A self-amplifying loop of TP53INP1 and P53 drives oxidative stress-induced apoptosis of bone marrow mesenchymal stem cells
AbstractBone marrow mesenchymal stem cell (BMSC) transplantation is a promising regenerative therapy; however, the survival rate of BMSCs after transplantation is low. Oxidative stress is one of the main reasons for the high apoptosis rate of BMSCs after transplantation, so there is an urgent need to explore the mechanism of oxidative stress-induced apoptosis of BMSCs. Our previous transcriptome sequencing results suggested that the expression of P53-induced nuclear protein 1 (TP53INP1) and the tumor suppressor P53 (P53) was significantly upregulated during the process of oxidative stress-induced apoptosis of BMSCs. The pr...
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
From ferroptosis to cuproptosis, and calcicoptosis, to find more novel metals-mediated distinct form of regulated cell death
AbstractRegulated cell death (RCD), also known as programmed cell death (PCD), plays a critical role in various biological processes, such as tissue injury/repair, development, and homeostasis. Dysregulation of RCD pathways can lead to the development of many human diseases, such as cancer, neurodegenerative disorders, and cardiovascular diseases. Maintaining proper metal ion homeostasis is critical for human health. However, imbalances in metal levels within cells can result in cytotoxicity and cell death, leading to a variety of diseases and health problems. In recent years, new types of metal overload-induced cell death...
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
FAM83B regulates mitochondrial metabolism and anti-apoptotic activity in pulmonary adenocarcinoma
This study aims to understand how increased FAM83B expression impacts mitochondrial activity, cell apoptosis, and chemotherapy effectiveness in LUAD. Multiple assays, such as CCK8, wound healing, EdU, and transwell assays, were employed to confirm the augmented chemotherapy resistance, heightened cell proliferation, migration, and invasion caused by FAM83B overexpression in LUAD cells. Furthermore, MIMP, MTG, and ATP assays were utilized to quantify changes in mitochondrial metabolism. In vitro functional assays were performed to evaluate the influence of FAM83B overexpression on the malignant progression and resistance me...
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
Supramolecular electrochemical probe based on the system of tetrazole derivative pillar[5]arene/methylene blue
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00591K, PaperLaysan Makhmutova, Dmitriy Shurpik, Olga Mostovaya, Natalia Lachugina, Alexander Gerasimov, Adelya Guseinova, Gennady Evtugyn, Ivan Stoikov For the first time, an original synthetic approach has been developed that makes it possible to introduce ten tetrazole fragments into the pillar[5]arene structure. A supramolecular electrochemical probe was assembled... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 1, 2024 Category: Molecular Biology Authors: Laysan Makhmutova Source Type: research
Structure and isomerization behavior relationships of new push –pull azo-pyrrole photoswitches
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.David Gallardo-Rosas, Jos é Manuel Guevara-Vela, Tomás Rocha-Rinza, Ruben Alfredo Toscano, Jose G. López-Cortés, M. Carmen Ortega-Alfaro A new family of stilbenyl-azopyrroles compounds 2a-d and 3a –d was efficiently obtained via a Mizoroki-Heck C-C-type coupling reaction between 2-(4’-iodophenyl-azo)-N-methyl pyrrole (1a) and different vinyl precursors. The influence of the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 1, 2024 Category: Molecular Biology Authors: David Gallardo-Rosas Source Type: research
Development of 18F-Labeled Azobenzothiazole Tracer for α-Synuclein Aggregates in the Brain
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00492B, PaperJiajun Wu, Meiting Mao, Jie Yang, Kexin Li, Pengxin Deng, Jing Zhong, Xiaoai Wu, Yan Cheng Nuclear imaging of aggregated α-synuclein pathology is in urgent clinical need for Parkinson’s disease, yet promising tracers for brain α-synuclein aggregates are still rare. In this work, a class of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 1, 2024 Category: Molecular Biology Authors: Jiajun Wu Source Type: research
Cuproptosis: unveiling a new frontier in cancer biology and therapeutics
Copper plays vital roles in numerous cellular processes and its imbalance can lead to oxidative stress and dysfunction. Recent research has unveiled a unique form of copper-induced cell death, termed cuproptos... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - May 1, 2024 Category: Molecular Biology Authors: Ying Feng, Zhibo Yang, Jianpeng Wang and Hai Zhao Tags: Review Source Type: research
Non-gastrointestinal stromal tumor, mesenchymal neoplasms of the gastrointestinal tract: a review of tumor genetics, pathology, and cross-sectional imaging findings
This article aims to elucidate the cross-sectional imaging findings associated with a wide spectrum of these tumors, providing insights that align with their histopathological features.Graphical abstract (Source: Abdominal Imaging)
Source: Abdominal Imaging - May 1, 2024 Category: Radiology Source Type: research
Translational two-pore PBPK model to characterize whole-body disposition of different-size endogenous and exogenous proteins
AbstractTwo-pore physiologically based pharmacokinetic (PBPK) modeling has demonstrated its potential in describing the pharmacokinetics (PK) of different-size proteins. However, all existing two-pore models lack either diverse proteins for validation or interspecies extrapolation. To fill the gap, here we have developed and optimized a translational two-pore PBPK model that can characterize plasma and tissue disposition of different-size proteins in mice, rats, monkeys, and humans. Datasets used for model development include more than 15 types of proteins: IgG (150 kDa), F(ab)2 (100 kDa), minibody (80 kDa), Fc-contain...
Source: Journal of Pharmacokinetics and Pharmacodynamics - May 1, 2024 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 29, Pages 2085: Optimization of Composite Enzymatic Extraction, Structural Characterization and Biological Activity of Soluble Dietary Fiber from Akebia trifoliata Peel
Yu
Huayan Zheng
In order to reduce the waste of Akebia trifoliata peel and maximize its utilization, in this study, on the basis of a single-factor experiment and the response surface method, the optimum technological conditions for the extraction of soluble dietary fiber from Akebia trifoliata peel with the compound enzyme method were obtained. The chemical composition, physical and chemical properties, structural characterization and biological activity of the purified soluble dietary fiber (AP-SDF) from the Akebia trifoliata peel were analyzed. We discovered that that the optimum yield was 20.87% under the conditi...
Source: Molecules - May 1, 2024 Category: Chemistry Authors: Ya Song Guoshun Sun Dian Wang Jin Chen Jun Lv Sixia Jiang Guoqiang Zhang Shirui Yu Huayan Zheng Tags: Article Source Type: research
Tetrahydrobiopterin metabolism attenuates ROS generation and radiosensitivity through LDHA S-nitrosylation: novel insight into radiogenic lung injury
Experimental & Molecular Medicine, Published online: 01 May 2024; doi:10.1038/s12276-024-01208-zRadiation therapy for cancer can harm healthy tissues, causing swelling and oxidative stress (an imbalance between free radicals and antioxidants in your body). This research examined the part of a molecule named tetrahydrobiopterin (BH4) in this. The scientists discovered that radiation therapy decreases the amount of BH4 in the body, which then leads to a rise in harmful reactive oxygen species (ROS - molecules that can damage cells). However, when BH4 amounts were artificially boosted, this lowered ROS levels and shielded...
Source: Experimental and Molecular Medicine - May 1, 2024 Category: Molecular Biology Authors: Yang Feng Yahui Feng Liming Gu Wei Mo Xi Wang Bin Song Min Hong Fenghao Geng Pei Huang Hongying Yang Wei Zhu Yang Jiao Qi Zhang Wei-Qun Ding Jianping Cao Shuyu Zhang Source Type: research
TLR7-dependent eosinophil degranulation links psoriatic skin inflammation to small intestinal inflammatory changes in mice
This study could possibly lead to new psoriasis treatments.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author. (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - May 1, 2024 Category: Molecular Biology Authors: Hee Joo Kim Jinsun Jang Kunhee Na Eun-Hui Lee Hyeon-Jung Gu Yoon Hee Lim Seul-A Joo Seung Eun Baek Joo-Young Roh Han-Joo Maeng Yun Hak Kim Young-Jae Lee Byung-Chul Oh YunJae Jung Source Type: research
Paradigm shift required for translational research on the brain
This study introduces a new translational research method that combines high-throughput analysis tools—which are techniques that can analyze a large amount of data quickly - like neuroimaging, multi-omics, and artificial intelligence (AI). The study suggests that combining neuroimaging, multi-omics, and AI can offer valuable insights, such as new disease markers, subtypes, and treatments. The authors believe this new method could overcome the limitations of traditional methods, leading to a better understanding of brain disorders and the development of new diagnostic tools and treatments.This summary was initially drafte...
Source: Experimental and Molecular Medicine - May 1, 2024 Category: Molecular Biology Authors: Jong Hyuk Yoon Dongha Lee Chany Lee Eunji Cho Seulah Lee Amaury Cazenave-Gassiot Kipom Kim Sehyun Chae Edward A. Dennis Pann-Ghill Suh Source Type: research
Socialized mitochondria: mitonuclear crosstalk in stress
Experimental & Molecular Medicine, Published online: 01 May 2024; doi:10.1038/s12276-024-01211-4Mitochondria, the energy producers in our cells, have a more intricate role than we thought. Kim and Lee’s study examines how mitochondria interact with the rest of the cell, especially the nucleus (cell’s control center), when under stress. They thoroughly reviewed existing research, focusing on the different ways mitochondria pass on information. They discovered that mitochondria can send messages to the nucleus using various molecules, including acetyl-coenzyme A, reactive oxygen species, calcium ions, and even small ...
Source: Experimental and Molecular Medicine - May 1, 2024 Category: Molecular Biology Authors: Kyung Hwa Kim Cho Bi Lee Source Type: research
Stress-induced epinephrine promotes hepatocellular carcinoma progression via the USP10-PLAGL2 signaling loop
This study offers new understanding of stress’s role in cancer progression and potential targets for HCC treatment. The scientists concluded that more research is required to fully comprehend these results for future cancer therapies.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author. (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - May 1, 2024 Category: Molecular Biology Authors: Chen Wang Jiaping Ni Dongqing Zhai Yanchao Xu Zijie Wu Yuyuan Chen Ning Liu Juan Du Yumeng Shen Guilai Liu Yong Yang Linjun You Weiwei Hu Source Type: research
