Performance of cardiac PET/CT with and without phase analysis for detection of scar in cardiac sarcoidosis: Comparison to cardiac magnetic resonance imaging
ConclusionSensitivity of gated PET MPI alone for scar detection in CS is suboptimal. Adding PET-derived volumes/function and phase analysis data results in improved detection and characterization of scar. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 20, 2021 Category: Nuclear Medicine Source Type: research

Quantifying microcalcification activity in the thoracic aorta
We describe aortic microcalcification activity (AMA), a novel method for quantifying18F-sodium fluoride (18F-NaF) uptake in the thoracic aorta.MethodsTwenty patients underwent two hybrid18F-NaF PET and computed tomography (CT) scans of the thoracic aorta less than three weeks apart. AMA, as well as maximum (TBRmax) and mean (TBRmean) tissue to background ratios, were calculated by two trained operators. Intra-observer repeatability, inter-observer repeatability and scan-rescan reproducibility were assessed. Each18F-NaF quantification method was compared to validated cardiovascular risk scores.ResultsAortic microcalcificati...
Source: Journal of Nuclear Cardiology - January 20, 2021 Category: Nuclear Medicine Source Type: research

Gated SPECT beyond myocardial perfusion: assessment of mechanical left ventricular synchrony
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 20, 2021 Category: Nuclear Medicine Source Type: research

Diastolic dyssynchrony by SPECT: A novel parameter to predict post-infarct adverse remodeling
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 20, 2021 Category: Nuclear Medicine Source Type: research

Comparison of 68 Ga-FAPI imaging and cardiac magnetic resonance in detection of myocardial fibrosis in a patient with chronic thromboembolic pulmonary hypertension
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 20, 2021 Category: Nuclear Medicine Source Type: research

Evaluation of dyssynchrony with nuclear cardiac imaging: New evidence for an old parameter
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 20, 2021 Category: Nuclear Medicine Source Type: research

Automated abstraction of myocardial perfusion imaging reports using natural language processing
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 20, 2021 Category: Nuclear Medicine Source Type: research

Role of 18 F-FDG PET/CT imaging in cardiac and pericardial masses
ConclusionsPET/CT was an effective additional image modality in patients with suspected malignant cardiac mass for further confirmation and to screen for potential metastasis. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 18, 2021 Category: Nuclear Medicine Source Type: research

Tracking the progress of inflammation with PET/MRI in a canine model of myocardial infarction
AbstractBackgroundFollowing myocardial infarction, tissue undergoes pathophysiological changes involving inflammation and scar tissue formation. However, little is known about the pathophysiology and prognostic significance of any corresponding changes in remote myocardium. The aim of this study was to investigate the potential application of a combined constant infusion of18F-FDG and Gd-DTPA to quantitate inflammation and extracellular volume (ECV) from 3 to 40 days after myocardial infarction.MethodsEight canine subjects were imaged at multiple time points following induction of an MI with a 60-minute concurrent constant...
Source: Journal of Nuclear Cardiology - January 18, 2021 Category: Nuclear Medicine Source Type: research

Drawing the line between a normal and mildly abnormal nuclear cardiology scan
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 18, 2021 Category: Nuclear Medicine Source Type: research

Health economics-based verification of functional myocardial ischemia evaluation of stable coronary artery disease in Japan: A long-term longitudinal study using propensity score matching
ConclusionsThe functional evaluation approach improved long-term clinical outcomes and reduced cumulative medical costs. As a result, the modality composition of functional myocardial ischemia evaluation was demonstrated to offer superior cost-effectiveness in stable CAD. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 18, 2021 Category: Nuclear Medicine Source Type: research

Evaluation of non-stenotic carotid atherosclerotic plaques with combined FDG-PET imaging and CT angiography in patients with ischemic stroke of unknown origin
AbstractObjectivesNon-stenotic plaques are an underestimated cause of ischemic stroke. Imaging aspects of high-risk carotid plaques can be identified on CT angiography (CTA) and 18F-fluoro-deoxyglucose positron emission tomography (FDG-PET) imaging. We evaluated in patients with cryptogenic ischemic stroke the usefulness of FDG-PET-CTA.Methods44 patients imaged with CTA and FDG-PET were identified retrospectively. Morphological features were identified on CTA. Intensity of FDG uptake in carotid arteries was quantified on PET.ResultsPatients were imaged 7 ± 8 days after stroke. 44 non-stenotic plaques with increased ...
Source: Journal of Nuclear Cardiology - January 18, 2021 Category: Nuclear Medicine Source Type: research

Nuclear cardiology in the literature: A selection of recent, original research papers
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 18, 2021 Category: Nuclear Medicine Source Type: research

Transient multifocal pulmonary uptake of 99mTc-sestamibi in myocardial perfusion imaging: Iatrogenic clot artifact
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 18, 2021 Category: Nuclear Medicine Source Type: research

The prognostic value of 123 I-mIBG SPECT cardiac imaging in heart failure patients: a systematic review
AbstractThis systematic review aimed to evaluate the prognostic value of Iodine123 Metaiodobenzylguanidine (123I-mIBG) SPECT myocardial imaging in patients with heart failure (HF) and to assess whether semi-quantitative SPECT scores can be useful for accurate risk stratification concerning arrhythmic event (AE) and sudden cardiac death (SCD) in this cohort. A systematic literature search of studies published until November 2020 regarding the application of123I-mIBG SPECT in HF patients was performed, in Pubmed, Scopus, Medline, Central (Cochrane Library) and Web Of Science databases, including the words “MIBG”,...
Source: Journal of Nuclear Cardiology - January 13, 2021 Category: Nuclear Medicine Source Type: research

Age- and sex-dependent changes of resting amygdalar activity in individuals free of clinical cardiovascular disease
This study sought to assess age- and sex-specific differences of resting amygdalar metabolic activity in the absence of clinical cardiovascular disease.MethodsAmygdalar metabolic activity was assessed in 563 patients who underwent multimodality imaging by18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography and echocardiography for the evaluation of cardiac function.ResultsAfter exclusion of 294 patients with structural or functional cardiovascular pathologies, 269 patients (128 women) remained in the final population.18F-FDG amygdalar activity significantly decreased with age in men (r =...
Source: Journal of Nuclear Cardiology - January 13, 2021 Category: Nuclear Medicine Source Type: research

Optimal interpretation of Tc99m PYP in 2020: Avoiding the million-dollar mistake
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 13, 2021 Category: Nuclear Medicine Source Type: research

Deriving myocardial blood flow reserve from perfusion datasets: Dream or reality?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 13, 2021 Category: Nuclear Medicine Source Type: research

The year ahead for ASNC
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 11, 2021 Category: Nuclear Medicine Source Type: research

Assessment of myocardial sympathetic innervation with 18F-FDOPA-PET/CT in patients with autonomic dysfunction: feasibility study in IPD patients
AbstractBackgroundDysfunction and denervation of myocardial nor-adrenergic sympathetic neurons has been documented in IPD patients with dysautonomia. The aim of this study was to evaluate the feasibility of single tracer imaging of myocardial sympathetic and cerebral striatal involvement in these patients.MethodsTwenty-two controls (mean-age 59.09  ± 12.39 years, 15 men) with no clinical autonomic-dysfunction and normal striatal-uptake in 18F-FDOPA-PET/CT; and 28 patients (mean-age 58.18 ± 8.25 years, 18 men) with autonomic-dysfunction (in Autonomic Function Tests) and striatal dop...
Source: Journal of Nuclear Cardiology - January 10, 2021 Category: Nuclear Medicine Source Type: research

Incidental detection of ATTR cardiac amyloidosis
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 10, 2021 Category: Nuclear Medicine Source Type: research

Divergence of acetate uptake in proinflammatory and inflammation-resolving macrophages: implications for imaging atherosclerosis
AbstractBackgroundMetabolic divergence of macrophages polarized into different phenotypes represents a mechanistically relevant target for non-invasive characterization of atherosclerotic plaques using positron emission tomography (PET). Carbon-11 (11C)-labeled acetate is a clinically available tracer which accumulates in atherosclerotic plaques, but its biological and clinical correlates in atherosclerosis are undefined.Methods and resultsHistological correlates of14C-acetate uptake were determined in brachiocephalic arteries of western diet-fed apoE−/− mice. The effect of polarizing stimuli on14C-acetate upta...
Source: Journal of Nuclear Cardiology - January 8, 2021 Category: Nuclear Medicine Source Type: research

Assessment of stress adequacy with adenosine: Does the answer lie in the spleen?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 8, 2021 Category: Nuclear Medicine Source Type: research

Cardiovascular disease in the literature: A selection of recent original research papers
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 8, 2021 Category: Nuclear Medicine Source Type: research

Spotlight on left ventricular dyssynchrony: Part 2 —Prognostic value
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 8, 2021 Category: Nuclear Medicine Source Type: research

Interpretation and clinical management of patients with “Fixed” myocardial perfusion defects
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 7, 2021 Category: Nuclear Medicine Source Type: research

Getting the right patient to angiography: Can we level the playing field?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 7, 2021 Category: Nuclear Medicine Source Type: research

Complementary role of hybrid imaging with SPECT myocardial perfusion and coronary CT angiography in hypertrophic cardiomyopathy
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 6, 2021 Category: Nuclear Medicine Source Type: research

The 2020 trials and tribulations
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 6, 2021 Category: Nuclear Medicine Source Type: research

Incidental extra-cardiac uptake of 99m Tc-pyrophosphate
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 6, 2021 Category: Nuclear Medicine Source Type: research

Fixed perfusion defects revisited
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 6, 2021 Category: Nuclear Medicine Source Type: research

Left ventricular mural thrombus appearing as a photopenic defect on myocardial viability PET imaging
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 5, 2021 Category: Nuclear Medicine Source Type: research

Takotsubo cardiomyopathy: What should myocardial perfusion imaging reveal
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 5, 2021 Category: Nuclear Medicine Source Type: research

Mechanical dyssynchrony and super-response to CRT
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 5, 2021 Category: Nuclear Medicine Source Type: research

Comparison of left ventricle mechanical dyssynchrony parameters in ischemic and non-ischemic patients using 13 N-NH 3 PET/CT
ConclusionsUsing a vasodilator as a stress, the PSD and PHB post-stress and ΔPSD were significantly higher in the ischemic patients than the non-ischemic group, while there were no significant differences in each cohort between stress and rest indices. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 4, 2021 Category: Nuclear Medicine Source Type: research

Cardiopulmonary transit time: A novel PET imaging biomarker of in vivo physiology for risk stratification of heart transplant recipients
AbstractBackgroundMyocardial blood flow (MBF) can be quantified using dynamic PET studies. These studies also inherently contain tomographic images of early bolus displacement, which can provide cardiopulmonary transit times (CPTT) as measure of cardiopulmonary physiology. The aim of this study was to assess the incremental prognostic value of CPTT in heart transplant (OHT) recipients.Methods94 patients (age 56  ± 16 years, 78% male) undergoing dynamic13N-ammonia stress/rest studies were included, of which 68 underwent right-heart catherization. A recently validated cardiac allograft vasculopathy ...
Source: Journal of Nuclear Cardiology - January 4, 2021 Category: Nuclear Medicine Source Type: research

(18)F-sodium fluoride PET in multiple myeloma: Linking cancer to atherosclerosis?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 4, 2021 Category: Nuclear Medicine Source Type: research

Evaluation of cardiac allograft vasculopathy by positron emission tomography
AbstractCardiac allograft vasculopathy (CAV) remains one of the most important late occurring complications in heart transplant (HT) recipients significantly effecting graft survival. Recently, there has been tremendous focus on the development of effective and safe non-invasive diagnostic strategies for the diagnosis of CAV employing a wide range of imaging technologies. During the past decade multiple studies have been published using positron emission tomography (PET) myocardial perfusion imaging, establishing the value of PET myocardial blood flow quantification for the evaluation of CAV. These independent investigatio...
Source: Journal of Nuclear Cardiology - January 3, 2021 Category: Nuclear Medicine Source Type: research

Prognostic value of myocardial perfusion imaging in patients with chronic kidney disease: A systematic review and meta-analysis
ConclusionsIn patients with CKD an abnormal myocardial perfusion at stress MPS is associated with adverse cardiovascular events. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 3, 2021 Category: Nuclear Medicine Source Type: research

Prognostic value of early left ventricular ejection fraction reserve during regadenoson stress solid-state SPECT-MPI
AbstractBackgroundWe hypothesized early post-stress left ventricular ejection fraction reserve (EFR) on solid-state-SPECT is associated with major cardiac adverse events (MACE).Methods151 patients (70  ± 12 years, male 50%) undergoing same-day rest/regadenoson stress99mTc-sestamibi solid-state SPECT were followed for MACE. Rest imaging was performed in the upright and supine positions. Early stress imaging was started 2 minutes after the regadenoson injection in the supine position and followed by late stress acquisition in the upright position. Total perfusion deficit (TPD) and functional paramet...
Source: Journal of Nuclear Cardiology - January 3, 2021 Category: Nuclear Medicine Source Type: research

Assessment of atherosclerosis in multiple myeloma and smoldering myeloma patients using 18 F- sodium fluoride PET/CT
AbstractBackgroundTo compare the NaF uptake in the thoracic aorta and whole heart, as an early indicator of atherosclerosis, in multiple myeloma (MM) and smoldering multiple myeloma (SMM) patients with a healthy control (HC) group.MethodsForty-four untreated myeloma patients (35 MM and nine SMM) and twenty-six age and gender-matched HC subjects were collected. Each individual ’s NaF uptake in three parts of the aorta (AA: ascending aorta, AR: aortic arch, DA: descending aorta) and the whole heart was segmented. Average global standardized uptake value means were derived by sum of the product of each slice area divide...
Source: Journal of Nuclear Cardiology - January 3, 2021 Category: Nuclear Medicine Source Type: research

Internal validation of myocardial flow reserve PET imaging using stress/rest myocardial activity ratios with Rb-82 and N-13-ammonia
The objective of the current study was to investigate the application of a simplified model for the estimation of MFR using only the stress/rest myocardial activity ratio (MAR) in patients undergoing rest –stress cardiac PET MPI.Methods and resultsRest and dipyridamole stress dynamic PET imaging was performed in consecutive patients using82Rb or13NH3 (n  = 250 each). Reference standard MFR was quantified using a standard one-tissue compartment model. Stress/rest myocardial activity ratio (MAR) was calculated using the LV-mean activity from 2 to 6 minutes post-injection. Simplified estimates of MFR (MFRE...
Source: Journal of Nuclear Cardiology - January 3, 2021 Category: Nuclear Medicine Source Type: research

Integrating baseline electrocardiography and myocardial perfusion imaging
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 3, 2021 Category: Nuclear Medicine Source Type: research

Nuclear imaging in cardiac paragangliomas: Diagnostic and follow-up
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 3, 2021 Category: Nuclear Medicine Source Type: research

Mechanical Dyssynchrony with Gated Myocardial Perfusion SPECT: Reproducibility is the Key
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 3, 2021 Category: Nuclear Medicine Source Type: research

Tc-99m HMDP bone scintigraphy for cardiac amyloidosis diagnosis: A false positive case
AbstractA 68-year-old man with heart failure (left ventricular ejection fraction = 30%) and normal coronary angiography underwent bone scintigraphy for suspected transthyretin-related cardiac amyloidosis (CA).1 He received 532 MBq (14.3 mCi) Tc-99m hydroxy-methyl-diphosphonate (HMDP) and data were acquired 2 hours after injection. On anterior and posterior whole-body scans (Figure  1 A and B), diffuse cardiac, hepatic, and soft-tissue uptake of the radiotracer was seen, in association with low skeletal uptake. It was established that the patient had recently been hospitalized for heart failure exacerbation and had rec...
Source: Journal of Nuclear Cardiology - January 3, 2021 Category: Nuclear Medicine Source Type: research

Integrating polymorphism signatures with myocardial perfusion imaging data to improve the prevention of coronary artery disease: Science or science-fiction?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 3, 2021 Category: Nuclear Medicine Source Type: research

Primary cardiac angiosarcoma with thrombosis and multiple bone marrow metastases mimicking lymphoma on 18 F-FDG PET/CT
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 3, 2021 Category: Nuclear Medicine Source Type: research

What is this image? 2021: Image 5
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 3, 2021 Category: Nuclear Medicine Source Type: research

Abnormal vasodilator stress electrocardiogram with normal myocardial perfusion: Clinical decision-making and review of literature
AbstractIschemic electrocardiographic (ECG) changes during vasodilator stress testing in the presence of abnormal myocardial perfusion imaging (MPI) are associated with more severe coronary artery disease (CAD). However, significance of ECG changes during vasodilator stress test with normal MPI has been controversial. Here, we discuss two cases of significant ischemic ECG changes with vasodilator stress and normal MPI, whose subsequent workup revealed severe obstructive CAD. We also review the available literature on the occurrence and mechanism of these discrepant findings and propose recommendations for management. (Sour...
Source: Journal of Nuclear Cardiology - January 1, 2021 Category: Nuclear Medicine Source Type: research