Isothiocyanates: Happy-Go-Lucky Reagents in Organic Synthesis
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00281D, Review ArticleBubul Das, Anjali Dahiya, Bhisma K Patel : Owing to their unique structural features, isothiocyanates (ITCs) are a class of highly useful and inimitable reagents as the N=C=S group serves both as electrophile and nucleophile in organic... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 19, 2024 Category: Molecular Biology Authors: Bubul Das Source Type: research
Synthesis of Deuteriodifluoromethylthiolated Isocoumarins-1- imines and Isocoumarins Enabled by Multi-Component Reagents System (MCRS)
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00328D, CommunicationXuemin Li, Haofeng Shi, Jiaxin He, Jialiang Wu, Fengxia Sun, Yunfei Du The combining use of BnSCF2D, mCPBA and Tf2O serves as an efficient multi-component reagents system (MCRS) for the synthesis of deuteriodifluoromethylthiolated isocoumarins-1-imines/isocoumarins via intramolecular cyclization/ deuteriodifluoromethylthiolation of 2-alkynylbenzamide/2-alkynylbenzoates. The approach... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 19, 2024 Category: Molecular Biology Authors: Xuemin Li Source Type: research
Natural products from human microbiome: an emergent frontier in organic synthesis and drug discovery
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00236A, Review ArticleGoverdhan Mehta, Saumitra Sengupta, Srihari Pabbaraja Often referred to as “second genome”, human microbiome is at the epicenter of a complex inter-habitat biochemical network, such as the “gut-brain axis”, which have emerged as significant determinant of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 19, 2024 Category: Molecular Biology Authors: Goverdhan Mehta Source Type: research
Halting the Vicious Cycle of Atopic Dermatitis: Empowered by Scientific Understanding
The progress in our understanding of atopic dermatitis (AD) (atopic eczema) in the last 10 years has been remarkable. Nearly half of the scientific papers ever published on AD have been written in the last 10 years. This contribution of knowledge, in parallel with technological and pharmaceutical progress, has transformed our ability to treat some of the most severe forms of AD. Notably, we have seen the advent of biologics such as the anti –IL-4 receptor biologic dupilumab (Simpson et al, 2016), 2 anti–IL-13 agents (tralokinumab [Wollenberg et al, 2021] and lebrikizumab [Silverberg et al, 2023]), and small-molecula...
Source: Journal of Investigative Dermatology - April 19, 2024 Category: Dermatology Authors: Sara J. Brown, Johann E. Gudjonsson Tags: Editorial Source Type: research
GSE255251 Integrative transcriptomic and proteomic profiling of subconfluent and confluent cancer cells
In this study we examine the impact of cell confluency on gene expression. We focused on Argonaute (AGO) protein dynamics and associated gene and protein expression in HEK293, A375, and SHSY5Y cell lines. As a measure of cell confluency, we observed a profound translocation of AGO2 into the nucleus. Therefore, we generated transcriptomic data using RNA sequencing to compare gene expression in subconfluent versus confluent cells, which highlighted significant alterations in gene regulation patterns directly corresponding to changes in cell density. Our study also encompasses miRNA profiling data obtained through small RNA s...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Other Homo sapiens Source Type: research
GSE249290 Integrative transcriptomic and proteomic profiling of the effects of cell confluency on gene expression
In this study we examine the impact of cell confluency on gene expression. We focused on Argonaute (AGO) protein dynamics and associated gene and protein expression in HEK293, A375, and SHSY5Y cell lines. As a consequence of cell confluency, AGO2 protein translocates into the nucleus. Therefore, we generated transcriptomic data using RNA sequencing to compare gene expression in subconfluent versus confluent cells, which highlighted significant alterations in gene regulation patterns directly corresponding to changes in cell density. Our study also encompasses miRNA profiling data obtained through small RNA sequencing, reve...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Molecules, Vol. 29, Pages 1867: NIMO: A Natural Product-Inspired Molecular Generative Model Based on Conditional Transformer
Ruibo Wu
Natural products (NPs) have diverse biological activity and significant medicinal value. The structural diversity of NPs is the mainstay of drug discovery. Expanding the chemical space of NPs is an urgent need. Inspired by the concept of fragment-assembled pseudo-natural products, we developed a computational tool called NIMO, which is based on the transformer neural network model. NIMO employs two tailor-made motif extraction methods to map a molecular graph into a semantic motif sequence. All these generated motif sequences are used to train our molecular generative models. Various NIMO models were trained ...
Source: Molecules - April 19, 2024 Category: Chemistry Authors: Xiaojuan Shen Tao Zeng Nianhang Chen Jiabo Li Ruibo Wu Tags: Article Source Type: research
Dess –Martin periodinane-mediated oxidation of the primary alcohol of cytidine into a carboxylic acid
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Alexandra R. E. Serre, Vibhu Jha, Ad èle Rivault, Leif A. Eriksson, Goreti Ribeiro Morais, Robert A. Falconer Herein we describe the first example of the conversion of the primary alcohol of cytidine into a carboxylic acid by use of the Dess –Martin periodinane oxidising agent. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 18, 2024 Category: Molecular Biology Authors: Alexandra R. E. Serre Source Type: research
Electro-oxidative three-component cascade coupling of isocyanides with elemental sulfur and amines for the synthesis of 2-aminobenzothiazoles
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00432A, PaperPeng-Fei Huang, Jia-Le Fu, Ying Peng, Jian-Hong Fan, Long-Jin Zhong, Kewen Tang, Yu Liu 2-Aminobenzothiazoles are commonly encountered in various functional compounds. Herein, we disclose an electro-oxidative three-component reaction for the effective synthesis of 2-aminobenzothiazoles under mild conditions, utilizing non-toxic and abundant elemental sulfur... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 18, 2024 Category: Molecular Biology Authors: Peng-Fei Huang Source Type: research
Revisiting Biginelli-like Reactions: Solvent Effects, Mechanisms, Biological Applications and Correction of Several Literature Reports
This study critically reevaluates reported Biginelli-like reactions using a Kamlet-Abboud-Taft-based solvent effect model. Surprisingly, structural misassignments were discovered in certain multicomponent reactions, leading to the identification of pseudo three-component derivatives... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 18, 2024 Category: Molecular Biology Authors: Brenno A. D. Neto Source Type: research
Photoproperties of Favipiravir and their 6-Substituted Analogues: Fluorescence Controlled through Halogen Substitution and Tautomerism
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00397G, PaperAngel H Romero, Marcos Couto, Ivan E Romero, German Fuentes, Mat ías N. Möller Herein, we showed the photophysical properties of the favipiravir and their 6-substituted analogues. Also, we interpreted the origin of the fluorescence of the favipiravir and their 6-substituted analogues as function... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 18, 2024 Category: Molecular Biology Authors: Angel H Romero Source Type: research
Base- and Sulfur- Promoted Oxidative Lactonization of Chalcone-Acetate Michael Adducts: Access to Pyran-2-ones
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00479E, CommunicationCao Nguyen Nguyen, Duc Toan Nguyen, Ha An Tran, Hung Dinh Mac, Thi Thu Tram Nguyen, Pascal Retailleau, Thanh Binh Nguyen A cost-effective, practical, straightforward and scalable synthesis of α-pyrones via base- and sulfur-promoted annulation of phenylacetates and chalcones. Generated in situ from the starting components by using dbu as a... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 18, 2024 Category: Molecular Biology Authors: Cao Nguyen Nguyen Source Type: research
Radiation for inflammatory breast cancer: Updates
Int Rev Cell Mol Biol. 2024;384:25-46. doi: 10.1016/bs.ircmb.2023.10.004. Epub 2023 Oct 19.ABSTRACTInflammatory breast cancer (IBC) is a diagnosis based on a constellation of clinical features of edema (peau d'orange) of a third or more of the skin of the breast with a palpable border and a rapid onset of breast erythema. Incidence of IBC has increased over time, although it still makes up only 1-4% of all breast cancer diagnoses. Despite recent encouraging data on clinical outcomes, the published local-regional control rates remain consistently lower than the rates for non-IBC. In this review, we focus on radiotherapy, pr...
Source: International Review of Cell and Molecular Biology - April 18, 2024 Category: Cytology Authors: Michael C Stauder Source Type: research
Inflammatory breast cancer (IBC) advocacy-Past, present and future!
In conclusion, in defining the evolving roles of Patient Advocacy in IBC over the past 25 years, we examine what has been done, along with its challenges, and what work still remains from the perspectives of different patient advocates.PMID:38637097 | DOI:10.1016/bs.ircmb.2023.11.001 (Source: International Review of Cell and Molecular Biology)
Source: International Review of Cell and Molecular Biology - April 18, 2024 Category: Cytology Authors: Jeannine Donahue Joshlyn Earls Valerie Fraser Ginny Mason Heather Pirowski Peggy Stephens Source Type: research
Inflammatory breast cancer: As surgical oncologists, what can we do?
Int Rev Cell Mol Biol. 2024;384:113-124. doi: 10.1016/bs.ircmb.2024.02.004. Epub 2024 Mar 28.ABSTRACTBreast cancer surgery is the primary treatment for early-stage breast cancer. However, inflammatory breast cancer (IBC), with its specific presentation characterized by skin invasion, is unfit for primary surgery. According to the different guidelines, the management of IBC is trimodal with the coordination of oncologists, surgeons, and radiation therapists. Advances in breast cancer imaging and the development of more targeted therapies make new challenges for this aggressive cancer. This chapter aims to provide an update ...
Source: International Review of Cell and Molecular Biology - April 18, 2024 Category: Cytology Authors: Hatem Bouzaiene Fatma Saadallah Hanen Bouaziz Olfa Jaidane Jamel Ben Hassouna Tarak Dhieb Khaled Rahal Source Type: research
