Socialized mitochondria: mitonuclear crosstalk in stress
Exp Mol Med. 2024 May 1. doi: 10.1038/s12276-024-01211-4. Online ahead of print.ABSTRACTTraditionally, mitochondria are considered sites of energy production. However, recent studies have suggested that mitochondria are signaling organelles that are involved in intracellular interactions with other organelles. Remarkably, stressed mitochondria appear to induce a beneficial response that restores mitochondrial function and cellular homeostasis. These mitochondrial stress-centered signaling pathways have been rapidly elucidated in multiple organisms. In this review, we examine current perspectives on how mitochondria communi...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Kyung Hwa Kim Cho Bi Lee Source Type: research
Tetrahydrobiopterin metabolism attenuates ROS generation and radiosensitivity through LDHA S-nitrosylation: novel insight into radiogenic lung injury
Exp Mol Med. 2024 May 1. doi: 10.1038/s12276-024-01208-z. Online ahead of print.ABSTRACTGenotoxic therapy triggers reactive oxygen species (ROS) production and oxidative tissue injury. S-nitrosylation is a selective and reversible posttranslational modification of protein thiols by nitric oxide (NO), and 5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for NO synthesis. However, the mechanism by which BH4 affects protein S-nitrosylation and ROS generation has not been determined. Here, we showed that ionizing radiation disrupted the structural integrity of BH4 and downregulated GTP cyclohydrolase I (GCH1), which ...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Yang Feng Yahui Feng Liming Gu Wei Mo Xi Wang Bin Song Min Hong Fenghao Geng Pei Huang Hongying Yang Wei Zhu Yang Jiao Qi Zhang Wei-Qun Ding Jianping Cao Shuyu Zhang Source Type: research
[ < sup > 68 < /sup > Ga]DOTATOC PET-derived radiomics to predict genetic background of head and neck paragangliomas: a pilot investigation
CONCLUSION: Radiomics features GLSZM-ZSNU and IB-TLSRE appear to reflect HNPGLs SDHx status and tumor behavior (metastatic vs. non-metastatic). If validated, especially IB-TLSRE might represent a simple and time-efficient radiomic index for SDHx variants early screening and prediction of tumor behavior in HNPGL cases.PMID:38687372 | DOI:10.1007/s00259-024-06735-5 (Source: Molecular Medicine)
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Miriam Pepponi Valentina Berti Elsa Fasciglione Flavio Montanini Letizia Canu Fabrice Hubele Elisabetta Abenavoli Vittorio Briganti Elena Rapizzi Anne Charpiot David Taieb Karel Pacak Bernard Goichot Alessio Imperiale Source Type: research
Multi-omics analysis reveals the association between specific solute carrier proteins gene expression patterns and the immune suppressive microenvironment in glioma
J Cell Mol Med. 2024 May;28(9):e18339. doi: 10.1111/jcmm.18339.ABSTRACTGlioma is the most prevalent malignant brain tumour. Currently, reshaping its tumour microenvironment has emerged as an appealing strategy to enhance therapeutic efficacy. As the largest group of transmembrane transport proteins, solute carrier proteins (SLCs) are responsible for the transmembrane transport of various metabolites and ions. They play a crucial role in regulating the metabolism and functions of malignant cells and immune cells within the tumour microenvironment, making them a promising target in cancer therapy. Through multidimensional da...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Wenjie Wu Cheng Jiang Wende Zhu Xiaobing Jiang Source Type: research
EANM position on positron emission tomography in suspected functional pituitary neuroendocrine tumours
Eur J Nucl Med Mol Imaging. 2024 Apr 30. doi: 10.1007/s00259-024-06728-4. Online ahead of print.NO ABSTRACTPMID:38687371 | DOI:10.1007/s00259-024-06728-4 (Source: Molecular Medicine)
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Donatienne Van Weehaeghe Bruno Lapauw Francesco Fraioli Diego Cecchin Antoine Verger Eric Guedj Nathalie L Albert Matthias Brendel Igor Yakushev Henryk Barthel Tatjana Traub-Weidinger Nelleke Tolboom Elsmarieke Van De Giessen Source Type: research
Malvidin attenuates trauma-induced heterotopic ossification of tendon in rats by targeting Rheb for degradation via the ubiquitin-proteasome pathway
This study aimed to investigate the effect of MA in treating trauma-induced HO and unravel its underlying mechanisms. Herein, the effectiveness of MA in preventing HO formation was assessed through local injection in a rat model. The potential mechanism underlying MA's treatment was investigated in the tendon-resident progenitor cells of tendon-derived stem cells (TDSCs), exploring its pathway in HO formation. The findings demonstrated that MA effectively hindered the osteogenic differentiation of TDSCs by inhibiting the mTORC1 signalling pathway, consequently impeding the progression of trauma-induced HO of Achilles tendo...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Huaji Jiang Yan Ding Xuemei Lin Qinyu Tian Yakui Liu Hebei He Yongfu Wu Xinggui Tian Stefan Zwingenberger Source Type: research
Fangchinoline inhibits growth and biofilm of Candida albicans by inducing ROS overproduction
J Cell Mol Med. 2024 May;28(9):e18354. doi: 10.1111/jcmm.18354.ABSTRACTInfections caused by Candida species, especially Candida albicans, threaten the public health and create economic burden. Shortage of antifungals and emergence of drug resistance call for new antifungal therapies while natural products were attractive sources for developing new drugs. In our study, fangchinoline, a bis-benzylisoquinoline alkaloid from Chinese herb Stephania tetrandra S. Moore, exerted antifungal effects on planktonic growth of several Candida species including C. albicans, with MIC no more than 50 μg/mL. In addition, results from micro...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Longfei Yang Xiaonan Wang Zhiming Ma Yujie Sui Xin Liu Source Type: research
Glutathione peroxidase 4 restrains temporomandibular joint osteoarthritis progression by inhibiting ferroptosis
In conclusion, GPX4 and ferroptosis regulated the progression of TMJOA. Targeting ferroptosis might be an effective therapeutic strategy for TMJOA patients in the clinic.PMID:38686488 | PMC:PMC11058612 | DOI:10.1111/jcmm.18377 (Source: Molecular Medicine)
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Chunyan Pang Hongmei Zhang Yi Liu Na Tang Kun Tian Yandong Mu Xue Li Li Xiao Source Type: research
Sirt7/HIC1 complex participates in hyperglycaemia-mediated EndMT via modulation of SDC1 expression in diabetic kidney disease and metabolic memory
This study demonstrated that the hyperglycaemia-mediated interaction between Sirt7 and HIC1 exerts a role in the metabolic memory in DKD by inactivating SDC1 transcription and mediating EndMT despite glucose normalization in HGECs.PMID:38686489 | PMC:PMC11058670 | DOI:10.1111/jcmm.18336 (Source: Molecular Medicine)
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Lihong Lu Minmin Zhu Qichao Wu Zhirong Sun Xiangyuan Chen Changhong Miao Source Type: research
A potassium-chloride co-transporter with altered genome architecture functions as a suppressor in glioma
J Cell Mol Med. 2024 May;28(9):e18352. doi: 10.1111/jcmm.18352.ABSTRACTGliomas, the most lethal tumours in brain, have a poor prognosis despite accepting standard treatment. Limited benefits from current therapies can be attributed to genetic, epigenetic and microenvironmental cues that affect cell programming and drive tumour heterogeneity. Through the analysis of Hi-C data, we identified a potassium-chloride co-transporter SLC12A5 associated with disrupted topologically associating domain which was downregulated in tumour tissues. Multiple independent glioma cohorts were included to analyse the characterization of SLC12A...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Hongwei Liu Zhouyang Pan Xuelei Lin Long Chen Qi Yang Wei Zhang Luohuan Dai Yihao Zhang Wang Li Yinhua Chen Kang Peng Siyi Wanggou Feiyue Zeng Xuejun Li Source Type: research
The role of anoctamin 1 in liver disease
J Cell Mol Med. 2024 May;28(9):e18320. doi: 10.1111/jcmm.18320.ABSTRACTLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the development of liver diseases. Anoctamin 1 (ANO1), a calcium-activated chloride channel (CaCC), plays an important role in epithelial cell secretion, proliferation and migration. ANO1 plays a key role in transcriptional...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Xin Li Yongfeng Wang Li Zhang Shun Yao Qian Liu Hai Jin Biguang Tuo Source Type: research
MFNet: Meta-learning based on frequency-space mix for MRI segmentation in nasopharyngeal carcinoma
J Cell Mol Med. 2024 May;28(9):e18355. doi: 10.1111/jcmm.18355.ABSTRACTDeep learning techniques have been applied to medical image segmentation and demonstrated expert-level performance. Due to the poor generalization abilities of the models in the deployment in different centres, common solutions, such as transfer learning and domain adaptation techniques, have been proposed to mitigate this issue. However, these solutions necessitate retraining the models with target domain data and annotations, which limits their deployment in clinical settings in unseen domains. We evaluated the performance of domain generalization met...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Yin Li Qi Chen Hao Li Song Wang Nutan Chen Ting Han Kai Wang Qingqing Yu Zhantao Cao Jun Tang Source Type: research
Comparative evaluation of bone marrow and dental pulp mesenchymal stem cells for motor functional recovery in rat sciatic nerve injury
This study delves into the impact of mesenchymal stem cells derived from bone marrow (BM-MSCs) and those sourced from dental pulp (DP-MSCs) on the recovery of motor function and morphological aspects of the rat's sciatic nerve after crush injuries. The findings highlight that the groups treated with BM-MSCs, DP-MSCs or a combination of both (BM + DP-MSCs) displayed enhanced sciatic functional index values when juxtaposed with the sham group. This points to bettered motor functionalities. A deeper morphological analysis showed that all the groups had retained perineurium structure and fascicular arrangement. Notably, the sh...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Elgin Or çum Uzunlu Zeki O ğurtan Source Type: research
Orexin-A mediates glioblastoma proliferation inhibition by increasing ferroptosis triggered by unstable iron pools and GPX4 depletion
In this report, we provide the first evidence that orexin-A exerts inhibitory effects on GBM proliferation via the induction of ferroptosis. This induction is achieved by instigating an unsustainable increase in iron levels and depletion of GPX4. Moreover, the regulation of TFRC, FTH1 and GPX4 expression through the targeting of NFE2L2 appears to be one of the potential mechanisms underlying orexin-A-induced ferroptosis.PMID:38685674 | PMC:PMC11058333 | DOI:10.1111/jcmm.18318 (Source: Molecular Medicine)
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Rengzheng Huan Jiqin Zhang Jianhe Yue Sha Yang Guoqiang Han Yuan Cheng Ying Tan Source Type: research
Long non-coding RNA H19 mediates osteogenic differentiation of bone marrow mesenchymal stem cells through the miR-29b-3p/DKK1 axis
This study aimed to explore the molecular mechanism of long non-coding RNA H19 in osteoporosis after SCI and provide new research directions for existing prevention strategies. We used small interfering RNA to knockdown H19 expression and regulated miR-29b-2p expression using miR-29b-3p mimetics and inhibitors. Western blotting, real-time fluorescence quantitative PCR, Alizarin red staining, alkaline phosphatase staining and double-luciferase reporter gene assays were used to assess gene expression, osteogenic ability and binding sites. lncRNA H19 was upregulated in BMSCs from the osteoporosis group, whereas miR-29b-3p was...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Sen Qin Da Liu Source Type: research
