Sirt7/HIC1 complex participates in hyperglycaemia-mediated EndMT via modulation of SDC1 expression in diabetic kidney disease and metabolic memory

This study demonstrated that the hyperglycaemia-mediated interaction between Sirt7 and HIC1 exerts a role in the metabolic memory in DKD by inactivating SDC1 transcription and mediating EndMT despite glucose normalization in HGECs.PMID:38686489 | PMC:PMC11058670 | DOI:10.1111/jcmm.18336

Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Lihong Lu Minmin Zhu Qichao Wu Zhirong Sun Xiangyuan Chen Changhong Miao Source Type: research