The ASCB and MBoC: Our cell biology power couple
Mol Biol Cell. 2024 May 1;35(5):ed1. doi: 10.1091/mbc.E24-04-0148.NO ABSTRACTPMID:38691466 | DOI:10.1091/mbc.E24-04-0148 (Source: Mol Biol Cell)
Source: Mol Biol Cell - May 1, 2024 Category: Molecular Biology Authors: Matthew D Welch Source Type: research
The GPR84 Antagonist GLPG1205 Reduces Features of Disease in Experimental Severe Asthma
Am J Respir Cell Mol Biol. 2024 May;70(5):424-427. doi: 10.1165/rcmb.2023-0221LE.NO ABSTRACTPMID:38690993 | DOI:10.1165/rcmb.2023-0221LE (Source: Mol Biol Cell)
Source: Mol Biol Cell - May 1, 2024 Category: Molecular Biology Authors: Chantal Donovan Andrew E Thorpe Henry M Gomez Olivia R Carroll Min Feng Xu Bai Hui Chen Jay C Horvat Brian G G Oliver Richard Y Kim Source Type: research
Development and validation of [18 F]-PSMA-1007 PET-based radiomics model to predict biochemical recurrence-free survival following radical prostatectomy
CONCLUSION: We developed and validated a novel [18 F]PSMA-1007 PET-based clinical-radiomics model that can predict BRFS following RP in prostate cancer patients. This model may be useful in identifying patients with a higher risk of BCR, thus enabling personalized risk stratification and tailored management strategies.PMID:38691111 | DOI:10.1007/s00259-024-06734-6 (Source: Molecular Medicine)
Source: Molecular Medicine - May 1, 2024 Category: Molecular Biology Authors: Tiancheng Li Mimi Xu Shuye Yang Guolin Wang Yinuo Liu Kaifeng Liu Kui Zhao Xinhui Su Source Type: research
Cryo-EM images of phase separated lipid bilayer vesicles analyzed with a machine learning approach
Biophys J. 2024 Apr 30:S0006-3495(24)00291-1. doi: 10.1016/j.bpj.2024.04.029. Online ahead of print.ABSTRACTLateral lipid heterogeneity (i.e., raft formation) in biomembranes plays a functional role in living cells. Three-component mixtures of low- and high-melting lipids plus cholesterol offer a simplified experimental model for raft domains in which a liquid-disordered (Ld) phase coexists with a liquid-ordered (Lo) phase. Using such models, we recently showed that cryogenic electron microscopy (cryo-EM) can detect phase separation in lipid vesicles based on differences in bilayer thickness. However, the considerable nois...
Source: Biophysical Journal - May 1, 2024 Category: Physics Authors: Karan D Sharma Milka Doktorova M Neal Waxham Frederick A Heberle Source Type: research
Role of the Ca < sub > V < /sub > 1.2 distal carboxy terminus in the regulation of L-type current
In conclusion, our results suggest that the interaction between DCRD and PCRD is sufficient to bring about the current inhibition and alter the voltage-dependent inactivation, possibly in an allosteric manner. Additionally, our data suggest that the DCtermD competitively modifies the calcium-dependent mechanism. The identified peptide sequence provides a valuable tool for further dissecting the molecular mechanisms that regulate L-type calcium channels' basal activity in cardiomyocytes.PMID:38691022 | DOI:10.1080/19336950.2024.2338782 (Source: Channels)
Source: Channels - May 1, 2024 Category: Molecular Biology Authors: Felipe Arancibia Daniela De Giorgis Franco Medina Tamara Hermosilla Felipe Simon Diego Varela Source Type: research
Research on the Effect and Mechanism of Selenium on Colorectal Cancer Through TRIM32
In conclusion, our findings provided evidence that Se inhibited the growth of colorectal cancer cells by down-regulating TRIM32.PMID:38691306 | DOI:10.1007/s12011-024-04206-4 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - May 1, 2024 Category: Biology Authors: Xiaohua Cai Yintong Su Jiayu Ning Xingxing Fan Mei Shen Source Type: research
Highly Enantio- and Diastereoselective Construction of Spirocyclic Oxindoles via a Palladium-Catalyzed Decarboxylative Asymmetric [4 + 2] Annulation Strategy
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00518J, CommunicationPengyuan You, Minjie Liu, Ke Zhang, Fan Yang, Zequn Tan, Fener Chen A palladium-catalyzed decarboxylative asymmetric [4 + 2] annulation of methyleneindolinones with a zwitterionic oxo-1,4-dipole intermediate was successfully developed to access spirocyclic oxindoles bearing two vicinal stereocenters in good yields with... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 1, 2024 Category: Molecular Biology Authors: Pengyuan You Source Type: research
A novel mitochondrial unfolded protein response-related risk signature to predict prognosis, immunotherapy and sorafenib sensitivity in hepatocellular carcinoma
AbstractHepatocellular carcinoma (HCC) is a common cause of cancer-associated death worldwide. The mitochondrial unfolded protein response (UPRmt) not only maintains mitochondrial integrity but also regulates cancer progression and drug resistance. However, no study has used the UPRmt to construct a prognostic signature for HCC. This work aimed to establish a novel signature for predicting patient prognosis, immune cell infiltration, immunotherapy, and chemotherapy response based on UPRmt-related genes (MRGs). Transcriptional profiles and clinical information were obtained from the TCGA and ICGC databases. Cox regression a...
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
Mechanism of bufalin inhibition of colon cancer liver metastasis by regulating M2-type polarization of Kupffer cells induced by highly metastatic colon cancer cells
AbstractPatients with metastatic colorectal cancer often have poor outcomes, primarily due to hepatic metastasis. Colorectal cancer (CRC) cells have the ability to secrete cytokines and other molecules that can remodel the tumor microenvironment, facilitating the spread of cancer to the liver. Kupffer cells (KCs), which are macrophages in the liver, can be polarized to M2 type, thereby promoting the expression of adhesion molecules that aid in tumor metastasis. Our research has shown that huachanshu (with bufalin as the main active monomer) can effectively inhibit CRC metastasis. However, the underlying mechanism still nee...
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
Retraction Note: Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma
(Source: Apoptosis)
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
LIPUS regulates the progression of knee osteoarthritis in mice through primary cilia-mediated TRPV4 channels
AbstractOsteoarthritis (OA) is a common disease in middle-aged and elderly people. An imbalance in calcium ion homeostasis will contribute to chondrocyte apoptosis and ultimately lead to the progression of OA. Transient receptor potential channel 4 (TRPV4) is involved in the regulation of intracellular calcium homeostasis. TRPV4 is expressed in primary cilia, which can sense mechanical stimuli from outside the cell, and its abnormal expression is closely related to the development of OA. Low-intensity pulsed ultrasound (LIPUS) can alleviate chondrocyte apoptosis while the exact mechanism is unclear. In this project, with t...
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
Transcription factor EB-mediated autophagy affects cell migration and inhibits apoptosis to promote endometriosis
This study aimed to investigate the effect of TFEB on the mechanism of endometriosis progression. The results showed that TFEB and autophagy-related protein LC3 are highly expressed in ectopic endometrium of patients with endometriosis, overexpression of TFEB in cultured human endometrial stromal cells (HESCs) by lentivirus not only promoted autophagy but also inhibited apoptosis. In addition, the migration and invasion ability of HESCs were enhanced by TFEB overexpression. Furthermore, inhibiting autophagy with specific inhibitors can attenuate migration and invasion of HESCs induced by TFEB. The rat models of endometrios...
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
Analysis and experimental validation of necroptosis-related molecular classification, immune signature and feature genes in Alzheimer ’s disease
In this study, we conducted non-negative matrix factorization clustering analysis to identify three subtypes of AD based on necroptosis-relevant genes. Notably, these subtypes exhibited varying necroptosis scores, clinical characteristics and immune infiltration signatures. Cluster B, characterized by high necroptosis scores, showed higher immune cell infiltration and was associated with a more severe pathology, potentially representing a high-risk subgroup. To identify potential biomarkers for AD within cluster B, we employed two machine learning algorithms: the least absolute shrinkage and selection operator regression a...
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
PANoptosis subtypes predict prognosis and immune efficacy in gastric cancer
AbstractPANoptosis is a form of inflammatory programmed cell death that is regulated by the PANoptosome. This PANoptosis possesses key characteristics of pyroptosis, apoptosis, and necroptosis, yet cannot be fully explained by any of these cell death modes. The unique nature of this cell death mechanism has garnered significant interest. However, the specific role of PANoptosis-associated features in gastric cancer (GC) is still uncertain. Patients were categorized into different PAN subtypes based on the expression of genes related to the PANoptosome. We conducted a systematic analysis to investigate the variations in pro...
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
Circ_0098823 binding with IGF2BP3 regulates DNM1L stability to promote metastasis of hepatocellular carcinoma via mitochondrial fission
This study uncovered a novel circ_0098823 with tumor-promoting effect, and the mechanism by which circ_0098823 participates in HCC progression through IGF2BP3-guided DNM1L. Our study broadens molecular understanding of HCC progression. (Source: Apoptosis)
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
