The prognostic implications of ST-segment and T-wave abnormalities in patients undergoing regadenoson stress SPECT myocardial perfusion imaging

ConclusionWhile patients with secondary ST/T abnormalities had significantly higher MACE risk, abnormal MPI or presence of myocardial ischemia on regadenoson SPECT-MPI in this group does not add prognostic information. Patients with primary ST abnormalities and T-wave abnormalities do not seem to have a significantly higher MACE risk compared to those with normal ECG; however, abnormal MPI or presence of myocardial ischemia, in these groups, correlates with higher MACE rates.
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research

Related Links:

Authors: Hatta T, Yoda S, Hayase M, Monno K, Hori Y, Fujito H, Suzuki Y, Matsumoto N, Okumura Y Abstract Left ventricular (LV) mechanical dyssynchrony assessed with phase analysis of electrocardiogram (ECG) -gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is useful for predicting major cardiac events (MCEs) in patients with cardiac dysfunction. However, there is no report on its usefulness in Japanese patients with known or suspected stable coronary artery disease (CAD) with preserved LV ejection fraction (LVEF).We retrospectively investigated 3,374 consecutive patients w...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
AbstractIntroductionWe investigated if uptake pattern on myocardial perfusion SPECT (MPS) in patients with left bundle branch block (LBBB) is related to myocardial fibrosis, myocardial wall motion, and electrocardiography (ECG) characteristics.MethodsTwenty-three patients (9 women) with LBBB, examined with MPS and cardiac magnetic resonance (CMR), were included. Tracer uptake on MPS was classified by visual interpretation as typical LBBB pattern (Defect+, n  = 13) or not (Defect−, n = 10) and quantitatively. CMR images were evaluated for wall thickness and for myocardial wall motion both b...
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
AbstractBackgroundThe prognostic value of myocardial perfusion imaging (MPI) in patients with known coronary artery disease (CAD) and high exercise capacity is still unknown. We sought to determine the MPI additional prognostic value over electrocardiography (ECG) stress testing alone in patients with known CAD who achieved  ≥ 10 metabolic equivalents (METs).Methods and ResultsWe evaluated 926 patients with known CAD referred for MPI with exercise stress. Patients were followed for a mean of 32.4  ± 9.7 months for the occurrence of all-cause death or nonfatal myocardial infarction...
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
Authors: Kurisu S, Nitta K, Sumimoto Y, Ikenaga H, Ishibashi K, Fukuda Y, Kihara Y Abstract Objective The frontal QRS-T angle on a 12-lead electrocardiogram (ECG) has recently become accepted as a variable of ventricular repolarization. We compared the effects of myocardial perfusion defect (MPD) on the frontal QRS-T angle between anterior and inferior myocardial infarction (MI) using single-photon emission computed tomography. Methods The frontal QRS-T angle was defined as the absolute value of the difference between the frontal plane QRS axis and T-wave axis. A QRS-T angle more than 90° was considered abnorma...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conclusion In the majority of patients with TTS perfusion in SPECT was normal or only minor perfusion defect was observed. Application of CT attenuation correction did not change the final result of myocardial perfusion imaging; therefore, the CT component of the SPECT/CT study performed for attenuation correction is not useful for TTS diagnosis.
Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Research articles: Imaging Source Type: research
AbstractBackgroundQuantitative cardiac contractile function assessment is the primary indicator of disease progression and therapeutic efficacy in small animals. Operator dependency is a major challenge with commonly used echocardiography. Simultaneous assessment of cardiac perfusion and function in nuclear scans would reduce burden on the animal and facilitate longitudinal studies. We evaluated the accuracy of contractile function measurements obtained from electrocardiogram-gated nuclear perfusion imaging compared with anatomic imaging.Methods and ResultsIn healthy C57Bl/6N mice (n  = 11),99mTc-sestamibi SP...
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
AbstractEvaluation of atypical presentation of angina chest pain in emergency department is difficult. Hospitalization of this patient may impose additional costs and waste the time, early discharge may lead to miss the patients. The aim of this study was to determine volubility of Single Photon Emission Computed Tomography (SPECT) in management of patients admitted to emergency department with atypical manifestations of angina pain, un-diagnostic Electrocardiogram (ECG) and negative enzyme. Half of 100 patients admitted to emergency department with atypical chest pain and un-diagnostic ECG who were candidate for admission...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
AbstractBackgroundIn patients undergoing regadenoson SPECT myocardial perfusion imaging (MPI), the prognostic value of ischemic ST-segment depression (ST ↓) and the optimal ST↓ threshold have not been studied.MethodsA retrospective cohort study of consecutive patients referred for regadenoson stress MPI was conducted. Patients with uninterpretable ECG were excluded. Two diagnostic thresholds of horizontal or downsloping ST ↓ were studied, ≥ 0.5 mm and ≥ 1.0 mm. The primary endpoint was the composite major adverse cardiac events (MACE) of cardiac death, myocardial i...
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
372Background: Left ventricular mechanical dyssynchrony (LVMD) may occur after acute myocardial infarction (AMI), and is closely associated with left ventricular (LV) dysfunction and poor prognosis. Previous studies found that LVMD is present in the infarcted area after AMI. However, whether the mechanical dyssynchrony present in remote myocardium outside the infarct area remains controversial. The mechanism of global and regional LVMD after AMI and its pathophysiological changes have not been well established. Objectives: To quantitatively evaluate the global and regional LVMD early after AMI by phase analysis of single p...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: New Developments: Metabolism, Perfusion and Analysis Methods Source Type: research
1160Objectives: Myocardial infarction (MI) may be the first manifestation of coronary artery disease (CAD) that is the major cause of death among adults. In China, there are about 500,000 new MI patients each year, the mortality rate caused by MI is high and growing rapidly. Heart failure is a common complication of acute myocardial infarction (AMI). The morbidity and mortality of heart failure after AMI is 32.4% and 21.6%. Left ventricular remodeling is a leading pathophysiology cause of heart failure in the process of from AMI to heart failure. Animal models on MI are essential for the better understanding of CAD, for di...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Basic Science Posters Source Type: research
More News: Cardiology | Cardiovascular | Electrocardiogram | Heart | Heart Attack | Lexiscan | Nuclear Medicine | Perfusion | SPECT | Study