Higher incidence of vasodilator-induced left ventricular cavity dilation by PET when compared to treadmill exercise-ECHO in hypertrophic cardiomyopathy
ConclusionPET-LVCD reflects greater degree of myopathy and microvascular dysfunction in HCM. Differences in the cardiac effects of exercise and vasodilators and timing of stress-image acquisition could underlie discordance in ischemic EKG changes and LVCD by ECHO and PET, in HCM. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 19, 2018 Category: Nuclear Medicine Source Type: research

Quantitative blood flow evaluation of vasodilation-stress compared with dobutamine-stress in patients with end-stage liver disease using 82 Rb PET/CT
AbstractBackgroundOur aim was to determine if end-stage liver disease (ESLD) is associated with an attenuated response to vasodilator-stress or dobutamine-stress using82Rb-PET MPI with blood flow quantification.Methods and ResultsPre-liver transplant patients who had a normal dipyridamole-stress (n  =  27) or dobutamine-stress (n  =  26)82Rb PET/CT MPI study with no identifiable coronary artery calcium were identified retrospectively and compared to a prospectively identified low-risk of liver disease dipyridamole-stress control group (n  =  20). The dipyridamole-stress liver disea...
Source: Journal of Nuclear Cardiology - November 19, 2018 Category: Nuclear Medicine Source Type: research

PET imaging of sympathetic innervation with [ 18 F]Flurobenguan vs [ 11 C] m HED in a patient with ischemic cardiomyopathy
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 19, 2018 Category: Nuclear Medicine Source Type: research

Hypertrophic cardiomyopathy with apical aneurysm: Unraveling contribution and usefulness of gating to myocardial perfusion SPECT and a multi-modality investigation
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 19, 2018 Category: Nuclear Medicine Source Type: research

Myocardial blood flow measures using cardiac positron emission tomography: Software comparisons
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 19, 2018 Category: Nuclear Medicine Source Type: research

New hardware, new software, different results: The estimation of left ventricular volumes and ejection fractions with gated myocardial perfusion SPECT
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 16, 2018 Category: Nuclear Medicine Source Type: research

Cardio-oncology: Understanding cardiotoxicity to guide patient focused imaging
AbstractCurrent cancer therapy has led to tremendous improvements in outcomes. These therapies rely both on established therapies, such as anthracyclines and radiation, and molecularly-targeted therapies, such as tyrosine kinase inhibitors and immune modulators. Integrative care for patients with cancer must consider the potential effects of these therapies on a variety of organ systems, including the cardiovascular system. As a result, specialties such as cardio-oncology have developed to identify these effects, determine how to best monitor for these effects, and how to treat and ultimately prevent these effects while al...
Source: Journal of Nuclear Cardiology - November 15, 2018 Category: Nuclear Medicine Source Type: research

Focal mass-like cardiac uptake on oncologic FDG PET/CT: Real lesion or atypical pattern of physiologic uptake?
ConclusionsFocal suspicious cardiac uptake on oncology FDG PET/CT warranted further evaluation. SUVmax ratio between the cardiac focus and surrounding background cardiac uptake and status of distant metastases might help to differentiate malignant from benign nature of the focal cardiac uptake on FDG PET/CT. Focal uptake of the right ventricle on oncologic FDG PET/CT is more likely suggestive of a neoplasm. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 15, 2018 Category: Nuclear Medicine Source Type: research

Ventricular synchrony is not significantly determined by absolute myocardial perfusion in patients with chronic heart failure: A 13 N-ammonia PET study
AbstractBackgroundIt is thought that heart failure (HF) patients may benefit from the evaluation of mechanical (dys)synchrony, and an independent inverse relationship between myocardial perfusion and ventricular synchrony has been suggested. We explore the relationship between quantitative myocardial perfusion and synchrony parameters when accounting for the presence and extent of fixed perfusion defects in patients with chronic HF.MethodsWe studied 98 patients with chronic HF who underwent rest and stress Nitrogen-13 ammonia PET. Multivariate analyses of covariance were performed to determine relevant predictors of synchr...
Source: Journal of Nuclear Cardiology - November 15, 2018 Category: Nuclear Medicine Source Type: research

The Tree of Life
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 14, 2018 Category: Nuclear Medicine Source Type: research

Assessment of four different cardiac softwares for evaluation of LVEF with CZT-SPECT vs CMR in 48 patients with recent STEMI
ConclusionQGS and MX were the two best-performing softwares to evaluate LVEF after recent STEMI. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 13, 2018 Category: Nuclear Medicine Source Type: research

Cardiovascular disease in the literature: A selection of recent original research papers
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 13, 2018 Category: Nuclear Medicine Source Type: research

The prognostic value of quantitating and localizing F-18 FDG uptake in cardiac sarcoidosis
AbstractBackgroundThere is no identified level of FDG uptake in cardiac sarcoidosis (CS) associated with increased risk of arrhythmias, conduction disease, heart failure, or death. We aim to utilize standardized uptake value (SUV) quantitation and localization to identify patients at increased risk of cardiac events.Methods and ResultsF18-FDG PET/CT with MPI was used in CS diagnosis (N = 67). Mean and max SUV were measured and grouped as basal, mid, and apical disease. Post-scan ventricular tachycardia, AICD placement, complete heart block, pacemaker placement, atrial fibrillation, heart failure, and cardiac-...
Source: Journal of Nuclear Cardiology - November 12, 2018 Category: Nuclear Medicine Source Type: research

Should positron emission tomography be the standard of care for non-invasive surveillance following cardiac transplantation?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 12, 2018 Category: Nuclear Medicine Source Type: research

Multimodal imaging of cardiac-calcified amorphous tumor
We present a case of a 78-year-male diagnosed with cardiac CAT after surgical resection. We could evaluate tumor aspects by multimodal imaging including echocardiography, contrast-enhanced computed tomography (CT), magnetic resonance image, and 18F-fluorodeoxyglucose-positron emission tomography/CT before surgery. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 12, 2018 Category: Nuclear Medicine Source Type: research

Myocardial blood flow quantification conventional single photon tracers: Yet another critical appraisal
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 12, 2018 Category: Nuclear Medicine Source Type: research

Patient motion correction for dynamic cardiac PET: Current status and challenges
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 12, 2018 Category: Nuclear Medicine Source Type: research

Heart rate and 123I-MIBG in heart failure with preserved ejection fraction: More variability and slower washout —A secret recipe for better survival
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 9, 2018 Category: Nuclear Medicine Source Type: research

ASNC at 25
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 9, 2018 Category: Nuclear Medicine Source Type: research

Effect of reduced photon count levels and choice of normal data on semi-automated image assessment in cardiac SPECT: Doing more with fewer counts
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 8, 2018 Category: Nuclear Medicine Source Type: research

Evaluation of the effect of reducing administered activity on assessment of function in cardiac gated SPECT
ConclusionsThe administered activity could be reduced to 25% of full dose without degrading the function assessment performance. Low dose reconstruction optimized for perfusion-defect detection can be reasonable for function assessment in gated SPECT. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 7, 2018 Category: Nuclear Medicine Source Type: research

Automated dynamic motion correction using normalized gradient fields for 82 rubidium PET myocardial blood flow quantification
ConclusionsAn image-based, automated motion-correction algorithm for dynamic PET across the entire dynamic sequence using normalized gradient fields matched the results of manual motion correction in reducing bias and variance in MBF and MFR, particularly in the RCA territory. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 7, 2018 Category: Nuclear Medicine Source Type: research

Pneumonectomy-related small omega ( ω ) sign and increased pulmonary uptake in myocardial perfusion imaging
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 7, 2018 Category: Nuclear Medicine Source Type: research

Utility of nuclear stress imaging in predicting long-term outcomes one-year post CABG Surgery
This study aimed to identify prognostic value of nuclear stress-imaging post-CABG.MethodsThis was a single center prospective study looking at long-term outcomes post-CABG. Per protocol participants underwent SPECT-MPI stress testing and coronary angiogram on the same day, 1-year following CABG. Defect size was semi-quantified. The primary outcomes were the composite of death and congestive heart failure.ResultsEighty-four participants underwent nuclear stress-imaging and angiography, with a median follow-up of 11.1 years. Three separate stress findings predicted the primary outcome: inability to reach stage 3 of a Bruce p...
Source: Journal of Nuclear Cardiology - November 5, 2018 Category: Nuclear Medicine Source Type: research

Nutrition, risk factors, prevention, and imaging: The 2018 Mario Verani Lecture
AbstractHeart disease has been the leading cause of death in the United States since 1918. Cardiac mortality rates have dramatically decreased in this era of advanced medical and interventional therapies. However, this has been aptly described as “mopping up the floor instead of turning off the faucet.” With this recognition, prevention in cardiology is poised to become a central focus. Within prevention, dietary intervention is recognized as the single largest opportunity for improved cardiovascular outcomes, including improvement or el imination of cardiac risk factors, prevention of myocardial infarction, st...
Source: Journal of Nuclear Cardiology - November 5, 2018 Category: Nuclear Medicine Source Type: research

Early nuclear stress testing after CABG: The new standard or too soon to tell?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 5, 2018 Category: Nuclear Medicine Source Type: research

Gastric wall uptake of Tc-99m sestamibi: Techniques to decrease uptake and minimize its consequences in myocardial perfusion SPECT
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 5, 2018 Category: Nuclear Medicine Source Type: research

Simplified quantification PET myocardial blood flow: The need for technical standardization
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 5, 2018 Category: Nuclear Medicine Source Type: research

Case presentation commentary on “Rosai-Dorfman disease and left ventricular noncompaction cardiomyopathy: A heart failure conundrum.”
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 5, 2018 Category: Nuclear Medicine Source Type: research

Patients with incidental findings on MPS CTAC
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 5, 2018 Category: Nuclear Medicine Source Type: research

Advanced cardiovascular imaging for the evaluation of cardiac sarcoidosis
AbstractCardiac sarcoidosis (CS) remains an intriguing infiltrating disorder and one of the most important forms of inflammatory cardiomyopathy. Identification of patients with CS is of extreme importance because they are at higher risk of sudden death, and heart-failure progression. And while it remains a diagnostic conundrum, a great amount of experience has been accumulated over the last decade with the advent of fluorine-18 fluorodeoxyglucose positron emission tomography and cardiac magnetic resonance with late gadolinium enhancement imaging. They have both proven to be advanced imaging techniques that provide importan...
Source: Journal of Nuclear Cardiology - November 2, 2018 Category: Nuclear Medicine Source Type: research

Comparison of diagnostic accuracy of PET-derived myocardial blood flow parameters: A meta-analysis
ConclusionshMBF showed the best sensitivity while RFR showed the best specificity in the diagnosis of significant coronary stenosis. MFR was less sensitive than hMBF and less specific than hMBF and RFR. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 2, 2018 Category: Nuclear Medicine Source Type: research

Examining a novel threshold for defining electrocardiographic ischemia with vasodilator stress
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - November 2, 2018 Category: Nuclear Medicine Source Type: research

Prognostic values of 123 I-MIBG myocardial scintigraphy and heart rate variability in patients with heart failure with preserved ejection fraction
AbstractBackgroundThe aim of this study was to evaluate the prognostic values of sympathetic nerve system using123I-MIBG myocardial scintigraphy and using Holter electrocardiogram (ECG) in patients with heart failure with preserved ejection fraction (HFpEF).Methods and resultsAmong 403 consecutive patients with stable HF who underwent123I-MIBG myocardial scintigraphy and Holter ECG, we identified 133 patients (64  ± 16 years) who had preserved ejection fraction (≥ 50%) by echocardiography. Multivariate Cox model was used to assess if washout rate (WR) by123I-MIBG scintigraphy and very lo...
Source: Journal of Nuclear Cardiology - November 1, 2018 Category: Nuclear Medicine Source Type: research

Prognostic value of left-ventricular systolic and diastolic dyssynchrony measured from gated SPECT MPI in patients with dilated cardiomyopathy
This study aims to evaluate the prognostic values of both systolic and diastolic dyssynchrony in patients with DCM.MethodsFifty-two patients with DCM were enrolled and divided into two groups according to cardiac deaths from the follow-up data. The phase-analysis technique was applied on resting gated short-axis SPECT MPI images to measure LV systolic and diastolic dyssynchrony, including phase standard deviation (PSD), phase histogram bandwidth (PBW), and phase entropy (PE). Variables withP
Source: Journal of Nuclear Cardiology - November 1, 2018 Category: Nuclear Medicine Source Type: research

Cardiovascular disease in the literature: A selection of recent original research papers
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - October 31, 2018 Category: Nuclear Medicine Source Type: research

Michael E. Phelps, PhD (born August 24, 1939)
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - October 31, 2018 Category: Nuclear Medicine Source Type: research

What is This Image? 2018: Image  4
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - October 31, 2018 Category: Nuclear Medicine Source Type: research

Predatory publications and their abuse of the open access model
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - October 30, 2018 Category: Nuclear Medicine Source Type: research

Incremental prognostic value of myocardial neuroadrenergic damage in patients with chronic congestive heart failure: An iodine-123 meta-iodobenzylguanidine scintigraphy study
AbstractBackgroundICD in primary prevention reduced mortality in patients with heart failure (HF); however, in about 80% of the ICD recipients an event requiring a device intervention will never occur. Thus, a reliable screening test included in a multiparametric approach to appropriately select patients to ICD implantation is increasingly required. Aim of the work was to assess if the Iodine-123 Meta-Iodobenzylguanidine scintigraphy (123I-mIBG) could be useful to identify patients with HF who would not benefit from the ICD implantation because at low risk of arrhythmias.Methods and resultsThis is a retrospective multicent...
Source: Journal of Nuclear Cardiology - October 30, 2018 Category: Nuclear Medicine Source Type: research

Cardiac sarcoidosis with complete metabolic response and resolution of left ventricular dysfunction complicated by subsequent VT storm
We present a case of cardiac sarcoidosis with significantly impaired ejection fraction that was diagnosed late in the course of disease with complete metabolic response to therapy and an improvement of LV function, but with a subsequent complication of ventricular tachycardia storm. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - October 30, 2018 Category: Nuclear Medicine Source Type: research

Meta-analysis for diagnostic tests
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - October 30, 2018 Category: Nuclear Medicine Source Type: research

Umbrella review and multivariate meta-analysis of diagnostic test accuracy studies on hybrid non-invasive imaging for coronary artery disease
ConclusionsNon-invasive hybrid imaging tests appear superior to anatomic or functional only tests to diagnose ischemia-provoking coronary lesions, whereas anatomic imaging is best to diagnose and/or rule out angiographically significant CAD.Systematic review registrationPROSPERO Registry Number CRD42018088528. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - October 29, 2018 Category: Nuclear Medicine Source Type: research

Imaging cardiac innervation in hereditary transthyretin (ATTRm) amyloidosis: A marker for neuropathy or cardiomyopathy in case of heart failure?
AbstractBackgroundNuclear imaging modalities using123Iodine-metaiodobenzylguanidine (123I-MIBG) and bone seeking tracers identify early cardiac involvement in ATTRm amyloidosis patients. However, little is known whether results from123I-MIBG scintigraphy actually correlate to markers for either cardiac autonomic neuropathy or cardiomyopathy.MethodsAll TTR mutation carriers and ATTRm patients who underwent both123I-MIBG and99mTechnetium-hydroxymethylene diphosphonate (99mTc-HDP) scintigraphy were included. Cardiomyopathy was defined as NT-proBNP  >  365 ng/L, and cardiac autonomic neuropathy as abnorma...
Source: Journal of Nuclear Cardiology - October 29, 2018 Category: Nuclear Medicine Source Type: research

Vessel-specific quantification of absolute myocardial blood flow, myocardial flow reserve and relative flow reserve by means of fused dynamic 13 NH 3 PET and CCTA: Ranges in a low-risk population and abnormality criteria
ConclusionsOur vessel-specific functional indexes and 3D displays offer promise to more closely replicate what is commonly performed during a catheterization session and have the potential of providing effective noninvasive tools for the identification of flow-limiting lesions and image-guided therapy. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - October 29, 2018 Category: Nuclear Medicine Source Type: research

The need for standardization of nuclear cardiology reporting and data system (NCAD-RADS): Learning from coronary artery disease (CAD), breast imaging (BI), liver imaging (LI), and prostate imaging (PI) RADS
AbstractNewer structured reporting manners, the reporting and data system (RADS), have made vast steps in improving standardized and structured reporting, allowing better communication between radiologists and referring providers. This has been implemented in several fields: breast (BI-RADS), lung (Lung-RADS), liver (LI-RADS), thyroid (TI-RADS), prostate (PI-RADS), and in cardiovascular radiology (CAD-RADS). The field of nuclear cardiology began its efforts of standardization years ago; however, a widespread standardized reporting structure has not yet been adopted. Such an approach in nuclear cardiology, the nuclear cardi...
Source: Journal of Nuclear Cardiology - October 29, 2018 Category: Nuclear Medicine Source Type: research

Nuclear cardiology in the literature: A selection of recent original research papers
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - October 29, 2018 Category: Nuclear Medicine Source Type: research

A quick glance at selected topics in this issue
Abstract“A quick glance at selected topics in this issue” aims to highlight contents of theJournal and provide a quick review to the readers. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - October 29, 2018 Category: Nuclear Medicine Source Type: research

Advances in coronary molecular imaging: Leveraging the power of image processing
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - October 26, 2018 Category: Nuclear Medicine Source Type: research

Comparison of two dipyridamole infusion protocols for myocardial perfusion imaging in subjects with low likelihood of significant obstructive coronary artery disease
AbstractBackgroundMyocardial perfusion imaging (MPI) with positron emission tomography allows accurate measurements of myocardial blood flow (MBF). Stress MBF thresholds have been proposed to provide diagnostic and prognostic information in different pathology. Most studies relying on dipyridamole use a 5-minute infusion protocol, while current guidelines recommend a 4-minute infusion. The purpose of this study is to compare the effects of different dipyridamole infusion times on stress MBF.MethodsThe charts of 2,207 patients who underwent rubidium-82 MPI were retrospectively reviewed and 147 subjects with low likelihood o...
Source: Journal of Nuclear Cardiology - October 26, 2018 Category: Nuclear Medicine Source Type: research