Lung Sestamibi Uptake on Myocardial Perfusion Imaging and Outcomes in Chronic Kidney Disease
Conclusions: LHR ≤0.28 and ≥0.33 are independently associated with higher risk for death in patients with CKD-ND and ESKD. Future studies are warranted to understand the association of extreme LHR values and outcomes in this high-risk population.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 25, 2021 Category: Urology & Nephrology Source Type: research

Point of Care Ultrasonography for Objective Assessment of Heart Failure: Integration of Cardiac, Vascular, and Extravascular Determinants of Volume Status
Background: Lingering congestion portends poor outcomes in patients with heart failure (HF) and is a key target in their management. Studies have shown that physical exam has low yield in this setting and conventional methods for more precise assessment and monitoring of volume status (e.g., body weight, natriuretic peptides, and chest radiography) have significant inherent shortcomings.Summary: Point of care ultrasonography (POCUS) is a noninvasive versatile bedside diagnostic tool that enhances the sensitivity of conventional physical examination to gauge congestion in these patients. It also aids in monitoring the effic...
Source: Cardiorenal Medicine - January 21, 2021 Category: Urology & Nephrology Source Type: research

Dynamic Changes in Portal Vein Flow during Decongestion in Patients with Heart Failure and Cardio-Renal Syndrome: A POCUS Case Series
Conclusions: Evaluation of abdominal venous congestion by point-of-care ultrasound could aid in diagnosis and follow-up of patients with congestive kidney injury.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 21, 2021 Category: Urology & Nephrology Source Type: research

Resurgence of Urgent-Start Peritoneal Dialysis in COVID-19 and Its Application to Advanced Heart Failure
Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 7, 2021 Category: Urology & Nephrology Source Type: research

Prediction of All-Cause Mortality Using an Echocardiography-Based Risk Score in Hemodialysis Patients
Conclusions: Echocardiographic indexes showed independent predictive power for mortality in ESRD patients and may constitute a promising prognostic tool in this population.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - December 17, 2020 Category: Urology & Nephrology Source Type: research

Prognostic Value of Estimated Glomerular Filtration Rate 3 –6 Months after Percutaneous Coronary Intervention
Conclusion: Post-PCI eGFR was more accurate for predicting patient outcomes than pre-PCI eGFR.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - December 17, 2020 Category: Urology & Nephrology Source Type: research

Effect of Cryptotanshinone on Measures of Rat Cardiomyocyte Oxidative Stress and Gene Activation Associated with Apoptosis
Conclusion: CTS protects cardiomyocytes against the H2O2-induced cellular injuries through ERK and NF- κB inactivation and ROS scavenging. Therefore, CTS is a promising reagent against ROS-induced cardiomyopathy.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - December 16, 2020 Category: Urology & Nephrology Source Type: research

Coronary Computed Tomography Angiography in Diagnosing Obstructive Coronary Artery Disease in Patients with Advanced Chronic Kidney Disease: A Systematic Review and Meta-Analysis
Conclusions: Based on limited data, CCTA appears to have comparable sensitivity but lower specificity relative to the non-kidney disease population.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - December 15, 2020 Category: Urology & Nephrology Source Type: research

Renal Dysfunction following Direct Current Cardioversion of Atrial Fibrillation: Incidence and Risk Factors
Conclusion: AKI following DCCV of AF is common, self-limited, and without the need for replacement therapies.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - December 9, 2020 Category: Urology & Nephrology Source Type: research

Contents Vol. 10, 2020
Cardiorenal Med 2020;10:I –VI (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - December 4, 2020 Category: Urology & Nephrology Source Type: research

Acknowlegement to Reviewers
Cardiorenal Med 2020;10:476 –477 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - December 4, 2020 Category: Urology & Nephrology Source Type: research

Publisher's Note
Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - November 30, 2020 Category: Urology & Nephrology Source Type: research

Dialysis Modality and Mortality in Heart Failure: A Retrospective Study of Incident Dialysis Patients
Conclusions: We found no difference in mortality by initial dialysis modality. Our data support the current practice of selecting dialysis modality based on patient preference for patients with pre-existing HF.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - November 25, 2020 Category: Urology & Nephrology Source Type: research

Serum Copeptin, NLPR3, and suPAR Levels among Patients with Autosomal-Dominant Polycystic Kidney Disease with and without Impaired Renal Function
Conclusions: This study showed that ADPKD patients with impaired and preserved renal function had higher copeptin, NLRP3, and suPAR levels than controls. Such findings support that cystogenesis and inflammation are associated with endothelial dysfunction, even in the early stages of ADKPD.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - November 17, 2020 Category: Urology & Nephrology Source Type: research

Measures of Loop Diuretic Efficiency and Prognosis in Chronic Kidney Disease
Conclusion: Low loop diuretic efficiency is independently associated with a shorter time to dialysis initiation and a higher risk for all-cause mortality in CKD.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 29, 2020 Category: Urology & Nephrology Source Type: research

Blood Urea Nitrogen to Creatinine Ratio and Long-Term Mortality in Patients with Acute Heart Failure: A Prospective Cohort Study and Meta-Analysis
Conclusions: Elevated BUN/Cr ratio is associated with poor prognosis in patients with AFH and is an independent predictor of all-cause mortality.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 28, 2020 Category: Urology & Nephrology Source Type: research

COVID-19-Associated Systemic Thromboembolism: A Case Report and Review of the Literature
Conclusions: Systemic anticoagulation could prove to be essential in the treatment of CO ­VID-19. Further studies are required to assess its role in improving long-term morbidity and mortality in these patients.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 22, 2020 Category: Urology & Nephrology Source Type: research

Usefulness of Peritoneal Ultrafiltration in Patients with Diuretic Resistant Heart Failure without End-Stage Renal Disease
Conclusion: Peritoneal UF is a treatment method that maintains renal function and electrolyte balance, improves cardiac function, and reduces hospitalizations in CRS patients. We observed that this treatment significantly increased functional capacity and quality of life and significantly reduced hospital admissions.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 6, 2020 Category: Urology & Nephrology Source Type: research

Serum Cystatin C, Klotho, and Neutrophil Gelatinase-Associated Lipocalin in the Risk Prediction of Acute Kidney Injury after Acute Myocardial Infarction
Conclusion: Elevated cystatin C levels are associated with AKI in patients with AMI. This study provides reliable evidence that cystatin C levels may be superior to serum creatinine for predicting AKI after AMI at admission.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 5, 2020 Category: Urology & Nephrology Source Type: research

A Prospective Single-Blind Randomized Trial of Ramipril, Eplerenone and Their Combination in Type 2 Diabetic Nephropathy
Conclusion: Addition of eplerenone to ACEI shows an added antialbuminuric effect without significant change of the serum K level compared with eplerenone or ACEI.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - September 30, 2020 Category: Urology & Nephrology Source Type: research

Slow Recovery from Critical Coronavirus Disease 2019 Pneumonia in an Immunosuppressed Renal Transplant Recipient with Early Acute Cardiorenal Syndrome
We report here the complete clinical course of a renal transplant recipient with critical COVID-19 pneumonia. In the early phase of SARS-Cov-2 infection, the patient exhibited extensive lung lesions and significant acute kidney and heart injuries, which required treatment in the ICU. After correcting the arrhythmia and heart failure, the patient recovered quickly from the acute kidney injury with a treatment of intensive diuresis and strict control of fluid intake. Without cessation of oral immunosuppressive agents, the patient presented a delayed and low antibody response against SARS-Cov-2 and reappeared positive for the...
Source: Cardiorenal Medicine - September 28, 2020 Category: Urology & Nephrology Source Type: research

The Impact of Diabetes Mellitus on Clinical Outcomes after Percutaneous Coronary Intervention with Drug-Eluting Stents for Left Main Distal Bifurcation Lesions in Patients with Chronic Kidney Disease
Conclusion: DM is strongly associated with adverse event after PCI for ULM distal bifurcation lesions in CKD patients compared to those without DM.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - September 7, 2020 Category: Urology & Nephrology Source Type: research

Chronic Kidney Disease in Adolescents after Surgery for Congenital Heart Disease
Conclusions: There was no evidence of CKD in the present population aged 10 –18 years. The significance of an eGFR between 60 and 90 mL min–1 1.73 m–2 is not concordant for this age range and requires further investigations.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - July 28, 2020 Category: Urology & Nephrology Source Type: research

Early Spot Urinary Sodium and Diuretic Efficiency in Acute Heart Failure and Concomitant Renal Dysfunction
Conclusions: In patients with AHF and RD at presentation, early spot UNa was inversely related to 24-h diuretic efficiency.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - July 28, 2020 Category: Urology & Nephrology Source Type: research

Association between Serum Dickkopf-1 (DKK-1) Glycoprotein and Calcific Deposits on Cardiac Valves and Carotid Intimal-Medial Thickness in Hemodialysis Patients
Conclusions: CVC is almost present in all HD patients. DKK-1 seems to have a direct relation with CVC and CIMT in HD patients. Age is the strongest independent determinant of CVC.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - July 8, 2020 Category: Urology & Nephrology Source Type: research

Cardiorenal Syndrome in Renal Transplant Recipients: Prevalence, Clinical Presentation, Treatment, and Outcome
Conclusion: CRS after renal transplantation was rare (#x3c;1.0%), but CRS in HFreF patients was associated with a poor outcome.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - July 6, 2020 Category: Urology & Nephrology Source Type: research

Weathering the Cytokine Storm in COVID-19: Therapeutic Implications
The objective of this article is to explore and comment on the potential role of the promising immunomodulatory therapies using pharmacological and nonpharmacological approaches to overcome the dysregulated proinflammatory response in COVID-19.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 29, 2020 Category: Urology & Nephrology Source Type: research

Clinical and Operative Determinants of Acute Kidney Injury after Cardiac Surgery
Conclusions: Use of minimally invasive surgery and therapies mitigating PSPAP and intraoperative blood loss may offer protection against CSA-AKI.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 29, 2020 Category: Urology & Nephrology Source Type: research

Clinical Characteristics and Outcomes of Community- and Hospital-Acquired Acute Kidney Injury with COVID-19 in a US Inner City Hospital System
Conclusion: We report a high burden of AKI among underserved COVID-19 patients with multiple comorbidities. Those who had HA-AKI had worse clinical outcomes compared to those who with CA-AKI. A history of heart failure is an independent predictor of AKI in patients with COVID-19.Cardiorenal Med 2020;10:223 –231 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 18, 2020 Category: Urology & Nephrology Source Type: research

NT-proBNP Concentration and Early Cardiac Dysfunction in Patients Receiving Dialysis: A Prospective Cohort Study
Conclusions: Our cohort study demonstrated that serial plasma NT-proBNP concentrations may be useful for early identification of individuals with worsening cardiac function over time.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - May 27, 2020 Category: Urology & Nephrology Source Type: research

Need for Objective Assessment of Volume Status in Critically Ill Patients with COVID-19: The Tri-POCUS Approach
As the coronavirus disease 2019 (COVID-19) continues to spread across the globe, the knowledge of its epidemiology, clinical features, and management is rapidly evolving. Nevertheless, the data on optimal fluid management strategies for those who develop critical illness remain sparse. Adding to the challenge, the fluid volume status of these patients has been found to be dynamic. Some present with several days of malaise, gastrointestinal symptoms, and consequent hypovolemia requiring aggressive fluid resuscitation, while a subset develop acute respiratory distress syndrome with renal dysfunction and lingering congestion ...
Source: Cardiorenal Medicine - May 27, 2020 Category: Urology & Nephrology Source Type: research

A Prospective, Randomized, Open-Label Trial of Atorvastatin versus Rosuvastatin in the Prevention of Contrast-Induced Acute Kidney Injury, Worsened Renal Function at 30 Days, and Clinical Events After Acute Coronary Angiography: the PRATO-ACS-2 Study
Conclusions: High-dose rosuvastatin or atorvastatin started upon hospital admission led to similar rates of AKI, 30-day renal function changes, and 12-month death or MI in NSTE-ACS patients who underwent an early invasive strategy (clinical trial registration: https://www.clinicaltrials.gov; unique identifier: NCT01870804).Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - May 20, 2020 Category: Urology & Nephrology Source Type: research

Fulminant Acute Kidney Injury in a Young Patient with Novel Coronavirus 2019
Coronavirus disease 2019 (COVID-19) is a global pandemic affecting more than 200 countries and 180,000 cases in the United States. While the outbreak began in China, the number of cases outside of China exceeded those in China on March 15, 2020 and are currently rising at an exponential rate. The number of fatalities in the United States are expected to exceed more than Italy and China. The disease is characterized predominantly as an acute respiratory illness. However, preliminary data suggests that kidney is a target for the virus and deterioration of renal function was associated with poor outcomes including in-hospital...
Source: Cardiorenal Medicine - May 6, 2020 Category: Urology & Nephrology Source Type: research

Adverse Drug Reactions during Real-Life Use of Direct Oral Anticoagulants in Italy: An Update Based on Data from the Italian National Pharmacovigilance Network
Conclusions from these studies are inconsistent and unsatisfactory. The evaluation of self-reported adverse drug reactions (ADR) available from databases of drug-regulatory agencies such as the Italian Medicines Agency (AIFA) pharmacovigilance database represents a novel aid to guide decision-making.Objective: To analyze potential suspected ADR of DOAC using a previously described risk index (RI) in daily clinical practice in Italy.Methods: The National Pharmacovigilance Network database (from the AIFA website) was searched in order to retrieve information on all ADR related to oral anticoagulants occurring from 2013 to 20...
Source: Cardiorenal Medicine - April 30, 2020 Category: Urology & Nephrology Source Type: research

Neurohormonal, Endocrine, and Immune Dysregulation and Inflammation in Cardiorenal Syndrome
“Organ crosstalk” is the complex physiological communication between different body systems, and it is necessary for the optimal equilibrium and functioning of the organism. In particular, heart and kidney function is tightly connected, and interplay between these two organs occurs through a vas t array of dynamic and bidirectional mechanisms. The term cardiorenal syndrome (CRS) indicates an interaction between the heart and kidneys in acute and chronic disease settings. In all types of CRS, multiple pathophysiological processes are implicated in the initiation and progression of organ inju ry. In addition to h...
Source: Cardiorenal Medicine - July 2, 2019 Category: Urology & Nephrology Source Type: research

Echocardiographic Findings in Patients with Mild to Moderate Chronic Kidney Disease without Symptomatic Heart Failure: A Population-Based Study
Conclusion: A significant association between mild to moderate impairment of renal function and echocardiographic markers of cardiac structure and diastolic function was observed, supporting the hypothesis that interaction between the kidney and heart exists even in the early stages of renal impairment.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 25, 2019 Category: Urology & Nephrology Source Type: research

Loss of the Normal Gradient in Arterial Compliance and Outcomes of Chronic Kidney Disease Patients
Conclusions: The PWV ratio, as a measure of loss of the normal gradient in arterial compliance, was associated with CKD patient outcome. Patients with advanced CKD and a higher PWV ratio had a significantly higher risk of adverse CKD outcome.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 25, 2019 Category: Urology & Nephrology Source Type: research

Plasma Lipopolysaccharide Concentrations in Cardiorenal Syndrome Type 1
Conclusion: CRS type 1 patients present with an increased level of LPS and there is a direct correlation between LPS and renal parameters. This pilot research is the first study to explore the premise of LPS as novel pathophysiological factor in CRS type 1.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 25, 2019 Category: Urology & Nephrology Source Type: research

Initial Concentrations of miR-1 MicroRNA Precursor and High-Sensitivity Troponin in the Diagnosis of Non-ST Myocardial Infarction among Patients with and Those without Chronic Kidney Disease
Conclusion: Circulating microRNA-1 is capable of early diagnosis of NSTEMI in patients with CKD suffering from chest pain.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 24, 2019 Category: Urology & Nephrology Source Type: research

< b > < i > APOL1 < /i > < /b > and Mortality in Patients on Dialysis
Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 11, 2019 Category: Urology & Nephrology Source Type: research

Effects of Bardoxolone Methyl on Magnesium in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease
Conclusions: Bard treatment results in significant decreases in serum magnesium that are not associated with changes in intracellular and urinary magnesium levels, indicating that magnesium decreases are not due to renal magnesium wasting or total body magnesium depletion. Importantly, the decreases in serum magnesium with Bard are not associated with adverse effects on QT interval.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 6, 2019 Category: Urology & Nephrology Source Type: research

Effects of Bardoxolone Methyl on QT Interval in Healthy Volunteers
Conclusions: In healthy subjects, treatment with 20 or 80 mg bardoxolone methyl did not affect the QTcF interval.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 3, 2019 Category: Urology & Nephrology Source Type: research

Cardiometabolic-Renal Disease in South Asians: Consensus Recommendations from the Cardio Renal Society of America
Background: Rates of cardiometabolic-renal disease are extremely high among South Asians (India, Pakistan, Bangladesh, Sri Lanka, Bhutan, the Maldives, and Nepal) residing in their home countries and worldwide. The Cardio Renal Society of America, National Kidney Foundation of Arizona, and Twinepidemic Inc. convened a task force to examine evidence and reach consensus regarding cardiometabolic-renal disease prevention in South Asians. The task force distilled the findings from 5 years of face-to-face and virtual meetings addressing questions derived from expert reviews of published data using the Delphi technique to create...
Source: Cardiorenal Medicine - May 10, 2019 Category: Urology & Nephrology Source Type: research

Community-Acquired Acute Kidney Injury as a Risk Factor of de novo Heart Failure Hospitalization
Conclusion: After controlling for baseline and clinical characteristics, patients with CA-AKI were at approximately twofold the risk of de novo HF hospitalization (within 90, 180, and 365 days) compared with those who did not have CA-AKI. Hence, detecting CA-AKI may provide an opportunity for early intervention at the primary care level to possibly delay HF development.Cardiorenal Med 2019;9:252 –260 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - May 10, 2019 Category: Urology & Nephrology Source Type: research

Survival Advantage of African American Dialysis Patients with End-Stage Renal Disease Causes Related to APOL1
Conclusions: These data suggest the hypothesis that the relative survival advantage of AA dialysis patients may be related toAPOL1 variation. Further large population-based genetic studies are required to test this hypothesis.Cardiorenal Med 2019;9:212 –221 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - April 17, 2019 Category: Urology & Nephrology Source Type: research

Key Updates in Cardio-Nephrology from 2018: Springboard to a Bright Future
Cardiorenal Med 2019;9:222 –228 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - April 17, 2019 Category: Urology & Nephrology Source Type: research

De novo Cardiac Valve Calcification after Hemodialysis in End-Stage Renal Disease Patients Predicts Future Cardiovascular Events: A Longitudinal Cohort Study
Conclusions: De novo CVC is an independent risk factor for MACE in hemodialysis patients, and regular CVC screening among hemodialysis patients without preexisting CVC may be helpful to identify patients at increased risk of adverse cardiovascular outcomes.Cardiorenal Med 2019;9:229 –239 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - April 17, 2019 Category: Urology & Nephrology Source Type: research

Multi-Omics Approach: New Potential Key Mechanisms Implicated in Cardiorenal Syndromes
Cardiorenal syndromes (CRS) include a scenario of clinical interactions characterized by the heart and kidney dysfunction. The crosstalk between cardiac and renal systems is clearly evidenced but not completely understood. Multi-factorial mechanisms leading to CRS do not involve only hemodynamic parameters. In fact, in recent works on organ crosstalk endothelial injury, the alteration of normal immunologic balance, cell death, inflammatory cascades, cell adhesion molecules, cytokine and chemokine overexpression, neutrophil migration, leukocyte trafficking, caspase-mediated induction of apoptotic mechanisms and oxidative st...
Source: Cardiorenal Medicine - April 3, 2019 Category: Urology & Nephrology Source Type: research

Central Venous Stenosis after Hemodialysis: Case Reports and Relationships to Catheters and Cardiac Implantable Devices
We describe two cases of end-stage renal disease patients with CIED and tunneled central venous catheter (CVC) who developed venous cava stenosis: (1) a 70-year-old man with sinus node disease and pacemaker in 2013, CVC, and a Brescia-Cimino forearm fistula in 2015; (2) a 75-year-old woman with previous ventricular arrhythmia with implanted defibrillator in 2014 and CVC in 2016. In either case, after about 1 year from CVC insertion, patients developed superior vena cava (SVC) syndrome due to stenosis diagnosed by axial computerized tomography. In case 1, the patient was not treated by angioplasty of SVC and removed CVC wit...
Source: Cardiorenal Medicine - March 7, 2019 Category: Urology & Nephrology Source Type: research

Multivessel Coronary Revascularization Strategies in Patients with Chronic Kidney Disease: A Meta-Analysis
Conclusions: PCI for patients with CKD and multivessel disease (multivessel CAD) had advantages over CABG with regard to short-term all-cause death and cerebrovascular accidents, but disadvantages regarding the risk of myocardial death, MI, and RR; there was no significant difference in the risk of long-term all-cause death and MACCE. Large randomized controlled trials are needed to confirm our findings.Cardiorenal Med 2019;9:145 –159 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - March 7, 2019 Category: Urology & Nephrology Source Type: research