Cardiometabolic-Renal Disease in South Asians: Consensus Recommendations from the Cardio Renal Society of America
Background: Rates of cardiometabolic-renal disease are extremely high among South Asians (India, Pakistan, Bangladesh, Sri Lanka, Bhutan, the Maldives, and Nepal) residing in their home countries and worldwide. The Cardio Renal Society of America, National Kidney Foundation of Arizona, and Twinepidemic Inc. convened a task force to examine evidence and reach consensus regarding cardiometabolic-renal disease prevention in South Asians. The task force distilled the findings from 5 years of face-to-face and virtual meetings addressing questions derived from expert reviews of published data using the Delphi technique to create...
Source: Cardiorenal Medicine - May 10, 2019 Category: Urology & Nephrology Source Type: research

Community-Acquired Acute Kidney Injury as a Risk Factor of de novo Heart Failure Hospitalization
Conclusion: After controlling for baseline and clinical characteristics, patients with CA-AKI were at approximately twofold the risk of de novo HF hospitalization (within 90, 180, and 365 days) compared with those who did not have CA-AKI. Hence, detecting CA-AKI may provide an opportunity for early intervention at the primary care level to possibly delay HF development.Cardiorenal Med 2019;9:252 –260 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - May 10, 2019 Category: Urology & Nephrology Source Type: research

Survival Advantage of African American Dialysis Patients with End-Stage Renal Disease Causes Related to APOL1
Conclusions: These data suggest the hypothesis that the relative survival advantage of AA dialysis patients may be related toAPOL1 variation. Further large population-based genetic studies are required to test this hypothesis.Cardiorenal Med 2019;9:212 –221 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - April 17, 2019 Category: Urology & Nephrology Source Type: research

Key Updates in Cardio-Nephrology from 2018: Springboard to a Bright Future
Cardiorenal Med 2019;9:222 –228 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - April 17, 2019 Category: Urology & Nephrology Source Type: research

De novo Cardiac Valve Calcification after Hemodialysis in End-Stage Renal Disease Patients Predicts Future Cardiovascular Events: A Longitudinal Cohort Study
Conclusions: De novo CVC is an independent risk factor for MACE in hemodialysis patients, and regular CVC screening among hemodialysis patients without preexisting CVC may be helpful to identify patients at increased risk of adverse cardiovascular outcomes.Cardiorenal Med 2019;9:229 –239 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - April 17, 2019 Category: Urology & Nephrology Source Type: research

Multi-Omics Approach: New Potential Key Mechanisms Implicated in Cardiorenal Syndromes
Cardiorenal syndromes (CRS) include a scenario of clinical interactions characterized by the heart and kidney dysfunction. The crosstalk between cardiac and renal systems is clearly evidenced but not completely understood. Multi-factorial mechanisms leading to CRS do not involve only hemodynamic parameters. In fact, in recent works on organ crosstalk endothelial injury, the alteration of normal immunologic balance, cell death, inflammatory cascades, cell adhesion molecules, cytokine and chemokine overexpression, neutrophil migration, leukocyte trafficking, caspase-mediated induction of apoptotic mechanisms and oxidative st...
Source: Cardiorenal Medicine - April 3, 2019 Category: Urology & Nephrology Source Type: research

Central Venous Stenosis after Hemodialysis: Case Reports and Relationships to Catheters and Cardiac Implantable Devices
We describe two cases of end-stage renal disease patients with CIED and tunneled central venous catheter (CVC) who developed venous cava stenosis: (1) a 70-year-old man with sinus node disease and pacemaker in 2013, CVC, and a Brescia-Cimino forearm fistula in 2015; (2) a 75-year-old woman with previous ventricular arrhythmia with implanted defibrillator in 2014 and CVC in 2016. In either case, after about 1 year from CVC insertion, patients developed superior vena cava (SVC) syndrome due to stenosis diagnosed by axial computerized tomography. In case 1, the patient was not treated by angioplasty of SVC and removed CVC wit...
Source: Cardiorenal Medicine - March 7, 2019 Category: Urology & Nephrology Source Type: research

Multivessel Coronary Revascularization Strategies in Patients with Chronic Kidney Disease: A Meta-Analysis
Conclusions: PCI for patients with CKD and multivessel disease (multivessel CAD) had advantages over CABG with regard to short-term all-cause death and cerebrovascular accidents, but disadvantages regarding the risk of myocardial death, MI, and RR; there was no significant difference in the risk of long-term all-cause death and MACCE. Large randomized controlled trials are needed to confirm our findings.Cardiorenal Med 2019;9:145 –159 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - March 7, 2019 Category: Urology & Nephrology Source Type: research

Calculated Serum Osmolality, Acute Kidney Injury, and Relationship to Mortality after Percutaneous Coronary Intervention
Conclusion: sOsmo is a valid and easily obtainable predictor of AKI after PCI. High sOsmo is associated with increased risk of AKI and 1-year mortality in patients undergoing PCI. Further research is warranted to clarify whether the use of an sOsmo-directed hydration protocol might reduce the incidence of AKI in patients undergoing PCI.Cardiorenal Med 2019;9:160 –167 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - March 7, 2019 Category: Urology & Nephrology Source Type: research

A Novel Fluorescent Clinical Method to Rapidly Quantify Plasma Volume
Conclusions: This minimally invasive fluorescent dye approach safely allowed for rapid, accurate, and reproducible determination of PV, BV, and dynamic monitoring of changes following fluid administration.Cardiorenal Med 2019;9:168 –179 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - March 7, 2019 Category: Urology & Nephrology Source Type: research

Cardiac Abnormalities in Children with Autosomal Recessive Polycystic Kidney Disease
Conclusions: Children with ARPKD show significantly impaired cardiac phenotype, characterized by high rates of LV abnormal geometry paired with systolic mechanical dysfunction.Cardiorenal Med 2019;9:180 –189 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - March 7, 2019 Category: Urology & Nephrology Source Type: research

Grading of Left Ventricular Diastolic Dysfunction with Preserved Systolic Function by the 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging Recommendations Contributes to Predicting Cardiovascular Events in Hemodialysis Patients
Conclusions: In maintenance hemodialysis patients with normal ventricular systolic function, a classification of LVDD by the 2016 ASE/EACVI recommendations may be a useful tool for predicting cardiovascular events.Cardiorenal Med 2019;9:190 –200 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - March 7, 2019 Category: Urology & Nephrology Source Type: research

Customization of Peritoneal Dialysis in Cardiorenal Syndrome by Optimization of Sodium Extraction
Conclusion: While these strategies could help with efficient sodium extraction and volume optimization, future studies are needed to evaluate their impact on the outcomes of this specific patient population.Cardiorenal Med 2019;9:117 –124 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - February 6, 2019 Category: Urology & Nephrology Source Type: research

NT-proBNP in the Prognosis of Death or Need for Renal Replacement Therapy in Patients with Stage 3 –5 Chronic Kidney Disease
Conclusions: NT-proBNP is an independent predictor of mortality in patients with CKD and can also be useful for CV risk stratification in this patient population.Cardiorenal Med 2019;9:125 –134 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - February 6, 2019 Category: Urology & Nephrology Source Type: research

Biomarkers of Inflammation, Fibrosis, and Acute Kidney Injury in Patients with Heart Failure with and without Left Ventricular Assist Device Implantation
Conclusions: The levels of NGAL and adiponectin were augmented in LVAD recipients, suggesting that renal functions were not restored with circulatory support. Larger studies should assess the predictability of these biomarkers of renal dysfunction in LVAD recipients.Cardiorenal Med 2019;9:108 –116 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 30, 2019 Category: Urology & Nephrology Source Type: research

Outcomes of Moderate-to-Severe Acute Kidney Injury following Left Ventricular Assist Device Implantation
Discussion: Risk-stratifying patients prior to LVAD placement in regard to AKI development may be a step toward improving surgical outcomes.Cardiorenal Med 2019;9:100 –107 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 23, 2019 Category: Urology & Nephrology Source Type: research

Prolonged Hyperglycemia and Renal Failure after Primary Percutaneous Coronary Intervention
Conclusion: HbA1c ≥7% was associated with a higher likelihood of AKI in STEMI patients treated with primary PCI.Cardiorenal Med 2019;9:92 –99 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 13, 2019 Category: Urology & Nephrology Source Type: research

Individualized Hemodialysis Treatment: A Perspective on Residual Kidney Function and Precision Medicine in Nephrology
Background: Residual kidney function (RKF) is often expected to inevitably and rapidly decline among hemodialysis patients and, hence, has been inadvertently ignored in clinical practice. The importance of RKF has been revisited in some recent studies. Given that patients with end-stage renal disease now tend to initiate maintenance hemodialysis therapy with higher RKF levels, there seem to be important opportunities for incremental hemo ­dialysis by individualizing the dose and frequency according to their RKF levels. This approach is realigned with precision medicine and patient-centeredness.Summary: In this article,...
Source: Cardiorenal Medicine - December 13, 2018 Category: Urology & Nephrology Source Type: research

Echocardiographic and Hemodynamic Parameters Associated with Diminishing Renal Filtration among Patients with Heart Failure with Preserved Ejection Fraction
Conclusion: Novel hemodynamic indices obtained by RHC may have predictive value for long-term renal dysfunction in patients with HFpEF.Cardiorenal Med 2019;9:83 –91 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - December 13, 2018 Category: Urology & Nephrology Source Type: research

Impaired Left Ventricular Global Longitudinal Strain among Patients with Chronic Kidney Disease and End-Stage Renal Disease and Renal Transplant Recipients
Conclusions: Renal disease proved to be associated with early and subclinical impairment of LV systolic function, which persists after starting dialysis and even in spite of successful kidney transplantation. An increased E/e ’ resulted to be the most powerful independent predictor of abnormal GLS.Cardiorenal Med 2019;9:61 –68 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - November 28, 2018 Category: Urology & Nephrology Source Type: research

In-Hospital Mortality and Major Adverse Cardiovascular Events after Kidney Transplantation in the United States
Conclusion: Despite increases in age at the time of KT, the absolute risk of perioperative MACEs has remained stable from 2004 to 2013. HF is a major component of postoperative MACEs in KT. Malnutrition and pulmonary hypertension are major nontraditional predictors of perioperative MACE outcomes.Cardiorenal Med 2019;9:51 –60 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - November 14, 2018 Category: Urology & Nephrology Source Type: research

Derived Subendocardial Viability Ratio and Cardiovascular Events in Patients with Chronic Kidney Disease
Conclusions: An SEVR #x3c; 130% predicts fatal and non-fatal cardiovascular events in non-dialysis CKD patients.Cardiorenal Med 2019;9:41 –50 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - November 8, 2018 Category: Urology & Nephrology Source Type: research

Enteral Baicalin, a Flavone Glycoside, Reduces Indicators of Cardiac Surgery-Associated Acute Kidney Injury in Rats
Conclusion: Our data indicated that baicalin mediated CPB/CA-induced AKI by decreasing the oxidative stress and inflammation in the renal tissues, and that baicalin possesses the potential to be developed as a therapeutic tool in clinical use for CSA-AKI.Cardiorenal Med 2019;9:31 –40 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - November 8, 2018 Category: Urology & Nephrology Source Type: research

Early Left Ventricular Dysfunction Detected by Speckle Tracking in Long-Term Hemodialysis Patients with Valvular Calcification
Conclusions: Cardiac VC diagnosed by echocardiography when it occurs in long-term hemodialysis patients may indicate more severe LVH, myocardial damage, and worse heart function in comparison to those without VC. Tissue Doppler imaging and 2D-STE can detect the subtle change of heart function in this population in the early stage of LV dysfunction when LVEF is normal.Cardiorenal Med 2019;9:22 –30 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 31, 2018 Category: Urology & Nephrology Source Type: research

Chronic Hyperkalemia in Cardiorenal Patients: Risk Factors, Diagnosis, and New Treatment Options
Chronic hyperkalemia (HK) is a serious medical condition that often manifests in patients with chronic kidney disease (CKD) and heart failure (HF) leading to poor outcomes and necessitating careful management by cardionephrologists. CKD, HF, diabetes, and renin-angiotensin-aldosterone system inhibitors use is known to induce HK. Current therapeutic options are not optimal, as pointed out by a large number of CKD and HF patients with HK. The following review will focus on the main risk factors for developing HK and also aims to provide a guide for a correct diagnosis and present new approaches to therapy.Cardiorenal Med 201...
Source: Cardiorenal Medicine - October 25, 2018 Category: Urology & Nephrology Source Type: research

Acknowledgement to the Reviewers
Cardiorenal Med 2018;8:340 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 10, 2018 Category: Urology & Nephrology Source Type: research

Contents Vol. 8, 2018
Cardiorenal Med 2018;8:I –V (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 10, 2018 Category: Urology & Nephrology Source Type: research

Impact of KDIGO-Defined Acute Kidney Injury on Mortality after Percutaneous Coronary Intervention for Acute Myocardial Infarction
Conclusion: A slight increase in serum creatinine was associated with a progressive increase in long-term mortality in patients with AKI according to the KDIGO definition.Cardiorenal Med 2018;8:332 –339 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - September 17, 2018 Category: Urology & Nephrology Source Type: research

Hepatorenal Syndrome or Hepatocardiorenal Syndrome: Revisiting Basic Concepts in View of Emerging Data
Background: Accumulating evidence on the pathophysiology of hepatorenal syndrome has challenged the conventional model of liver-kidney connection. While liver cirrhosis is traditionally considered the origin of a cascade of pathophysiologic mechanisms directly affecting other organs such as the kidney, emerging data point to the heart as the potential mediator of the untoward renal effects.Summary: Herein, we briefly review the often-overlooked contribution of the heart to circulatory dysfunction in hepatorenal syndrome and put forward evidence arguing for the involvement of systemic inflammation and endothelial dysfunctio...
Source: Cardiorenal Medicine - September 17, 2018 Category: Urology & Nephrology Source Type: research

Levels of Proinflammatory Cytokines, Oxidative Stress, and Tissue Damage Markers in Patients with Acute Heart Failure with and without Cardiorenal Syndrome Type 1
Conclusion: Patients affected by CRS type 1 present increased levels of proinflammatory cytokines and oxidative stress markers, increased levels of tissue damage markers, and lower hemoglobin levels. All these factors may be implicated in the pathophysiology of CRS type 1 syndrome.Cardiorenal Med 2018;8:321 –331 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - September 11, 2018 Category: Urology & Nephrology Source Type: research

Urine Cofilin-1 Detection for Predicting Type 1 Cardiorenal Syndrome in the Coronary Care Unit: A Gold Nanoparticle- and Laser-Based Approach
Conclusions: The gold nanoparticle-based immunoassay LSPCFB could exploit the potential of urine cofilin-1 as a single biomarker to predict CRS among CCU patients.Cardiorenal Med 2018;8:302 –310 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - August 17, 2018 Category: Urology & Nephrology Source Type: research

Relationship between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and Estimated Glomerular Filtration Rate in the General Chinese Population
Conclusion: In this single-center study with moderate sample size, the data showed no relationship of PCSK9 levels with normal or decreased eGFR in untreated patients with normal SCr, suggesting that further studies may be needed to understand the relationship between PCSK9 and lipid disorder in different stage of kidney dysfunction.Cardiorenal Med 2018;8:311 –320 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - August 17, 2018 Category: Urology & Nephrology Source Type: research

Cardionephrology: Proposal for a Futuristic Educational Approach to a Contemporary Need
The field of cardiorenal medicine is vast, rapidly expanding, and complex. Conventional nephrology training programs provide the fellows with the necessary core knowledge to provide general care for patients with renal and cardiovascular diseases. However, there is a need for focused training of interested physicians to master the specialized aspects of these exceedingly common clinical scenarios and optimize the care of such patients. A cardionephrology-focused training can add value to the nephrology subspecialty and potentially increase its attractiveness for a significant subset of trainees. Herein, we provide a propos...
Source: Cardiorenal Medicine - August 8, 2018 Category: Urology & Nephrology Source Type: research

Detection of Atherosclerotic Cardiovascular Disease in Patients with Advanced Chronic Kidney Disease in the Cardiology and Nephrology Communities
Conclusions: The survey results reveal a lack of consensus among providers caring for patients with advanced CKD about the management of ASCVD in this setting. Future randomized controlled trials will be needed to better inform the clinical management of ASCVD in these patients. The limitations of the study include its small sample size and the relatively low response rate among the respondents.Cardiorenal Med 2018;8:285 –295 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - August 3, 2018 Category: Urology & Nephrology Source Type: research

Hyponatremia in Acute Heart Failure in Relation to Hematocrit Levels: Clinical Relevance and Prognostic Implication
Conclusions: Low hematocrit levels in AHF patients with hyponatremia characterize a population that is more difficult to decongest and has poor clinical outcome. In contrast, patients with hyponatremia but normal hematocrit are better decongested and have better short-term outcome.Cardiorenal Med 2018;8:259 –270 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - July 25, 2018 Category: Urology & Nephrology Source Type: research

Left Ventricular Strain and Dyssynchrony in Young and Middle-Aged Peritoneal Dialysis Patients and Healthy Controls: A Case-Matched Study
Conclusions: Despite preserved LVEF, young and middle-aged PD patients developed LV dysfunction and myocardial systolic dyssynchrony earlier compared with controls.Cardiorenal Med 2018;8:271 –284 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - July 25, 2018 Category: Urology & Nephrology Source Type: research

CXCL12 in Patients with Chronic Kidney Disease and Healthy Controls: Relationships to Ambulatory 24-Hour Blood Pressure and Echocardiographic Measures
Conclusions: The results of our study point towards a link between CXCL12 and LVH as well as blood pressure control among patients with CKD, supporting the thesis that CXCL12 may be regarded as a new potential uremic toxin.Cardiorenal Med 2018;8:249 –258 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - July 18, 2018 Category: Urology & Nephrology Source Type: research

Plasma Level of Retinol-Binding Protein 4, N-Terminal proBNP and Renal Function in Older Patients Hospitalized for Heart Failure
Conclusion: Our results show that RBP4 is affected by GFR but cannot be considered as an independent biomarker of heart muscle dysfunction.Cardiorenal Med 2018;8:237 –248 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - July 4, 2018 Category: Urology & Nephrology Source Type: research

Differential Impact of Chronic Kidney Disease on Coronary Calcification and Atherosclerosis in Asymptomatic Individuals with or without Diabetes: Analysis from a Coronary Computed Tomographic Angiography Registry
Conclusions: The presence of CKD did not have a significant impact on the development of coronary atherosclerosis, but affected the progression of coronary calcification more markedly from the stage of moderate CKD in nondiabetics. However, in diabetics, the deterioration of renal function was significantly associated with the development of coronary atherosclerosis and calcification from the stage of mild CKD.Cardiorenal Med 2018;8:228 –236 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 29, 2018 Category: Urology & Nephrology Source Type: research

Metabolic Syndrome and the Iodine-Dose/Creatinine Clearance Ratio as Determinants of Contrast-Induced Acute Kidney Injury
Conclusions: We showed that MetS is a strong risk factor for CI-AKI in nondiabetic patients undergoing elective coronary interventions; and the I-dose/CrCl ratio is a strong predictor of CI-AKI in these patients. We suggest that clinicians identify MetS patients and calculate their I-dose/CrCl ratio before coronary interventions.Cardiorenal Med 2018;8:217 –227 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 15, 2018 Category: Urology & Nephrology Source Type: research

Determinants of Monocyte Apoptosis in Cardiorenal Syndrome Type 1
Conclusion: CRS type 1 induces dual apoptotic pathway activation in monocytes; the two pathways converged on caspase-3. Many factors may induce activation of both intrinsic and extrinsic apoptotic pathways in CRS type 1 patients, such as upregulation of proinflammatory cytokines and hypoxia/ischemia. Further investigations are necessary to corroborate the present findings, and to better understand the pathophysiological mechanism and consequent therapeutic and prognostic implications for CRS type 1.Cardiorenal Med 2018;8:208 –216 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - May 30, 2018 Category: Urology & Nephrology Source Type: research

Epicardial Fat Thickness in Patients with Autosomal Dominant Polycystic Kidney Disease
Conclusion: Our data showed that EAT was higher in ADPKD patients than in EH subjects and independently correlated with LVMi. EAT measurement can be a useful marker for the cardiovascular risk stratification in ADPKD.Cardiorenal Med 2018;8:199 –207 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - May 4, 2018 Category: Urology & Nephrology Source Type: research

Revascularization versus Medical Management of Coronary Artery Disease in Prerenal Transplant Patients: A Meta-Analysis
Introduction: End-stage renal disease requiring renal transplantation comprises a growing patient population at risk for cardiovascular disease (CVD) morbidity and mortality in large part due to accelerated atherosclerosis. Consequently, these patients are at even higher risk of major surgical CVD mortality. A paucity of research has addressed the posttransplantation CVD outcomes related to different treatment strategies in this patient population and therefore, there are no specific preoperative guidelines regarding management of coronary artery disease in this high-risk population undergoing renal transplantation.Objecti...
Source: Cardiorenal Medicine - May 2, 2018 Category: Urology & Nephrology Source Type: research

ω-3 Polyunsaturated Fatty Acid Postconditioning Protects the Isolated Perfused Rat Heart from Ischemia-Reperfusion Injury
Conclusion:ω-3 PUFA postconditioning possesses good cardioprotective effects and may be developed into a therapeutic strategy for myocardial I/R injury.Cardiorenal Med 2018;8:173 –182 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - April 11, 2018 Category: Urology & Nephrology Source Type: research

Pulmonary Catherization Data Correlate Poorly with Renal Function in Heart Failure
Conclusion: These findings suggest that, as assessed by pulmonary artery catherization, none of the factors – PCWP, PASP, PADP, or CI – play a prominent role in cardiorenal syndromes.Cardiorenal Med 2018;8:183 –191 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - April 11, 2018 Category: Urology & Nephrology Source Type: research

Preeclampsia as a Form of Type 5 Cardiorenal Syndrome: An Underrecognized Entity in Women ’s Cardiovascular Health
Background: Preeclampsia is a multisystem vascular disorder of pregnancy that remains a leading cause of maternal and fetal morbidity and mortality. Preeclampsia remains an underrecognized risk factor for future cardiovascular and kidney disease in women and represents the confluence of preexisting vascular risk factors with superimposed endothelial injury from placental mediated anti-angiogenic factors.Summary: This review highlights the close relationship between preeclampsia and future cardiovascular and kidney disease. It describes the pathophysiology and current understanding of biomarkers that form the molecular sign...
Source: Cardiorenal Medicine - April 4, 2018 Category: Urology & Nephrology Source Type: research

Impact of Chronic Kidney Disease on Cardiovascular and Renal Events in Patients Undergoing Percutaneous Coronary Intervention with Everolimus-Eluting Stent: Risk Stratification with C-Reactive Protein
Conclusion: CKD combined with CRP predicted more clinical events in patients undergoing PCI with EES.Cardiorenal Med 2018;8:151 –159 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - March 28, 2018 Category: Urology & Nephrology Source Type: research

Personalized Statin Therapy and Coronary Atherosclerotic Plaque Burden in Asymptomatic Low/Intermediate-Risk Individuals
Conclusion: These findings suggest that individuals with higher coronary plaque burden are more likely to get greater benefit from statin therapy even among asymptomatic individuals with low cardiovascular risk.Cardiorenal Med 2018;8:140 –150 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - March 26, 2018 Category: Urology & Nephrology Source Type: research

lncRNA UCA1 Is a Novel Regulator in Cardiomyocyte Hypertrophy through Targeting the miR-184/HOXA9 Axis
Cardiac hypertrophy is closely associated with a series of cardiovascular diseases, including heart failure and sudden death in particular. An in-depth comprehension of the pathogenesis of cardiac hypertrophy will improve the diagnosis and therapy of cardiac hypertrophy. It has been acknowledged that long noncoding RNAs/microRNAs (lncRNAs/miRNAs) are crucial regulators in diverse biological processes, including various cardiovascular diseases, in multiple manners. Nevertheless, the biological roles of lncRNA UCA1 and miR-184 in cardiac hypertrophy are scarcely reported. In this paper, qRT-PCR analysis exhibited that lncRNA...
Source: Cardiorenal Medicine - March 21, 2018 Category: Urology & Nephrology Source Type: research

High Right Ventricular Stroke Work Index Is Associated with Worse Kidney Function in Patients with Heart Failure with Preserved Ejection Fraction
Conclusion: High right ventricular workload indicated by high RVSWI is associated with worse renal function in patients with Cpc-PH. Further prospective studies are needed to better understand this association.Cardiorenal Med 2018;8:123 –129 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - February 28, 2018 Category: Urology & Nephrology Source Type: research