The evolution of the prognostic value of regadenoson SPECT myocardial perfusion imaging
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 28, 2020 Category: Nuclear Medicine Source Type: research

Asystole following Regadenoson administration: Review of literature, risk factors and management
AbstractRegadenoson, a selective A2A receptor agonist, is widely used for vasodilator stress myocardial perfusion imaging and has a superior adverse effect profile when compared with other agents. However, with widespread use, there have been several reported cases of Regadenoson induced bradyarrhythmias and even asystole in patients with no known conduction system disease. In this article, we report a case of asystole following Regadenoson administration, evaluate mechanisms and risk factors for Regadenoson induced bradyarrhythmias to better identify patients at risk. We also review the available treatment options and pro...
Source: Journal of Nuclear Cardiology - May 27, 2020 Category: Nuclear Medicine Source Type: research

Quantitative Assessment of Cardiac Hypermetabolism and Perfusion for Diagnosis of Cardiac Sarcoidosis
AbstractBackgroundQuantitative assessment of cardiac hypermetabolism from18Flourodeoxy glucose (FDG) positron emission tomography (PET) may improve diagnosis of cardiac sarcoidosis (CS). We assessed different approaches for quantification of cardiac hypermetabolism and perfusion in patients with suspected CS.Methods and resultsConsecutive patients undergoing18FDG PET assessment for possible CS between January 2014 and March 2019 were included. Cardiac hypermetabolism was quantified using maximal standardized uptake value (SUVMAX), cardiometabolic activity (CMA) and volume of inflammation, using relative thresholds (1.3 &ti...
Source: Journal of Nuclear Cardiology - May 27, 2020 Category: Nuclear Medicine Source Type: research

Gender differences in outcome in patients with diabetes mellitus
ConclusionsThe prognosis of diabetic patients for MACEs is different in men and women stratified by CAD. The worst prognosis for MACEs occurs in women with known CAD. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 26, 2020 Category: Nuclear Medicine Source Type: research

Parameters of left ventricular systolic and diastolic dyssynchrony on radionuclide imaging to improve cardiac resynchronization therapy in heart failure patients with dilated cardiomyopathy
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 26, 2020 Category: Nuclear Medicine Source Type: research

Value of combined perfusion and metabolic tracers versus stress –rest perfusion imaging for coronary heart disease
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 26, 2020 Category: Nuclear Medicine Source Type: research

To what extent are perfusion defects seen by myocardial perfusion SPECT in patients with left bundle branch block related to myocardial infarction, ECG characteristics, and myocardial wall motion?
AbstractIntroductionWe investigated if uptake pattern on myocardial perfusion SPECT (MPS) in patients with left bundle branch block (LBBB) is related to myocardial fibrosis, myocardial wall motion, and electrocardiography (ECG) characteristics.MethodsTwenty-three patients (9 women) with LBBB, examined with MPS and cardiac magnetic resonance (CMR), were included. Tracer uptake on MPS was classified by visual interpretation as typical LBBB pattern (Defect+, n  = 13) or not (Defect−, n = 10) and quantitatively. CMR images were evaluated for wall thickness and for myocardial wall motion both b...
Source: Journal of Nuclear Cardiology - May 25, 2020 Category: Nuclear Medicine Source Type: research

ASNC ’s efforts during the COVID-19 pandemic
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 25, 2020 Category: Nuclear Medicine Source Type: research

Comparison of myocardial blood flow and flow reserve with dobutamine and dipyridamole stress using rubidium-82 positron emission tomography
The objective of this study was to compare the hyperemic myocardial blood flow (MBF) and myocardial flow reserve (MFR) obtained with dobutamine to those of dipyridamole in patients referred for myocardial perfusion imaging (MPI) using82Rb positron emission tomography.MethodsOne hundred and fifty-six patients who underwent a82Rb PET MPI study with dobutamine stress were included. A matching cohort of patients who underwent a82Rb PET MPI study with dipyridamole stress was created, accounting for sex, age, history of coronary artery disease (CAD), prior revascularization, CAD risk factors, body mass index, and MPI interpretat...
Source: Journal of Nuclear Cardiology - May 24, 2020 Category: Nuclear Medicine Source Type: research

How can we take creative research a step further?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 24, 2020 Category: Nuclear Medicine Source Type: research

A potential pitfall in the use of 99m Tc-PYP imaging for diagnosing cardiac ATTR amyloidosis
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 24, 2020 Category: Nuclear Medicine Source Type: research

A positive Tc-99m PYP scan in a patient with cardiac sarcoidosis
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 22, 2020 Category: Nuclear Medicine Source Type: research

Evaluation of the diagnostic value of joint PET myocardial perfusion and metabolic imaging for vascular stenosis in patients with obstructive coronary artery disease
ConclusionsThe joint evaluation of PET rest MPI and MMI could improve the diagnostic performance for obstructive CAD. The multivariate model (MBF, SCR, and MIS) combined with SVM outperformed other methods. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 21, 2020 Category: Nuclear Medicine Source Type: research

A preliminary evaluation of a high temporal resolution data-driven motion correction algorithm for rubidium-82 on a SiPM PET-CT system
ConclusionThe DDMC algorithm shows great promise in rubidium MPI PET with substantial improvements in image quality and the potential to salvage images considered non-diagnostic due to significant motion blurring. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 21, 2020 Category: Nuclear Medicine Source Type: research

18F-FDG PET/CT identifying cardiac abscess formation prior to cardiac CT
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 21, 2020 Category: Nuclear Medicine Source Type: research

Rubidium-82 generator yield and efficiency for PET perfusion imaging: Comparison of two clinical systems
In this study, the82Rb isotope yield and production efficiency of two FDA-approved82Sr/82Rb generators were compared.MethodsN  = 515 sequential daily quality assurance (QA) reports from 9 CardioGen-82® and 9 RUBY-FILL® generators were reviewed over a period of 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL® system to determine an empirical correction-factor used to convert CardioGen-82® daily QA values of82Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mL·min−1) to RUBY-FILL® equivalent values (integrated &lsquo...
Source: Journal of Nuclear Cardiology - May 20, 2020 Category: Nuclear Medicine Source Type: research

Increased lung signal as a hint of COVID-19 infection on Tc-99m-sestamibi myocardial perfusion scintigraphy
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 20, 2020 Category: Nuclear Medicine Source Type: research

A machine learning-based approach to directly compare the diagnostic accuracy of myocardial perfusion imaging by conventional and cadmium-zinc telluride SPECT
AbstractBackgroundWe evaluated the performance of conventional (C) single-photon emission computed tomography (SPECT) and cadmium-zinc-telluride (CZT)-SPECT in a large cohort of patients with suspected or known coronary artery disease (CAD) and compared the diagnostic accuracy of the two systems using machine learning (ML) algorithms.Methods and ResultsA total of 517 consecutive patients underwent stress myocardial perfusion imaging (MPI) by both C-SPECT and CZT-SPECT. In the overall population, an excellent correlation between stress MPI data and left ventricular (LV) functional parameters measured by C-SPECT and by CZT-S...
Source: Journal of Nuclear Cardiology - May 18, 2020 Category: Nuclear Medicine Source Type: research

Cardiac software repeatability beyond correlations: Clinical outcomes matter
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 18, 2020 Category: Nuclear Medicine Source Type: research

Proliferation PET tracer 11 C-4DST PET/CT depicts hibernating myocardium
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 18, 2020 Category: Nuclear Medicine Source Type: research

Duration of proton pump inhibitor abstinence before myocardial perfusion scintigraphy
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 18, 2020 Category: Nuclear Medicine Source Type: research

Hypertrophic cardiomyopathy incidentally detected by 99mTc-HAS-D scintigraphy
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 18, 2020 Category: Nuclear Medicine Source Type: research

Duration of proton pump inhibitor abstinence before MPI
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 18, 2020 Category: Nuclear Medicine Source Type: research

Coronary microvascular dysfunction in patients with psoriasis
AbstractBackgroundPsoriasis is a common chronic inflammatory skin disorder that is associated with excess cardiovascular risk. Inflammation is a key mediator in the onset and progression of these cardiometabolic abnormalities; however, the excess cardiovascular risk conferred by psoriatic disease remains understudied. We investigated the prevalence and severity of CMD in patients with psoriasis and determined whether CMD is a result of CV risk factors and atherosclerotic burden.MethodsThis was a consecutive retrospective cohort study of patients with psoriasis, normal myocardial perfusion, and LV ejection fraction (EF) &th...
Source: Journal of Nuclear Cardiology - May 17, 2020 Category: Nuclear Medicine Source Type: research

Deep learning, another important tool for improving acquisition efficiency in SPECT MPI Imaging
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 17, 2020 Category: Nuclear Medicine Source Type: research

Guidance and best practices for nuclear cardiology laboratories during the coronavirus disease 2019 (COVID-19) pandemic: An Information Statement from ASNC and SNMMI
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 15, 2020 Category: Nuclear Medicine Source Type: research

Feasibility study of PET dynamic imaging of [ 18 F]DHMT for quantification of reactive oxygen species in the myocardium of large animals
ConclusionsA dynamic PET imaging technique for [18F]DHMT was developed with full and simplified kinetic modeling for absolute quantification of myocardial superoxide production in a large animal model. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 15, 2020 Category: Nuclear Medicine Source Type: research

Technetium pyrophosphate nuclear scintigraphy for cardiac amyloidosis: Imaging at 1 vs 3 hours and planar vs SPECT/CT
ConclusionThese data support the recommendation that SPECT/CT should be obtained in addition to planar images when performing nuclear scintigraphy for the detection of cardiac amyloidosis. A 1-hour planar and SPECT/CT protocol appears optimal. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 15, 2020 Category: Nuclear Medicine Source Type: research

Are we good enough in the evaluation of MPI using Rubidium82 with PMT PET/CT? A comparison to SiPM PET/CT
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 15, 2020 Category: Nuclear Medicine Source Type: research

Value of SiPM PET in myocardial perfusion imaging using Rubidium-82
ConclusionSiPM PET provides an improved image quality in comparison with PMT PET. Defect interpretation, interpreter ’s confidence, and absolute blood flow measurements were comparable between both systems. SiPM PET is therefore a reliable technique for MPI using Rb-82.Trial registrationToetsingOnline NL63853.075.17. Registered 13 November, 2017. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 14, 2020 Category: Nuclear Medicine Source Type: research

Machine learning-based risk model using 123 I-metaiodobenzylguanidine to differentially predict modes of cardiac death in heart failure
AbstractBackgroundCardiac sympathetic dysfunction is closely associated with cardiac mortality in patients with chronic heart failure (CHF). We analyzed the ability of machine learning incorporating123I-metaiodobenzylguanidine (MIBG) to differentially predict risk of life-threatening arrhythmic events (ArE) and heart failure death (HFD).Methods and ResultsA model was created based on patients with documented 2-year outcomes of CHF (n  = 526; age, 66 ± 14 years). Classifiers were trained using 13 variables including age, gender, NYHA functional class, left ventricular ejection fractio...
Source: Journal of Nuclear Cardiology - May 14, 2020 Category: Nuclear Medicine Source Type: research

Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2019: Positron emission tomography, computed tomography and magnetic resonance
AbstractIn 2019, theJournal of Nuclear Cardiology published excellent articles pertaining to imaging in patients with cardiovascular disease. In this review we will summarize a selection of these articles to provide a concise review of the main advancements that have recently occurred in the field and provide the reader with an opportunity to review a wide selection of articles. In this first article of this 2-part series we will focus on publications dealing with positron emission tomography, computed tomography and magnetic resonance. We will specifically discuss imaging as it relates to coronary artery disease, atherosc...
Source: Journal of Nuclear Cardiology - May 14, 2020 Category: Nuclear Medicine Source Type: research

Radiation exposure after myocardial perfusion imaging with Cadmium-Zinc-Telluride camera versus conventional camera
AbstractBackgroundPatient exposure to radiation during the management of coronary heart disease (CHD) can be reduced with more efficient technologies in nuclear medicine, such as the Cadmium-Zinc-Telluride (CZT) gamma-camera for myocardial perfusion imaging (MPI) studies. However, it has been suggested that CZT has lower specificity, which might lead to more downstream radiological procedures, particularly among obese individuals.Methods and ResultsWe evaluated 244 patients with suspected CHD who underwent CZT-SPECT and matched 1:1 according to sex, age, and body mass index (BMI) with those undergoing MPI study with the An...
Source: Journal of Nuclear Cardiology - May 14, 2020 Category: Nuclear Medicine Source Type: research

Coronary microvascular dysfunction post acute myocardial infarction
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 14, 2020 Category: Nuclear Medicine Source Type: research

Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2019: Single-photon emission computed tomography
AbstractIn 2019, theJournal of Nuclear Cardiology published excellent articles pertaining to imaging in patients with cardiovascular disease. In this review, we will summarize a selection of these articles to provide a concise review of the main advancements that have recently occurred in the field and provide the reader with an opportunity to review a wide selection of articles. In the first article of this 2-part series, we focused on publications dealing with positron emission tomography, computed tomography, and magnetic resonance. This review will place emphasis on myocardial perfusion imaging using single-photon emis...
Source: Journal of Nuclear Cardiology - May 14, 2020 Category: Nuclear Medicine Source Type: research

Assessment of left ventricular volumes and ejection fraction using ultra-low-dose thallium-201 SPECT on a CZT camera: a comparison with magnetic resonance imaging
ConclusionsLeft ventricular volumes and ejection fraction assessed via ultra-low-dose CZT-SPECT showed very good correlation with the values obtained by MRI. A moderate correlation was found for myocardial mass. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 14, 2020 Category: Nuclear Medicine Source Type: research

Paul J. Cannon, MD (1933 –2018)
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 14, 2020 Category: Nuclear Medicine Source Type: research

Left ventricular systolic and diastolic dyssynchrony to improve cardiac resynchronization therapy response in heart failure patients with dilated cardiomyopathy
This study aims to explore the predictive values of both systolic LVMD and diastolic LVMD for CRT in DCM patients.MethodsEighty-four consecutive CRT patients with both DCM and complete left bundle branch block (CLBBB) who received gated resting SPECT MPI at baseline were included in the present study. The phase analysis technique was applied on resting gated short-axis SPECT MPI images to measure systolic LVMD and diastolic LVMD, characterized by phase standard deviation (PSD) and phase histogram bandwidth (PBW). CRT response was defined as ≥ 5% improvement of LVEF at 6-month follow-up. Variables withP
Source: Journal of Nuclear Cardiology - May 13, 2020 Category: Nuclear Medicine Source Type: research

Is faster always better? What is the implication of a shorter time to imaging with tetrofosmin compared to sestamibi?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 13, 2020 Category: Nuclear Medicine Source Type: research

Finding hope amidst a pandemic
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 13, 2020 Category: Nuclear Medicine Source Type: research

Anomalous origin of the left coronary artery in patient with reduction of right coronary artery flow reserve detected by CZT camera
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 13, 2020 Category: Nuclear Medicine Source Type: research

Cardiovascular disease in the literature: A selection of recent original research papers
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 13, 2020 Category: Nuclear Medicine Source Type: research

99m Tc-labelled bone tracer myocardial quantification: About correlation with heart function
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 13, 2020 Category: Nuclear Medicine Source Type: research

Stress myocardial perfusion imaging in patients presenting with syncope: Comparison of PET vs. SPECT
AbstractBackgroundThe role of myocardial perfusion imaging (MPI) in patients with suspected coronary artery disease (CAD) presenting with syncope is controversial. We aimed to determine diagnostic yield of MPI for evaluation of syncope in patients without known CAD, as a function of pre-test patient risk and test modality (PET vs SPECT).MethodsBetween 1/2010 and 12/2016, 1324 consecutive patients presenting with syncope without known CAD underwent MPI with PET (n  = 640) or SPECT (n = 684). Rates of abnormal MPI (summed difference score (SDS) >  2 or left ventricular ejection fr...
Source: Journal of Nuclear Cardiology - May 13, 2020 Category: Nuclear Medicine Source Type: research

Mycotic coronary aneurysm detected by 18F-FDG PET/CT: A case report
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 13, 2020 Category: Nuclear Medicine Source Type: research

Technical aspects of gated SPECT MPI assessment of left ventricular dyssynchrony used in the VISION-CRT study
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 11, 2020 Category: Nuclear Medicine Source Type: research

Prognostic value of coronary risk factors, exercise capacity and single photon emission computed tomography in liver transplantation candidates: A 5-year follow-up study
ConclusionsMost deaths following OLT are noncardiovascular. Nonetheless, abnormal perfusion is prevalent in this high-risk population and a stronger predictor of cardiovascular morbidity and mortality than functional status. A combined assessment of functional status and myocardial perfusion identifies those at highest risk of all-cause death. (Exercise Capacity and Single Photon Emission Computed Tomography in Liver Transplantation Candidates [ExSPECT]; ClinicalTrials.gov Identifier: NCT03864497). (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 11, 2020 Category: Nuclear Medicine Source Type: research

In celebration of being alive
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 11, 2020 Category: Nuclear Medicine Source Type: research

Transient myocardial ischemia due to corticosteroid use in a patient with multiple sclerosis diagnosed with myocardial perfusion imaging
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 11, 2020 Category: Nuclear Medicine Source Type: research

The Mediastinum is LIT
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 11, 2020 Category: Nuclear Medicine Source Type: research