Fulminant Acute Kidney Injury in a Young Patient with Novel Coronavirus 2019
Coronavirus disease 2019 (COVID-19) is a global pandemic affecting more than 200 countries and 180,000 cases in the United States. While the outbreak began in China, the number of cases outside of China exceeded those in China on March 15, 2020 and are currently rising at an exponential rate. The number of fatalities in the United States are expected to exceed more than Italy and China. The disease is characterized predominantly as an acute respiratory illness. However, preliminary data suggests that kidney is a target for the virus and deterioration of renal function was associated with poor outcomes including in-hospital...
Source: Cardiorenal Medicine - May 6, 2020 Category: Urology & Nephrology Source Type: research
Adverse Drug Reactions during Real-Life Use of Direct Oral Anticoagulants in Italy: An Update Based on Data from the Italian National Pharmacovigilance Network
Conclusions from these studies are inconsistent and unsatisfactory. The evaluation of self-reported adverse drug reactions (ADR) available from databases of drug-regulatory agencies such as the Italian Medicines Agency (AIFA) pharmacovigilance database represents a novel aid to guide decision-making.Objective: To analyze potential suspected ADR of DOAC using a previously described risk index (RI) in daily clinical practice in Italy.Methods: The National Pharmacovigilance Network database (from the AIFA website) was searched in order to retrieve information on all ADR related to oral anticoagulants occurring from 2013 to 20...
Source: Cardiorenal Medicine - April 30, 2020 Category: Urology & Nephrology Source Type: research
Neurohormonal, Endocrine, and Immune Dysregulation and Inflammation in Cardiorenal Syndrome
“Organ crosstalk” is the complex physiological communication between different body systems, and it is necessary for the optimal equilibrium and functioning of the organism. In particular, heart and kidney function is tightly connected, and interplay between these two organs occurs through a vas t array of dynamic and bidirectional mechanisms. The term cardiorenal syndrome (CRS) indicates an interaction between the heart and kidneys in acute and chronic disease settings. In all types of CRS, multiple pathophysiological processes are implicated in the initiation and progression of organ inju ry. In addition to hemodynam...
Source: Cardiorenal Medicine - July 2, 2019 Category: Urology & Nephrology Source Type: research
Echocardiographic Findings in Patients with Mild to Moderate Chronic Kidney Disease without Symptomatic Heart Failure: A Population-Based Study
Conclusion: A significant association between mild to moderate impairment of renal function and echocardiographic markers of cardiac structure and diastolic function was observed, supporting the hypothesis that interaction between the kidney and heart exists even in the early stages of renal impairment.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 25, 2019 Category: Urology & Nephrology Source Type: research
Loss of the Normal Gradient in Arterial Compliance and Outcomes of Chronic Kidney Disease Patients
Conclusions: The PWV ratio, as a measure of loss of the normal gradient in arterial compliance, was associated with CKD patient outcome. Patients with advanced CKD and a higher PWV ratio had a significantly higher risk of adverse CKD outcome.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 25, 2019 Category: Urology & Nephrology Source Type: research
Plasma Lipopolysaccharide Concentrations in Cardiorenal Syndrome Type 1
Conclusion: CRS type 1 patients present with an increased level of LPS and there is a direct correlation between LPS and renal parameters. This pilot research is the first study to explore the premise of LPS as novel pathophysiological factor in CRS type 1.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 25, 2019 Category: Urology & Nephrology Source Type: research
Initial Concentrations of miR-1 MicroRNA Precursor and High-Sensitivity Troponin in the Diagnosis of Non-ST Myocardial Infarction among Patients with and Those without Chronic Kidney Disease
Conclusion: Circulating microRNA-1 is capable of early diagnosis of NSTEMI in patients with CKD suffering from chest pain.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 24, 2019 Category: Urology & Nephrology Source Type: research
< b > < i > APOL1 < /i > < /b > and Mortality in Patients on Dialysis
Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 11, 2019 Category: Urology & Nephrology Source Type: research
Effects of Bardoxolone Methyl on Magnesium in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease
Conclusions: Bard treatment results in significant decreases in serum magnesium that are not associated with changes in intracellular and urinary magnesium levels, indicating that magnesium decreases are not due to renal magnesium wasting or total body magnesium depletion. Importantly, the decreases in serum magnesium with Bard are not associated with adverse effects on QT interval.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 6, 2019 Category: Urology & Nephrology Source Type: research
Effects of Bardoxolone Methyl on QT Interval in Healthy Volunteers
Conclusions: In healthy subjects, treatment with 20 or 80 mg bardoxolone methyl did not affect the QTcF interval.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 3, 2019 Category: Urology & Nephrology Source Type: research
Cardiometabolic-Renal Disease in South Asians: Consensus Recommendations from the Cardio Renal Society of America
Background: Rates of cardiometabolic-renal disease are extremely high among South Asians (India, Pakistan, Bangladesh, Sri Lanka, Bhutan, the Maldives, and Nepal) residing in their home countries and worldwide. The Cardio Renal Society of America, National Kidney Foundation of Arizona, and Twinepidemic Inc. convened a task force to examine evidence and reach consensus regarding cardiometabolic-renal disease prevention in South Asians. The task force distilled the findings from 5 years of face-to-face and virtual meetings addressing questions derived from expert reviews of published data using the Delphi technique to create...
Source: Cardiorenal Medicine - May 10, 2019 Category: Urology & Nephrology Source Type: research
Community-Acquired Acute Kidney Injury as a Risk Factor of de novo Heart Failure Hospitalization
Conclusion: After controlling for baseline and clinical characteristics, patients with CA-AKI were at approximately twofold the risk of de novo HF hospitalization (within 90, 180, and 365 days) compared with those who did not have CA-AKI. Hence, detecting CA-AKI may provide an opportunity for early intervention at the primary care level to possibly delay HF development.Cardiorenal Med 2019;9:252 –260 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - May 10, 2019 Category: Urology & Nephrology Source Type: research
Survival Advantage of African American Dialysis Patients with End-Stage Renal Disease Causes Related to APOL1
Conclusions: These data suggest the hypothesis that the relative survival advantage of AA dialysis patients may be related toAPOL1 variation. Further large population-based genetic studies are required to test this hypothesis.Cardiorenal Med 2019;9:212 –221 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - April 17, 2019 Category: Urology & Nephrology Source Type: research
Key Updates in Cardio-Nephrology from 2018: Springboard to a Bright Future
Cardiorenal Med 2019;9:222 –228 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - April 17, 2019 Category: Urology & Nephrology Source Type: research
De novo Cardiac Valve Calcification after Hemodialysis in End-Stage Renal Disease Patients Predicts Future Cardiovascular Events: A Longitudinal Cohort Study
Conclusions: De novo CVC is an independent risk factor for MACE in hemodialysis patients, and regular CVC screening among hemodialysis patients without preexisting CVC may be helpful to identify patients at increased risk of adverse cardiovascular outcomes.Cardiorenal Med 2019;9:229 –239 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - April 17, 2019 Category: Urology & Nephrology Source Type: research
