Photoinduced metal-free trifluoro/perfluoroalkylation of heteroarenes
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00511B, CommunicationRavi Prakash Singh, Shashank Singh A practical and straightforward protocol to access trifluoromethylated/perfluoroalkylated heteroarenes via radical type nucleophilic substitution rather than typical radical type electrophilic substitution is described here. The substrate scope was observed to... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 29, 2024 Category: Molecular Biology Authors: Ravi Prakash Singh Source Type: research
Promoting Translational Approaches in Psychiatry
The relative lack of progress in psychiatry compared to other medical disciplines over the past half century reflects the rudimentary experimental approaches available until recently. We now have a range of advanced tools that for the first time enable penetrating studies of the brain. These tools make it possible to understand how a cell ’s molecular constituents drive that cell’s functioning within a larger neural circuit, and we are just beginning to decode how circuits generate behaviors. Likewise, we can understand how experience affects those circuits and in turn alters the molecular constituents of individual ce...
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Eric Nestler Tags: PLENARY I: BIG PICTURE Source Type: research
The Impact of Translational Neuroscience Approaches on the Treatment of Substance Use Disorders
Addiction is a brain disorder shaped by strong biosocial factors and resulting in devastating consequences to individuals and to society. Three decades of significant progress in genetics and neuroscience research, coupled with the advent of new molecular and brain imaging tools have helped characterize the cellular and network processes participating in the transition from drug use into addiction. This has opened up the opportunity for new therapeutics that target mechanisms involved with neuroplasticity. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Nora D. Volkow Source Type: research
Early Resource Scarcity Causes Lasting Effects on Cognition and Sex-Specific Molecular Changes in Cortex
Brief early adversity can promote later resilience to substance use disorder (SUD). Our laboratory models this using the Limited Bedding/Nesting (LBN) manipulation, reducing resources only in rat pups ’ first week of life. LBN increases maternal pup-directed care at the expense of self-care. We found LBN decreases motivation for morphine. Here explore how LBN alters risky decision-making and potential mechanisms by which LBN has lasting effects on cognition. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Debra Bangasser Source Type: research
Abnormal Neuronal Excitability and Excitatory Neurotransmission in a Human iPSC Model of 22q11.2 Deletion Syndrome
In this study, we investigated the functional impact of 22q11.2 deletion on human cortical neurons using induced pluripotent stem cell (iPSC) models. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Jidong Guo, Weibo Niu, Bruce Cuthbert, Brett Henshey, Nicholas Massa, Opal Ousley, David Parker, Bradley Pearce, Elaine Walker, Joseph F. Cubells, Erica Duncan, Zhexing Wen Source Type: research
Cell Type-Specific Multi-Omics Analysis of Cocaine Use Disorder in the Human Caudate Nucleus Suggests Phosphodiesterases as a Pharmacological Target
Structural and functional alterations have been reported in the reward circuitry of the human brain in cocaine use disorder (CUD) but their molecular underpinnings remain poorly understood. Epigenetics and gene expression are highly cell-type specific highlighting the need for studying the CUD brain at single-cell resolution. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Lea Zillich, Annasara Artioli, Veronika Phorala, Eric Zillich, Ammar Jabali, Rainer Spanagel, Marcella Rietschel, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt Source Type: research
The Development of Neuroimaging Methodologies to Assist in the Diagnosis and Treatment of Alzheimer ’s Disease
Neuroimaging methodologies have seen some of their finest applications in neurodegenerative disorders such as Alzheimer ’s disease (AD). The diagnosis of AD has long been facilitated by structural (MRI) and functional (FDG PET) imaging techniques. The advent of AD-specific molecular imaging in the form of amyloid and tau PET has transformed clinical research in AD, which can now be conducted in biomarker confirmed participants. These methods have also transformed therapeutic research, as illustrated through the emergence of the first disease-modifying treatments for AD. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Christopher van Dyck Tags: Plenary and Symposium Abstracts 2 Source Type: research
Translational Strategies for Understanding Neural Circuitry Dysfunction in Schizophrenia
The locus of the disease process in most psychiatric disorders, the human brain, is an appropriately privileged organ that is currently not subjected to biopsy in the diagnostic process of psychiatric illnesses for both clinical and ethical reasons. As a result, research in psychiatry has lacked the means to directly study the molecular and structural alterations of the brain at cell type-specific resolution in the living state, a key strategy that has led to major advances in understanding diseases of other organs that are biopsied. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: David Lewis Source Type: research
Systems Biology Dissection of PTSD in Multiple Regions, Omics, and Cell-Types of the Brain
In this study, we employed a multi-omic systems biology approach to pinpoint regions, omics, and cell-types with disease-associated alteration. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Nikolaos Daskalakis, Artemis Iatrou, Chris Chatzinakos, Aarti Jajoo, Clara Snijders, PEC-PTSD Brainomics, Charles Nemeroff, Joel Kleinman, Kerry Ressler Source Type: research
From Decisions to Molecular Mechanisms: Investigating the Influence of Adolescent THC Exposure on Adult Decision Making
Despite debates around the addiction liability of cannabis, approximately 10-30% of regular users meet the criteria for Cannabis Use Disorder (CUD). One of the strongest predictors for the development of CUD is adolescent cannabis use, and emerging data now indicate that use of high potency products may potentiate this CUD risk. However, the causal relationship between adolescent exposure, THC potency, and addiction-related behavior remains contested. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Jacqueline-Merie Ferland, Daniel A. Garcia, Graeme Betts, Mason M. Silveira, Joao Bronze de Firmino, Catharine A. Winstanley, Yasmin L. Hurd Tags: SYMPOSIUM Source Type: research
Genotype-Environment Interactions at the Interface Between Psychosocial and Physical Health in Children
Psychosocial experiences affect children's development and health. Urban environments in particular expose children to chronic stress, which impacts the HPA axis and leads to an altered glucocorticoid response. Because glucocorticoids have a major anti-inflammatory action, negative psychosocial experiences may be associated with immunological disorders, including asthma. However, the molecular mechanisms underlying the effect of negative psychosocial experiences on asthma and their interaction with genetic risk remain unknown. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Ali Ranjbaran, Julong Wei, Justyna Resztak, Henriette Mair-Mejers, Julian Bruinsma, Adnan Alazizi, Xiaoquan Wen, Richard Slatcher, Samuele Zilioli, Roger Pique-Regi, Francesca Luca Source Type: research
Brain and Peripheral Whole Transcriptome Correlates of Depressive Disorders: Peripheral is Central to the Pathology
The human anterior-insula (Ant-Ins) and subgenual-anterior-cingulate (sgACC) are brain regions that regulate mood, but studies dissecting the molecular neurobiology of this network in mood disorders are sparse. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Dhivya Arasappan, Dennis Wylie, Abigail Spears, Simran Shah, Katrina Benjamin, Dayne Mayfield, Pavan K. Auluck, Ajeet Mandal, Yiyin Lui, Nirmala Akula, Stefano Marenco, Paul Rathouz, Francis McMahon, Mbemba Jabbi Tags: SYMPOSIUM Source Type: research
Multi-Omics Profiling of Human Hippocampus Reveals Increased Inflammation and Transcription Instability in Major Depressive Disorder
To decipher hippocampus cellular and molecular changes in major depression (MDD), we sequenced single-nucleus RNA (snRNA-seq) and accessible chromatin (snATAC-seq), spatial RNA (Visium, 10X Genomics) and multiome via deterministic barcoding in intact tissue (DBiT-seq). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Yang Xiao, Madeline Mariani, Graham Su, Yanxiang Deng, Cheick A. Sissoko, Tianyu Li, Sai Ma, Zhiliang Bai, Yang Liu, Gorazd Rosoklija, Tingting Wu, Andrew J. Dwork, Rene Hen, J. John Mann, Rong Fan, Kam Leong, Maura Boldrini Source Type: research
38. Identifying Novel Molecular Drivers of Autoimmunity in Paraneoplastic Anti-NMDAR Encephalitis
Paraneoplastic anti-NMDAR encephalitis is characterized by psychosis, mood symptoms, catatonia, seizures, and movement disorders in association with a teratoma. Symptoms are caused by antibodies targeting the NMDA receptor. Early resection of the tumor abrogates neuropsychiatric disease, suggesting tumor-associated drivers of autoimmunity. Recent evidence has identified ectopic lymphoid tissue in anti-NMDAR-associated teratomas; however, little is understood about the role of the tumor microenvironment in promoting autoimmunity. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Tova Gardin, Marcello DiStasio, Caleigh Mandel-Brehm, Sagar Bhatta, David Hafler Source Type: research
489. Deciphering the Molecular Basis of Aging in Substance Use Disorder: Integrative Transcriptomic and Methylomic Analysis
Substance Use Disorder (SUD) contributes to the early onset of age-related diseases and mortality. Although Accelerated Aging (AA) in people with SUD (pSUD) is a key factor in these outcomes, as indicated by changes in Epigenetic Clocks (EC), existing assessments of AA in pSUD primarily utilize ECs designed for non-brain tissues. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Bruno Kluwe-Schiavon, Gabriel R. Fries, Laura Stertz, Thomas Meyer, Consuelo Walss-Bass Source Type: research
