183. A Multimodal Investigation of the Antidepressant Mechanisms of rTMS: Glutamatergic Metabolism Influences Changes in Functional Connectivity

Normalization of aberrant functional connectivity may underlie the antidepressant effects of repetitive transcranial magnetic stimulation (rTMS). The underlying molecular basis of such changes remains unknown, limiting discovery and evaluation of therapeutic targets. Using proton magnetic resonance spectroscopy, we evaluated how neurometabolites related to seed-based whole-brain connectivity and corresponding depression symptoms prior to and following rTMS.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research