Glutathione peroxidase 4 restrains temporomandibular joint osteoarthritis progression by inhibiting ferroptosis
In conclusion, GPX4 and ferroptosis regulated the progression of TMJOA. Targeting ferroptosis might be an effective therapeutic strategy for TMJOA patients in the clinic.PMID:38686488 | PMC:PMC11058612 | DOI:10.1111/jcmm.18377 (Source: J Cell Mol Med)
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Chunyan Pang Hongmei Zhang Yi Liu Na Tang Kun Tian Yandong Mu Xue Li Li Xiao Source Type: research
Sirt7/HIC1 complex participates in hyperglycaemia-mediated EndMT via modulation of SDC1 expression in diabetic kidney disease and metabolic memory
This study demonstrated that the hyperglycaemia-mediated interaction between Sirt7 and HIC1 exerts a role in the metabolic memory in DKD by inactivating SDC1 transcription and mediating EndMT despite glucose normalization in HGECs.PMID:38686489 | PMC:PMC11058670 | DOI:10.1111/jcmm.18336 (Source: J Cell Mol Med)
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Lihong Lu Minmin Zhu Qichao Wu Zhirong Sun Xiangyuan Chen Changhong Miao Source Type: research
Malvidin attenuates trauma-induced heterotopic ossification of tendon in rats by targeting Rheb for degradation via the ubiquitin-proteasome pathway
This study aimed to investigate the effect of MA in treating trauma-induced HO and unravel its underlying mechanisms. Herein, the effectiveness of MA in preventing HO formation was assessed through local injection in a rat model. The potential mechanism underlying MA's treatment was investigated in the tendon-resident progenitor cells of tendon-derived stem cells (TDSCs), exploring its pathway in HO formation. The findings demonstrated that MA effectively hindered the osteogenic differentiation of TDSCs by inhibiting the mTORC1 signalling pathway, consequently impeding the progression of trauma-induced HO of Achilles tendo...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Huaji Jiang Yan Ding Xuemei Lin Qinyu Tian Yakui Liu Hebei He Yongfu Wu Xinggui Tian Stefan Zwingenberger Source Type: research
Expression of human dCTP pyrophosphatase 1 (DCTPP1) and its association with cisplatin resistance characteristics in ovarian cancer
In this study, we aimed to understand the role of DCTPP1 in cancer progression and cisplatin response. Using publicly available databases, we analysed the expression and clinical significance of DCTPP1 in ovarian cancer. Our bioinformatics analysis confirmed that DCTPP1 is significantly overexpressed in ovarian cancer and is closely associated with tumour progression and poor prognosis after cisplatin treatment. We also found that DCTPP1 located in oxidoreductase complex and may be involved in various biological processes related to cisplatin resistance, including pyrimidine nucleotide metabolism, the P53 signalling pathwa...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Yu Wang Xiangyun Chen Qiduan Chen Tiancai Liu Yingsong Wu Liping Huang Yao Chen Source Type: research
Fangchinoline inhibits growth and biofilm of Candida albicans by inducing ROS overproduction
J Cell Mol Med. 2024 May;28(9):e18354. doi: 10.1111/jcmm.18354.ABSTRACTInfections caused by Candida species, especially Candida albicans, threaten the public health and create economic burden. Shortage of antifungals and emergence of drug resistance call for new antifungal therapies while natural products were attractive sources for developing new drugs. In our study, fangchinoline, a bis-benzylisoquinoline alkaloid from Chinese herb Stephania tetrandra S. Moore, exerted antifungal effects on planktonic growth of several Candida species including C. albicans, with MIC no more than 50 μg/mL. In addition, results from micro...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Longfei Yang Xiaonan Wang Zhiming Ma Yujie Sui Xin Liu Source Type: research
Multi-omics analysis reveals the association between specific solute carrier proteins gene expression patterns and the immune suppressive microenvironment in glioma
J Cell Mol Med. 2024 May;28(9):e18339. doi: 10.1111/jcmm.18339.ABSTRACTGlioma is the most prevalent malignant brain tumour. Currently, reshaping its tumour microenvironment has emerged as an appealing strategy to enhance therapeutic efficacy. As the largest group of transmembrane transport proteins, solute carrier proteins (SLCs) are responsible for the transmembrane transport of various metabolites and ions. They play a crucial role in regulating the metabolism and functions of malignant cells and immune cells within the tumour microenvironment, making them a promising target in cancer therapy. Through multidimensional da...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Wenjie Wu Cheng Jiang Wende Zhu Xiaobing Jiang Source Type: research
Glycerol 3-phosphate dehydrogenases (1 and 2) in cancer and other diseases
Exp Mol Med. 2024 May 1. doi: 10.1038/s12276-024-01222-1. Online ahead of print.ABSTRACTThe glycerol 3-phosphate shuttle (GPS) is composed of two different enzymes: cytosolic NAD+-linked glycerol 3-phosphate dehydrogenase 1 (GPD1) and mitochondrial FAD-linked glycerol 3-phosphate dehydrogenase 2 (GPD2). These two enzymes work together to act as an NADH shuttle for mitochondrial bioenergetics and function as an important bridge between glucose and lipid metabolism. Since these genes were discovered in the 1960s, their abnormal expression has been described in various metabolic diseases and tumors. Nevertheless, it took a lo...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Sehyun Oh Xuan Linh Mai Jiwoo Kim Arvie Camille V de Guzman Ji Yun Lee Sunghyouk Park Source Type: research
RNA-binding proteins and exoribonucleases modulating miRNA in cancer: the enemy within
Exp Mol Med. 2024 May 1. doi: 10.1038/s12276-024-01224-z. Online ahead of print.ABSTRACTRecent progress in the investigation of microRNA (miRNA) biogenesis and the miRNA processing machinery has revealed previously unknown roles of posttranscriptional regulation in gene expression. The molecular mechanistic interplay between miRNAs and their regulatory factors, RNA-binding proteins (RBPs) and exoribonucleases, has been revealed to play a critical role in tumorigenesis. Moreover, recent studies have shown that the proliferation of hepatocellular carcinoma (HCC)-causing hepatitis C virus (HCV) is also characterized by close ...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Yoona Seo Jiho Rhim Jong Heon Kim Source Type: research
Stress-induced epinephrine promotes hepatocellular carcinoma progression via the USP10-PLAGL2 signaling loop
Exp Mol Med. 2024 May 1. doi: 10.1038/s12276-024-01223-0. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is associated with a poor prognosis. Our previous study demonstrated that Pleomorphic adenoma gene like-2 (PLAGL2) was a potential therapeutic target in HCC. However, the mechanisms that lead to the upregulation of PLAGL2 in HCC remain unclear. The present study revealed that stress-induced epinephrine increased the expression of PLAGL2, thereby promoting the progression of HCC. Furthermore, PLAGL2 knockdown inhibited epinephrine-induced HCC development. Mechanistically, epinephrine upregulated ubiquitin-s...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Chen Wang Jiaping Ni Dongqing Zhai Yanchao Xu Zijie Wu Yuyuan Chen Ning Liu Juan Du Yumeng Shen Guilai Liu Yong Yang Linjun You Weiwei Hu Source Type: research
Paradigm shift required for translational research on the brain
Exp Mol Med. 2024 May 1. doi: 10.1038/s12276-024-01218-x. Online ahead of print.ABSTRACTBiomedical research on the brain has led to many discoveries and developments, such as understanding human consciousness and the mind and overcoming brain diseases. However, historical biomedical research on the brain has unique characteristics that differ from those of conventional biomedical research. For example, there are different scientific interpretations due to the high complexity of the brain and insufficient intercommunication between researchers of different disciplines owing to the limited conceptual and technical overlap of...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Jong Hyuk Yoon Dongha Lee Chany Lee Eunji Cho Seulah Lee Amaury Cazenave-Gassiot Kipom Kim Sehyun Chae Edward A Dennis Pann-Ghill Suh Source Type: research
TLR7-dependent eosinophil degranulation links psoriatic skin inflammation to small intestinal inflammatory changes in mice
Exp Mol Med. 2024 May 1. doi: 10.1038/s12276-024-01225-y. Online ahead of print.ABSTRACTRecent evidence of gut microbiota dysbiosis in the context of psoriasis and the increased cooccurrence of inflammatory bowel disease and psoriasis suggest a close relationship between skin and gut immune responses. Using a mouse model of psoriasis induced by the Toll-like receptor (TLR) 7 ligand imiquimod, we found that psoriatic dermatitis was accompanied by inflammatory changes in the small intestine associated with eosinophil degranulation, which impaired intestinal barrier integrity. Inflammatory responses in the skin and small inte...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Hee Joo Kim Jinsun Jang Kunhee Na Eun-Hui Lee Hyeon-Jung Gu Yoon Hee Lim Seul-A Joo Seung Eun Baek Joo-Young Roh Han-Joo Maeng Yun Hak Kim Young-Jae Lee Byung-Chul Oh YunJae Jung Source Type: research
Mrgprb2-mediated mast cell activation exacerbates Modic changes by regulating immune niches
Exp Mol Med. 2024 May 1. doi: 10.1038/s12276-024-01230-1. Online ahead of print.ABSTRACTModic changes are radiographic features associated with microfracture, low-virulence organism infection and chronic inflammation with inflammatory cell infiltration in the vertebral endplate region. Mast cells, as innate immune cells similar to macrophages, are present in painful degenerated intervertebral discs. However, the involvement and mechanisms of mast cells in the development of Modic changes remain unclear. Herein, we found increased mast cell infiltration in samples from patients with Modic changes and in mouse models of Modi...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Zhongyin Ji Jie Li Siyue Tao Hui Li Xiangxi Kong Bao Huang Zhenhua Feng Xiaoan Wei Zeyu Zheng Jian Chen Binhui Chen Junhui Liu Fengdong Zhao Source Type: research
Targeting pyruvate dehydrogenase kinase 1 overcomes EGFR C797S mutation-driven osimertinib resistance in non-small cell lung cancer
In this study, we explored the role of pyruvate dehydrogenase kinase 1 (PDK1) in osimertinib resistance. Patients exhibiting osimertinib resistance initially displayed elevated PDK1 expression. Osimertinib-resistant cell lines with the EGFR C797S mutation were established using A549, NCI-H292, PC-9, and NCI-H1975 NSCLC cells for both in vitro and in vivo investigations. These EGFR C797S mutant cells exhibited heightened phosphorylation of EGFR, leading to the activation of downstream oncogenic pathways. The EGFR C797S mutation appeared to increase PDK1-driven glycolysis through the EGFR/AKT/HIF-1α axis. Combining osimerti...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Wonyoung Park Shibo Wei Chu-Long Xie Jung Ho Han Bo-Sung Kim Bosung Kim Jung-Sook Jin Eun-Sun Yang Min Kyoung Cho Dongryeol Ryu Hao-Xian Yang Sung-Jin Bae Ki-Tae Ha Source Type: research
Glutamine-derived aspartate is required for eIF5A hypusination-mediated translation of HIF-1 α to induce the polarization of tumor-associated macrophages
Exp Mol Med. 2024 May 1. doi: 10.1038/s12276-024-01214-1. Online ahead of print.ABSTRACTTumor-associated macrophages (TAMs) are vital contributors to the growth, metastasis, and therapeutic resistance of various cancers, including hepatocellular carcinoma (HCC). However, the exact phenotype of TAMs and the mechanisms underlying their modulation for therapeutic purposes have not been determined. Here, we present compelling evidence that glutamine-derived aspartate in TAMs stimulates spermidine production through the polyamine synthesis pathway, thereby increasing the translation efficiency of HIF-1α via eIF5A hypusination....
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Dong-Ho Kim Yoo Na Kang Jonghwa Jin Mihyang Park Daehoon Kim Ghilsuk Yoon Jae Won Yun Jaebon Lee Soo Young Park Yu Rim Lee Jun-Kyu Byun Yeon-Kyung Choi Keun-Gyu Park Source Type: research
Neutrophils and neutrophil extracellular traps in oral health and disease
Exp Mol Med. 2024 May 1. doi: 10.1038/s12276-024-01219-w. Online ahead of print.ABSTRACTNeutrophils perform essential functions in antimicrobial defense and tissue maintenance at mucosal barriers. However, a dysregulated neutrophil response and, in particular, the excessive release of neutrophil extracellular traps (NETs) are implicated in the pathology of various diseases. In this review, we provide an overview of the basic concepts related to neutrophil functions, including NET formation, and discuss the mechanisms associated with NET activation and function in the context of the prevalent oral disease periodontitis.PMID...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Tae Sung Kim Niki M Moutsopoulos Source Type: research
