PBPK-PD model for predicting morphine pharmacokinetics, CNS effects and naloxone antagonism in humans

In conclusion, the pharmacokinetics and pharmacodynamics of morphine and M6G, antagonistic effects of naloxone against morphine-induced CNS effects may be successfully predicted using the developed PBPK-PD model based on the parameters derived from in vitro, in silico, or animal studies.PMID:38570601 | DOI:10.1038/s41401-024-01255-2

Source: Acta Pharmacologica Sinica - April 3, 2024 Category: Drugs & Pharmacology Authors: Rui-Jing Mu Tian-Lei Liu Xiao-Dong Liu Li Liu Source Type: research