PBPK-PD model for predicting morphine pharmacokinetics, CNS effects and naloxone antagonism in humans
In conclusion, the pharmacokinetics and pharmacodynamics of morphine and M6G, antagonistic effects of naloxone against morphine-induced CNS effects may be successfully predicted using the developed PBPK-PD model based on the parameters derived from in vitro, in silico, or animal studies.PMID:38570601 | DOI:10.1038/s41401-024-01255-2
Source: Acta Pharmacologica Sinica - Category: Drugs & Pharmacology Authors: Rui-Jing Mu Tian-Lei Liu Xiao-Dong Liu Li Liu Source Type: research
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