Clinical significance of quantitative assessment of glucose utilization in patients with ischemic cardiomyopathy
ConclusionsMyocardial glucose utilization was influenced by substrates and medications, including statins and DPP4i. MRGlu could discriminate between viable and non-viable myocardium, and MRGlu in transmural match and reverse mismatch may be prognostic predictors of cardiovascular death in patients with ischemic cardiomyopathy. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 14, 2018 Category: Nuclear Medicine Source Type: research

“Apical thinning”: Relations between myocardial wall thickness and apical left ventricular tracer uptake as assessed with positron emission tomography myocardial perfusion imaging
ConclusionsApical thinning is a highly prevalent finding during 13N-ammonia PET-MPI that is not solely attributable to true anatomical apical wall thickness or the partial volume effect. Other factors that yet need to be identified seem to have a more prominent impact. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 14, 2018 Category: Nuclear Medicine Source Type: research

A quick glance at selected topics in this issue
Abstract“A quick glance at selected topics in this issue” aims to highlight contents of the Journal and provide a quick review to the readers. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 14, 2018 Category: Nuclear Medicine Source Type: research

FDG PET/CT for the diagnosis and management of infective endocarditis: Expert consensus vs evidence-based practice
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 14, 2018 Category: Nuclear Medicine Source Type: research

Joseph P. Kriss, MD (1915-1989)
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 14, 2018 Category: Nuclear Medicine Source Type: research

Rosai –Dorfman disease and left ventricular noncompaction cardiomyopathy: A heart failure conundrum
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 14, 2018 Category: Nuclear Medicine Source Type: research

PET-based myocardial efficiency: Powerful yet under-utilized —now simpler than ever
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 10, 2018 Category: Nuclear Medicine Source Type: research

Non-invasive assessment of endarteritis in Marfan syndrome with aortic dissection after surgical treatment
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 9, 2018 Category: Nuclear Medicine Source Type: research

Fluoride imaging of atherosclerotic plaques: Moving from macro to microcalcifications?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 9, 2018 Category: Nuclear Medicine Source Type: research

Evaluation of different respiratory gating schemes for cardiac SPECT
ConclusionsAG and CG methods show better performance for motion reduction and are recommended for clinical respiratory gating SPECT implementation. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 7, 2018 Category: Nuclear Medicine Source Type: research

Factors relevant to atrial 18 F-fluorodeoxyglucose uptake in atrial fibrillation
ConclusionsAtrial uptake was present in persistent AF and localized mainly in the right atrium, whereas bilateral AAs could be equally involved. Multiple factors contributed to the increased activity in atrium; in particular, the EAT activity was independently correlated with the activity of the atrium and AA. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 7, 2018 Category: Nuclear Medicine Source Type: research

Giant primary pericardial synovial sarcoma in an adolescent with cardiac tamponade: Contrast-enhanced CT and 18 F-FDG PET/CT findings
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 7, 2018 Category: Nuclear Medicine Source Type: research

Prolonged left ventricular dysfunction following pharmacologic stress myocardial perfusion imaging: Should we be less stunned than in the past?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 7, 2018 Category: Nuclear Medicine Source Type: research

Faces of phase
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 7, 2018 Category: Nuclear Medicine Source Type: research

Variances of dietary preparation for suppression of physiological 18 F-FDG myocardial uptake in the presence of cardiac sarcoidosis: A systematic review
ConclusionsVariation in measures used, dietary prescriptions, fasting times, species and study quality makes result comparison and applicability difficult. Definitive dietary recommendations are not possible based on current evidence. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 7, 2018 Category: Nuclear Medicine Source Type: research

Nuclear cardiology in the literature: A selection of recent, original research papers
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 2, 2018 Category: Nuclear Medicine Source Type: research

What is This Image? 2018: Image  2 Result
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 2, 2018 Category: Nuclear Medicine Source Type: research

123 I-meta-Iodobenzylguanidine Imaging in Patients with Cardiac Resynchronization Therapy: Results are Intriguing, but Unknowns Remain
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 1, 2018 Category: Nuclear Medicine Source Type: research

Value of gated-SPECT MPI for ischemia-guided PCI of non-culprit vessels in STEMI patients with multivessel disease after primary PCI
This article reviews the current state of the literature evaluating outcomes of those previously randomized to revascularization of non-culprit stenosis around the time of the STEMI. We propose a new study design to utilize gated-SPECT in the decision process by using an ischemic burden of  >  5% as a cut-off for revascularization vs. complete revascularization without ischemia assessment. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 1, 2018 Category: Nuclear Medicine Source Type: research

Cardiovascular disease in the literature: A selection of recent original research papers
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 1, 2018 Category: Nuclear Medicine Source Type: research

Imaging infective endocarditis: Adherence to a diagnostic flowchart and direct comparison of imaging techniques
ConclusionsThis study demonstrates that the evaluated imaging-in-endocarditis-flowchart is applicable in daily clinical practice. Echocardiography, MDCTA, and FDG-PET/CT provide relevant complementary diagnostic information, particularly in patients with intracardiac prosthetic material. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 31, 2018 Category: Nuclear Medicine Source Type: research

Improving perfusion defect detection with respiratory motion correction in cardiac SPECT at standard and reduced doses
ConclusionsRespiratory-binned acquisitions can improve perfusion-defect detection accuracy over traditional reconstruction both at standard dose and at reduced dose. Motion correction may contribute to achieving further dose reduction while maintaining the diagnostic accuracy of traditional acquisitions. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 30, 2018 Category: Nuclear Medicine Source Type: research

Tc-99m pyrophosphate imaging for transthyretin cardiac amyloidosis: Importance of estimation of cancer risk with the modality
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 27, 2018 Category: Nuclear Medicine Source Type: research

A high exercise workload of ≥ 10 METS predicts a low risk of significant ischemia and cardiac events in older adults
We examined the workload achieved, prevalence and predictors of ischemia, and MACE (cardiac death, non-fatal MI, late revascularization) in a cohort of 382 patients ≥ 65 years of age who underwent exercise99mTc SPECT MPI. The cohort was 64.4% male and 36.9% had known coronary artery disease (CAD). All achieved ≥ 85% of maximum age-predicted heart rate. A workload of ≥ 10 METS was achieved in 25.4%; 50.3% attained 7-9 METS, and 24.4% reached
Source: Journal of Nuclear Cardiology - July 26, 2018 Category: Nuclear Medicine Source Type: research

Role of PET/CT in multimodality imaging in differentiating cardiac sarcoidosis from arrhythmogenic right ventricular dysplasia
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 26, 2018 Category: Nuclear Medicine Source Type: research

Hal O. Anger, DSc (hon) (1920-2005)
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 26, 2018 Category: Nuclear Medicine Source Type: research

Ramp filter artifact associated with filtered backprojection, resolved with iterative reconstruction
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 25, 2018 Category: Nuclear Medicine Source Type: research

How useful is 18F-FDG PET/CT in patients with suspected vascular graft infection?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 25, 2018 Category: Nuclear Medicine Source Type: research

Dose reduction is good but it is image quality that matters
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 24, 2018 Category: Nuclear Medicine Source Type: research

Multimodality assessment of ventricular pseudoaneurysm after non-reperfused acute myocardial infarction
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 24, 2018 Category: Nuclear Medicine Source Type: research

Quantification of 11 C-PIB kinetics in cardiac amyloidosis
ConclusionAn irreversible two-tissue model best describes the11C-PIB uptake in cardiac amyloidosis. RI and SUV correlate well withKi from the 2Tirr model. RI and SUV discriminate better between amyloidosis patients and controls thanKi based on population-average metabolite correction. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 23, 2018 Category: Nuclear Medicine Source Type: research

Can 99m Tc-labeled RBC-equilibrium radionuclide angiocardiography be an adjunct imaging biomarker for marrow hyperplasia in beta-thalassemia major patients?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 23, 2018 Category: Nuclear Medicine Source Type: research

Value of simultaneous assessment of cardiac functions by PET/MRI
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 20, 2018 Category: Nuclear Medicine Source Type: research

Striking a balance in the discussion of the benefits of imaging tests and risks of radiation exposure
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 20, 2018 Category: Nuclear Medicine Source Type: research

Long-term prognostic value of low-dose normal stress-only myocardial perfusion imaging by wide beam reconstruction: A competing risk analysis
ConclusionsLow-dose normal stress-only WBR MPS has a reliable long-term prognostic value in patients with suspected or known CAD. This finding supports the introduction of such a method into clinical practice with a consistent dose optimization in the interest of patients and exposed staff. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 19, 2018 Category: Nuclear Medicine Source Type: research

In appreciation of our 2017 reviewers
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 19, 2018 Category: Nuclear Medicine Source Type: research

Chagas heart disease: A contemporary review
AbstractChagas disease is caused by a parasite infection endemic of the Americas. Traditionally observed in rural areas of Latin America, current migration trends have turned Chagas disease into a global epidemic. Acute infection is rarely severe and once it resolves, some patients can develop cardiomyopathy as part of the chronic form many years later. Multiple factors related with both the host and the parasite determine the susceptibility and progression to cardiomyopathy. Current imaging techniques are able to identify cardiac autonomic denervation, perfusion abnormalities, and myocardial fibrosis at an early of stage ...
Source: Journal of Nuclear Cardiology - July 18, 2018 Category: Nuclear Medicine Source Type: research

Cardiac amyloidosis imaging with amyloid positron emission tomography: A systematic review and meta-analysis
AbstractBackgroundRecent progress in amyloid positron emission tomography (PET) has enabled the targeted imaging of cardiac amyloidosis with accuracy. We performed a systematic review and meta-analysis on the diagnostic performance of cardiac amyloidosis using amyloid PET.MethodsA systematic search was performed using key words: cardiac amyloidosis, amyloid, and PET. We estimated the pooled sensitivity, specificity, positive and negative likelihood ratio (LR), and diagnostic odds ratio (DOR). Furthermore, the semiquantitative parameters of PET were evaluated to diagnose cardiac amyloidosis and discern its type [systemic li...
Source: Journal of Nuclear Cardiology - July 18, 2018 Category: Nuclear Medicine Source Type: research

Cardiovascular risk prediction models with myocardial perfusion imaging in chronic kidney disease: ACCESSing digits or focusing on the patient?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 16, 2018 Category: Nuclear Medicine Source Type: research

Poor tracking of myocardial walls and inaccurate estimation of systolic parameters in myocardial hypertrophy on gated myocardial perfusion SPECT resulted from erroneous placement of region of interest and contouring: A pitfall of commercially available software packages for cardiac analysis
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 13, 2018 Category: Nuclear Medicine Source Type: research

B. Leonard Holman, MD. (1941 –1998)
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 13, 2018 Category: Nuclear Medicine Source Type: research

In search of the vulnerable patient or the vulnerable plaque: 18 F-sodium fluoride positron emission tomography for cardiovascular risk stratification
AbstractCardiovascular disease (CVD) remains a leading cause of death. Preventative therapies that reduce CVD are most effective when targeted to individuals at high risk. Current risk stratification tools have only modest prognostic capabilities, resulting in over-treatment of low-risk individuals and under-treatment of high-risk individuals. Improved methods of CVD risk stratification are required. Molecular imaging offers a novel approach to CVD risk stratification. In particular,18F-sodium fluoride (18F-NaF) positron emission tomography (PET) has shown promise in the detection of both high-risk atherosclerotic plaque f...
Source: Journal of Nuclear Cardiology - July 10, 2018 Category: Nuclear Medicine Source Type: research

Prognostic effect and modulation of cardiac sympathetic function in heart failure patients treated with cardiac resynchronization therapy
AbstractBackgroundCardiac autonomic dysfunction as assessed by123I-metaiodobenzylguanidine (123I-mIBG) scintigraphy is associated with poor prognosis in heart failure (HF) patients. Although cardiac resynchronization therapy (CRT) has emerged as an effective therapy in improving outcomes on HF patients, its effect on cardiac sympathetic nervous function is still not fully understood. We aimed to study the value of pre-implantation123I-mIBG late heart-to-mediastinum ratio (HMR) as a predictor of response and outcomes after CRT and to correlate modification in this parameter with CRT response and functional improvement.Metho...
Source: Journal of Nuclear Cardiology - July 10, 2018 Category: Nuclear Medicine Source Type: research

Integrating imaging modalities for diagnosing cardiac amyloidosis
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 9, 2018 Category: Nuclear Medicine Source Type: research

Early infected aneurysm with 18 F-FDG uptake prior to substantial anatomical changes
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 9, 2018 Category: Nuclear Medicine Source Type: research

PET myocardial blood flow is now officially declared ready for prime time (and a little bit about how the US coding/valuation/coverage system works)
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 6, 2018 Category: Nuclear Medicine Source Type: research

What is this image? 2018: Image  2
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 3, 2018 Category: Nuclear Medicine Source Type: research

Stomach interference in 82 Rb-PET myocardial perfusion imaging
AbstractBackground82Rubidium(82Rb)-positron-emission-tomography (PET) is prone to some of the same imaging artifacts as single-photon-emission-computed-tomography myocardial perfusion imaging (MPI) including interference from excessive subdiaphragmatic activity. Our aim was to determine associations between clinical parameters and MPI interference including any potential correlation between interference severity and stomach volume.Methods and resultsTwo hundred men and women fasted two hours prior to standard clinical82Rb myocardial perfusion rest/stress PET. Images were analyzed for radiotracer interference between left v...
Source: Journal of Nuclear Cardiology - July 2, 2018 Category: Nuclear Medicine Source Type: research

Emerging imaging targets for infiltrative cardiomyopathy: Inflammation and fibrosis
AbstractMolecular imaging in infiltrative cardiomyopathies is increasingly penetrating the clinical arena. Current approaches target the infiltrate directly, or its metabolic, physiologic, or functional consequences. Inflammation may not just play a role as the infiltrative mechanism itself. It is also thought to play a key role in the development and progression of heart failure in general, because it promotes the development of tissue fibrosis. The cascade leading from tissue damage to inflammation and further to fibrosis and loss of function has emerged as a therapeutic target. This review focuses (1) on novel tracers o...
Source: Journal of Nuclear Cardiology - July 2, 2018 Category: Nuclear Medicine Source Type: research

The ASNC Industry Forum: Advancing a Cherished Relationship
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 2, 2018 Category: Nuclear Medicine Source Type: research