Cell Type-Specific Multi-Omics Analysis of Cocaine Use Disorder in the Human Caudate Nucleus Suggests Phosphodiesterases as a Pharmacological Target

Structural and functional alterations have been reported in the reward circuitry of the human brain in cocaine use disorder (CUD) but their molecular underpinnings remain poorly understood. Epigenetics and gene expression are highly cell-type specific highlighting the need for studying the CUD brain at single-cell resolution.

Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Lea Zillich, Annasara Artioli, Veronika Phorala, Eric Zillich, Ammar Jabali, Rainer Spanagel, Marcella Rietschel, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt Source Type: research