Experimentalis)
Source: Acta Neurobiologiae Experimentalis - July 27, 2019 Category: Neurology Authors: Bryda J, Zagaja M, Szewczyk A, Andres-Mach M Tags: Acta Neurobiol Exp (Wars) Source Type: research

Prenatal ethanol intoxication and maternal intubation stress alter cell survival and apoptosis in the postnatal development of rat hippocampus.
Abstract It is well known that the fetal ethanol exposure and prenatal stress may have adverse effects on brain development. Interestingly, some morphological and functional recovery from their teratogenic effects that take place during brain maturation. However, mechanisms that underlie this recovery are not fully elucidated. The aim of this study was to examine whether the postnatal attenuation of fetal alcohol - and maternal stress‑induced morphological and functional deficits correlates with compensatory changes in the expression/activation of the brain proteins involved in inflammation, cell survival and ap...
Source: Acta Neurobiologiae Experimentalis - July 27, 2019 Category: Neurology Authors: Elibol B, Beker M, Sahbaz CD, Kilic U, Jakubowska-Doğru E Tags: Acta Neurobiol Exp (Wars) Source Type: research

The effects of moderate running exercise and L-tyrosine on penicillin-induced epileptiform activity in rats.
This study was conducted to evaluate the effects of treadmill exercise and L-tyrosine treatment on the frequency and amplitude of epileptiform activity in rats. A total of 32 male albino Wistar rats were randomly divided into four groups: control, exercise, L-tyrosine, and exercise + L-tyrosine. L‑tyrosine was supplemented by oral gavage (500 mg/kg/day, 2.5 mL solution). The treatments were performed 5 days a week for 10 weeks. The rats were anesthetized and then administered 500 IU penicillin into the left cerebral cortex using a microinjector and electrocorticogram (ECoG) activity was recorded for 3 hours using a Power...
Source: Acta Neurobiologiae Experimentalis - July 27, 2019 Category: Neurology Authors: Kayacan Y, Kisa EC, Ghojebeigloo BE, Kocacan SE, Ayyildiz M, Agar E Tags: Acta Neurobiol Exp (Wars) Source Type: research

Short-term exposure to high ‑intensity sound induces hearing loss and apoptosis in guinea pigs.
Short-term exposure to high‑intensity sound induces hearing loss and apoptosis in guinea pigs. Acta Neurobiol Exp (Wars). 2019;79(2):155-168 Authors: Liu Y, Wang H, Liu Z, Gu Y, Xin L, Liu J, Fan H Abstract The aim of this study was to investigate the effect and underlying mechanisms of short-term high-intensity sound exposure on guinea pigs to mimic the effects of non-lethal anti-riot weapons. A total of 92 male adult guinea pigs were exposed to high-intensity sound at 0 dB, 110 dB and 130 dB for 5 min. Basic clinical observation, repellent behaviour detection, peripheral blood routine examination,...
Source: Acta Neurobiologiae Experimentalis - July 27, 2019 Category: Neurology Authors: Liu Y, Wang H, Liu Z, Gu Y, Xin L, Liu J, Fan H Tags: Acta Neurobiol Exp (Wars) Source Type: research

Prevention of cadmium-induced neurotoxicity in rats by essential nutrients present in nuts.
Abstract Cadmium, a heavy metal with no physiological function in the human body, is considered a bio-hazard. It is also considered to be a potent neurotoxin. The primary sources of cadmium exposure are diet and cigarette smoke. It has been postulated that nutritional deficiencies can increase the risk of cadmium toxicity. Nuts provide essential nutrients which are necessary for the maintenance of brain health in humans. The present study was designed to investigate the possible protective effects of almond and walnut supplementation on cadmium-induced neurotoxicity. Cadmium was orally administered at a dose of 50...
Source: Acta Neurobiologiae Experimentalis - July 27, 2019 Category: Neurology Authors: Batool Z, Agha F, Tabassum S, Batool TS, Siddiqui RA, Haider S Tags: Acta Neurobiol Exp (Wars) Source Type: research

Modulation of catalase, copper and zinc in the hippocampus and the prefrontal cortex in social isolation-induced depression in male rats.
In this study, 16 male Sprague-Dawley rats were randomly divided into two groups: socialized and socially isolated. After one week of acclimatization, animals were housed in isolation for 14 days. Rats in the social group were socialized together for 14 days. On day 15, the forced swim test was performed and blood sugar was analyzed. The brain was removed immediately for biochemical analysis. Socially isolated rats showed more pronounced depressive-like behavior in the forced swim test than socialized rats. Moreover, socially isolated rats demonstrated significantly lower copper and zinc concentrations, as well as a marked...
Source: Acta Neurobiologiae Experimentalis - July 27, 2019 Category: Neurology Authors: Famitafreshi H, Karimian M Tags: Acta Neurobiol Exp (Wars) Source Type: research

N1-P2: Neural markers of temporal expectation and response discrimination in interval timing.
In conclusion, our study contributes to the growing neurocognitive literature on interval timing by capturing different aspects of a timing task; namely, N1-related expectation and P2-related response discrimination processes. PMID: 31342955 [PubMed - in process] (Source: Acta Neurobiologiae Experimentalis)
Source: Acta Neurobiologiae Experimentalis - July 27, 2019 Category: Neurology Authors: Duzcu H, Özkurt TE, Mapelli I, Hohenberger A Tags: Acta Neurobiol Exp (Wars) Source Type: research

miRNA-223-3p and let-7b-3p as potential blood biomarkers associated with the ischemic penumbra in rats.
Abstract The present study aimed to identify commonalities in the microRNA (miRNA) expression profiles of the brain ischemic penumbra and the blood after hyperacute ischemic stroke and then to address whether the miRNA profile of blood has potential usefulness as a diagnostic biomarker of hyperacute ischemic stroke. Blood was collected from the jugular vein 4 h after permanent middle cerebral artery occlusion (pMCAO). After venous blood was collected, the rats were decapitated immediately, and brain ischemic penumbra samples were collected. Hematoxylin and eosin staining was used to observe the histopathological c...
Source: Acta Neurobiologiae Experimentalis - July 27, 2019 Category: Neurology Authors: Li S, Chen L, Zhou X, Li J, Liu J Tags: Acta Neurobiol Exp (Wars) Source Type: research

The effect of bupropion augmentation of minocycline in the treatment of depression.
Abstract The aim of the current study was to analyse the augmentation of minocycline with bupropion in treating depression. 'Saline' (10 ml/kg), 'minocycline per se' (25 mg/kg), 'minocycline per se' (50 mg/kg), 'bupropion per se' (5 mg/kg), 'bupropion per se' (10 mg/kg) and 'bupropion + minocycline' (5 mg/kg + 25 mg/kg each) were administered to mice via the intraperitoneal route. In the forced swim and tail suspension test, the immobility period was analysed after 30 min of the treatment. Monoamines like dopamine, norepinephrine and serotonin levels were analysed in brain areas such as the whole brain, hippocampu...
Source: Acta Neurobiologiae Experimentalis - July 27, 2019 Category: Neurology Authors: Bendale M, DSouza SR, Addepalli V, Kale PP Tags: Acta Neurobiol Exp (Wars) Source Type: research

Distinct classes of low frequency ultrasonic vocalizations in rats during sexual interactions relate to different emotional states.
This study examined low-frequency ultrasonic vocalizations (lUSVs) in rats during two types of sexual interactions; postejaculatory interval (PEI) and barrier - noncontact (NC) test. We report distinct classes of lUSVs that can be assigned to different emotional states; relaxation vs. frustration. Totally flat, 22-kHz calls (Class A), were observed during the relaxation state following ejaculation; characterized by immobilization or grooming during the PEI. On the other hand, two-three component lUSVs (Class B) that start at a higher frequency (45-kHz: flat, upward or short signal) and then shift to 35-23-kHz (mostly to 28...
Source: Acta Neurobiologiae Experimentalis - May 2, 2019 Category: Neurology Authors: Bialy M, Podobinska M, Barski J, Bogacki-Rychlik W, Sajdel-Sulkowska EM Tags: Acta Neurobiol Exp (Wars) Source Type: research

Antidepressant and anxiolytic efficacy of single, chronic and concomitant use of vortioxetine, dapoxetine and fluoxetine in prenatally stressed rats.
Abstract Depression is a highly prevalent social disease. Despite significant medical progress, therapeutic solutions for optimising treatment of this disease are still being sought. The aim of this study was to assess, using the forced swimming test, locomotor activity test and two compartment exploratory test, for a reduction in immobility time (a measure of anti-depressant efficacy), locomotor activity and anxiolytic effectiveness after single, repeated, and combined administration of vortioxetine (2.5 mg/kg - a multimodal SMS), dapoxetine (3.0 mg/kg - an SSRI used in premature ejaculation disorders) and fluoxe...
Source: Acta Neurobiologiae Experimentalis - May 2, 2019 Category: Neurology Authors: Ratajczak PK, Kus K, Zaprutko T, Szczepański M, Nowakowska E Tags: Acta Neurobiol Exp (Wars) Source Type: research