SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture
ConclusionCalcification imaging alone can only accurately identify highly calcified, stable, fibrocalcific plaques. To identify high-risk plaques, with little or no calcification, hybrid imaging of calcification and inflammation could provide diagnostic benefit. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 27, 2021 Category: Nuclear Medicine Source Type: research

Diagnostic challenges in primary cardiac lymphoma, the opportunity of 18F-FDG PET/CT integrated with contrast-enhanced CT
ConclusionThe intensity- and volume-based PET parameters of PCL were significantly higher than those of PCA. The enhancement pattern and tumor morphology were also different. According to these characteristics, the two most common types of primary cardiac malignancies can be differentiated. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 27, 2021 Category: Nuclear Medicine Source Type: research

Left ventricular strain analysis by positron emission tomography: Beyond myocardial perfusion
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 27, 2021 Category: Nuclear Medicine Source Type: research

Large-vessel vasculitis with persistent exertional dyspnea in a 75-year-old woman
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 26, 2021 Category: Nuclear Medicine Source Type: research

A quick glance at selected topics in this issue
Abstract“A quick glance at selected topics in this issue” aims to highlight contents of theJournal and provide a quick review to the readers. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 25, 2021 Category: Nuclear Medicine Source Type: research

Hemiplegic migraine episode triggered by regadenoson
AbstractSPECT and PET myocardial perfusion imaging (MPI) are widely used to evaluate patients for coronary artery disease. Regadenoson (a selective A2A adenosine receptor agonist) is a commonly used vasodilator agent for stress MPI because of its safety profile and ease of use. Common adverse reactions such as headache, shortness of breath, flushing, and chest and abdominal discomfort are typically mild and can be effectively reversed using methylxanthines such as aminophylline and caffeine. Neurological adverse reactions such as seizure and stroke have rarely been reported with the use of regadenoson. The hemodynamic chan...
Source: Journal of Nuclear Cardiology - July 25, 2021 Category: Nuclear Medicine Source Type: research

PET/CT for endocarditis in the ACC/AHA 2020 valve guidelines: Ready for prime time?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 22, 2021 Category: Nuclear Medicine Source Type: research

Automated artificial intelligence quantification of aortic atherosclerotic calcifications by 18F-sodium fluoride PET/CT
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 21, 2021 Category: Nuclear Medicine Source Type: research

Sources of error with cardiovascular PET/CT and PET/MRI and questions to be answered to achieve clinical usefulness
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 21, 2021 Category: Nuclear Medicine Source Type: research

Diagnosis of left ventricular hypertrophy using non-ECG-gated  15O-water PET
AbstractAimTo develop a method for diagnosing left ventricular (LV) hypertrophy from cardiac perfusion15O-water positron emission tomography (PET).MethodsWe retrospectively pooled data from 139 subjects in four research cohorts. LV remodeling patterns ranged from normal to severe eccentric and concentric hypertrophy.15O-water PET scans (n = 197) were performed with three different PET devices. A low-end scanner (66 scans) was used for method development, and remaining scans with newer devices for a blinded evaluation. Dynamic data were converted into parametric images of perfusable tissue fraction for semi-automatic deline...
Source: Journal of Nuclear Cardiology - July 20, 2021 Category: Nuclear Medicine Source Type: research

Improving detection accuracy of perfusion defect in standard dose SPECT-myocardial perfusion imaging by deep-learning denoising
AbstractBackgroundWe previously developed a deep-learning (DL) network for image denoising in SPECT-myocardial perfusion imaging (MPI). Here we investigate whether this DL network can be utilized for improving detection of perfusion defects in standard-dose clinical acquisitions.MethodsTo quantify perfusion-defect detection accuracy, we conducted a receiver-operating characteristic (ROC) analysis on reconstructed images with and without processing by the DL network using a set of clinical SPECT-MPI data from 190 subjects. For perfusion-defect detection hybrid studies were used as ground truth, which were created from clini...
Source: Journal of Nuclear Cardiology - July 19, 2021 Category: Nuclear Medicine Source Type: research

99mTechnetium-pyrophosphate cardiac scintigraphy cases from a busy nuclear cardiology laboratory
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 19, 2021 Category: Nuclear Medicine Source Type: research

The assessment of left ventricular mechanical dyssynchrony from gated 99mTc-tetrofosmin SPECT and gated 18F-FDG PET by QGS: a comparative study
ConclusionGated MPS and gated FDG PET can assess LVMD. The methods cannot be used interchangeably. Establishing reference ranges and cut-off values is difficult due to the lack of an external gold standard. Further prospective research is necessary. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 19, 2021 Category: Nuclear Medicine Source Type: research

Correction to: ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI Expert consensus recommendations for multimodality imaging in cardiac amyloidosis: Part 2 of 2 —Diagnostic criteria and appropriate utilization
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 19, 2021 Category: Nuclear Medicine Source Type: research

Effects of mineralocorticoid receptor antagonist eplerenone on cardiac sympathetic nerve activity and left ventricular remodeling after reperfusion therapy in patients with first ST-segment elevation myocardial infarction
AbstractPurposeThe activation of the renin-angiotensin-aldosterone system prevents the uptake of norepinephrine and promotes structural remodeling of the heart. The mineralocorticoid receptor antagonist (MRA) eplerenone prevents left ventricular (LV) remodeling in patients with acute myocardial infarction, but its influence on cardiac sympathetic nerve activity (CSNA) has not been determined.MethodsWe retrospectively evaluated the first ST-segment elevation myocardial infarction (STEMI) patients in our database who underwent123I-metaiodobenzylguanidine (MIBG) scintigraphy 3 weeks after admission. Eighty-four STEMI patients...
Source: Journal of Nuclear Cardiology - July 16, 2021 Category: Nuclear Medicine Source Type: research

Is your ischemic patient an ISCHEMIA patient?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 16, 2021 Category: Nuclear Medicine Source Type: research

Correction to: ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: Part 1 of 2 —evidence base and standardized methods of imaging
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 14, 2021 Category: Nuclear Medicine Source Type: research

Call for manuscripts for themed issue on coronary microvascular disease
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 13, 2021 Category: Nuclear Medicine Source Type: research

Scintillation cameras: A new clinical era has come
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 12, 2021 Category: Nuclear Medicine Source Type: research

Cardiac sarcoidosis with thickening myocardium
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 9, 2021 Category: Nuclear Medicine Source Type: research

Reverse remodeling of small pulmonary arteries and right ventricle in pulmonary arterial hypertension
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 9, 2021 Category: Nuclear Medicine Source Type: research

Integration of quantitative absolute myocardial blood flow estimates from dynamic CZT-SPECT improves the detection of coronary artery disease
AbstractBackgroundBalanced ischemia with multi-vessel coronary artery disease (CAD) is difficult to diagnose with semiquantitative single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). Dynamic cardiac SPECT provides quantitative estimations of stenosis severity and ischemic burden by assessing myocardial flow reserve (MFR) and myocardial blood flow (MBF). The aim of this study was to evaluate the incremental value of dynamic SPECT in multi-vessel coronary artery disease (CAD).MethodsPatients with suspected CAD who underwent dynamic ECG-gated dipyridamole MPI and coronary angiography within ...
Source: Journal of Nuclear Cardiology - July 8, 2021 Category: Nuclear Medicine Source Type: research

Nuclear cardiology in the literature: A selection of recent, original research papers
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 8, 2021 Category: Nuclear Medicine Source Type: research

Diagnostic safety of a machine learning-based automatic patient selection algorithm for stress-only myocardial perfusion SPECT
AbstractBackgroundStress-only myocardial perfusion imaging (MPI) markedly reduces radiation dose, scanning time, and cost. We developed an automated clinical algorithm to safely cancel unnecessary rest imaging with high sensitivity for obstructive coronary artery disease (CAD).Methods and ResultsPatients without known CAD undergoing both MPI and invasive coronary angiography from REFINE SPECT were studied. A machine learning score (MLS) for prediction of obstructive CAD was generated using stress-only MPI and pre-test clinical variables. An MLS threshold with a pre-defined sensitivity of 95% was applied to the automated pa...
Source: Journal of Nuclear Cardiology - July 6, 2021 Category: Nuclear Medicine Source Type: research

MIBG cardiac imaging compared to ejection fraction in evaluation of cardiotoxicity: a systematic review
ConclusionAlthough studies had high methodological variability, cardiac sympathetic innervation imaging seems to be a promising tool for assessing early cardiotoxicity. Further studies are needed to analyze its diagnostic value in this scenario. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 6, 2021 Category: Nuclear Medicine Source Type: research

Transient ischemic dilation or transient RV visualization in patients with normal SPECT stress myocardial perfusion imaging: Correlation with CT coronary artery calcium scoring and coronary angiography
ConclusionIn patients with normal stress SPECT MPI and TID or TRV, the incidence of severe obstructive CAD was relatively low and predominantly single-vessel CAD. These findings do not support the concept that TID or TRV with normal stress MPI is predictive of high-risk CAD. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 6, 2021 Category: Nuclear Medicine Source Type: research

Infective Endocarditis White Blood Cell Imaging: Is There an Added Value to the First-Line Imaging?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 6, 2021 Category: Nuclear Medicine Source Type: research

Localization of myocardial FDG uptake for prognostic risk stratification in corticosteroid-na ïve cardiac sarcoidosis
ConclusionsFDG uptake in the RV or basal anterolateral area of the LV with myocardial perfusion abnormality provides long-term prognostic risk stratification in patients with corticosteroid-na ïve CS. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 6, 2021 Category: Nuclear Medicine Source Type: research

The prognostic role of cardiac positron emission tomography imaging in patients with sarcoidosis: A systematic review
ConclusionAlthough available evidence indicates FDG PET can be used in the risk stratification of patients with CS, our findings show further studies are needed to quantify the effect in this patient group. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 6, 2021 Category: Nuclear Medicine Source Type: research

Cardiac PET in aortic stenosis: Potential role in risk refinement?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 6, 2021 Category: Nuclear Medicine Source Type: research

Interatrial septal 99mTc-pyrophosphate uptake and reduced strain in wild-type transthyretin amyloid cardiomyopathy
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 6, 2021 Category: Nuclear Medicine Source Type: research

68Ga-FAPI PET/MRI in Coronary Heart Disease
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 6, 2021 Category: Nuclear Medicine Source Type: research

The value of 18F-FDG PET/CT in two cases of Primary Pericardial Mesothelioma
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 6, 2021 Category: Nuclear Medicine Source Type: research

Cardiovascular disease in the literature: A selection of recent original research papers
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 6, 2021 Category: Nuclear Medicine Source Type: research

[18F]FDG PET-CT in the diagnosis of bacterial pericarditis
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 6, 2021 Category: Nuclear Medicine Source Type: research

ASNC and the new world of medical education: A glimpse of the future
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 6, 2021 Category: Nuclear Medicine Source Type: research

Functional innervation imaging in the evaluation of cardiotoxicity: Just the beginning of the journey
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 6, 2021 Category: Nuclear Medicine Source Type: research

Artificial intelligence-based attenuation correction; closer to clinical reality?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 6, 2021 Category: Nuclear Medicine Source Type: research

Carried away with the flow to maintain the reserve
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 6, 2021 Category: Nuclear Medicine Source Type: research

Whole-body PET angiography on semiconductor PET/CT
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 6, 2021 Category: Nuclear Medicine Source Type: research

Addendum to ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: Part 1 of 2 —evidence base and standardized methods of imaging
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 1, 2021 Category: Nuclear Medicine Source Type: research

Myocardial blood flow quantitation with the SPECT technique: Is it ready to be a substitute for PET myocardial blood flow quantitation?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - June 27, 2021 Category: Nuclear Medicine Source Type: research

Jnc awards
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - June 27, 2021 Category: Nuclear Medicine Source Type: research

Accurate quantification of myocardial perfusion
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - June 25, 2021 Category: Nuclear Medicine Source Type: research

Reasons for discordance between positron emission tomography (PET) myocardial perfusion imaging (MPI) results and subsequent management
ConclusionReferral rates for coronary angiography after PET correlate with severity of ischemia. However, there appear to be opportunities to reconsider testing for instances when results will not change clinical management. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - June 24, 2021 Category: Nuclear Medicine Source Type: research

18F-FDG PET/CT improves diagnostic certainty in native and prosthetic valve Infective Endocarditis over the modified Duke Criteria
ConclusionPET improves diagnostic certainty when combined with mDC in NVE and PVE. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - June 24, 2021 Category: Nuclear Medicine Source Type: research

Cardiac CZT-SPECT: More than left ventricular imaging
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - June 24, 2021 Category: Nuclear Medicine Source Type: research

MIBG and imaging of cardiac adrenergic system: From heart failure to ventricular arrhythmias and atrial fibrillation, through cardiac asynchrony. What else?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - June 24, 2021 Category: Nuclear Medicine Source Type: research

Adding value to myocardial perfusion scintigraphy: A prediction tool to predict adverse cardiac outcomes and risk stratify
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - June 24, 2021 Category: Nuclear Medicine Source Type: research

Myocardial perfusion imaging performed by dedicated cardiac cadmium-zinc-telluride camera in dextrocardia with situs inversus: A case report
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - June 24, 2021 Category: Nuclear Medicine Source Type: research