Left main coronary artery vasospasm: A case report of misdiagnosed severe coronary artery disease
CONCLUSION: LMCA spasm is rare but can mimic CAD leading to misdiagnosis and unnecessary surgery. Physicians should have a high suspicion for spasm especially in patients with anginal chest pain who lack CAD risk factors. CCTA can unmask spasm and prevent unnecessary interventions.PMID:35592822 | PMC:PMC9111888 | DOI:10.1016/j.amsu.2022.103691 (Source: Annals of Medicine)
Source: Annals of Medicine - May 20, 2022 Category: Internal Medicine Authors: Mahmoud Ismayl Waiel Abusnina Noraldeen El Yousfi Ahmed Aboeata Nattapong Sricharoen Source Type: research
Rest/stress myocardial perfusion imaging by positron emission tomography with 18F-Flurpiridaz: A feasibility study in mice
ConclusionOur findings suggest that a simplified assessment of relative myocardial perfusion and CFR, based on image-derived tracer uptake, is feasible with18F-flurpiridaz in mice, enabling high-throughput mechanistic CFR studies in rodents. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 28, 2022 Category: Nuclear Medicine Source Type: research
Regadenoson is Safe and Reduces Systemic Inflammation Post Lung Transplantation
We hypothesized that regadenoson, an adenosine A2A receptor (A2AR)- selective agonist, will attenuate the ischemia-reperfusion injury in lung transplant recipients. Clinical trial (NCT03072589) evaluated the safety of regadenoson infusion during and after lung transplantation. Primary graft dysfunction (PGD) scores and selected molecular biomarkers were also assessed. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2022 Category: Transplant Surgery Authors: Y. Zhao, J. Rabin, E. Mostafa, E. Fleischmann, M. Al-Suqi, U. Dhru, M.R. Conaway, J. Linden, A.S. Krupnick, S.P. Atamas, C.L. Lau Tags: (1042) Source Type: research
Molecules, Vol. 27, Pages 2287: Ligand and Structure-Based In Silico Determination of the Most Promising SARS-CoV-2 nsp16-nsp10 2 & prime;-o-Methyltransferase Complex Inhibitors among 3009 FDA Approved Drugs
Molecules, Vol. 27, Pages 2287: Ligand and Structure-Based In Silico Determination of the Most Promising SARS-CoV-2 nsp16-nsp10 2′-o-Methyltransferase Complex Inhibitors among 3009 FDA Approved Drugs
Molecules doi: 10.3390/molecules27072287
Authors:
Ibrahim H. Eissa
Mohamed S. Alesawy
Abdulrahman M. Saleh
Eslam B. Elkaeed
Bshra A. A. Alsfouk
Abdul-Aziz M. M. El-Attar
Ahmed M. Metwaly
As a continuation of our earlier work against SARS-CoV-2, seven FDA-approved drugs were designated as the best SARS-CoV-2 nsp16-nsp10 2′-o-methyltransferase (2′OMTase) inhibitors throug...
Source: Molecules - March 31, 2022 Category: Chemistry Authors: Ibrahim H. Eissa Mohamed S. Alesawy Abdulrahman M. Saleh Eslam B. Elkaeed Bshra A. A. Alsfouk Abdul-Aziz M. M. El-Attar Ahmed M. Metwaly Tags: Article Source Type: research
Safety and tolerability of regadenoson compared with dipyridamole in myocardial perfusion imaging in patients scheduled to undergo medium to high-risk noncardiac surgery: a randomized controlled study
Conclusion
In our group of patients scheduled for myocardial perfusion imaging for preoperative assessment, the two agents, regadenoson and dipyridamole, have no significant differences in the frequency of mild adverse reactions and in aminophylline use, with regadenoson also having the advantage of faster symptom resolution. Nevertheless, dipyridamole can be considered as a well-tolerated and low-cost alternative. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Transient Opening of the Blood-Brain Barrier by Vasoactive Peptides to Increase CNS Drug Delivery: Reality Versus Wishful Thinking?
CONCLUSION: Vasoactive peptides remain an understudied class of drugs with the potential to increase drug delivery and improve treatment in patients with brain tumors and other neurologic diseases. Dozens of vasoactive peptides have yet to be formally evaluated for this important clinical effect. This narrative review summarizes the available data on vasoactive peptides, highlighting agents that deserve further in vitro and in vivo investigations.PMID:35100958 | DOI:10.2174/1570159X20999220131163504 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - February 1, 2022 Category: Drugs & Pharmacology Authors: Matthew A Smith-Cohn Nicholas B Burley Stuart A Grossman Source Type: research
Transient Opening of the Blood-Brain Barrier by Vasoactive Peptides to Increase CNS Drug Delivery: Reality Versus Wishful Thinking?
CONCLUSION: Vasoactive peptides remain an understudied class of drugs with the potential to increase drug delivery and improve treatment in patients with brain tumors and other neurologic diseases. Dozens of vasoactive peptides have yet to be formally evaluated for this important clinical effect. This narrative review summarizes the available data on vasoactive peptides, highlighting agents that deserve further in vitro and in vivo investigations.PMID:35100958 | DOI:10.2174/1570159X20999220131163504 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - February 1, 2022 Category: Drugs & Pharmacology Authors: Matthew A Smith-Cohn Nicholas B Burley Stuart A Grossman Source Type: research
Role of sex hormones in modulating myocardial perfusion and coronary flow reserve
CONCLUSION: Our experimental data in mice indicate that sex differences in myocardial perfusion are primarily driven by testosterone. Given the diagnostic importance of PET-MPI in clinical routine, further studies are warranted to determine whether testosterone levels affect the interpretation of myocardial perfusion findings in patients.PMID:35024889 | DOI:10.1007/s00259-022-05675-2 (Source: Molecular Medicine)
Source: Molecular Medicine - January 13, 2022 Category: Molecular Biology Authors: Ahmed Haider Susan Bengs Angela Portmann Alexia Rossi Hazem Ahmed Dominik Etter Geoffrey I Warnock Nidaa Mikail Muriel Gr ämer Alexander Meisel Livio Gisler Caitlin Jie Claudia Keller Sebastian Kozerke Bruno Weber Roger Schibli Linjing Mu Philipp A Kaufm Source Type: research
Role of sex hormones in modulating myocardial perfusion and coronary flow reserve
ConclusionOur experimental data in mice indicate that sex differences in myocardial perfusion are primarily driven by testosterone. Given the diagnostic importance of PET-MPI in clinical routine, further studies are warranted to determine whether testosterone levels affect the interpretation of myocardial perfusion findings in patients. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 13, 2022 Category: Nuclear Medicine Source Type: research
Multi-parametric cardiovascular magnetic resonance with regadenoson stress perfusion is safe following pediatric heart transplantation and identifies history of rejection and cardiac allograft vasculopathy
The progressive risk of graft failure in pediatric heart transplantation (PHT) necessitates close surveillance for rejection and coronary allograft vasculopathy (CAV). The current gold standard of surveillance... (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - November 22, 2021 Category: Radiology Authors: Nazia Husain, Kae Watanabe, Haben Berhane, Aditi Gupta, Michael Markl, Cynthia K. Rigsby and Joshua D. Robinson Tags: Research Source Type: research
Feasibility of computed tomography perfusion in patients with chronic total occlusion undergoing percutaneous coronary intervention
We aimed to establish the feasibility and safety of dynamic regadenoson computed tomography perfusion (CTP) in patients with chronic total occlusion (CTO) undergoing percutaneous coronary intervention (PCI). Ten consecutive CTO patients with preserved left ventricular ejection fraction ( ≥50%) underwent dynamic CTP prior to and at least 3 months after successful CTO recanalization. Quantitative absolute and indexed values of stress myocardial blood flow (MBF) were measured for each myocardial segment, and perfusion defect size was defined by the number of segments with indexed MBF ≤0.78. (Source: Journal of Cardiovascu...
Source: Journal of Cardiovascular Computed Tomography - November 13, 2021 Category: Radiology Authors: Maksymilian P. Opolski, Jacek Kwiecinski, Anna Oleksiak, Mariusz Kruk, Artur Debski, Paul Knaapen, Stefan P. Schumacher, Antoni Zysk, Adam Witkowski, Cezary Kepka Source Type: research
The Feasibility, Tolerability, Safety, and Accuracy of Low-radiation Dynamic Computed Tomography Myocardial Perfusion Imaging With Regadenoson Compared With Single-photon Emission Computed Tomography
Conclusions:
This study demonstrated that CT-MPI is safe, well tolerated, and can be performed with comparable radiation exposure to SPECT. CT-MPI has the benefit of providing both complete anatomic coronary evaluation and assessment of myocardial perfusion. (Source: Journal of Thoracic Imaging)
Source: Journal of Thoracic Imaging - October 28, 2021 Category: Radiology Tags: Original Articles Source Type: research
