Heterogeneity and Plasticity of CD4 T Helper (Th) and Innate Lymphoid Cell (ILC) Subsets
Immunonology IG Seminar
Dr. Jinfang Zhu received his Ph.D. in biochemistry and molecular biology from the Shanghai Institute of Biochemistry, Chinese Academy of Sciences. He completed his postdoctoral training at the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, with late Dr. William E. Paul, studying CD4 T helper cell differentiation controlled by key transcription factors including GATA3 and T-bet. He started his own group in the Laboratory of Immunology as an Earl Stadtman investigator, and is now the section chief of the Molecular and Cellular Immunoregulation Section in the Laborator...
Source: Videocast - All Events - June 12, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Regulating Autoimmunity and Autoinflammation: Cytokine blockade and beyond
Immunonology IG Seminar
Richard Siegel's interest in immunology and apoptosis began in the late 1980's at the University of Pennsylvania School of Medicine where he was an M.D., Ph.D. student. Working with Mark Greene and John Reed, he studied the influence of bcl-2 on T cell apoptosis and repertoire selection. He trained in Internal Medicine and Rheumatology at Hospital of the University of Pennsylvania, and moved to the NIH in 1996 to do postdoctoral training with Michael Lenardo in the Laboratory of Immunology in the National Institute of Allergy and Infectious Disease. There he studied apoptosis signaling and the molec...
Source: Videocast - All Events - May 29, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Understanding Molecular Signatures of Aging
The Trans-NIH GeroScience Interest Group (GSIG), cordially invites you to its spring seminar, featuring Dr. GR Scott Budinger. Dr. Budinger is the Chief of Pulmonary and Critical Care in the Department of Medicine at Northwestern University Feinberg School of Medicine and is the Ernest S. Bazley Professor of Airway Diseases and a Professor of Medicine (Pulmonary and Critical Care) and of Cell and Molecular Biology. The Budinger laboratory is interested in understanding how aging biology intersects with the age-related risk of acute and chronic lung diseases. The Budinger lab is testing whether a decline in the function of...
Source: Videocast - All Events - May 24, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Biowulf Seminar Series: Cryo-EM studies of glutamate receptors and nucleosomes
Biowulf Seminar Series
Electron microscopy (EM) has been traditionally used to calculate three-dimensional reconstructions that were interpreted using high-resolution structures determined by X-ray crystallography and NMR to provide biological insights into the function of large macromolecular assemblies. However, recent technological and methodological developments in cryo-EM have now made it possible to routinely study biological macromolecules of lower molecular weight at near-atomic resolutions, thus opening up an interesting area of determining three dimensional structures of novel complexes. Here, I will discuss the ...
Source: Videocast - All Events - May 2, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Uncovering Unknown Unknowns of Gene Regulation
NIH Director's Seminar Series
Identification of genes and processes associated with specific biological phenotypes is a fundamental step toward understanding the molecular basis of development and pathogenesis. This seminar will discuss the use of integrative systems biology approaches to uncover unknown unknowns of gene regulation. Dr. Raja Jothi will discuss data-driven efforts toward identification and characterization of genes with previously unknown roles in embryonic stem cell biology and findings on an unanticipated role for intragenic enhancers in attenuating their host gene expression.Air date: 4/13/2018 12:00:00 ...
Source: Videocast - All Events - March 26, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Analysis of RBC Derived Microparticles from Sickle Cell Mice using Mass Spectrometry: The Impact of Sickle Cell Disease Induced Oxidative Stress on MP Proteome
Proteomics Interest Group
Polymerization of sickle cell hemoglobin S (HbS) is recognized as a key event in the pathophysiology of sickle cell disease (SCD). Repeated HbS polymerization promotes an altered red blood cell (RBC) membrane, hemolysis, and microparticles (MP) formation, which have been shown to play a significant role in the interaction of RBCs with vascular endothelium and progression of vaso-occlusive events. We have recently reported that free HbS oxidizes faster, remains locked in a highly oxidizing form (ferryl) longer and loses heme faster than normal HbA. The first part of this seminar will focus on the L...
Source: Videocast - All Events - March 21, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Innate Lymphoid cell (ILC) subsets Controlled by Dynamic Expression of Master Regulators
Immunonology IG Seminar
Dr. Jinfang Zhu received his Ph.D. in biochemistry and molecular biology from the Shanghai Institute of Biochemistry, Chinese Academy of Sciences. He completed his postdoctoral training at the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, with late Dr. William E. Paul, studying CD4 T helper cell differentiation controlled by key transcription factors including GATA3 and T-bet. He started his own group in the Laboratory of Immunology as an Earl Stadtman investigator, and is now the section chief of the Molecular and Cellular Immunoregulation Section in the Laborator...
Source: Videocast - All Events - March 16, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
PD-1 Cancer Immunotherapy
NCI Center for Cancer Research Eminent Lecture Series
Gordon J. Freeman, PhD works in the Department of Medical Oncology at Dana-Farber Cancer Institute and is Professor of Medicine at Harvard Medical School. Dr. Freeman earned his BA in Biochemistry and Molecular Biology, and PhD in Microbiology and Molecular Genetics from Harvard University. His research has identified the major pathways that control the immune response by inhibiting T cell activation (PD-1/PD-L1 and B7-2/CTLA-4) or stimulating T cell activation (B7-2/CD28).
In 2000, Dr. Freeman discovered PD-L1 and PD-L2, and showed they were ligands for PD-1, thus def...
Source: Videocast - All Events - March 16, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
RNA Methylation in Gene Expression Regulation
NCI's Center for Cancer Research (CCR) Grand Rounds
Chuan He, Ph.D., is the John T. Wilson Distinguished Service Professor in the Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics at the University of Chicago. He was born in P. R. China in 1972 and received his B.S. (1994) from the University of Science and Technology of China. He received his Ph.D. degree from Massachusetts Institute of Technology in chemistry in 2000 with Professor Stephen J. Lippard. After being trained as a Damon-Runyon postdoctoral fellow with Professor Gregory L. Verdine at Harvard Unive...
Source: Videocast - All Events - February 20, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Sensing from within: how the immune system discriminates friend from foe
NIH Director's Wednesday Afternoon Lecture Series
The Fitzgerald lab is focused on understanding the molecular mechanisms controlling the inflammatory response. We are interested in determining how the immune system discriminates between pathogens, resident microflora and host molecules to both protect the host from infection and avoid damaging inflammatory diseases. We employ multifaceted approaches including immunology, biochemistry, molecular biology and genetics to understand these mechanisms.For more information go tohttps://oir.nih.gov/wals/2017-2018/Air date: 4/25/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 14, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Foxo1 regulates commensalism via modulating goblet cell mucus secretion
Immunonology IG Seminar
Dr. Wu completed his M.D. studies in China at Shanghai Jiaotong University School of Medicine, and then studied immunology and matrix biology as a graduate student at Muenster University, Germany. His main focus was T cell migration during the central nervous system (CNS) inflammation. He joined Dr. Vijay Kuchroo ’ s lab in Brigham and Women ’ s Hospital, Harvard Medical School as a postdoctoral fellow where he studied the molecular regulation of T cell differentiation during inflammation and autoimmunity. In 2017, Dr. Wu started a position as an NIH Stadtman Tenure-Track Investigator at the Exp...
Source: Videocast - All Events - February 12, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
HPV VLPs: Nature ’ s Nanoparticles for Prevention and Treatment of Cancer
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. John Schiller graduated from the University of Wisconsin-Madison with a B.S. in molecular biology in 1975. In 1982, he received a Ph.D. from the Department of Microbiology of the University of Washington in Seattle, then joined the NCI Laboratory of Cellular Oncology as a National Research Service Award postdoctoral fellow in 1983. Dr. Schiller became a senior staff fellow in the Laboratory of Cellular Oncology in 1986 and a senior investigator in 1992. He became chief of the Neoplastic Disease Section of the lab in 1998, deputy lab chief in 2000 and designated as...
Source: Videocast - All Events - February 5, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Application of MALDI-Ion Mobility Mass Spectrometry in Biological Analysis
Proteomics Interest Group
Ion mobility (IM) spectrometry is a robust method that allows for the rapid separation and detection of a wide range of compounds. In this technique, ions in the drift cell obtain an average drift velocity from an electric field based upon their collision cross section (W) or shape, which allows for the separation of molecules depending upon their three-dimensional structure. Combining matrix-assisted laser desorption/ionization (MALDI) mass spectrometry with IM results in the fast sorting of biomolecules in complex mixtures along trend lines. In this 2D analysis of biological families, lipids, pe...
Source: Videocast - All Events - January 29, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Joseph J. Kinyoun Memorial Lecture - Antibodies Against Ebola and Lassa: A Global Collaboration
Joseph J. Kinyoun Memorial Lecture 2017
Dr. Erica Ollmann Saphire, director of the Viral Hemorrhagic Fever Immunotherapeutic Consortium (VIC), will deliver the 2017 Joseph J. Kinyoun Memorial Lecture.
Her talk, “ Antibodies Against Ebola and Lassa: A Global Collaboration, ” will explore the features of antibodies that protect against these deadly viruses and the ongoing need for scientists to collaborate in this research to establish a complete knowledge base. During the past three years, VIC researchers from dozens of labs on five continents have studied these protective antibodies. The VIC aims to fill critical knowl...
Source: Videocast - All Events - November 27, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Stem Cell Aging
GeroScience Interest Group
The Trans-NIH GeroScience Interest Group (GSIG), cordially invites you to its fall seminar, featuring Dr. Sean Morrison. Dr. Morrison is the Director of the Children ’ s Medical Center Research Institute at UT Southwestern and is the Mary McDermott Cook Chair in Pediatric Genetics as well as an Investigator of the Howard Hughes Medical Institute. The Morrison laboratory studies the cellular and molecular mechanisms that regulate the function of stem cells and cancer cells in the nervous and hematopoietic systems. The laboratory is particularly interested in the mechanisms that regulate stem cel...
Source: Videocast - All Events - October 26, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
