From Decisions to Molecular Mechanisms: Investigating the Influence of Adolescent THC Exposure on Adult Decision Making
Despite debates around the addiction liability of cannabis, approximately 10-30% of regular users meet the criteria for Cannabis Use Disorder (CUD). One of the strongest predictors for the development of CUD is adolescent cannabis use, and emerging data now indicate that use of high potency products may potentiate this CUD risk. However, the causal relationship between adolescent exposure, THC potency, and addiction-related behavior remains contested. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Jacqueline-Merie Ferland, Daniel A. Garcia, Graeme Betts, Mason M. Silveira, Joao Bronze de Firmino, Catharine A. Winstanley, Yasmin L. Hurd Tags: SYMPOSIUM Source Type: research
Genotype-Environment Interactions at the Interface Between Psychosocial and Physical Health in Children
Psychosocial experiences affect children's development and health. Urban environments in particular expose children to chronic stress, which impacts the HPA axis and leads to an altered glucocorticoid response. Because glucocorticoids have a major anti-inflammatory action, negative psychosocial experiences may be associated with immunological disorders, including asthma. However, the molecular mechanisms underlying the effect of negative psychosocial experiences on asthma and their interaction with genetic risk remain unknown. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Ali Ranjbaran, Julong Wei, Justyna Resztak, Henriette Mair-Mejers, Julian Bruinsma, Adnan Alazizi, Xiaoquan Wen, Richard Slatcher, Samuele Zilioli, Roger Pique-Regi, Francesca Luca Source Type: research
Brain and Peripheral Whole Transcriptome Correlates of Depressive Disorders: Peripheral is Central to the Pathology
The human anterior-insula (Ant-Ins) and subgenual-anterior-cingulate (sgACC) are brain regions that regulate mood, but studies dissecting the molecular neurobiology of this network in mood disorders are sparse. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Dhivya Arasappan, Dennis Wylie, Abigail Spears, Simran Shah, Katrina Benjamin, Dayne Mayfield, Pavan K. Auluck, Ajeet Mandal, Yiyin Lui, Nirmala Akula, Stefano Marenco, Paul Rathouz, Francis McMahon, Mbemba Jabbi Tags: SYMPOSIUM Source Type: research
Multi-Omics Profiling of Human Hippocampus Reveals Increased Inflammation and Transcription Instability in Major Depressive Disorder
To decipher hippocampus cellular and molecular changes in major depression (MDD), we sequenced single-nucleus RNA (snRNA-seq) and accessible chromatin (snATAC-seq), spatial RNA (Visium, 10X Genomics) and multiome via deterministic barcoding in intact tissue (DBiT-seq). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Yang Xiao, Madeline Mariani, Graham Su, Yanxiang Deng, Cheick A. Sissoko, Tianyu Li, Sai Ma, Zhiliang Bai, Yang Liu, Gorazd Rosoklija, Tingting Wu, Andrew J. Dwork, Rene Hen, J. John Mann, Rong Fan, Kam Leong, Maura Boldrini Source Type: research
38. Identifying Novel Molecular Drivers of Autoimmunity in Paraneoplastic Anti-NMDAR Encephalitis
Paraneoplastic anti-NMDAR encephalitis is characterized by psychosis, mood symptoms, catatonia, seizures, and movement disorders in association with a teratoma. Symptoms are caused by antibodies targeting the NMDA receptor. Early resection of the tumor abrogates neuropsychiatric disease, suggesting tumor-associated drivers of autoimmunity. Recent evidence has identified ectopic lymphoid tissue in anti-NMDAR-associated teratomas; however, little is understood about the role of the tumor microenvironment in promoting autoimmunity. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Tova Gardin, Marcello DiStasio, Caleigh Mandel-Brehm, Sagar Bhatta, David Hafler Source Type: research
489. Deciphering the Molecular Basis of Aging in Substance Use Disorder: Integrative Transcriptomic and Methylomic Analysis
Substance Use Disorder (SUD) contributes to the early onset of age-related diseases and mortality. Although Accelerated Aging (AA) in people with SUD (pSUD) is a key factor in these outcomes, as indicated by changes in Epigenetic Clocks (EC), existing assessments of AA in pSUD primarily utilize ECs designed for non-brain tissues. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Bruno Kluwe-Schiavon, Gabriel R. Fries, Laura Stertz, Thomas Meyer, Consuelo Walss-Bass Source Type: research
440. Sex Differences in Gene Expression Across the Striatum in Psychosis
Psychosis is a defining feature of schizophrenia and highly prevalent in bipolar disorder. Despite known sex differences in the symptoms and progression of these disorders, little is known about the underlying molecular mechanisms driving these differences. Prior work from our group identified diurnal alterations in gene expression across the human striatum in psychosis. Here, we investigated sex differences in the transcriptome within striatal subregions in subjects with psychosis. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Kyle Ketchesin, Megan Perez, Wei Zong, Madeline Scott, Marianne Seney, RuoFei Yin, Mariah Hildebrand, Kelly Cahill, Vaishnavi Shankar, Jill Glausier, David Lewis, George Tseng, Colleen McClung Source Type: research
400. Polygenic Architecture of Metabolic Markers Reveals Distinct Patterns of Overlap With Psychiatric Disorders
Psychiatric disorders and their comorbid somatic diseases are associated with differences in the concentration of metabolites in blood plasma. It is unknown whether shared genetic components or lifestyle factors drive these associations. Charting the genetic architecture of these markers enables us to better understand the innate susceptibility to metabolic dysfunction and associated diseases, revealing underlying molecular mechanisms as potential therapeutic targets. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Dennis van der Meer, Zillur Rahman, Aigar Ottas, Pravesh Parekh, Gleda Kutrolli, Ida S ønderby, Nadine Parker, Markos Tesfaye, Piotr Jaholkowski, Guy Hindley, Elise Koch, Nils Eiel Steen, Srdjan Djurovic, Kevin O'Connell, Olav Smeland, Oleksandr Frei, Ke Source Type: research
354. Molecular Insights Into the Timecourse of Chronic Posttraumatic Pain Development Using the Single Prolonged Stress Model in Rats
Chronic pain is common after traumatic stress exposure, and novel preventative therapeutics against chronic posttraumatic pain (CPTP) are urgently needed. We recently showed that CPTP-like behavior was reduced in rats via the FKBP51 antagonist, SAFit2, and that SAFit2 administration early following stress led to the greatest CPTP-like reduction. Here, we aimed to gain insight into the molecular basis of this timing effect. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Lauren McKibben, Samuel McLean, Sandrine G éranton, Roxana Florea, Ying Zhao, Jacqueline Mickelson, Liz Albertorio-Saez, Felix Hausch, Sarah Linnstaedt Source Type: research
299. Peripheral Epigenetic Estimates of Brain Cell Types in Externalizing Behaviours
Externalizing neurodevelopmental disorders (NDDs) are common and no effective treatment exists. The exact molecular aetiology of these disorders and -associated behaviours remains unclear, but different brain cell types (BCTs), including microglia, might play an important role. However, the lack of brain samples hamper research on the role of microglia in NDDs. Recently, it has been shown that brain-derived DNA methylation (DNAm), which is cell-type specific, can be used to retrieve BCT proportions. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Mandy Meijer, Michael Kobor Source Type: research
216. Paranode Length in the Prefrontal Cortex of Subjects With Major Depression and Rats Under Chronic Unpredictable Stress
Disturbances of connectivity in the prefrontal cortex may involve molecular changes at myelin sheaths, the nodes of Ranvier (NRs) along them or at paranodes, specialized regions of the sheaths that enclose NRs. Chronic stress in rats and major depression (MDD) are associated with reduced NR length. However, it is not known whether the length of paranodes, which are essential to node formation, is disturbed in MDD or chronically stressed rats. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Jose Miguel-Hidalgo, Isabella Kelly, Grazyna Rajkowska Source Type: research
197. Toll-Like Receptor 9 (TLR9) Inhibition Attenuates Chronic Stress-Induced Social Behavior Deficits
Stress is a major risk factor for psychiatric disorders including major depressive disorder (MDD). Toll like receptor 9 (TLR9) is a critical sensor for danger-associated molecular patterns (DAMPs) and a crucial marker of inflammation. Clinical and preclinical studies show evidence for elevation of DAMP signaling in MDD patients and in animal models of depression. We used restraint stress (RS) mouse model, a well-accepted animal model to evaluate the role of TLR9 in behavioral deficits and neuroimmune changes induced by chronic stress. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Dania Jose, Amit Kumar Madeshiya, Ashutosh Tripathi, Tela Todd, Joao Quevedo, Anilkumar Pillai Source Type: research
183. A Multimodal Investigation of the Antidepressant Mechanisms of rTMS: Glutamatergic Metabolism Influences Changes in Functional Connectivity
Normalization of aberrant functional connectivity may underlie the antidepressant effects of repetitive transcranial magnetic stimulation (rTMS). The underlying molecular basis of such changes remains unknown, limiting discovery and evaluation of therapeutic targets. Using proton magnetic resonance spectroscopy, we evaluated how neurometabolites related to seed-based whole-brain connectivity and corresponding depression symptoms prior to and following rTMS. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Meghan Gonsalves, Jennifer Barredo, Emily DeLuca, Marilena DeMayo, Ashley Harris, Tara White, Linda Carpenter Source Type: research
169. Natural Language Processing Analysis of Psychiatric Progress Notes: An Innovative Approach to Real-Time Unbiased Construct Quantification
Objective quantification of psychiatric symptoms is crucial for both research and clinical care. Despite the existence of various psychometric evaluation methods (e.g. questionnaires, standardized interviews), these tools remain underutilized. Recent advancements in natural language processing (NLP) offer a novel and unbiased approach to analyzing medical records. Furthermore, transdiagnostic symptom- and construct-based psychiatric evaluations have become increasingly relevant for elucidating molecular brain alterations. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Jonathan Vogelgsang, Vincent Holstein, Shu Dan, Joshua Abston, Tom McCoy, Torsten Klengel, Kerry Ressler, Sabina Berretta Source Type: research
Regulation of Hypoxia Dependent Reprogramming of Cancer Metabolism: Role of HIF-1 and Its Potential Therapeutic Implications in Leukemia
This article examines various cancer cell metabolisms, metabolic alterations that can take place in cancer cells, metabolic pathways, and molecular aspects of metabolic alteration in cancer cells placing special attention on the consequences of hypoxia-inducible factor and summarising some of their novel targets in the treatment of cancer including leukemia. A brief description of HIF-1α's role and target in a few common types of hematological malignancies (leukemia) is also elucidated in the present article.PMID:38679971 | DOI:10.31557/APJCP.2024.25.4.1121 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Sandeep Pandey Ranjana Singh Nimra Habib Ramesh Mani Tripathi Rashmi Kushwaha Abbas Ali Mahdi Source Type: research
