Abstract 119: Comparison of Gated SPECT, Echocardiography and Angiography Ejection Fractions [Session Title: Poster Session I]
In this study we found a tendency for SPECT to overestimate the ejection fraction in post-stress gated studies compared with echocardiography and cath. Although several factors may have contributed to this observation, it is possible that the SPECT EF is augmented by the vasodilator effect of the stress pharmacologic agent. Further studies are needed to better qualify these findings. Meanwhile, given the importance of accurate quantification of a resting ejection fraction, especially as it relates evaluation of significant of valvular abnormalities or device therapy in heart failure, reliance on a SPECT-derived ejection fr...
Source: Circulation: Cardiovascular Quality and Outcomes - March 31, 2017 Category: Cardiology Authors: Kolakalapudi, P., Omar, M., Omar, B., Malozzi, C. Tags: Session Title: Poster Session I Source Type: research
Common genetic polymorphisms of adenosine A2A receptor do not influence response to regadenoson
Pharmacogenomics Ahead of Print. (Source: Future Medicine: Pharmacogenomics)
Source: Future Medicine: Pharmacogenomics - March 30, 2017 Category: Genetics & Stem Cells Source Type: research
Common genetic polymorphisms of adenosine A2A receptor do not influence response to regadenoson
Pharmacogenomics April 2017, Vol. 18, No. 6, Pages 523-529. (Source: Future Medicine: Pharmacogenomics)
Source: Future Medicine: Pharmacogenomics - March 30, 2017 Category: Genetics & Stem Cells Source Type: research
Stress SPECT Myocardial Perfusion Imaging in End-Stage Renal Disease
AbstractPurpose of ReviewPatients with end-stage renal disease (ESRD) have an increased risk of cardiovascular morbidity and mortality. Cardiac risk assessment, though challenging, is critical in these high-risk patients, particularly in the pre-transplant population. In this review, we discuss the burden of coronary artery disease in the ESRD population and review the literature on the diagnostic and prognostic performance, clinical value, and future directions of single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) in ESRD patients.Recent FindingsStress myocardial perfusion imaging provid...
Source: Current Cardiovascular Imaging Reports - March 17, 2017 Category: Radiology Source Type: research
The effect of regadenoson on the integrity of the human blood –brain barrier, a pilot study
This study was conducted to determine if standard doses of regadenoson transiently disrupt the human BBB allowing higher concentrations of systemically administered imaging agents to enter the brain. Patients without known intracranial disease undergoing clinically indicated pharmacologic cardiac stress tests were eligible for this study. They received regadenoson (0.4 mg) followed by brain imaging with either99mTc-sestamibi for SPECT or visipaque for CT imaging. Pre- and post-regadenoson penetration of imaging agents into brain were quantified [SPECT: radioactive counts, CT: Hounsfield units (HU)] and compared using a ma...
Source: Journal of Neuro-Oncology - March 16, 2017 Category: Cancer & Oncology Source Type: research
The EXERRT trial: “EXErcise to Regadenoson in Recovery Trial”: A phase 3b, open-label, parallel group, randomized, multicenter study to assess regadenoson administration following an inadequate exercise stress test as compared to regadenoson without exercise for myocardial perfusion imaging using a SPECT protocol
ConclusionsAdministering regadenoson during recovery from inadequate exercise results in comparable categorization of segments with RPDs and with careful monitoring appears to be well tolerated in patients without signs/symptoms of ischemia during exercise and recovery. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - February 20, 2017 Category: Nuclear Medicine Source Type: research
The significance of post-stress decrease in left ventricular ejection fraction in patients undergoing regadenoson stress gated SPECT myocardial perfusion imaging
ConclusionsIn patients selected to undergo coronary angiography following regadenoson stress GSPECT-MPI, a decrease in LVEF after regadenoson stress is not predictive of severe/extensive CAD or adverse clinical outcomes, irrespective of MPI findings. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - February 7, 2017 Category: Nuclear Medicine Source Type: research
Myocardial Blood Flow and Inflammatory Cardiac Sarcoidosis
Conclusions
Sarcoid-mediated myocardial inflammation is associated with a regional impairment of coronary circulatory function. The association between immune-suppressive treatment-related alterations in myocardial inflammation and changes in coronary vasodilator capacity suggests direct adverse effect of inflammation on coronary circulatory function in cardiac sarcoidosis. (Source: Journal of the American College of Cardiology: Cardiovascular Imaging)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - February 5, 2017 Category: Radiology Authors: Kruse, M. J., Kovell, L., Kasper, E. K., Pomper, M. G., Moller, D. R., Solnes, L., Chen, E. S., Schindler, T. H. Tags: Original Research Source Type: research
Impact of pharmacological stress agent on patient motion during rubidium-82 myocardial perfusion PET/CT
ConclusionsThe choice of stressing protocol impacts significantly on patient motion. Patients stressed with regadenoson have significantly lower motion scores than those stressed with adenosine, using local protocols. This motion is more likely to be associated with a drift of the heart away from a baseline position, coinciding with the termination of infusion. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 3, 2017 Category: Nuclear Medicine Source Type: research
Regadenoson
(Source: Reactions Weekly)
Source: Reactions Weekly - December 31, 2016 Category: Drugs & Pharmacology Source Type: research
Myocardial stress perfusion magnetic resonance: initial experience in a pediatric and young adult population using regadenoson
ConclusionRegadenoson might be a safe and feasible pharmacologic stress agent for use in cardiac MR in older pediatric patients with congenital heart disease and acquired heart disease. The ease of use as a bolus and the advantage of a prolonged hyperemia make its use appealing in pediatrics. In a limited number of cases, regadenoson stress perfusion showed excellent agreement with cardiac catheterization. Regadenoson might be a viable pharmacologic stress agent in this population. (Source: Pediatric Radiology)
Source: Pediatric Radiology - December 28, 2016 Category: Radiology Source Type: research
Regadenoson-induced complete heart block and asystole: A real possibility nuclear laboratories should be aware of
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - December 19, 2016 Category: Nuclear Medicine Source Type: research
Myocardial perfusion SPECT 2015 in Germany. Results of the 7th survey.
CONCLUSION: The 2015 MPS survey reveals a high-grade adherence of routine MPS practice to current guidelines. The positive trend in MPS performance and number of MPS already observed in 2012 continues. Educational training remains necessary in the field of SPECT scoring.
PMID: 27909712 [PubMed - as supplied by publisher] (Source: Nuklearmedizin)
Source: Nuklearmedizin - December 1, 2016 Category: Radiology Authors: Lindner O, Burchert W, Schäfer W, Hacker M Tags: Nuklearmedizin Source Type: research
Validation of a Na+-shift binding assay for estimation of the intrinsic efficacy of ligands at the A2A adenosine receptor
Discussion We conclude that the Na+-shift assay proposed herein for the A2A receptors has been validated and represents a rapid, economic and efficient functional binding assay to be used in a drug development program for early estimation of the intrinsic efficacy of hits. (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2016 Category: Drugs & Pharmacology Source Type: research
The impact of combination of regadenoson and isometric exercise on image quality of myocardial perfusion scintigraphy
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - October 31, 2016 Category: Nuclear Medicine Source Type: research
