Cardiac PET/MRI enters the clinical arena! Finally …
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 23, 2018 Category: Nuclear Medicine Source Type: research

Stress myocardial blood flow correlates with ventricular function and synchrony better than myocardial perfusion reserve: A Nitrogen-13 ammonia PET study
AbstractBackgroundCardiac PET quantifies stress myocardial blood flow (MBF) and perfusion reserve (MPR), while ECG-gated datasets can measure components of ventricular function simultaneously. Stress MBF seems to outperform MPR in the detection of significant CAD. However, it is uncertain which perfusion measurement is more related to ventricular function. We hypothesized that stress MBF correlates with ventricular function better than MPR in patients studied for suspected myocardial ischemia.MethodsWe studied 248 patients referred to a rest and adenosine-stress Nitrogen-13 ammonia PET. We performed a multivariate analysis...
Source: Journal of Nuclear Cardiology - May 23, 2018 Category: Nuclear Medicine Source Type: research

What is this image? 2018: image  6 result
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 23, 2018 Category: Nuclear Medicine Source Type: research

Mechanical dyssynchrony according to validated cut-off values using gated SPECT myocardial perfusion imaging
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 23, 2018 Category: Nuclear Medicine Source Type: research

Machine learning in the integration of simple variables for identifying patients with myocardial ischemia
AbstractBackgroundA significant number of variables are obtained when characterizing patients suspected with myocardial ischemia or at risk of MACE. Guidelines typically use a handful of them to support further workup or therapeutic decisions. However, it is likely that the numerous available predictors maintain intrinsic complex interrelations. Machine learning (ML) offers the possibility to elucidate complex patterns within data to optimize individual patient classification. We evaluated the feasibility and performance of ML in utilizing simple accessible clinical and functional variables for the identification of patien...
Source: Journal of Nuclear Cardiology - May 22, 2018 Category: Nuclear Medicine Source Type: research

The evolving landscape of nuclear imaging in cardiac amyloidosis
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 18, 2018 Category: Nuclear Medicine Source Type: research

A tale of two phases: Can the worst of scans become the best of scans with motion correction?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 18, 2018 Category: Nuclear Medicine Source Type: research

Positron emission tomography for diagnosis of prosthetic valve endocarditis
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 18, 2018 Category: Nuclear Medicine Source Type: research

Stress for a stressed out heart: Classic cardiac PET findings in takotsubo cardiomyopathy
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 18, 2018 Category: Nuclear Medicine Source Type: research

Optimizing radionuclide protocols: Dotting our I ’s and crossing our T’s
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 15, 2018 Category: Nuclear Medicine Source Type: research

Is there a role for cardiac positron emission tomography in hypertrophic cardiomyopathy?
AbstractCoronary microvascular dysfunction and, its functional consequence, myocardial ischemia are common pathologic features in patients with hypertrophic cardiomyopathy (HCM). Both have been commonly invoked as potential triggers of and/or contributors to the underlying pathophysiological processes leading to heart failure, and malignant ventricular arrhythmias. Positron emission tomography (PET) with myocardial blood flow quantification provides a unique opportunity to evaluate the integrity and function of the coronary microcirculation in HCM. The purpose of the present review is to summarize all the pertinent literat...
Source: Journal of Nuclear Cardiology - May 14, 2018 Category: Nuclear Medicine Source Type: research

Can positron emission tomography help stratify the risk of sudden cardiac death in patients with hypertrophic cardiomyopathy?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 14, 2018 Category: Nuclear Medicine Source Type: research

Multimodality imaging of the left ventricle: Choosing soundly
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 11, 2018 Category: Nuclear Medicine Source Type: research

Correction to: ACC/AATS/AHA/ASE/ASNC/SCAI/SCCT/STS 2017 Appropriate Use Criteria for Coronary Revascularization in Patients With Stable Ischemic Heart Disease
To more clearly reflect the relationship between iFR (instantaneous wave-free ratio) and FFR (fractional flow reserve), this Correction document highlights the following changes to the original document published in theJournal of Nuclear Cardiology; the version available atJACC [1] has been updated to reflect the changes, withJACC’s Correction document available at [2]. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 10, 2018 Category: Nuclear Medicine Source Type: research

Cardiac MRI for the evaluation of oncologic cardiotoxicity
AbstractCancer therapeutics-related cardiac dysfunction (CTRCD) is a well-established adverse effect resulting from a number of cancer therapeutics. Newer immunotherapy has been associated with cardiomyopathy and myocarditis making comprehensive imaging useful for early recognition. Cardiac MRI (CMR) offers a comprehensive evaluation to detect CTRCD. Established guidelines for monitoring left ventricular ejection fraction for potential cardiotoxicity have recently incorporated CMR. We will review the utility of CMR in contemporary evaluation for potential oncologic cardiotoxicity. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 7, 2018 Category: Nuclear Medicine Source Type: research

18-FDG-PET in a patient cohort suspected for cardiac sarcoidosis: Right ventricular uptake is associated with pathological uptake in mediastinal lymph nodes
ConclusionRight ventricular involvement seems to be more common in patients who also have findings suggestive of suspected systemic sarcoidosis, compared with patients with PET findings indicative of isolated cardiac disease. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 2, 2018 Category: Nuclear Medicine Source Type: research

Simultaneous determination of dynamic cardiac metabolism and function using PET/MRI
ConclusionPET/MR with continuous FDG infusion captures dynamic changes in both cardiac metabolism and contractile function. This technique warrants evaluation in human cardiac disease for assessment of subtle functional and metabolic abnormalities. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 1, 2018 Category: Nuclear Medicine Source Type: research

What is This Image? 2018: Image 1
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 30, 2018 Category: Nuclear Medicine Source Type: research

Imaging inflammation in atherosclerotic plaques: Just make it easy!
AbstractThe presence of inflammatory cells is a hallmark of unstable atherosclerotic plaques. Several imaging approaches have been developed for the noninvasive detection of inflammatory activities in atherosclerotic plaques. Positron emission tomography (PET) imaging with the injection of 18F-fluorodeoxyglucose (FDG) is currently the most widely used imaging technique to evaluate the density of activated macrophages in atherosclerotic plaques. Nevertheless, FDG-PET imaging has logistical and technical constraints that represent an important obstacle to the wider use of this approach for the evaluation of patients with ath...
Source: Journal of Nuclear Cardiology - April 26, 2018 Category: Nuclear Medicine Source Type: research

Determining post-test risk in a national sample of stress nuclear myocardial perfusion imaging reports: Implications for natural language processing tools
ConclusionsPost-test ischemic risk was determinable but rarely reported in this sample of stress MPI reports. This supports the potential use of NLP to help clarify risk. Further study of NLP in this context is needed. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 25, 2018 Category: Nuclear Medicine Source Type: research

Iodine-123-metaiodobenzylguanidine cardiac SPECT imaging in the qualification of heart failure patients for ICD implantation
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 25, 2018 Category: Nuclear Medicine Source Type: research

Relationship between microvascular changes, autonomic denervation, and myocardial fibrosis in Chagas cardiomyopathy: Evaluation by MRI and SPECT imaging
ConclusionCombined myocardial analysis of the extent and location of autonomic denervation, hypoperfusion, and scarring may allow for better understanding of the pathophysiology of Chagas cardiomyopathy. Autonomic myocardial denervation may be a more sensitive marker of cardiac involvement in Chagas Disease than finding by other imaging modalities. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 25, 2018 Category: Nuclear Medicine Source Type: research

Sex and age differences in the association of heart rate responses to adenosine and myocardial ischemia in patients undergoing myocardial perfusion imaging
AbstractBackgroundIn light of growing cardiovascular mortality rates observed in young women, sexual dimorphism in cardiac autonomic nervous control is gaining increasing attention. Heart rate responses to adenosine mirror autonomic activity and may carry important prognostic information.Methods and ResultsHemodynamic changes during adenosine stress were retrospectively analysed in a propensity-matched cohort of 1932 consecutive patients undergoing myocardial perfusion single-photon-emission computed tomography (MPI-SPECT). Heart rate (HR) and systolic blood pressure (SBP) increased during adenosine infusion (P 
Source: Journal of Nuclear Cardiology - April 23, 2018 Category: Nuclear Medicine Source Type: research

Machine learning for nuclear cardiology: The way forward
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 20, 2018 Category: Nuclear Medicine Source Type: research

Warranty period of normal stress myocardial perfusion imaging in hypertensive patients: A parametric survival analysis
AbstractBackgroundWe evaluated the warranty period of a normal stress myocardial perfusion single-photon emission computed tomography (MPS) in hypertensive patients.Methods and ResultsA total of 471 consecutive hypertensive patients with suspected coronary artery disease and normal perfusion at stress MPS were followed for a mean of 76 ± 21 months. Endpoint events were cardiac death or nonfatal myocardial infarction. With Cox analysis, age (hazard ratio 1.1,P 
Source: Journal of Nuclear Cardiology - April 20, 2018 Category: Nuclear Medicine Source Type: research

ASNC International!
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 18, 2018 Category: Nuclear Medicine Source Type: research

Anti-inflammatory effect of statin in coronary aneurysms late after Kawasaki disease
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 17, 2018 Category: Nuclear Medicine Source Type: research

Correction to: Adverse effects associated with regadenoson myocardial perfusion imaging
Near the beginning of the first sentence in the second paragraph of the Introduction the parenthetical phrase should read: (single bolus of 400 mcg given intravenously, IV). The dosage of mcg was incorrectly published as 200. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 17, 2018 Category: Nuclear Medicine Source Type: research

Review of cardiovascular imaging in the Journal of Nuclear Cardiology in 2017. Part 2 of 2: Myocardial perfusion imaging
AbstractIn 2017, theJournal of Nuclear Cardiology published many high-quality articles. In this review, we will summarize a selection of these articles to provide a concise review of the main advancements that have recently occurred in the field. In the first article of this 2-part series, we focused on publications dealing with positron emission tomography, computed tomography, and magnetic resonance. This review will place emphasis on myocardial perfusion imaging using single-photon emission computed tomography summarizing advances in the field including prognosis, safety and tolerability, the impact of imaging on manage...
Source: Journal of Nuclear Cardiology - April 16, 2018 Category: Nuclear Medicine Source Type: research

Effect of reduced photon count levels and choice of normal data on semi-automated image assessment in cardiac SPECT
AbstractBackgroundThe SMARTZOOM multifocal collimator from Siemens Healthcare was developed to improve the γ-photon sensitivity in myocardial perfusion imaging without truncating the field of view. As part of the IQ-SPECT package, it may be used to reduce radiopharmaceutical dose to patients, as well as acquisition time. The aim of this study was twofold: (1) to evaluate the influence of dose reduction in semi-automated MPI scoring, with focus on different strategies for the choice of normal data (count-matched, full-count), and (2) to evaluate the effect of dose reduction afforded by Siemens’ IQ-SPECT package....
Source: Journal of Nuclear Cardiology - April 13, 2018 Category: Nuclear Medicine Source Type: research

Noninvasive estimation of quantitative myocardial blood flow with Tc-99m MIBI by a compartment model analysis in rat
ConclusionsMBF estimation by a compartment model analysis using TP map could facilitate absolute MBF measurement in rats. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 13, 2018 Category: Nuclear Medicine Source Type: research

CT attenuation correction for thallium SPECT MPI and other benefits of multimodality imaging
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 13, 2018 Category: Nuclear Medicine Source Type: research

Count density curves for gated SPECT myocardial perfusion imaging studies: An overview of technical considerations, patterns in various arrhythmia-related artifacts, and a technologist ’s guide for curve plotting
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 13, 2018 Category: Nuclear Medicine Source Type: research

Cardiovascular disease in the literature: A selection of recent original research papers
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 12, 2018 Category: Nuclear Medicine Source Type: research

A quick glance at selected topics in this issue
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 12, 2018 Category: Nuclear Medicine Source Type: research

Incidental findings on hybrid SPECT-CT and PET-CT scanners: Is it time for new training and reporting guidelines?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 12, 2018 Category: Nuclear Medicine Source Type: research

Chronic total occlusion without collateral blood flow does not exclude myocardial viability and subsequent recovery after revascularization
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 12, 2018 Category: Nuclear Medicine Source Type: research

Nuclear cardiology in the literature: A selection of recent, original research papers
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 12, 2018 Category: Nuclear Medicine Source Type: research

Prognostic utility of splenic response ratio in dipyridamole PET myocardial perfusion imaging
ConclusionsSRR is a novel imaging metric to identify patients with sub-maximal vasodilator stress and an incremental prognostic marker in patients with normal SDS and SSS (Clinical Trial Registration:https://clinicaltrials.gov/ct2/show/NCT01128023). (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 12, 2018 Category: Nuclear Medicine Source Type: research

Balancing statistical significance and clinical relevance
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 12, 2018 Category: Nuclear Medicine Source Type: research

The continual innovation of commercial PET/CT solutions in nuclear cardiology: Siemens Healthineers
AbstractCardiac PET/CT is an evolving, non-invasive imaging modality that impacts patient management in many clinical scenarios. Beyond offering the capability to assess myocardial perfusion, inflammatory cardiac pathologies, and myocardial viability, cardiac PET/CT also allows for the non-invasive quantitative assessment of myocardial blood flow (MBF) and myocardial flow reserve (MFR). Recognizing the need for an enhanced comprehension of coronary physiology, Siemens Healthineers implemented a sophisticated solution for the calculation of MBF and MFR in 2009. As a result, each aspect of their innovative scanner and image-...
Source: Journal of Nuclear Cardiology - April 10, 2018 Category: Nuclear Medicine Source Type: research

Coronary circulation: Pressure/flow parameters for assessment of ischemic heart disease
AbstractBoth invasive and non-invasive parameters have been reported for assessment of the physiological status of the coronary circulation. Fractional flow reserve and coronary (or myocardial) flow reserve may be obtained by invasive or non-invasive means. These metrics of coronary stenosis severity have achieved wide clinical acceptance for guiding revascularization decisions and risk stratification. Other indices are obtained invasively (e.g., instantaneous wave-free ratio, iFR; hyperemic stenosis resistance) or non-invasively (e.g., PET absolute myocardial blood flow (mL/min/g)) and have been used for the same purposes...
Source: Journal of Nuclear Cardiology - April 10, 2018 Category: Nuclear Medicine Source Type: research

Correction to: Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC
AbstractThe above position statement originally published containing errors in the author metadata; specifically, the Expert Content Reviewers —Andrew Einstein, Raymond Russell and James R. Corbett—were tagged as full authors of the paper. The article metadata has now been corrected to remove Drs. Einstein, Russell and Corbett from the author line, and the PubMed record has been updated accordingly. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 10, 2018 Category: Nuclear Medicine Source Type: research

Analysis of stress-only imaging, comparing upright and supine CZT camera acquisition to conventional gamma camera images with and without attenuation correction, with coronary angiography as a reference
AbstractBackgroundDiagnostic performance of stress-only imaging using a Cadmium-Zinc-Telluride (CZT) camera has not been directly compared in the same patients to stress-only attenuation-corrected conventional Anger camera images.Methods112 subjects with correlative coronary angiographic data and 40 subjects with
Source: Journal of Nuclear Cardiology - March 26, 2018 Category: Nuclear Medicine Source Type: research

Cardiac stress imaging for the prediction of very long-term outcomes: Dobutamine stress echocardiography or dobutamine 99m Tc-sestamibi SPECT?
ConclusionsDSE and MPI are comparable in predicting long-term cardiac mortality and hard cardiac events in patients unable to perform exercise testing. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - March 26, 2018 Category: Nuclear Medicine Source Type: research

CME instructions: Myocardial 123 I-metaiodobenzylguanidine imaging in hypertension and left ventricular hypertrophy
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - March 26, 2018 Category: Nuclear Medicine Source Type: research

Blood pool and tissue phase patient motion effects on 82 rubidium PET myocardial blood flow quantification
ConclusionsPatient motion was most prevalent in the blood phase and MBF and MFR errors increased most substantially with motion in the inferior direction. Motion correction focused on these motions is needed to reduce MBF and MFR errors. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - March 23, 2018 Category: Nuclear Medicine Source Type: research

Prediction of 14-year cardiovascular outcomes by dobutamine stress 99mTc-tetrofosmin myocardial perfusion SPECT; methodological issues in prediction studies
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - March 16, 2018 Category: Nuclear Medicine Source Type: research

How variable are the volumetric measurements from gated perfusion SPECT when a one-day stress-rest protocol is used?
AbstractBackgroundUsing myocardial perfusion scintigraphy (MPS), an increase in left ventricular (LV) volumes or a decrease in ejection fraction (EF) from rest to stress may be clinically important. The variation in these measures between the low-dose stress acquisition and high-dose rest acquisition in a one-day stress-rest protocol has not been established. We assessed the reproducibility of gated volumetric indices between stress and rest and the normal variation in ungated TID ratio for a one-day stress-rest99mTc-tetrofosmin protocol.MethodsTwo thousand and one hundred and fifty eight (2158)99mTc-tetrofosmin MPS patien...
Source: Journal of Nuclear Cardiology - March 15, 2018 Category: Nuclear Medicine Source Type: research