Multi-Omics Profiling of Human Hippocampus Reveals Increased Inflammation and Transcription Instability in Major Depressive Disorder

To decipher hippocampus cellular and molecular changes in major depression (MDD), we sequenced single-nucleus RNA (snRNA-seq) and accessible chromatin (snATAC-seq), spatial RNA (Visium, 10X Genomics) and multiome via deterministic barcoding in intact tissue (DBiT-seq).

Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Yang Xiao, Madeline Mariani, Graham Su, Yanxiang Deng, Cheick A. Sissoko, Tianyu Li, Sai Ma, Zhiliang Bai, Yang Liu, Gorazd Rosoklija, Tingting Wu, Andrew J. Dwork, Rene Hen, J. John Mann, Rong Fan, Kam Leong, Maura Boldrini Source Type: research