CCR Grand Rounds: Learning the Molecular Logic of Cancer
CCR Grand Rounds “ Learning the Molecular Logic of Cancer ” Eliezer Van Allen, M.D.Associate Professor, Medicine, Harvard Medical SchoolChief, Division of Population Sciences, Dana-Farber Cancer InstituteFriday, April 26, 202412:00 – 1:00 p.m.Lipsett AmphitheaterDr. Eliezer (Eli) Van Allen is an Associate Professor of Medicine at Harvard Medical School, Chief of the Division of Population Sciences at the Dana-Farber Cancer Institute, an Institute Member at the Broad Institute of MIT and Harvard, and a Member Researcher in The Parker Institute for Cancer Immunotherapy at the Dana-Farber Cancer Institute. As both ...
Source: Videocast - All Events - April 16, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
CCR Grand Rounds: Glypicans as Cancer Targets for CAR-T Immunotherapy
CCR Grand Rounds “ Glypicans as Cancer Targets for CAR-T Immunotherapy ” Mitchell Ho, Ph.D.Senior Investigator& Deputy ChiefLaboratory of Molecular BiologyCenter for Cancer Research, NCIFriday, April 19, 202412:00 – 1:00 p.m.Lipsett AmphitheaterAlso available to view via NIH Videocast.Dr. Mitchell Ho is a Senior Investigator and Deputy Chief of the Laboratory of Molecular Biology and Director of the Antibody Engineering Program at the Center for Cancer Research, NCI. Dr. Ho's research encompasses investigating molecular mechanisms by which glypicans such as GPC1, GPC2 and GPC3 regulate Wnt signaling, as well as d...
Source: Videocast - All Events - April 15, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
Demystifying Medicine — Thomas Insel and George Koob discuss mental health and alcohol use
Dr. Insel, a psychiatrist and neuroscientist, is a national leader in mental health research, policy, and technology. He served as director of the National Institute of Mental Health from 2002 to 2015. Upon leaving the NIH, Insel co-founded Mindstrong Health, a start-up assisting people with serious mental illness; served as a special advisor to California Governor Gavin Newsom; co-founded Humanest Care, a therapeutic online community for recovery; and in 2022, joined Vanna Health as a co-founder and executive chair. Dr. Koob, an internationally recognized expert on alcohol and stress and the neurobiology of alcohol and dr...
Source: Videocast - All Events - April 9, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
HIV Structural Biology Meeting
The National Institute for Allergy and Infectious Diseases will host the annual HIV Structural Biology Meeting Monday, June 24th and Tuesday, June 25th, 2024 at the NIH Natcher Conference Center in Bethesda, MD. The meeting will feature presentations from the Centers for HIV Structural Biology program, invited lectures and short talks selected from submitted abstracts. Poster sessions will be held each day to encourage networking and collaboration among HIV Cellular, Molecular and Structural Biologists. The meeting is expected to attract over 300 participants from the extramural and intramural research community.Air date: ...
Source: Videocast - All Events - March 7, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
HIV Structural Biology Meeting
The National Institute for Allergy and Infectious Diseases will host the annual HIV Structural Biology Meeting Monday, June 24th and Tuesday, June 25th, 2024 at the NIH Natcher Conference Center in Bethesda, MD. The meeting will feature presentations from the Centers for HIV Structural Biology program, invited lectures and short talks selected from submitted abstracts. Poster sessions will be held each day to encourage networking and collaboration among HIV Cellular, Molecular and Structural Biologists. The meeting is expected to attract over 300 participants from the extramural and intramural research community.Air date: ...
Source: Videocast - All Events - March 7, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH ProtIG seminar, Ling Hao: Capturing Organelle Dynamics in Neurons by Mass Spectrometry-based Omics Methods
Lysosomes and mitochondria are membrane-bound organelles in the cell and their dysfunctions have been linked to numerous human diseases, such as neurodegeneration, cancer, and cardiovascular disorders. These organelles are highly dynamic and frequently interact with other cellular components in a transient fashion, which are difficult to capture with traditional immunoprecipitation methods. Here, I will present our recent efforts in developing mass spectrometry-based multi-omics, proximity labeling, organelle isolation, and dynamic SILAC proteomic methods to characterize organelle microenvironment and protein dynamics in h...
Source: Videocast - All Events - February 6, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
Immunological mechanisms of mRNA vaccines- NIH FDA COVID-19 SIG Lecture Series
The production of antibodies (Abs) with high affinity and pathogen neutralization potential is crucial for preventing and fighting pathogen infection. To produce such Abs, na ï ve B cells are activated in response to cognate antigen and subsequently undergo rounds of somatic hypermutation and selection in germinal centers, specialized microanatomical sites in secondary lymphoid organs. This process of affinity maturation is tightly regulated by a specialized subset of CD4 T cells named T follicular helper (Tfh) cells. Our laboratory is interested in dissecting the complex biology of Tfh cells. Understanding (1) how Tfh di...
Source: Videocast - All Events - February 2, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
WALS: The Structure and Mechanism of Cell Surface Signaling Complexes
Yvonne Jones is co-Head of STRUBI and Deputy Head of the NDM. Her own research group is focused on the structural biology of extracellular recognition and signaling complexes. The group's core techniques include protein crystallography and cryo electron microscopy, which are used to generate high resolution structural information. Importantly, studies using these techniques are integrated with advanced light microscopy and cryo electron tomography, as well as cell-based functional studies, to probe molecular mechanisms at the cell surface. The group's research addresses fundamental questions about cell-cell signaling syste...
Source: Videocast - All Events - December 22, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH FDA COVID-19 SIG Lecture Series- Michela Locci Ph.D.
The production of antibodies (Abs) with high affinity and pathogen neutralization potential is crucial for preventing and fighting pathogen infection. To produce such Abs, na ï ve B cells are activated in response to cognate antigen and subsequently undergo rounds of somatic hypermutation and selection in germinal centers, specialized microanatomical sites in secondary lymphoid organs. This process of affinity maturation is tightly regulated by a specialized subset of CD4 T cells named T follicular helper (Tfh) cells. Our laboratory is interested in dissecting the complex biology of Tfh cells. Understanding (1) how Tfh di...
Source: Videocast - All Events - December 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
How does the Plasma Membrane Participate in Receptor-Mediated Cell Signaling?
Cells are poised to respond to their physical environment and must distinguish specific stimuli from biological noise. Specific response mechanisms depend on collective molecular interactions that are regulated in time and space by the plasma membrane and its connections with the cytoskeleton and intracellular structures. Molecular stimuli engage their specific receptors to initiate a transmembrane signal, and the surrounding system efficiently rearranges to amplify this nanoscale interaction to microscale assemblies, yielding a cellular response that often reaches to longer length scales within the organism. A striking ex...
Source: Videocast - All Events - November 21, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
CCR Grand Rounds: A Garden of Forking Paths: Branching, Switching, and Reversing in Homologous Recombination
CCR Grand Rounds “ A Garden of Forking Paths: Branching, Switching, and Reversing in Homologous Recombination ” Michael Lichten, Ph.D.NIH Scientist EmeritusLaboratory of Biochemistry and Molecular BiologyCenter for Cancer Research, NCI Friday, October 20, 202312:00 – 1:00 p.m.Lipsett AmphitheaterAir date: 10/20/2023 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 11, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
WALS: The World of Insect-Bacterial Symbiosis: What we have and have not learned
Nancy Moran, Ph.D., is the Raymer Chair and professor of integrative biology at the University of Texas at Austin. She earned her B.A. from the University of Texas at Austin in biology in 1976, and then moved to the University of Michigan to earn her Ph.D. in zoology in 1982. She has served on the faculty at the University of Arizona (1986-2010), Yale University (2010-2013) and UT Austin (2013-present). Moran ’ s research has long focused on symbiotic bacteria that live in insects, especially on their evolutionary histories, genomics and biological functions in hosts. Her recent research projects have involved symbiosis ...
Source: Videocast - All Events - October 5, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
WALS Lecture: Laura Niedernhofer Ph.D.
Laura Niedernhofer joined the University of Minnesota in July 2018 to direct the new Institute on the Biology of Aging& Metabolism ;(external link)(iBAM) and Medical Discovery Team on the Biology of Aging. She is also a Professor in the Department of Biochemistry, Molecular Biology and Biophysics at UMN. Dr. Niedernhofer ’ s expertise is in DNA damage and repair, genome instability disorders, cellular senescence and aging. Her research program is centered on studying fundamental mechanisms of aging and developing therapeutics to target them. Her research program implements a murine model of a human progeroid syndrome...
Source: Videocast - All Events - October 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Generative Biology: Learning to Program Cellular Machines
My general scientific interests are in understanding how genetically encoded molecular programs can yield the remarkable behaviors observed in biological organisms, at multiple scales. I began my research career as a biophysical chemist and structural biologist studying problems such as the evolutionary optimization of enzymes, how protein structure is encoded in sequence, and the determinants of protein-protein interaction specificity. My research has gradually shifted towards utilizing this mechanistic understanding of molecules as a foundation to study how systems of interacting molecules assemble to yield cellular or o...
Source: Videocast - All Events - August 22, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
The neurobiology and evolution of vocal learning and spoken language
This lecture, established in 2011, recognizes Marshall Nirenberg for his work to decipher the genetic code, which resulted in his receiving the 1968 Nobel Prize in Physiology or Medicine. Nirenberg ’ s research career at the NIH spanned more than 50 years, and his research also focused on neuroscience, neural development, and the homeobox genes. The Nirenberg lecture recognizes outstanding contributions to genetics and molecular biology.
The focus of Jarvis' research is the vocal learning capabilities in birds and how they learn to mimic sounds.His research with songbirds is being used to show the evolution of human l...
Source: Videocast - All Events - August 1, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
