Role of the Ca < sub > V < /sub > 1.2 distal carboxy terminus in the regulation of L-type current

In conclusion, our results suggest that the interaction between DCRD and PCRD is sufficient to bring about the current inhibition and alter the voltage-dependent inactivation, possibly in an allosteric manner. Additionally, our data suggest that the DCtermD competitively modifies the calcium-dependent mechanism. The identified peptide sequence provides a valuable tool for further dissecting the molecular mechanisms that regulate L-type calcium channels' basal activity in cardiomyocytes.PMID:38691022 | DOI:10.1080/19336950.2024.2338782
Source: Channels - Category: Molecular Biology Authors: Source Type: research