Modulating intestinal health: Impact of chitooligosaccharide molecular weight on suppressing RAGE expression and inflammatory response in methylglyoxal-induced advanced glycation end-products
In this study, we investigated the effects of chitooligosaccharides (COSs) of different molecular weights (<1 kDa, 1-3 kDa, 3-5 kDa, 5-10 kDa, and >10 kDa) on MGO-induced intestinal barrier dysfunction. We investigated the effect of COSs on inhibiting intracellular MGO accumulation/MGO-derived AGEs production and regulating the receptor for AGE (RAGE)-mediated downstream protein expression, including proteins related to apoptosis and inflammation, intestinal barrier integrity, and paracellular permeability. Pretreatment with COSs ameliorated MGO-induced increased RAGE protein expression, activation of apoptotic casca...
Source: International Journal of Biological Macromolecules - April 30, 2024 Category: Biochemistry Authors: Chi Heung Cho Young Sung Jung Mingyeong Kim Ulfah Dwi Kurniawati Yongeun Kim Mi-Jin Yim Dae-Sung Lee Jae-Young Je Sang-Hoon Lee Source Type: research
Visible-Light-Induced Three-Component Reactions of α-Diazoesters, Quinazolinones and Cyclic Ethers Selectively Lead to Quinazoline-Based Hybrids
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00295D, PaperYiyuan Peng, Yan Liu, Qin Yang, Wei Wang, Yang Fu, Qiuping Ding An effective approach for the construction of 4-short-chain ether attached carbonyl group-substituted quinazolines was developed. The visible-light-induced three-component reactions of α-diazoesters, quinazolinones, and cyclic ethers, with broad substrate scope and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 30, 2024 Category: Molecular Biology Authors: Yiyuan Peng Source Type: research
High expression of Testin predicted worse prognosis in pancreatic adenocarcinoma associated with immune infiltration
ConclusionsThe present study suggested thatTES could function as a supporter and prognostic marker of PAAD, and it might work via inducing immune infiltration. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 30, 2024 Category: Cytology Source Type: research
The c-Abl-RACK1-FAK signaling axis promotes renal fibrosis in mice through regulating fibroblast-myofibroblast transition
Renal fibrosis is a prevalent manifestation of chronic kidney disease (CKD), and effective treatments for this disease are currently lacking. Myofibroblasts, which originate from interstitial fibroblasts, aggr... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 30, 2024 Category: Molecular Biology Authors: Qianyi Bao, Anyu Wang, Wenxuan Hong, Yushu Wang, Baojie Li, Lin He, Xiaodong Yuan and Gang Ma Tags: Research Source Type: research
Loss of tumor-derived SMAD4 enhances primary tumor growth but not metastasis following BMP4 signalling
Bone morphogenetic protein 4 (BMP4) is a potent inhibitor of breast cancer metastasis. However, a tumor-promoting effect of BMP4 is reported in other tumor types, especially when SMAD4 is inactive. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 30, 2024 Category: Molecular Biology Authors: Lap Hing Chi, Andrew D. Redfern, Suraya Roslan, Ian P. Street, Allan D. Burrows and Robin L. Anderson Tags: Research Source Type: research
Overexpressed KCNK1 regulates potassium channels affecting molecular mechanisms and biological pathways in bladder cancer
ConclusionsKCNK1 was significantly overexpressed in BC. A complex and sophisticated three-dimensional spatial transcriptional regulatory network existed in the KCNK1 TSS and promoted the upregulated of KCNK1 expression. The high expression of KCNK1 might be involved in the cell cycle, cellular metabolism, and tumour microenvironment through the regulation of potassium channels, and ultimately contributed to the deterioration of BC. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 30, 2024 Category: Research Source Type: research
Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer ’s disease
by Abdallah M. Eteleeb, Brenna C. Novotny, Carolina Soriano Tarraga, Christopher Sohn, Eliza Dhungel, Logan Brase, Aasritha Nallapu, Jared Buss, Fabiana Farias, Kristy Bergmann, Joseph Bradley, Joanne Norton, Jen Gentsch, Fengxian Wang, Albert A. Davis, John C. Morris, Celeste M. Karch, Richard J. Perrin, Bruno A. Benitez, Oscar Harari
Unbiased data-driven omic approaches are revealing the molecular heterogeneity of Alzheimer disease. Here, we used machine learning approaches to integrate high-throughput transcriptomic, proteomic, metabolomic, and lipidomic profiles with clinical and neuropathological data from multiple h...
Source: PLoS Biology: Archived Table of Contents - April 30, 2024 Category: Biology Authors: Abdallah M. Eteleeb Source Type: research
Single-cell RNA-seq of < i > Drosophila miranda < /i > testis reveals the evolution and trajectory of germline sex chromosome regulation
by Kevin H-C. Wei, Kamalakar Chatla, Doris Bachtrog
Although sex chromosomes have evolved from autosomes, they often have unusual regulatory regimes that are sex- and cell-type-specific such as dosage compensation (DC) and meiotic sex chromosome inactivation (MSCI). The molecular mechanisms and evolutionary forces driving these unique transcriptional programs are critical for genome evolution but have been, in the case of MSCI inDrosophila, subject to continuous debate. Here, we take advantage of the younger sex chromosomes inD.miranda (XR and the neo-X) to infer how former autosomes acquire sex-chromosome-specific regula...
Source: PLoS Biology: Archived Table of Contents - April 30, 2024 Category: Biology Authors: Kevin H-C. Wei Source Type: research
Synergistic epistasis among cancer drivers can rescue early tumors from the accumulation of deleterious passengers
by Carla Alejandre, Jorge Calle-Espinosa, Jaime Iranzo
Epistasis among driver mutations is pervasive and explains relevant features of cancer, such as differential therapy response and convergence towards well-characterized molecular subtypes. Furthermore, a growing body of evidence suggests that tumor development could be hampered by the accumulation of slightly deleterious passenger mutations. In this work, we combined empirical epistasis networks, computer simulations, and mathematical models to explore how synergistic interactions among driver mutations affect cancer progression under the burden of slightly deleteriou...
Source: PLoS Computational Biology - April 30, 2024 Category: Biology Authors: Carla Alejandre Source Type: research
Glutamine-mediated epigenetic regulation of cFLIP underlies resistance to TRAIL in pancreatic cancer
Experimental & Molecular Medicine, Published online: 30 April 2024; doi:10.1038/s12276-024-01231-0Pancreatic ductal adenocarcinoma (PDAC), a severe form of pancreatic cancer with a low survival rate, was the focus of this study. The aim was to understand why PDAC is resistant to TRAIL-induced programmed cell death (apoptosis). The study found that PDAC cells need glutamine (a type of amino acid) to be resistant to TRAIL-induced apoptosis. Without glutamine, these cells are more likely to undergo TRAIL-induced apoptosis due to a decrease in a protein called cFLIP. This protein’s regulation involves a process with glut...
Source: Experimental and Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Ji Hye Kim Jinyoung Lee Se Seul Im Boyun Kim Eun-Young Kim Hyo-Jin Min Jinbeom Heo Eun-Ju Chang Kyung-Chul Choi Dong-Myung Shin Jaekyoung Son Source Type: research
PIDA-Promoted metal-free [3 + 2] heteroannulation of β-ketothioamides with 4-hydroxy coumarins: chemo-/regioselective access to furo[3,2-c]chromen-4-ones at room temperature
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00438H, PaperAnup Kumar Yadav, Dhananjay Yadav, Vipin Kumar, Subhasish Ray, Maya Shankar Singh Herein, we report a viable protocol to access furo[3,2-c]chromen-4-ones engaging easily accessible 4-hydroxy coumarins as a three-atom CCO unit and thioamides as a C2 coupling partner mediated by phenyliodine(III) diacetate... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 29, 2024 Category: Molecular Biology Authors: Anup Kumar Yadav Source Type: research
BPO-Promoted [4 + 2] cyclization of enaminones and o-phenylenediamines to 2-acyl quinoxalines via a cascade transamination and C –H amination
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00494A, CommunicationHeng Feng, Jie Hou, Xiaonan Mu, Renhua Zheng, Xiao Geng, Lei Wang Rapid assembly of quinoxalines in a single step from easily available precursors have been recognized as an ideal platform in term of efficiency and operation. Herein, we report a BPO-promoted... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 29, 2024 Category: Molecular Biology Authors: Heng Feng Source Type: research
N-Functionalization of β-aminophosphonates: cytotoxic effects of the new derivatives
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00243A, PaperGy örgy Keglevich, Petra Regina Varga, Emőke Dinnyési, Zsuzsanna Szalai, Szilvia Bősze, Oláhné Szabó Rita, László Drahos, Konstantin Karaghiosoff β-Alkylamino-ethylphosphonates were subjected to the Kabachnik–Fields reaction and acylation to afford new derivatives with cytotoxic activity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 29, 2024 Category: Molecular Biology Authors: Gy örgy Keglevich Source Type: research
Antimicrobial sesterterpenoids with a unique 5/8/6/5 tetracyclic carbon-ring-system and diepoxide polyketides from a deep sea-sediment-sourced fungus Chaetomium globosum SD-347
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00449C, PaperXiao-Dong Li, Xiao-Ming Li, Bin-Gui Wang, Xin Li Two new sesterterpenoids, sesterchaetins A and B (1 and2), and two new diepoxide polyketides, chaetoketoics A and B (3 and 4), were characterized from the culture extract ofChaetomium... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 29, 2024 Category: Molecular Biology Authors: Xiao-Dong Li Source Type: research
Development of an efficient and scalable bioprocess for the plant hormone 12-OPDA: Overcoming hurdles of nature ´s biosynthesis
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Tim Guntelmann, Karl-Josef Dietz, Harald Gr öger Besides its native biological function as plant hormone, cis-(+)-12-oxo-phytodienoic acid (12-OPDA) serves as a metabolite for the cellular formation of (-)-jasmonic acid and also turned out to have an influence... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 29, 2024 Category: Molecular Biology Authors: Tim Guntelmann Source Type: research
