Evaluating the use of pharmacological stress agents during single-photon emission computed tomography myocardial perfusion imaging tests after inadequate exercise stress test
ConclusionsCompared to adenosine and dipyridamole, regadenoson is preferred by nuclear imaging center staff and associated with operational efficiencies after inadequate EST in real-world practice SPECT-MPI. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - March 11, 2021 Category: Nuclear Medicine Source Type: research
Cardiovascular magnetic resonance stress and rest T1-mapping using regadenoson for detection of ischemic heart disease compared to healthy controls
Adenosine stress T1-mapping on cardiovascular magnetic resonance (CMR) can differentiate between normal, ischemic, infarcted, and remote myocardial tissue classes without the need for contrast agents. Regadenoson, a selective coronary vasodilator, is often used in stress perfusion imaging when adenosine is contra-indicated, and has advantages in ease of administration, safety profile, and clinical workflow. We aimed to characterize the regadenoson stress T1-mapping response in healthy individuals, and to investigate its ability to differentiate between myocardial tissue classes in patients with coronary artery disease (CAD...
Source: International Journal of Cardiology - March 8, 2021 Category: Cardiology Authors: Matthew K. Burrage, Mayooran Shanmuganathan, Ambra Masi, Evan Hann, Qiang Zhang, Iulia A. Popescu, Rajkumar Soundarajan, Joana Leal Pelado, Kelvin Chow, Stefan Neubauer, Stefan K. Piechnik, Vanessa M. Ferreira Source Type: research
Regadenoson
(Source: Reactions Weekly)
Source: Reactions Weekly - March 1, 2021 Category: Drugs & Pharmacology Source Type: research
Lung Sestamibi Uptake on Myocardial Perfusion Imaging and Outcomes in Chronic Kidney Disease
Conclusions: LHR ≤0.28 and ≥0.33 are independently associated with higher risk for death in patients with CKD-ND and ESKD. Future studies are warranted to understand the association of extreme LHR values and outcomes in this high-risk population.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 25, 2021 Category: Urology & Nephrology Source Type: research
Comparison of left ventricle mechanical dyssynchrony parameters in ischemic and non-ischemic patients using 13 N-NH 3 PET/CT
ConclusionsUsing a vasodilator as a stress, the PSD and PHB post-stress and ΔPSD were significantly higher in the ischemic patients than the non-ischemic group, while there were no significant differences in each cohort between stress and rest indices. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 4, 2021 Category: Nuclear Medicine Source Type: research
Impaired Myocardial Perfusion on Stress CMR Correlates With Invasive FFR in Children With Coronary Anomalies.
CONCLUSIONS: Assessment of myocardial perfusion using non-invasive sCMR concurred with FFR, particularly if performed with close proximity in time, and may contribute to risk stratification and decision making in children with AAOCA and/or MB.
PMID: 33385986 [PubMed - as supplied by publisher] (Source: The Journal of Invasive Cardiology)
Source: The Journal of Invasive Cardiology - January 3, 2021 Category: Cardiology Tags: J Invasive Cardiol Source Type: research
Prognostic value of early left ventricular ejection fraction reserve during regadenoson stress solid-state SPECT-MPI
ConclusionsReduced early post-stress EFR on vasodilator stress solid-state SPECT is associated with MACE. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - January 3, 2021 Category: Nuclear Medicine Source Type: research
Prognostic value of absent left ventricular ejection fraction reserve with regadenoson SPECT MPI
ConclusionsIn patients undergoing regadenoson SPECT MPI, absent LVEF reserve is not associated with worse cardiac outcomes. Thus, routine reporting of both post-stress and rest LVEF measurements in this setting may not be necessary. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - October 21, 2020 Category: Nuclear Medicine Source Type: research
Stimulation of the hepatic arterial buffer response using exogenous adenosine: hepatic rest/stress perfusion imaging
ConclusionHAPI could be a useful new hepatic function test. Neither splenic ‘switch-off’ nor hepatic arterial ‘switch-on’ identifies adequacy of stress in MPI.Key Points• This article describes a new method for assessing arterial perfusion of the liver and its capacity to respond to an infusion of adenosine, a substance that normally ‘drives’ hepatic arterial flow.• Hepatic arterial flow increased in response to adenosine, sometimes dramatically. Adenosine is already used clinically to stimulate myocardial blood flow in patients with suspected coronary disease, but the increase in flow did not correlate wit...
Source: European Radiology - October 13, 2020 Category: Radiology Source Type: research
The diagnostic and prognostic value of near-normal perfusion or borderline ischemia on stress myocardial perfusion imaging
ConclusionNear-normal MPI and borderline ischemia on SPECT-MPI provide no significant prognostic information in predicting hard cardiac events but are associated with higher rates of obstructive angiographic CAD and coronary revascularizations. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - October 9, 2020 Category: Nuclear Medicine Source Type: research
The prognostic implications of ST-segment and T-wave abnormalities in patients undergoing regadenoson stress SPECT myocardial perfusion imaging
ConclusionWhile patients with secondary ST/T abnormalities had significantly higher MACE risk, abnormal MPI or presence of myocardial ischemia on regadenoson SPECT-MPI in this group does not add prognostic information. Patients with primary ST abnormalities and T-wave abnormalities do not seem to have a significantly higher MACE risk compared to those with normal ECG; however, abnormal MPI or presence of myocardial ischemia, in these groups, correlates with higher MACE rates. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - October 8, 2020 Category: Nuclear Medicine Source Type: research
Blood-Brain Barrier Disruption in Neuro-Oncology: Strategies, Failures, and Challenges to Overcome
The blood-brain barrier (BBB) presents a formidable challenge in the development of effective therapeutics in neuro-oncology. This has fueled several decades of efforts to develop strategies for disrupting the BBB, but progress has not been satisfactory. As such, numerous drug- and device-based methods are currently being investigated in humans. Through a focused assessment of completed, active, and pending clinical trials, our first aim in this review is to outline the scientific foundation, successes, and limitations of the BBBD strategies developed to date. Among 35 registered trials relevant to BBBD in neuro-oncology i...
Source: Frontiers in Oncology - September 17, 2020 Category: Cancer & Oncology Source Type: research
Practical instructions for using drugs in CT and MR cardiac imaging
AbstractThe progressive increase in numbers of noninvasive cardiac imaging examinations broadens the spectrum of knowledge radiologists are expected to acquire in the management of drugs during CT coronary angiography (CTCA) and cardiac MR (CMR) to improve image quality for optimal visualization and assessment of the coronary arteries and adequate MR functional analysis. Aim of this review is to provide an overview on different class of drugs (nitrate, beta-blockers, ivabradine, anxiolytic, adenosine, dobutamine, atropine, dipyridamole and regadenoson) that can be used in CTCA and CMR, illustrating their main indications, ...
Source: La Radiologia Medica - August 23, 2020 Category: Radiology Source Type: research
More Purinergic Receptors Deserve Attention as Therapeutic Targets for the Treatment of Cardiovascular Disease.
Abstract
Cardiovascular disease is a major cause of morbidity and mortality worldwide. Innovative new treatment options for this cardiovascular pandemic are urgently needed. Activation of purinergic receptors (PRs) is critically involved in the development and progression of cardiovascular disease including atherosclerosis, ischemic heart disease, hypertension and diabetes. PRs have been targeted for the treatment of several cardiovascular diseases in a clinical setting. The P2Y12R antagonists such as clopidogrel, ticagrelor and others are the most successful class of purinergic drugs targeting platelets f...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 20, 2020 Category: Physiology Authors: Wernly B, Zhou Z Tags: Am J Physiol Heart Circ Physiol Source Type: research
Evolution of symptoms in patients with stable angina after normal regadenoson myocardial perfusion imaging: The Radionuclide Imaging and Symptomatic Evolution study (RISE )
ConclusionsPatients with stable chest pain and normal MPI experience significant improvement in functional status, quality of life, and disease perception in the short term. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 3, 2020 Category: Nuclear Medicine Source Type: research
