Regadenoson Reduces Soluble Receptor for Advanced Glycation End-Products in Lung Recipients
CONCLUSIONS: In vivo and in vitro studies suggest that A2AR activation reduces sRAGE in part by inhibiting MMP-9 production by monocytes/macrophages. These results suggest a novel molecular mechanism by which A2AR agonists reduces primary graft dysfunction.PMID:36921749 | DOI:10.1016/j.athoracsur.2023.03.007 (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - March 15, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Yunge Zhao Urmil Dhru Emily Fleischmann Ezzat Mostafa Manal Al-Suqi Mark R Conaway Alexander S Krupnick Joel Linden Joseph Rabin Christine L Lau Source Type: research
Regadenoson Reduces Soluble Receptor for Advanced Glycation End-Products in Lung Recipients
CONCLUSIONS: In vivo and in vitro studies suggest that A2AR activation reduces sRAGE in part by inhibiting MMP-9 production by monocytes/macrophages. These results suggest a novel molecular mechanism by which A2AR agonists reduces primary graft dysfunction.PMID:36921749 | DOI:10.1016/j.athoracsur.2023.03.007 (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - March 15, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Yunge Zhao Urmil Dhru Emily Fleischmann Ezzat Mostafa Manal Al-Suqi Mark R Conaway Alexander S Krupnick Joel Linden Joseph Rabin Christine L Lau Source Type: research
Indicators of abnormal PET coronary flow capacity in detecting cardiac ischemia
AbstractCoronary flow capacity (CFC) categorizes severity of left ventricular (LV) ischemia by PET myocardial blood flow (MBF). Our objective was to correlate abnormal CFC with other indicators of regional ischemia. Data were examined retrospectively for 231 patients evaluated for known/suspected CAD who underwent rest and regadenoson-stress82Rb PET/CT. MBF and myocardial flow reserve (MFR) were quantified, from which CFC was categorized as Normal CFC (1), Minimally reduced (2), Mildly reduced (3), Moderately reduced (4), and Severely reduced (5) for the three main arterial territories as well as globally. Relative perfusi...
Source: The International Journal of Cardiovascular Imaging - March 1, 2023 Category: Radiology Source Type: research
Splenic switch-off in regadenoson 82Rb-PET myocardial perfusion imaging: assessment of clinical utility
ConclusionLack of splenic response based on visual or quantitative assessment of SSO may be used to identify an inadequate vasodilatory response. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 6, 2023 Category: Nuclear Medicine Source Type: research
Indicators of abnormal PET coronary flow capacity in detecting cardiac ischemia
AbstractCoronary flow capacity (CFC) categorizes severity of left ventricular (LV) ischemia by PET myocardial blood flow (MBF). Our objective was to correlate abnormal CFC with other indicators of regional ischemia. Data were examined retrospectively for 231 patients evaluated for known/suspected CAD who underwent rest and regadenoson-stress82Rb PET/CT. MBF and myocardial flow reserve (MFR) were quantified, from which CFC was categorized as Normal CFC (1), Minimally reduced (2), Mildly reduced (3), Moderately reduced (4), and Severely reduced (5) for the three main arterial territories as well as globally. Relative perfusi...
Source: The International Journal of Cardiovascular Imaging - December 21, 2022 Category: Radiology Source Type: research
What Is the Rhythm?
An 88-year-old white man presented to our hospital for a regadenoson stress test. He had a history of coronary artery disease and had stents placed in both the left anterior descending and the left circumflex arteries 7 years earlier. He was taking metoprolol succinate 25 mg/day. He was not taking digoxin or any antiarrhythmic drugs. A recent echocardiogram showed normal left ventricular systolic function and mild aortic stenosis. The nursing staff noticed severe bradycardia. Blood pressure was normal, and the p atient was asymptomatic. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - October 31, 2022 Category: Cardiology Authors: Mazen M. Kawji Source Type: research
Ischemic heart disease : More than just chronic CAD
Radiologie (Heidelb). 2022 Nov;62(11):960-970. doi: 10.1007/s00117-022-01078-4. Epub 2022 Oct 27.ABSTRACTCLINICAL/METHODOLOGICAL ISSUE: Myocardial ischemia as a reduction in perfusion with therefore oxygen deficiency of vital cardiomyocytes. Thus primary and secondary prophylaxis of myocardial infarction and it's complications.STANDARD RADIOLOGICAL METHODS: Adenosine-regadenoson stress magnetic resonance imaging (AR-stress MRI), computed tomography coronary angiography (CTCA).METHODOLOGICAL INNOVATIONS: Non-invasive stress testing using AR-stress MRI to exclude relevant obstructive coronary artery disease (CAD).PERFORMANCE...
Source: Nuklearmedizin - October 27, 2022 Category: Radiology Authors: Sebastian Reinartz Katharina Fischbach Source Type: research
Ischemic heart disease : More than just chronic CAD
Radiologie (Heidelb). 2022 Nov;62(11):960-970. doi: 10.1007/s00117-022-01078-4. Epub 2022 Oct 27.ABSTRACTCLINICAL/METHODOLOGICAL ISSUE: Myocardial ischemia as a reduction in perfusion with therefore oxygen deficiency of vital cardiomyocytes. Thus primary and secondary prophylaxis of myocardial infarction and it's complications.STANDARD RADIOLOGICAL METHODS: Adenosine-regadenoson stress magnetic resonance imaging (AR-stress MRI), computed tomography coronary angiography (CTCA).METHODOLOGICAL INNOVATIONS: Non-invasive stress testing using AR-stress MRI to exclude relevant obstructive coronary artery disease (CAD).PERFORMANCE...
Source: Nuklearmedizin - October 27, 2022 Category: Radiology Authors: Sebastian Reinartz Katharina Fischbach Source Type: research
