Safety measures and clinical outcome of Nuclear Cardiology Department during Covid-19 lockdown pandemic: Northern Italy experience
ConclusionStrict ad hoc hygiene protocol for Covid-19 pandemic avoids diagnostic-therapeutic delay and lengthening of waiting lists. Our experience confirms that pursuing WHO recommendations and recent indication of ASNC and SNMMI is safe for both health providers and patients. Moreover, the incidence of significant inducible ischemia rises when correct stratification of patients is performed. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 30, 2020 Category: Nuclear Medicine Source Type: research
Early onset of left ventricular regional asynchrony in arteries with sub-clinical stenosis
ConclusionA subgroup of coronary territories with normal relative perfusion and normal or non-obstructive coronary disease may have reduced MFR, which is signaled physiologically by a mild degree of left ventricular asynchrony. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 22, 2020 Category: Nuclear Medicine Source Type: research
18 F-Sodium fluoride uptake is associated with severity of atherosclerotic stenosis in stable ischemic heart disease
ConclusionCoronary arterial 18F-NaF uptake is associated with coronary stenosis severity in patients with stable coronary artery disease.18F-NaF PET studies may be useful for characterizing coronary atherosclerotic plaques. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 15, 2020 Category: Nuclear Medicine Source Type: research
Regadenoson versus dipyridamole: Evaluation of stress myocardial blood flow response on a CZT-SPECT camera
ConclusionsOur results suggest that dipyridamole and regadenoson induce equivalent hyperemia in dynamic SPECT with similar stress MBF and MFR in comparable patients. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 9, 2020 Category: Nuclear Medicine Source Type: research
The prognostic utility of regadenoson SPECT myocardial perfusion imaging in patients with end-stage renal disease: The largest cohort to date
ConclusionIn the largest cohort to date, we demonstrated the incremental prognostic value of abnormal MPI in predicting MACE risk in ESRD patients. Given its size, our study provides improved risk estimates in this population compared to previous reports. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 5, 2020 Category: Nuclear Medicine Source Type: research
Regadenoson administration and QT interval prolongation during pharmacological radionuclide myocardial perfusion imaging
Publication date: Available online 3 July 2020Source: Indian Heart JournalAuthor(s): Arsalan Rafiq, Gayathri Kamalakkannan, Tausif Chughtai, Umair Ashraf, Yash Patel, Farbod Raiszadeh, Eduard Sklyar, Maryam Afshar, Jonathan N. Bella (Source: Indian Heart Journal)
Source: Indian Heart Journal - July 4, 2020 Category: Cardiology Source Type: research
Regadenoson administration and QT interval prolongation during pharmacological radionuclide myocardial perfusion imaging.
The objective of our study is to assess change in QTc interval with Regadenoson administration during myocardial perfusion imaging (MPI). We conducted a retrospective, observational analysis of 1497 consecutive patients who underwent pharmacological radionuclide MPI. On multivariate logistic regression analyses, there was no statistical significance of QTc prolongation when adjusted for ischemia/fixed perfusion defect on MPI and QT prolonging medications being taken prior to stress testing. However, a positive stress ECG after Regadenoson injection had a statistical significance (p value 0.0004). Regadenoson is a safe drug...
Source: Indian Heart J - June 30, 2020 Category: Cardiology Authors: Rafiq A, Chughtai T, Ashraf U, Patel Y, Raiszadeh F, Sklyar E, Afshar M, Bella JN, Kamalakkannan G Tags: Indian Heart J Source Type: research
Cardiac magnetic resonance imaging myocardial perfusion reserve index in heart transplant patients.
CONCLUSION: Stress cardiac MRI with regadenoson is safe. In the absence of epicardial coronary artery disease, patients with heart transplants have lower MPRI than patients without transplants, suggesting microvascular disease. The hemodynamic response to regadenoson is less pronounced in patients with heart transplants than in patients without heart transplants.
PMID: 32493651 [PubMed - as supplied by publisher] (Source: Radiologia)
Source: Radiologia - May 30, 2020 Category: Radiology Authors: Jiménez-Jaso JM, Ezponda A, Sáenz-Diez JM, Caballeros M, Rábago G, Bastarrika G Tags: Radiologia Source Type: research
The evolution of the prognostic value of regadenoson SPECT myocardial perfusion imaging
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 27, 2020 Category: Nuclear Medicine Source Type: research
Asystole following Regadenoson administration: Review of literature, risk factors and management
AbstractRegadenoson, a selective A2A receptor agonist, is widely used for vasodilator stress myocardial perfusion imaging and has a superior adverse effect profile when compared with other agents. However, with widespread use, there have been several reported cases of Regadenoson induced bradyarrhythmias and even asystole in patients with no known conduction system disease. In this article, we report a case of asystole following Regadenoson administration, evaluate mechanisms and risk factors for Regadenoson induced bradyarrhythmias to better identify patients at risk. We also review the available treatment options and pro...
Source: Journal of Nuclear Cardiology - May 26, 2020 Category: Nuclear Medicine Source Type: research
Early onset of left ventricular regional asynchrony as an indicator of compromised coronary flow capacity and sub-clinical arterial stenosis
Conclusions: Our results indicate that CFC classification of arterial territories allows identification of LV ischemia at a subcritical degree of coronary stenosis. Further studies are warranted to determine whether the mild degrees of hypoperfusion and asynchrony seen at low levels of CFC have prognostic implications. . *p<0.05 vs CFC1; p<0.05 vs CFC2; §p<0.05 vs CFC3CategoryCFC1 (N = 95)CFC2 (N = 53)CFC3 (N = 110)CFC4 (N = 40)CFC5 (N = 17)% stenosis21±32%29±34%30±38%45±42%*75±37%*â §Asynch+SSS1.1±0.91.5±1.52.3±1.4*â 3.9&plusm...
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Van Tosh, A., Votaw, J., Cooke, C., Cao, J. J., Palestro, C., Nichols, K. Tags: Vascular Imaging and Systems Biology (Basic Science, Cardio) Source Type: research
Data-driven motion correction for cardiac PET
Conclusions: From phantom data, we have demonstrated that application of the data-driven motion correction algorithm has the potential to completely correct varying degrees of cardiac motion. For clinical cases, the DDMC algorithm was able to restore all non-diagnostic cases and allow clinical interpretation. As motion degraded images are usually non diagnostic this method, once clinically validated, will avoid the need for a repeat scan and further radiation exposure. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Armstrong, I., Hayden, C., Arumugam, P. Tags: Motion Correction PET Source Type: research
Comparison of weight- and BMI-adjusted dosing for dynamic 82Rb PET myocardial perfusion imaging
Conclusions: The use of a BMI-dosing protocol significantly reduced both the frequency and severity of PET saturation, as well as significantly reducing the overall mean 82Rb dose and effective radiation exposure that patients received. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Arida-Moody, L., Moody, J., Poitrasson-Riviere, A., Hagio, T., Renaud, J., Weinberg, R., Corbett, J., Ficaro, E., Murthy, V. Tags: Clinical Science (Poster Session) Source Type: research
Quantitative myocardial perfusion 82Rb-PET assessed by hybrid PET/coronary CT: normal values and diagnostic performance
Conclusions: Normal sMBF, rMBF and MFR values are provided for 82Rb-PET based on normal CCTA. To detect patients with ischemia, global sMBF provided higher diagnostic accuracy than MFR. Using sMBF-threshold of 3.5 ml/mg/min on 82Rb-PET/CT yielded similar NPV (96%) as CCTA to rule out CAD. Hence, resting scan could be omitted in patients with sMBF values above reference. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Freitag, M., Bremerich, j., Wild, D., Haaf, P., Zellweger, M., Caobelli, F. Tags: Clinical Science (Poster Session) Source Type: research
Patient motion quality assurance metrics for accurate myocardial blood flow quantification with rubidium-82 PET imaging
Conclusions: The variation of the LV blood-to-tissue spillover parameter, COV(FV), is most predictive of patient motion, providing a useful QA metric and indicator of the subsequent uncertainty in the compartment model-derived MBF estimates for Rb82 PET images. References: [1] Murthy VL et al. Clinical quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC. J Nucl Cardiol 2018. Feb;25(1):269-297. [2] Lee BC et al. Automated dynamic motion correction using normalized gradient fields for 82rubidium PET myocardial blood flow quantification. J Nucl Cardiol 2018....
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Renaud, J., Poitrasson-Riviere, A., Moody, J., Hagio, T., Corbett, J., Weinberg, R., Murthy, V., Ficaro, E. Tags: Clinical Science (Poster Session) Source Type: research
