In-Hospital Mortality and Major Adverse Cardiovascular Events after Kidney Transplantation in the United States
Conclusion: Despite increases in age at the time of KT, the absolute risk of perioperative MACEs has remained stable from 2004 to 2013. HF is a major component of postoperative MACEs in KT. Malnutrition and pulmonary hypertension are major nontraditional predictors of perioperative MACE outcomes.Cardiorenal Med 2019;9:51 –60 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - November 14, 2018 Category: Urology & Nephrology Source Type: research

Derived Subendocardial Viability Ratio and Cardiovascular Events in Patients with Chronic Kidney Disease
Conclusions: An SEVR #x3c; 130% predicts fatal and non-fatal cardiovascular events in non-dialysis CKD patients.Cardiorenal Med 2019;9:41 –50 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - November 8, 2018 Category: Urology & Nephrology Source Type: research

Enteral Baicalin, a Flavone Glycoside, Reduces Indicators of Cardiac Surgery-Associated Acute Kidney Injury in Rats
Conclusion: Our data indicated that baicalin mediated CPB/CA-induced AKI by decreasing the oxidative stress and inflammation in the renal tissues, and that baicalin possesses the potential to be developed as a therapeutic tool in clinical use for CSA-AKI.Cardiorenal Med 2019;9:31 –40 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - November 7, 2018 Category: Urology & Nephrology Source Type: research

Early Left Ventricular Dysfunction Detected by Speckle Tracking in Long-Term Hemodialysis Patients with Valvular Calcification
Conclusions: Cardiac VC diagnosed by echocardiography when it occurs in long-term hemodialysis patients may indicate more severe LVH, myocardial damage, and worse heart function in comparison to those without VC. Tissue Doppler imaging and 2D-STE can detect the subtle change of heart function in this population in the early stage of LV dysfunction when LVEF is normal.Cardiorenal Med 2019;9:22 –30 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 31, 2018 Category: Urology & Nephrology Source Type: research

Chronic Hyperkalemia in Cardiorenal Patients: Risk Factors, Diagnosis, and New Treatment Options
Chronic hyperkalemia (HK) is a serious medical condition that often manifests in patients with chronic kidney disease (CKD) and heart failure (HF) leading to poor outcomes and necessitating careful management by cardionephrologists. CKD, HF, diabetes, and renin-angiotensin-aldosterone system inhibitors use is known to induce HK. Current therapeutic options are not optimal, as pointed out by a large number of CKD and HF patients with HK. The following review will focus on the main risk factors for developing HK and also aims to provide a guide for a correct diagnosis and present new approaches to therapy.Cardiorenal Med 201...
Source: Cardiorenal Medicine - October 25, 2018 Category: Urology & Nephrology Source Type: research

Acknowledgement to the Reviewers
Cardiorenal Med 2018;8:340 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 10, 2018 Category: Urology & Nephrology Source Type: research

Contents Vol. 8, 2018
Cardiorenal Med 2018;8:I –V (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 10, 2018 Category: Urology & Nephrology Source Type: research

Impact of KDIGO-Defined Acute Kidney Injury on Mortality after Percutaneous Coronary Intervention for Acute Myocardial Infarction
Conclusion: A slight increase in serum creatinine was associated with a progressive increase in long-term mortality in patients with AKI according to the KDIGO definition.Cardiorenal Med 2018;8:332 –339 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - September 17, 2018 Category: Urology & Nephrology Source Type: research

Hepatorenal Syndrome or Hepatocardiorenal Syndrome: Revisiting Basic Concepts in View of Emerging Data
Background: Accumulating evidence on the pathophysiology of hepatorenal syndrome has challenged the conventional model of liver-kidney connection. While liver cirrhosis is traditionally considered the origin of a cascade of pathophysiologic mechanisms directly affecting other organs such as the kidney, emerging data point to the heart as the potential mediator of the untoward renal effects.Summary: Herein, we briefly review the often-overlooked contribution of the heart to circulatory dysfunction in hepatorenal syndrome and put forward evidence arguing for the involvement of systemic inflammation and endothelial dysfunctio...
Source: Cardiorenal Medicine - September 17, 2018 Category: Urology & Nephrology Source Type: research

Levels of Proinflammatory Cytokines, Oxidative Stress, and Tissue Damage Markers in Patients with Acute Heart Failure with and without Cardiorenal Syndrome Type 1
Conclusion: Patients affected by CRS type 1 present increased levels of proinflammatory cytokines and oxidative stress markers, increased levels of tissue damage markers, and lower hemoglobin levels. All these factors may be implicated in the pathophysiology of CRS type 1 syndrome.Cardiorenal Med 2018;8:321 –331 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - September 11, 2018 Category: Urology & Nephrology Source Type: research

Urine Cofilin-1 Detection for Predicting Type 1 Cardiorenal Syndrome in the Coronary Care Unit: A Gold Nanoparticle- and Laser-Based Approach
Conclusions: The gold nanoparticle-based immunoassay LSPCFB could exploit the potential of urine cofilin-1 as a single biomarker to predict CRS among CCU patients.Cardiorenal Med 2018;8:302 –310 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - August 17, 2018 Category: Urology & Nephrology Source Type: research

Relationship between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and Estimated Glomerular Filtration Rate in the General Chinese Population
Conclusion: In this single-center study with moderate sample size, the data showed no relationship of PCSK9 levels with normal or decreased eGFR in untreated patients with normal SCr, suggesting that further studies may be needed to understand the relationship between PCSK9 and lipid disorder in different stage of kidney dysfunction.Cardiorenal Med 2018;8:311 –320 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - August 17, 2018 Category: Urology & Nephrology Source Type: research

Cardionephrology: Proposal for a Futuristic Educational Approach to a Contemporary Need
The field of cardiorenal medicine is vast, rapidly expanding, and complex. Conventional nephrology training programs provide the fellows with the necessary core knowledge to provide general care for patients with renal and cardiovascular diseases. However, there is a need for focused training of interested physicians to master the specialized aspects of these exceedingly common clinical scenarios and optimize the care of such patients. A cardionephrology-focused training can add value to the nephrology subspecialty and potentially increase its attractiveness for a significant subset of trainees. Herein, we provide a propos...
Source: Cardiorenal Medicine - August 8, 2018 Category: Urology & Nephrology Source Type: research

Detection of Atherosclerotic Cardiovascular Disease in Patients with Advanced Chronic Kidney Disease in the Cardiology and Nephrology Communities
Conclusions: The survey results reveal a lack of consensus among providers caring for patients with advanced CKD about the management of ASCVD in this setting. Future randomized controlled trials will be needed to better inform the clinical management of ASCVD in these patients. The limitations of the study include its small sample size and the relatively low response rate among the respondents.Cardiorenal Med 2018;8:285 –295 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - August 3, 2018 Category: Urology & Nephrology Source Type: research

Hyponatremia in Acute Heart Failure in Relation to Hematocrit Levels: Clinical Relevance and Prognostic Implication
Conclusions: Low hematocrit levels in AHF patients with hyponatremia characterize a population that is more difficult to decongest and has poor clinical outcome. In contrast, patients with hyponatremia but normal hematocrit are better decongested and have better short-term outcome.Cardiorenal Med 2018;8:259 –270 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - July 25, 2018 Category: Urology & Nephrology Source Type: research

Left Ventricular Strain and Dyssynchrony in Young and Middle-Aged Peritoneal Dialysis Patients and Healthy Controls: A Case-Matched Study
Conclusions: Despite preserved LVEF, young and middle-aged PD patients developed LV dysfunction and myocardial systolic dyssynchrony earlier compared with controls.Cardiorenal Med 2018;8:271 –284 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - July 25, 2018 Category: Urology & Nephrology Source Type: research

CXCL12 in Patients with Chronic Kidney Disease and Healthy Controls: Relationships to Ambulatory 24-Hour Blood Pressure and Echocardiographic Measures
Conclusions: The results of our study point towards a link between CXCL12 and LVH as well as blood pressure control among patients with CKD, supporting the thesis that CXCL12 may be regarded as a new potential uremic toxin.Cardiorenal Med 2018;8:249 –258 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - July 18, 2018 Category: Urology & Nephrology Source Type: research

Plasma Level of Retinol-Binding Protein 4, N-Terminal proBNP and Renal Function in Older Patients Hospitalized for Heart Failure
Conclusion: Our results show that RBP4 is affected by GFR but cannot be considered as an independent biomarker of heart muscle dysfunction.Cardiorenal Med 2018;8:237 –248 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - July 4, 2018 Category: Urology & Nephrology Source Type: research

Differential Impact of Chronic Kidney Disease on Coronary Calcification and Atherosclerosis in Asymptomatic Individuals with or without Diabetes: Analysis from a Coronary Computed Tomographic Angiography Registry
Conclusions: The presence of CKD did not have a significant impact on the development of coronary atherosclerosis, but affected the progression of coronary calcification more markedly from the stage of moderate CKD in nondiabetics. However, in diabetics, the deterioration of renal function was significantly associated with the development of coronary atherosclerosis and calcification from the stage of mild CKD.Cardiorenal Med 2018;8:228 –236 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 29, 2018 Category: Urology & Nephrology Source Type: research

Metabolic Syndrome and the Iodine-Dose/Creatinine Clearance Ratio as Determinants of Contrast-Induced Acute Kidney Injury
Conclusions: We showed that MetS is a strong risk factor for CI-AKI in nondiabetic patients undergoing elective coronary interventions; and the I-dose/CrCl ratio is a strong predictor of CI-AKI in these patients. We suggest that clinicians identify MetS patients and calculate their I-dose/CrCl ratio before coronary interventions.Cardiorenal Med 2018;8:217 –227 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 15, 2018 Category: Urology & Nephrology Source Type: research

Determinants of Monocyte Apoptosis in Cardiorenal Syndrome Type 1
Conclusion: CRS type 1 induces dual apoptotic pathway activation in monocytes; the two pathways converged on caspase-3. Many factors may induce activation of both intrinsic and extrinsic apoptotic pathways in CRS type 1 patients, such as upregulation of proinflammatory cytokines and hypoxia/ischemia. Further investigations are necessary to corroborate the present findings, and to better understand the pathophysiological mechanism and consequent therapeutic and prognostic implications for CRS type 1.Cardiorenal Med 2018;8:208 –216 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - May 30, 2018 Category: Urology & Nephrology Source Type: research

Epicardial Fat Thickness in Patients with Autosomal Dominant Polycystic Kidney Disease
Conclusion: Our data showed that EAT was higher in ADPKD patients than in EH subjects and independently correlated with LVMi. EAT measurement can be a useful marker for the cardiovascular risk stratification in ADPKD.Cardiorenal Med 2018;8:199 –207 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - May 4, 2018 Category: Urology & Nephrology Source Type: research

Revascularization versus Medical Management of Coronary Artery Disease in Prerenal Transplant Patients: A Meta-Analysis
Introduction: End-stage renal disease requiring renal transplantation comprises a growing patient population at risk for cardiovascular disease (CVD) morbidity and mortality in large part due to accelerated atherosclerosis. Consequently, these patients are at even higher risk of major surgical CVD mortality. A paucity of research has addressed the posttransplantation CVD outcomes related to different treatment strategies in this patient population and therefore, there are no specific preoperative guidelines regarding management of coronary artery disease in this high-risk population undergoing renal transplantation.Objecti...
Source: Cardiorenal Medicine - May 2, 2018 Category: Urology & Nephrology Source Type: research

ω-3 Polyunsaturated Fatty Acid Postconditioning Protects the Isolated Perfused Rat Heart from Ischemia-Reperfusion Injury
Conclusion:ω-3 PUFA postconditioning possesses good cardioprotective effects and may be developed into a therapeutic strategy for myocardial I/R injury.Cardiorenal Med 2018;8:173 –182 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - April 11, 2018 Category: Urology & Nephrology Source Type: research

Pulmonary Catherization Data Correlate Poorly with Renal Function in Heart Failure
Conclusion: These findings suggest that, as assessed by pulmonary artery catherization, none of the factors – PCWP, PASP, PADP, or CI – play a prominent role in cardiorenal syndromes.Cardiorenal Med 2018;8:183 –191 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - April 10, 2018 Category: Urology & Nephrology Source Type: research

Preeclampsia as a Form of Type 5 Cardiorenal Syndrome: An Underrecognized Entity in Women ’s Cardiovascular Health
Background: Preeclampsia is a multisystem vascular disorder of pregnancy that remains a leading cause of maternal and fetal morbidity and mortality. Preeclampsia remains an underrecognized risk factor for future cardiovascular and kidney disease in women and represents the confluence of preexisting vascular risk factors with superimposed endothelial injury from placental mediated anti-angiogenic factors.Summary: This review highlights the close relationship between preeclampsia and future cardiovascular and kidney disease. It describes the pathophysiology and current understanding of biomarkers that form the molecular sign...
Source: Cardiorenal Medicine - April 4, 2018 Category: Urology & Nephrology Source Type: research

Impact of Chronic Kidney Disease on Cardiovascular and Renal Events in Patients Undergoing Percutaneous Coronary Intervention with Everolimus-Eluting Stent: Risk Stratification with C-Reactive Protein
Conclusion: CKD combined with CRP predicted more clinical events in patients undergoing PCI with EES.Cardiorenal Med 2018;8:151 –159 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - March 27, 2018 Category: Urology & Nephrology Source Type: research

Personalized Statin Therapy and Coronary Atherosclerotic Plaque Burden in Asymptomatic Low/Intermediate-Risk Individuals
Conclusion: These findings suggest that individuals with higher coronary plaque burden are more likely to get greater benefit from statin therapy even among asymptomatic individuals with low cardiovascular risk.Cardiorenal Med 2018;8:140 –150 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - March 26, 2018 Category: Urology & Nephrology Source Type: research

lncRNA UCA1 Is a Novel Regulator in Cardiomyocyte Hypertrophy through Targeting the miR-184/HOXA9 Axis
Cardiac hypertrophy is closely associated with a series of cardiovascular diseases, including heart failure and sudden death in particular. An in-depth comprehension of the pathogenesis of cardiac hypertrophy will improve the diagnosis and therapy of cardiac hypertrophy. It has been acknowledged that long noncoding RNAs/microRNAs (lncRNAs/miRNAs) are crucial regulators in diverse biological processes, including various cardiovascular diseases, in multiple manners. Nevertheless, the biological roles of lncRNA UCA1 and miR-184 in cardiac hypertrophy are scarcely reported. In this paper, qRT-PCR analysis exhibited that lncRNA...
Source: Cardiorenal Medicine - March 21, 2018 Category: Urology & Nephrology Source Type: research

High Right Ventricular Stroke Work Index Is Associated with Worse Kidney Function in Patients with Heart Failure with Preserved Ejection Fraction
Conclusion: High right ventricular workload indicated by high RVSWI is associated with worse renal function in patients with Cpc-PH. Further prospective studies are needed to better understand this association.Cardiorenal Med 2018;8:123 –129 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - February 28, 2018 Category: Urology & Nephrology Source Type: research

The Effect of Mitochondrial Complex I-Linked Respiration by Isoflurane Is Independent of Mitochondrial Nitric Oxide Production
Conclusion: Isoflurane has clearly distinguishable effects on different states of mitochondrial respiration during the oxidation of complex I substrates. The uncoupling effect during state 2 respiration and the attenuation of state 3 respiration may contribute to the mechanism of APC-induced cardioprotection. These effects of isoflurane do not depend on endogenous mitochondrial NO, as the NOS inhibitor L-NIO did not alter the effects of isoflurane on mitochondrial respiration.Cardiorenal Med 2018;8:113 –122 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - February 1, 2018 Category: Urology & Nephrology Source Type: research

The Role of Dendritic and Endothelial Cells in Cardiorenal Syndrome
Backgrounds: Dendritic cells (DCs) are antigen-presenting cells that play a central role in innate and adaptive immune responses; however, the cross talk between cardiac and renal DCs in cardiorenal syndrome (CRS) has not yet been fully elucidated. In this setting, endothelial cells (ECs) also contribute to immune responses.Summary: DC and EC activation and dysfunction have a central role in the pathogenesis of CRS. Regarding immune responses in CRS, it is unknown whether ECs may serve as antigen-presenting cells or act synergistically with DCs to actively participate in innate and adaptive immune responses. This review fi...
Source: Cardiorenal Medicine - January 22, 2018 Category: Urology & Nephrology Source Type: research

Statins and New-Onset Diabetes in Cardiovascular and Kidney Disease Cohorts: A Meta-Analysis
Conclusions: It is imperative that patients on statin therapy be monitored carefully for NODM. However, it can be argued that the risk of statin therapy is offset by the multitude of cardiovascular and kidney-protective effects provided by such an important and highly effective therapeutic agent.Cardiorenal Med 2018;8:105 –112 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 22, 2018 Category: Urology & Nephrology Source Type: research

Relevance of B-Lines on Lung Ultrasound in Volume Overload and Pulmonary Congestion: Clinical Correlations and Outcomes in Patients on Hemodialysis
Background: Volume overload in patients on hemodialysis (HD) is an independent risk factor for cardiovascular mortality. B-lines detected on lung ultrasound (BLUS) assess extravascular lung water. This raises interest in its utility for assessing volume status and cardiovascular outcomes.Methods: End-stage renal disease patients on HD at the Island Rehab Center being older than 18 years were screened. Patients achieving their dry weight (DW) had a lung ultrasound in a supine position. Scores were classified as mild (0-14), moderate (15-30), and severe (>30) for pulmonary congestion. Patients with more than 60 were furth...
Source: Cardiorenal Medicine - November 28, 2017 Category: Urology & Nephrology Source Type: research

Combination Therapy with Renin-Angiotensin System Blockers and Vitamin D Receptor Activators for Predialysis Patients Is Associated with the Incidence of Cardiovascular Events after Dialysis Initiation: A Multicenter Nonrandomized Prospective Cohort Study
Conclusion: Combination therapy with RASBs and VDRAs in patients before dialysis initiation was associated with a reduction in CV events during maintenance dialysis.Cardiorenal Med 2018;8:71-81 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - November 2, 2017 Category: Urology & Nephrology Source Type: research

Plasma Volume and Renal Function Predict Six-Month Survival after Hospitalization for Acute Decompensated Heart Failure
Conclusions: Increased %#x0394;PV and BUN at discharge predicted worse 6-month survival in patients with ADHF. Decreased %#x0394;PV with low BUN or high GFR at discharge was associated with improved survival.Cardiorenal Med 2018;8:61-70 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - November 2, 2017 Category: Urology & Nephrology Source Type: research

One-Year Conservative Care Using Sodium Bicarbonate Supplementation Is Associated with a Decrease in Electronegative LDL in Chronic Kidney Disease Patients: A Pilot Study
Background: Chronic kidney disease (CKD) patients develop metabolic acidosis when approaching stages 3 and 4, a period in which accelerated atherogenesis may ensue. Studies in vitro show that low pH may increase low-density lipoprotein (LDL) oxidation, suggesting a role for chronic metabolic acidosis in atherosclerosis. The present study attempted to evaluate the effects of conservative care using oral sodium bicarbonate (NaHCO3) supplementation on the electronegative LDL [LDL(-)], a minimally oxidized LDL, plasma levels in CKD patients.Methods: Thirty-one CKD patients were followed by a multidisciplinary team during 15 mo...
Source: Cardiorenal Medicine - October 25, 2017 Category: Urology & Nephrology Source Type: research

A Profile of Renal Function in Northern Cameroonians with Essential Hypertension
Background/Aim: The two-way cause and effect relationship existing between high blood pressure and kidney dysfunction is currently a well-documented phenomenon with patients in either category being almost equally predisposed to the other pathology. Our goal was to assess the renal function capacity of hypertensive patients in our setting.Methods: This cross-sectional descriptive study involved the determination of blood pressure levels and the collection of blood and urine samples for the measurement of renal function markers. Hypertensive patients who came for medical follow-up constituted the study participants, and wer...
Source: Cardiorenal Medicine - October 25, 2017 Category: Urology & Nephrology Source Type: research

Relevance of Endothelial Cell-Specific Molecule 1 (Endocan) Plasma Levels for Predicting Pulmonary Infection after Cardiac Surgery in Chronic Kidney Disease Patients: The Endolung Pilot Study
Conclusion: This pilot study showed that a specific study to assess the link between endocan plasma levels and pulmonary infection after cardiac surgery in CKD patients is of potential utility.Cardiorenal Med 2018;8:1-8 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 25, 2017 Category: Urology & Nephrology Source Type: research

Eicosapentaenoic Acid as a Potential Therapeutic Approach to Reduce Cardiovascular Risk in Patients with End-Stage Renal Disease on Hemodialysis: A Review
Background: Patients with end-stage renal disease on hemodialysis have excess cardiovascular disease (CVD) burden with substantially increased CV event rates compared with the general population.Summary: Traditional interventions that, according to standard clinical guidelines, reduce CV risk such as antihypertensive therapy, diet, exercise, and statins are not similarly effective in the hemodialysis population. This raises the question of whether additional risk factors, such as enhanced inflammation and oxidative stress, may drive the increased CVD burden in hemodialysis patients. Eicosapentaenoic acid (EPA), an omega-3 ...
Source: Cardiorenal Medicine - October 25, 2017 Category: Urology & Nephrology Source Type: research

Role of Body Mass Index in Acute Kidney Injury Patients after Cardiac Surgery
Background/Aims: To explore the association of body mass index (BMI) with the risk of developing acute kidney injury after cardiac surgery (CS-AKI) and for AKI requiring renal replacement therapy (AKI-RRT) after cardiac surgery.Methods: Clinical data of 8,455 patients undergoing cardiac surgery, including demographic preoperative, intraoperative, and postoperative data were collected. Patients were divided into underweight (BMI (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 25, 2017 Category: Urology & Nephrology Source Type: research

Insulin Resistance in Kidney Disease: Is There a Distinct Role Separate from That of Diabetes or Obesity
Insulin resistance is a central component of the metabolic dysregulation observed in obesity, which puts one at risk for the development of type 2 diabetes and complications related to diabetes such as chronic kidney disease. Insulin resistance and compensatory hyperinsulinemia place one at risk for other risk factors such as dyslipidemia, hypertension, and proteinuria, e.g., development of kidney disease. Our traditional view of insulin actions focuses on insulin-sensitive tissues such as skeletal muscle, liver, adipose tissue, and the pancreas. However, insulin also has distinct actions in kidney tissue that regulate gro...
Source: Cardiorenal Medicine - October 25, 2017 Category: Urology & Nephrology Source Type: research

Elevated Phosphate Levels Trigger Autophagy-Mediated Cellular Apoptosis in H9c2 Cardiomyoblasts
Conclusion: The results suggest that hyperphosphate in H9c2 cardiomyoblasts would lead to cellular apoptosis via autophagy, which is mediated by the pAMPK signaling pathway. Our findings revealed the possible mechanism responsible for the heart damage under hyperphosphatemia.Cardiorenal Med 2018;8:31-40 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 25, 2017 Category: Urology & Nephrology Source Type: research

Acknowledgement to the Reviewers
Cardiorenal Med 2017;7:342 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 25, 2017 Category: Urology & Nephrology Source Type: research

Contents Vol. 7, 2017
Cardiorenal Med 2017;7:I-VI (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 25, 2017 Category: Urology & Nephrology Source Type: research

Evaluation of the Predictive Value of the Serum Calcium-Magnesium Ratio for All-Cause and Cardiovascular Mortality in Incident Dialysis Patients
Conclusion: A high Ca-Mg ratio was significantly associated with all-cause and cardiovascular mortality, and it was more accurate than serum Mg.Cardiorenal Med 2018;8:50-60 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 25, 2017 Category: Urology & Nephrology Source Type: research

Acknowledgement to the Reviewers
Cardiorenal Med 2017;7:342 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 10, 2017 Category: Urology & Nephrology Source Type: research

Contents Vol. 7, 2017
Cardiorenal Med 2017;7:I-VI (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 10, 2017 Category: Urology & Nephrology Source Type: research

Evaluation of the Predictive Value of the Serum Calcium-Magnesium Ratio for All-Cause and Cardiovascular Mortality in Incident Dialysis Patients
Conclusion: A high Ca-Mg ratio was significantly associated with all-cause and cardiovascular mortality, and it was more accurate than serum Mg.Cardiorenal Med 2018;8:50-60 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 10, 2017 Category: Urology & Nephrology Source Type: research

Insulin Resistance in Kidney Disease: Is There a Distinct Role Separate from That of Diabetes or Obesity?
Insulin resistance is a central component of the metabolic dysregulation observed in obesity, which puts one at risk for the development of type 2 diabetes and complications related to diabetes such as chronic kidney disease. Insulin resistance and compensatory hyperinsulinemia place one at risk for other risk factors such as dyslipidemia, hypertension, and proteinuria, e.g., development of kidney disease. Our traditional view of insulin actions focuses on insulin-sensitive tissues such as skeletal muscle, liver, adipose tissue, and the pancreas. However, insulin also has distinct actions in kidney tissue that regulate gro...
Source: Cardiorenal Medicine - September 29, 2017 Category: Urology & Nephrology Source Type: research