Hemiplegic migraine episode triggered by regadenoson
AbstractSPECT and PET myocardial perfusion imaging (MPI) are widely used to evaluate patients for coronary artery disease. Regadenoson (a selective A2A adenosine receptor agonist) is a commonly used vasodilator agent for stress MPI because of its safety profile and ease of use. Common adverse reactions such as headache, shortness of breath, flushing, and chest and abdominal discomfort are typically mild and can be effectively reversed using methylxanthines such as aminophylline and caffeine. Neurological adverse reactions such as seizure and stroke have rarely been reported with the use of regadenoson. The hemodynamic chan...
Source: Journal of Nuclear Cardiology - July 25, 2021 Category: Nuclear Medicine Source Type: research
Myocardial Perfusion Reserve in Children with Friedreich Ataxia
AbstractChildren with Friedreich ’s ataxia (FA) are at risk of perioperative morbidity and mortality from severe unpredictable heart failure. There is currently no clear way of identifying patients at highest risk. We used myocardial perfusion reserve (MPR), an MRI technique used to assess the maximal myocardial blood flow above baseline, to help determine potential surgical risk in FA subjects. In total, seven children with genetically confirmed FA, ages 8–17 years, underwent MPR stress testing using regadenoson. Six of the seven demonstrated impaired endocardial perfusion during coronary hyperemia. The same six were...
Source: Pediatric Cardiology - July 10, 2021 Category: Cardiology Source Type: research
Measuring myocardial blood flow with 82rubidium using Gjedde –Patlak–Rutland graphical analysis
ConclusionsGPR analysis offers promise as a valid and analytically simpler technique for measuring myocardial blood flow, which, as with any clearance measured from GPR analysis, has units of ml/min/ml total tissue volume, and merits development as a polar map display. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - June 2, 2021 Category: Nuclear Medicine Source Type: research
Improved Myocardial Blood Flow Estimation with Residual Activity and Motion Correction in 18F-flurpiridaz PET myocardial perfusion imaging
Conclusions: MBF estimation with MC and RAC improves the diagnostic performance of same day rest/stress18F-flurpiridaz PET MPI. RAC and MC seems to be the critical correction in evaluation dynamic rest/stress PET flow obtained with F-18 Flurpiridaz. Table 1. AUC for the detection of obstructive CAD by minimal segmental stress MBF and MFR with and without motion correction and residual activity correctionAUC [95% CI]MC/RACNo MC/RACNo MC/No RACStress MBF0.89 [0.85-0.93]0.84 [0.79-0.90]0.78 [0.72-0.85]MFR0.83 [0.77-0.90]0.77 [0.70-0.84]0.69 [0.62-0.77] MC: motion correction, RAC: residual activity correction (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Otaki, Y., Van Kriekinge, S., Wei, C.-C., Kavanagh, P., Singh, A., Parekh, T., DiCarli, M., Buckley, C., Berman, D., Slomka, P. Tags: Myocardial Perfusion and Technical Advances Source Type: research
Quantitative Myocardial Blood Flow and Reserve with Low Dose Rest/High Dose Stress Regadenoson PET/CT-MPI: The Utility of Residual Activity Correction With N-13 Ammonia
Conclusion: Using the prescribed low dose rest/high dose stress regadenoson N-13 ammonia PET/CT-MPI protocol, residual activity subtraction results in only a modest downward adjustment to the measured flow and reserve metrics of 4% or less. More aggressive dose reduction with N13-ammonia for the stress dose trace activity will be feasible using residual activity subtraction methodology. Acknowledgements: We would like to thank Angelina Aviles for data entry. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Feldkamp, A., Yap, W., Donald, J., Press, B., Dilberto, A., Feldkamp, M., Rosamond, T. Tags: Myocardial Perfusion and Technical Advances Source Type: research
Explainable prediction of all-cause mortality from myocardial PET flow and perfusion images using deep learning
Conclusions: The DL network was trained directly with PET dynamic flow and static perfusion PET polar map image data, which allows for improved patient risk stratification, compared to established quantitative methods for PET flow or perfusion assessment. The network also highlights specific polar map image regions associated with risk of mortality, providing an explanation of the patient-specific risk estimation to the physician. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Singh, A., Otaki, Y., Kavanagh, P., Van Kriekinge, S., Miller, R., Chih-Chun, W., Parekh, T., Gransar, H., Chen, N., Berman, D., Slomka, P. Tags: Myocardial Perfusion and Technical Advances Source Type: research
A case study confirming the reliability of Gated N13 ammonia PET/CT over Tc-99m Sestamibi D-SPECT in diagnosing cardiovascular disease
Conclusions: The reviewed case had microvascular dysfunction due to calcification of coronary microvessels which was not detected by gated Tc-99m Sestamibi D-SPECT. The N13 ammonia PET/CT technique was shown to be more specific in diagnosing hidden CMD defects and multivessel CAD. Further reviews will be needed to verify the feasibility of early use of N13 ammonia with PET/CT in order to save time and reduce costs. Acknowledgements: The author recognizes the contribution and support provided by the technologists at the Dept. of Nuclear Medicine at Brigham and Women’s Hospital, Boston, MA.Special thanks for Leonas Nal...
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: El Khatib, S. Tags: Technologist Student Oral Session II Source Type: research
Regional versus global PET function and perfusion computations for detecting cardiac ischemia
Conclusions: Anatomic (>70% stenosis) & functional (regional perfusion abnormalities & LV asynchrony) evidence of myocardial ischemia correspond more closely to regional than global abnormalities of CFC. This suggests that territorial, rather than global, CFC values may potentially have greater value for identifying risk for future cardiovascular events. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Van Tosh, A., Cao, J. J., Palestro, C., Nichols, K. Tags: Clinical Science Source Type: research
Quantitative Assessment of Early Post Injection Stress-First Tetrofosmin Acquisition: Implications for Laboratory Efficiency and Potentially Reducing Patient and Staff Risk During the Covid-19 Pandemic
Conclusions: Early post-stress imaging appears feasible with Tc-99m tetrofosmin and CZT instrumentation, with no difference in heart/blood pool ratios between early and late acquisitions, and early heart/liver ratios well above 1. This protocol permits rapid acquisitions, reduces patient/staff interaction times, and almost halves the time a patient needs to be in the lab. A blinded read of early and late acquisitions to determine image quality and diagnostic certainty appears warranted. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Case, J., Courter, S., McGhie, A., Moloney, E., Case, K., Burgett, E., Bateman, T. Tags: Clinical Science Source Type: research
Comparison of stress myocardial Flow Response using regadenoson and dipyridamole in SPECT
Conclusions: Dipyridamole and regadenoson induced equivalent hyperemia with similar global stress MBF and MFR on a low-risk population without confounding factors. These results should be confirmed on a large, prospective and randomized study, including healthy young patients and also high risk patients. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: BAILLY, M., BRANA, Q., THIBAULT, F., Courtehoux, M., METRARD, G., ANGOULVANT, D., Santiago-Ribeiro, M.-J. Tags: Clinical Science Source Type: research
Comparison of regadenoson and dypiridamole myocardial blood flow and coronary flow reserve hyperemic response by non-invasive quantitative N-13 ammonia PET.
1653Introduction: Regadenoson is currently the most commonly used drug for pharmacologic stress myocardial perfusion imaging. Given its more selective A2A agonist-driven vasodilatory properties when compared to adenosine or dipyridamole, the accuracy of measuring true hyperemia after the standard bolus of N-13 ammonia injection remains to be fully established. Our aim was to use quantitative N-13 ammonia PET myocardial perfusion for assessing myocardial blood flow (MBF) and coronary flow reserve (CFR) response to regadenoson (REG) and dipyridamole (DIP) in patients with an intermediate pre-test likelihood of coronary arter...
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Nguyen, T., Lin, D., Grandis, D., Qasim, A., Hernandez Pampaloni, M. Tags: Clinical Science Source Type: research
Effects of two patient-specific dosing protocols on measurement of myocardial blood flow with 3D < sup > 82 < /sup > Rb cardiac PET
CONCLUSIONS: Patient-specific dosing according to BMI is an effective method for guideline-directed dose reduction while maintaining image quality and accuracy for routine MBF and MFR quantification.PMID:33982174 | DOI:10.1007/s00259-021-05385-1 (Source: Molecular Medicine)
Source: Molecular Medicine - May 13, 2021 Category: Molecular Biology Authors: Liliana Arida-Moody Jonathan B Moody Jennifer M Renaud Alexis Poitrasson-Rivi ère Tomoe Hagio Anne M Smith Edward P Ficaro Venkatesh L Murthy Source Type: research
Effects of two patient-specific dosing protocols on measurement of myocardial blood flow with 3D < sup > 82 < /sup > Rb cardiac PET
CONCLUSIONS: Patient-specific dosing according to BMI is an effective method for guideline-directed dose reduction while maintaining image quality and accuracy for routine MBF and MFR quantification.PMID:33982174 | DOI:10.1007/s00259-021-05385-1 (Source: Molecular Medicine)
Source: Molecular Medicine - May 13, 2021 Category: Molecular Biology Authors: Liliana Arida-Moody Jonathan B Moody Jennifer M Renaud Alexis Poitrasson-Rivi ère Tomoe Hagio Anne M Smith Edward P Ficaro Venkatesh L Murthy Source Type: research
Stress testing and myocardial perfusion imaging for patients after recovery from severe COVID-19 infection requiring hospitalization: A single-center experience
ConclusionOver time, more patients that recover from COVID-19 infection will require MPI testing for myocardial ischemia evaluation. Our study provides some information regarding performing stress testing in patients who have recently recovered from COVID-19 infections requiring hospitalization. Further studies are recommended to establish formal protocols for testing in this cohort. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 26, 2021 Category: Nuclear Medicine Source Type: research
Regadenoson Mycardial Contrast Echocardiography Perfusion Imaging for Detection of Allograft Coronary Vasculopathy
Due to the often asymptomatic nature of cardiac allograft vasculopathy (CAV) serial surveillance is recommended for all cardiac transplant (OHT) recipients. Ideally, CAV surveillance should be non-invasive, not involve ionizing radiation, and discriminate diffuse CAV from focal obstructions. We hypothesized that vasodilator stress myocardial contrast echocardiography (MCE) perfusion imaging can non-invasively detect microvascular impact of diffuse or focal CAV. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 20, 2021 Category: Transplant Surgery Authors: J. Steiner, J. Hodovan, N. Colaco, L. Masha, D. Meyers, J. Lindner Tags: (74) Source Type: research
