Possible Association of Pulmonary Atresia with In-Utero Coxsackievirus B Exposure
AbstractGestational viral infection has been associated with congenital heart disease (CHD). Few studies, however, have studied the potential role of gestational Coxsackievirus B (CVB) exposure in the pathogenesis of CHD. We prospectively enrolled women with pregnancies affected by CHD to explore possible associations with in utero CVB exposure. Serum samples were obtained from 122 women referred for fetal echocardiography between 2006 and 2018. We quantified CVB IgG and IgM levels, with titers  ≥ 15.0 U/mL considered positive and measured neutralizing antibodies for three CVB serotypes: CVB1, CVB3, and CVB4. Using ...
Source: Pediatric Cardiology - May 18, 2022 Category: Cardiology Source Type: research

Current Practices in Treating Cardiomyopathy and Heart Failure in Duchenne Muscular Dystrophy (DMD): Understanding Care Practices in Order to Optimize DMD Heart Failure Through ACTION
AbstractCardiac disease has emerged as a leading cause of mortality in Duchenne muscular dystrophy in the current era. This survey sought to identify the diagnostic and therapeutic approach to DMD among pediatric cardiologists in Advanced Cardiac Therapies Improving Outcomes Network. Pediatric cardiology providers within ACTION (a multi-center pediatric heart failure learning network) were surveyed regarding their approaches to cardiac care in DMD. Thirty-one providers from 23 centers responded. Cardiac MRI and Holter monitoring are routinely obtained, but the frequency of use and indications for ordering these tests varie...
Source: Pediatric Cardiology - May 18, 2022 Category: Cardiology Source Type: research

Pediatric Patients Undergoing a Fontan Operation or with a High RACHS-1 Score Require Monitoring for Chronic Kidney Disease in Early Childhood
We examined the frequency of and risk factors for pediatric CKD development in patients with congenital heart disease (CHD) at least 2  years after cardiac surgery. This was a cross-sectional study of 147 patients who underwent open-heart surgery for CHD at Kagoshima University Hospital from April 2010 to March 2017. Data on demographics, acute kidney injury after cardiac surgery, cyanotic heart disease, Fontan circulation, medica tions in the perioperative period, and Risk Adjustment for Congenital Heart Surgery-1 (RACHS-1) category were recorded. CKD was defined using the current classification system described in the N...
Source: Pediatric Cardiology - May 18, 2022 Category: Cardiology Source Type: research

Pulmonary Versus Systemic Outflow Obstruction in Functionally Univentricular Hearts with Isomerism: An Observation
AbstractOur objective was to review our experience with isomerism associated with univentricular hearts and evaluate the prevalence of pulmonary versus systemic outflow obstruction. We identified those prenatally or postnatally diagnosed, between September 2004 and October 2021, with right and left isomerism and a functionally univentricular heart. We identified 62, 51 prenatally and 11 postnatally. Of the 62, 61 had prenatal care for an 84% (51/61) prenatal detection rate. Of the 62, 36 (58%) had right isomerism. Of the 51 prenatally diagnosed, 36 were live-born, 13 had fetal demise, and two underwent elective termination...
Source: Pediatric Cardiology - May 18, 2022 Category: Cardiology Source Type: research

Upcoming Events in Pediatric Cardiology
(Source: Pediatric Cardiology)
Source: Pediatric Cardiology - May 18, 2022 Category: Cardiology Source Type: research

Parent-Provider Communication in Hospitalized Children with Advanced Heart Disease
This study explored how parents of hospitalized children with advanced heart disease perceived communication with their child ’s providers. We performed a prospective survey study of parents and physicians of children with advanced heart disease age 30 days to 19 years admitted to the hospital for >  7 days over a 1-year period at a single institution (n = 160 parent-provider pairs). Descriptive statistics were primarily used and Fisher exact tests and kappa statistics were used to assess agreement. All parents rated communication with their child’s care team as excellent, very good, or good, but 56% of p...
Source: Pediatric Cardiology - May 10, 2022 Category: Cardiology Source Type: research

Mitochondrial Dysfunction in Cyanotic Congenital Heart Disease: A Promising Therapeutic Approach for the Future
In this study, mitochondrial morphology and function, myocardial fibrosis, and myocyte atypia were evaluated in myocardial biopsy tissue of pediatric patients with cyanotic and acyanotic CHD, five from each group. After histopathological evaluation of myocardial tissue specimens, mitochondrial morphology and network were analyzed by immunofluorescence staining using an anti-Tom20 antibody, electron transport chain complexes of myocardium were examined by cytochrome c oxidase/succinate dehydrogenase staining, and the amount of ATP was measured by bioluminescence assay. In addition, cardiac markers have been tested to be rev...
Source: Pediatric Cardiology - May 10, 2022 Category: Cardiology Source Type: research

Upcoming Events in Pediatric Cardiology
(Source: Pediatric Cardiology)
Source: Pediatric Cardiology - May 7, 2022 Category: Cardiology Source Type: research

Eisenmenger Syndrome Among Children with Unrepaired Congenital Heart Defects in Yunnan, China
AbstractEisenmenger syndrome is a life-threatening complication of congenital heart defects (CHD). Since Eisenmenger syndrome among children of repaired CHD is rare, very few studies have had the necessary data to investigate its distribution in children. The current study used data collected in rural China to investigate the prevalence of Eisenmenger syndrome in children with unrepaired CHD. Data were from the 2006 to 2016 patient medical records of China California Heart Watch, which is a traveling cardiology clinic in Yunnan Province, China. Patients were included if they (1) aged 18 or below, (2) had CHD(s), and (3) th...
Source: Pediatric Cardiology - May 6, 2022 Category: Cardiology Source Type: research

Coarctation of the Aorta and Anomalous Origin of the Left Coronary from the Opposite Sinus of Valsalva in a 6-Year-Old Male
We report the first case in the literature of coarctation of the aorta associated with ALCA from the opposite aortic sinus and describe surgical correction of these two lesions. (Source: Pediatric Cardiology)
Source: Pediatric Cardiology - May 6, 2022 Category: Cardiology Source Type: research

Physical Frailty is Modifiable in Young Cardiac Rehabilitation Patients
This study established that frailty exhibits discriminatory utility across pediatric-onset CVD groups at baseline and is significantly modifiable over time. Improvements in frailty and other fitness metrics are likely due to a combination of post-operative recovery, post-diagnosis pharmacological and li festyle changes, and CR. Further study of this frailty tool is needed to explore its prognostic utility. (Source: Pediatric Cardiology)
Source: Pediatric Cardiology - May 5, 2022 Category: Cardiology Source Type: research

Cardiopulmonary Exercise Performance in the Pediatric and Young Adult Population Before and During the COVID-19 Pandemic
In conclusion, cardiopulmonary exercise performance, notably aerobic activity, decreased during the COVID-19 pandemic in children, adolescents and young adults compared to pre-pandemic values. This decline was most notable in those with the highest pre-pandemic aerobic capacity values and was independent of somatic growth or changes in BMI. This study has public health implications and demonstrates the importance of PA on overall cardiovascular health. (Source: Pediatric Cardiology)
Source: Pediatric Cardiology - May 3, 2022 Category: Cardiology Source Type: research

Screening Echocardiography Identifies Risk Factors for Pulmonary Hypertension at Discharge in Premature Infants with Bronchopulmonary Dysplasia
ConclusionIn our cohort of premature infants with BPD, 36  weeks PMA screening echocardiogram identified patients at increased risk for BPD-PH at discharge when ASD, RVH, or impaired RV function were present. Larger prospective studies are indicated to validate these findings. (Source: Pediatric Cardiology)
Source: Pediatric Cardiology - April 29, 2022 Category: Cardiology Source Type: research

The First Evaluation of Remote Magnetic Navigation-Guided Pediatric Ventricular Arrhythmia Ablation
This study aimed to compare procedural and long-term outcomes between RMN-guided and manual (MAN)-guided VA ablation in children. This single-center, retrospective study included all CA procedures for VA performed in children with or without structural heart disease from 2008 until 2020. Two study groups were defined by CA technique: RMN or MAN. Primary outcome was recurrence of VA. Baseline clinical, procedural and safety data were also evaluated. This study included 22 patients, who underwent 30 procedures, with a median age of 15 (IQR 14 –17; range 1–17) years and a mean weight of 57 ± 20 kg. In total, 14 proc...
Source: Pediatric Cardiology - April 29, 2022 Category: Cardiology Source Type: research

Exercise Capacity After Arterial Switch Operation in Patients with D-Transposition of Great Arteries: Does the Coronary Artery Anatomy Matter?
AbstractVariant coronary anatomy (VarCA) is frequent in D-Transposition of the great arteries (d-TGA). There are a paucity of data on the effect of the VarCA on the exercise capacity (XC) in patients with repaired d-TGA. This retrospective study included patients with d-TGA who underwent an arterial switch operation (ASO) and had at least one cardiopulmonary exercise test (CPET). Data from the treadmill CPET and simultaneously performed spirometry were collected. The parameters of CPET were compared between patients with usual anatomy vs. VarCA. Longitudinal changes in XC in patients with ASO were also analyzed. A total of...
Source: Pediatric Cardiology - April 28, 2022 Category: Cardiology Source Type: research