Electrochemical Benzylic Deuteration of p-QMs Enabling the Synthesis of Benzylic Deuterated Diarylmethanes
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00537F, CommunicationYunying Yan, Jianjun Hao, Yulin Peng, Mengyun Yin, Linhai Jing, Pan Han Herein, electroreductive umpolung benzylic deuteration of p-QMs using cheap and easily accessible D2O as a deuterium source was realized. Various value-added benzylic deuterated diarylmethanes can be synthesized without the requirement... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 30, 2024 Category: Molecular Biology Authors: Yunying Yan Source Type: research
A gram-scale synthesis of very-long chain polyunsaturated fatty acids (VLC-PUFAs)
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00536H, PaperChangqing Song, Alex Wade, Jon D. Rainier Herein we describe gram scale syntheses of VLC-PUFA 32:6 n-3 and 34:6 n-3 in 6 synthetic steps in 40% yield from DHA. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 30, 2024 Category: Molecular Biology Authors: Changqing Song Source Type: research
Structure and Interaction in 2D Organized Assembles of Cationic Lipids with Tryptophan: An Experimental and Computational Investigation
New J. Chem., 2024, Accepted Manuscript DOI: 10.1039/D3NJ05931F, PaperBiplab Roy, Panneerselvam Murugesan, Archita Patnaik Molecular association of lipid membranes is an important tool to understand their biological functions. Engineered nano/microscopic lipid surface structures enable controlled surface properties such as adhesion, wetting and molecular recognition,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - April 30, 2024 Category: Chemistry Authors: Biplab Roy Source Type: research
A New Methodology for the Oxygen Measurement in Lung Tissue of an Aged Ferret Model Proves Hypoxia During COVID-19
This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/). .PMID:38687560 | DOI:10.1165/rcmb.2024-0005OC (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - April 30, 2024 Category: Molecular Biology Authors: Katrin Wirz Claudia Schulz Franz S öbbeler Federico Armando Georg Beythien Ingo Gerhauser Nicole de Buhr Veronika Pilchov á Christian Meyer Zu Natrup Wolfgang Baumg ärtner Sabine K ästner Maren von K öckritz-Blickwede Source Type: research
Novel Insecticidal Butenolide-Containing Methylxanthine Derivatives: Synthesis, Crystal Structure, Biological Activity Evaluation, DFT Calculation and Molecular Docking
Chem Biodivers. 2024 Apr 30:e202400823. doi: 10.1002/cbdv.202400823. Online ahead of print.ABSTRACTThe design of novel agrochemicals starting from bioactive natural products is one of the most effective ways in the discovery and development of new pesticidal agents. In this paper, a series of novel butenolide-containing methylxanthine derivatives (Ia-Ir) were designed based on natural methylxanthine caffeine and stemofoline, and the derivatized insecticide flupyradifurone of the latter. The structures of the synthesized compounds were confirmed via1H NMR, 13C NMR, HRMS and X-ray single crystal diffraction analyses. The bio...
Source: Chemistry and Biodiversity - April 30, 2024 Category: Biochemistry Authors: Lei Wang Wenqi Fan Na Yang Lixia Xiong Baolei Wang Source Type: research
Bioactive Profiling, Antibacterial Efficacy and Computational Modelling of Myrtus Communis Essential Oil (Morocco)
This study focuses on the development of Myrtus communis L., a medicinal plant found in the mountains of Morocco. The first, an analysis carried out on leaves using the inductively coupled plasma spectrometry technique, showed the almost total absence of heavy metals. Furthermore, we aim to identify the chemical composition of its essential oils by gas chromatography-mass spectrometry (GC/MS) analysis and assess its antibacterial efficacy in vitro and in silico. The average yield of essential oils was 0.9 %±0.06, and GC/MS analysis identified 35 constituents, with myrcene (27,38 %), limonene (16,51 %), α-pinene (7,32 %) ...
Source: Chemistry and Biodiversity - April 30, 2024 Category: Biochemistry Authors: Mouhcine Hayani Tariq Benabbouha Nidal Naceiri Mrabti Said Eljebri Maryame Sabiri Touriya Zair Source Type: research
The role of anoctamin 1 in liver disease
J Cell Mol Med. 2024 May;28(9):e18320. doi: 10.1111/jcmm.18320.ABSTRACTLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the development of liver diseases. Anoctamin 1 (ANO1), a calcium-activated chloride channel (CaCC), plays an important role in epithelial cell secretion, proliferation and migration. ANO1 plays a key role in transcriptional...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Xin Li Yongfeng Wang Li Zhang Shun Yao Qian Liu Hai Jin Biguang Tuo Source Type: research
MFNet: Meta-learning based on frequency-space mix for MRI segmentation in nasopharyngeal carcinoma
J Cell Mol Med. 2024 May;28(9):e18355. doi: 10.1111/jcmm.18355.ABSTRACTDeep learning techniques have been applied to medical image segmentation and demonstrated expert-level performance. Due to the poor generalization abilities of the models in the deployment in different centres, common solutions, such as transfer learning and domain adaptation techniques, have been proposed to mitigate this issue. However, these solutions necessitate retraining the models with target domain data and annotations, which limits their deployment in clinical settings in unseen domains. We evaluated the performance of domain generalization met...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Yin Li Qi Chen Hao Li Song Wang Nutan Chen Ting Han Kai Wang Qingqing Yu Zhantao Cao Jun Tang Source Type: research
Comparative evaluation of bone marrow and dental pulp mesenchymal stem cells for motor functional recovery in rat sciatic nerve injury
This study delves into the impact of mesenchymal stem cells derived from bone marrow (BM-MSCs) and those sourced from dental pulp (DP-MSCs) on the recovery of motor function and morphological aspects of the rat's sciatic nerve after crush injuries. The findings highlight that the groups treated with BM-MSCs, DP-MSCs or a combination of both (BM + DP-MSCs) displayed enhanced sciatic functional index values when juxtaposed with the sham group. This points to bettered motor functionalities. A deeper morphological analysis showed that all the groups had retained perineurium structure and fascicular arrangement. Notably, the sh...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Elgin Or çum Uzunlu Zeki O ğurtan Source Type: research
Single cell sequencing data identify distinct B cell and fibroblast populations in stricturing Crohn's disease
J Cell Mol Med. 2024 May;28(9):e18344. doi: 10.1111/jcmm.18344.ABSTRACTSingle cell RNA sequencing of human full thickness Crohn's disease (CD) small bowel resection specimens was used to identify potential therapeutic targets for stricturing (S) CD. Using an unbiased approach, 16 cell lineages were assigned within 14,539 sequenced cells from patient-matched SCD and non-stricturing (NSCD) preparations. SCD and NSCD contained identical cell types. Amongst immune cells, B cells and plasma cells were selectively increased in SCD samples. B cell subsets suggested formation of tertiary lymphoid tissue in SCD and compared with NS...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: David T Humphreys Amy Lewis Belen Pan-Castillo Giulio Berti Charles Mein Eva Wozniak Hannah Gordon Radha Gadhok Annamaria Minicozzi Joanna ChinAleong Roger Feakins Eleni Giannoulatou Louisa K James Andrew J Stagg James Oliver Lindsay Andrew Silver Source Type: research
Long non-coding RNA H19 mediates osteogenic differentiation of bone marrow mesenchymal stem cells through the miR-29b-3p/DKK1 axis
This study aimed to explore the molecular mechanism of long non-coding RNA H19 in osteoporosis after SCI and provide new research directions for existing prevention strategies. We used small interfering RNA to knockdown H19 expression and regulated miR-29b-2p expression using miR-29b-3p mimetics and inhibitors. Western blotting, real-time fluorescence quantitative PCR, Alizarin red staining, alkaline phosphatase staining and double-luciferase reporter gene assays were used to assess gene expression, osteogenic ability and binding sites. lncRNA H19 was upregulated in BMSCs from the osteoporosis group, whereas miR-29b-3p was...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Sen Qin Da Liu Source Type: research
Decoding dynamic interactions between EGFR-TKD and DAC through computational and experimental approaches: A novel breakthrough in lung melanoma treatment
This study focuses on CTX-1, exploring its interaction with the pivotal EGFR-TKD protein, a crucial target in lung cancer therapeutics. A meticulous molecular docking analysis revealed that CTX-1 exhibits a noteworthy binding affinity of -7.9 kcal/mol, challenging Erlotinib, a conventional lung cancer medication, which displayed a binding affinity of -7.3 kcal/mol. For a deeper understanding of CTX-1's molecular mechanics, this study employed rigorous 100-ns molecular dynamics simulations, demonstrating CTX-1's remarkable stability in comparison with erlotinib. The Molecular Mechanics Poisson-Boltzmann Surface Area (MM-PBS...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Rajesh Kumar Meher Showkat Ahmad Mir Kritika Singh Nobendu Mukerjee Binata Nayak Ajoy Kumer Torki A Zughaibi Mohd Shahnawaz Khan Shams Tabrez Source Type: research
Orexin-A mediates glioblastoma proliferation inhibition by increasing ferroptosis triggered by unstable iron pools and GPX4 depletion
In this report, we provide the first evidence that orexin-A exerts inhibitory effects on GBM proliferation via the induction of ferroptosis. This induction is achieved by instigating an unsustainable increase in iron levels and depletion of GPX4. Moreover, the regulation of TFRC, FTH1 and GPX4 expression through the targeting of NFE2L2 appears to be one of the potential mechanisms underlying orexin-A-induced ferroptosis.PMID:38685674 | PMC:PMC11058333 | DOI:10.1111/jcmm.18318 (Source: J Cell Mol Med)
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Rengzheng Huan Jiqin Zhang Jianhe Yue Sha Yang Guoqiang Han Yuan Cheng Ying Tan Source Type: research
High-fat diet enhances cell proliferation and compromises intestinal permeability in a translational canine intestinal organoid model
CONCLUSIONS: By employing canine intestinal organoid systems, we provide compelling insights into the impact of PA on intestinal physiology. These findings underscore the importance of considering both cell proliferative activity and epithelial integrity in comprehending the repercussions of HFDs on intestinal health. Our study contributes to a deeper understanding of the consequences of HFD on intestinal homeostasis, utilizing valuable translational in vitro models derived from dogs.PMID:38689222 | DOI:10.1186/s12860-024-00512-w (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 30, 2024 Category: Molecular Biology Authors: Itsuma Nagao Yoko M Ambrosini Source Type: research
The modulation of autophagy and unfolded protein response by ent-kaurenoid derivative CPUK02 in human colorectal cancer cells
CONCLUSIONS: The study findings suggest CPUK02 may exert its cytotoxic effects by inhibiting UPR and autophagy flux in colorectal cancer cells.PMID:38689181 | DOI:10.1007/s11033-024-09541-2 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 30, 2024 Category: Molecular Biology Authors: Sedigheh Rezayi Morvarid Siri Nasim Rahmani-Kukia Mozhdeh Zamani Sanaz Dastghaib Pooneh Mokarram Source Type: research
